Phantom, volunteer, and patient scans were performed on GE 1.5T TwinSpeed and 3.0T VH/i (HDx, GE Healthcare, Waukesha, WI) MRI systems. Informed consent and permission from our Institutional Review Board (IRB) were obtained for all human scanning. Images were collected using a 2D fast spin-echo (FSE) sequence and a 3D spoiled gradient echo (SPGR) sequence modified for use with the IDEAL method (6 (link),35 (link)). The echo times that maximize the SNR performance for conventional 3-pt water-fat separation were used for 3-pt IDEAL scans. (6 (link),35 (link),36 (link)). In addition, a multi-echo 3D-SPGR pulse sequence was used to collect 6-pt images for simultaneous separation of water, fat and T2* using the T2*-IDEAL reconstruction (26 (link)).
Imaging was performed with a variety of applications to demonstrate the improved water-fat decomposition using MP-IDEAL, including knee, ankle, breast, spine, brachial plexus, pelvis and abdominal scans. For each dataset, three online reconstructions were performed using the same source data: conventional IDEAL reconstruction with no multipeak correction, MP-IDEAL using a pre-calibrated spectrum (pre-calibrated MP-IDEAL) and MP-IDEAL using the self-calibrated spectrum (self-calibrated MP-IDEAL). T2*-IDEAL and its multipeak reconstruction was used in the case of 6-pt acquisitions. Images from the three reconstructions were compared and the residual fat signal in the water images was examined as a measure of fat suppression. Contrast-to-Noise ratios (CNRs) were obtained in one knee scan to quantify the contrast improvement. Residue maps were also created to visualize and compare the goodness of fit for different methods. In addition, a region growing algorithm was applied in all reconstructions to avoid water-fat swapping (34 (link)).
Imaging was performed with a variety of applications to demonstrate the improved water-fat decomposition using MP-IDEAL, including knee, ankle, breast, spine, brachial plexus, pelvis and abdominal scans. For each dataset, three online reconstructions were performed using the same source data: conventional IDEAL reconstruction with no multipeak correction, MP-IDEAL using a pre-calibrated spectrum (pre-calibrated MP-IDEAL) and MP-IDEAL using the self-calibrated spectrum (self-calibrated MP-IDEAL). T2*-IDEAL and its multipeak reconstruction was used in the case of 6-pt acquisitions. Images from the three reconstructions were compared and the residual fat signal in the water images was examined as a measure of fat suppression. Contrast-to-Noise ratios (CNRs) were obtained in one knee scan to quantify the contrast improvement. Residue maps were also created to visualize and compare the goodness of fit for different methods. In addition, a region growing algorithm was applied in all reconstructions to avoid water-fat swapping (34 (link)).