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> Anatomy > Body Location or Region > Oropharynxs

Oropharynxs

The oropharynx is the middle part of the pharynx located behind the mouth.
It is responsible for swallowing and includes the soft palate, tonsils, and base of the tongue.
Reseach on the oropharynx can provide insights into various physiological and pathological processes, such as respiratory function, swallowing disorders, and infections.
PubCompare.ai can help optimize your oropharynx research by surfacing relevant literature, preprints, and patents, and using AI-powered comparisons to identify the most reproducible and accurate methods.
Improve the quality and reliability of your oropharynx studies with this innovative platform.

Most cited protocols related to «Oropharynxs»

1
CT Imaging of COVID-19 Patients in China
Cited 75 times
Our institutional review board waived the requirement to obtain written informed consent for this retrospective case series, which evaluated de-identified data and involved no potential risk to patients. To avert any potential breach of confidentiality, no link between the patients and the researchers was made available.
From January 18, 2020, until January 27, 2020, 21 patients admitted to three hospitals in three provinces in China with confirmed 2019-nCoV underwent chest CT. Ten patients were from Zhuhai (Guangdong Province) and were imaged with 1-mm-thick slices with a UCT 760 scanner (United Imaging, Shanghai, China). Nine patients were from Nanchang (Jiangxi Province) and were imaged with 8-mm-thick slices with an Emotion 16 scanner (Siemens Healthineers, Erlangen, Germany). Two patients were from Qingdao (Shandong Province) and were imaged with 5-mm-thick slices, one with a BrightSpeed scanner (GE Medical Systems, Milwaukee, Wis) and one with an Aquilion ONE scanner (Toshiba Medical Systems, Tokyo, Japan). All scans were obtained with the patient in the supine position during end-inspiration without intravenous contrast material. All patients were positive for 2019-nCov at laboratory testing of respiratory secretions obtained by means of bronchoalveolar lavage, endotracheal aspirate, nasopharyngeal swab, or oropharyngeal swab.
Patient selection for this study was consecutive in each of the three institutions, and no exclusion criteria were applied (Table 1). In addition to age and sex, clinical information collected included severity and time course of symptoms as well as travel and exposure history.
Chung M., Bernheim A., Mei X., Zhang N., Huang M., Zeng X., Cui J., Xu W., Yang Y., Fayad Z.A., Jacobi A., Li K., Li S, & Shan H. (2020). CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV). Radiology.
Publication 2020
Bronchoalveolar Lavage Chest Contrast Media Emotions Ethics Committees, Research Inhalation Nasopharynx Oropharynxs Patients Radionuclide Imaging Respiratory Rate SARS-CoV-2 Secretions, Bodily
2
Comprehensive Head and Neck Cancer Cell Panel
Cited 28 times
A panel of 122 human head and neck cell lines was assembled from a number of different researchers, institutions, and suppliers. This panel was chosen to represent each of the major HNSCC sites: oral cavity, oropharynx, hypopharynx, and larynx. Also chosen for study were anaplastic and papillary thyroid cancer, adenoid cystic carcinoma cell lines, and cell lines derived from lymph node metastases. In some cases isogenic cell line pairs were obtained, which included cells derived from both the primary tumor and lymph node metastases from the same patient. Also included were cell lines from cutaneous SCC, leukoplakia, immortalized primary keratinocytes, and normal epithelium.
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.E, & Myers J.N. (2011). Assembly And Initial Characterization Of A Panel Of 85 Genomically Validated Cell Lines From Diverse Head And Neck Tumor Sites. Clinical cancer research : an official journal of the American Association for Cancer Research, 17(23), 7248-7264.
Publication 2011
Adenoid Cystic Carcinoma Anaplasia Cell Lines Cells Epithelium Head Homo sapiens Hypopharynx Keratinocyte Larynx Leukoplakia Lymph Node Metastasis Neck Neoplasms Oral Cavity Oropharynxs Papillary Thyroid Carcinoma Patients Skin Squamous Cell Carcinoma of the Head and Neck
3
Lopinavir-Ritonavir for COVID-19 Monitoring
Cited 21 times
Patients were assessed once daily by trained nurses using diary cards that captured data on a seven-category ordinal scale and on safety from day 0 to day 28, hospital discharge, or death. Safety was monitored by the Good Clinical Practice office from Jin Yin-tan Hospital. Other clinical data were recorded using the WHO-ISARIC (World Health Organization–International Severe Acute Respiratory and Emerging Infections Consortium) case record form (https://isaric.tghn.org).16 Serial oropharyngeal swab samples were obtained on day 1 (before lopinavir–ritonavir was administered) and on days 5, 10, 14, 21, and 28 until discharge or death had occurred and were tested at Teddy Clinical Research Laboratory (Tigermed–DiAn Joint Venture), using quantitative real-time RT-PCR (see the Supplementary Appendix). RNA was extracted from clinical samples with the MagNA Pure 96 system, detected and quantified by Cobas z480 qPCR (Roche), with the use of LightMix Modular SARS-CoV-2 (COVID19) assays (TIB MOBIOL). These samples were obtained for all 199 patients who were still alive at every time point. Sampling did not stop when a swab at a given time point was negative. Baseline throat swabs were tested for detection of E gene, RdRp gene, and N gene, and samples on the subsequent visits were quantitatively and qualitatively detected for E gene. Clinical data were recorded on paper case record forms and then double-entered into an electronic database and validated by trial staff.
Cao B., Wang Y., Wen D., Liu W., Wang J., Fan G., Ruan L., Song B., Cai Y., Wei M., Li X., Xia J., Chen N., Xiang J., Yu T., Bai T., Xie X., Zhang L., Li C., Yuan Y., Chen H., Li H., Huang H., Tu S., Gong F., Liu Y., Wei Y., Dong C., Zhou F., Gu X., Xu J., Liu Z., Zhang Y., Li H., Shang L., Wang K., Li K., Zhou X., Dong X., Qu Z., Lu S., Hu X., Ruan S., Luo S., Wu J., Peng L., Cheng F., Pan L., Zou J., Jia C., Wang J., Liu X., Wang S., Wu X., Ge Q., He J., Zhan H., Qiu F., Guo L., Huang C., Jaki T., Hayden F.G., Horby P.W., Zhang D, & Wang C. (2020). A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19. The New England Journal of Medicine.
Publication 2020
Biological Assay COVID 19 Genes Infection lopinavir-ritonavir drug combination Nurses Oropharynxs Patient Discharge Patients Pharynx Real-Time Polymerase Chain Reaction Respiratory Rate Safety SARS-CoV-2
4
COVID-19 Virus Isolation from Patients
Cited 18 times
Virus isolation from patient samples was deemed not to be human subjects research by the National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention (CDC) (research determination no. 0900f3eb81ab4b6e). Clinical specimens from a case-patient who had acquired COVID-19 during travel to China and who was identified in Washington, USA, were collected as described (1 (link)). Nasopharyngeal (NP) and oropharyngeal (OP) swab specimens were collected on day 3 postsymptom onset, placed in 2–3 mL of viral transport medium, used for molecular diagnosis, and frozen. Confirmed PCR-positive specimens were aliquoted and refrozen until virus isolation was initiated.
Harcourt J., Tamin A., Lu X., Kamili S., Sakthivel S.K., Murray J., Queen K., Tao Y., Paden C.R., Zhang J., Li Y., Uehara A., Wang H., Goldsmith C., Bullock H.A., Wang L., Whitaker B., Lynch B., Gautam R., Schindewolf C., Lokugamage K.G., Scharton D., Plante J.A., Mirchandani D., Widen S.G., Narayanan K., Makino S., Ksiazek T.G., Plante K.S., Weaver S.C., Lindstrom S., Tong S., Menachery V.D, & Thornburg N.J. (2020). Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States. Emerging Infectious Diseases, 26(6), 1266-1273.
Full text: Click here
Publication 2020
COVID 19 Freezing Immunization isolation Molecular Diagnostics Nasopharynx Oropharynxs Patient Isolation Patients Respiration Disorders Virus
5
Isolation of Primary Human Epithelial Cells
Cited 16 times
Primary human epidermal and cervical keratinocytes were isolated from fresh surgical specimens. Primary esophageal and oropharyngeal epithelial cells were obtained from commercial sources. Primary human skin and cervix fibroblasts were obtained from fresh surgical specimens.
Ridky T.W., Chow J.M., Wong D.J, & Khavari P.A. (2010). Invasive 3-Dimensional Organotypic Neoplasia from Multiple Normal Human Epithelia. Nature medicine, 16(12), 1450-1455.
Publication 2010
Cervix Uteri Epidermis Epithelial Cells Fibroblasts Homo sapiens Keratinocyte Neck Operative Surgical Procedures Oropharynxs Skin

Most recents protocols related to «Oropharynxs»

1
Influenza A Dynamics in Dog Oropharynx
Not available on PMC !

Example 13

Influenza A nucleoprotein was detected in the oropharyngeal swab collected from one of the virus-inoculated dogs at 24 hours p.i. The oropharyngeal swabs collected from one dog at 72, 84, and 120 hours p.i., and another dog at 108, 120, and 132 hours p.i., were positive for virus by quantitative real-time RT-PCR (Table 11). The absolute number of influenza M gene copies per μL of swab extract increased with time from 3 to 6 days p.i. No virus was detected in the rectal swabs.

US11865172B2. Materials and methods for respiratory disease control in canines (2024-01-09). UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. [US], CORNELL RESEARCH FOUNDATION, INC. [US], The Government of The United States of America as represented by The Secretary of the Department of [US]. Inventors: Patti Cynthia Crawford [US], Paul J. Gibbs [US], Edward J. Dubovi [US], Ruben Omar Donis [US], Jacqueline Katz [US], Alexander I. Klimov [US], Nallakannu P. Lakshmanan [US], Melissa Anne Lum [US], Daniel Ghislena Emiel Goovaerts [NL], Mark William Mellencamp [US], Nancy J. Cox [US], William L. Castleman [US].
Full text: Click here
Patent 2024
Genes Influenza Influenza A virus nucleoprotein, Measles virus Oropharynxs Real-Time Polymerase Chain Reaction Rectum Virus
2
ORGAVADS: Surgical Resectable HNSCC
Eligibility criteria are described in Table 1. The ORGAVADS study focuses on patients with surgically resectable HNSCC who undergo surgery at François Baclesse Center and Caen University Hospital Center. After patient screening according to criteria, and the patient’s non-opposition, the patient will be enrolled in the study. An identification number will be thus assigned to each patient to be used throughout the study.

ORGAVADS study inclusion and exclusion criteria

Inclusion criteriaNon-inclusion criteria
Patient  ≥ 18 yearsPregnant women
Histologically confirmed squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx or larynxPatient deprived of liberty or placed under the authority of a tutor
Patients for whom oncologic surgery is planned or who have recently undergone surgery of the tumor of oral cavity, oropharynx, hypopharynx or larynx
Subject affiliated to a social security regimen
No opposition to participate to the study
Perréard M., Florent R., Divoux J., Grellard J.M., Lequesne J., Briand M., Clarisse B., Rousseau N., Lebreton E., Dubois B., Harter V., Lasne-Cardon A., Drouet J., Johnson A., Le Page A.L., Bazille C., Jeanne C., Figeac M., Goardon N., Vaur D., Micault E., Humbert M., Thariat J., Babin E., Poulain L., Weiswald L.B, & Bastit V. (2023). ORGAVADS: establishment of tumor organoids from head and neck squamous cell carcinoma to assess their response to innovative therapies. BMC Cancer, 23, 223.
Full text: Click here
Publication 2023
Eligibility Determination Hypopharynx Mouth Neoplasms Operative Surgical Procedures Oropharynxs Patients Squamous Cell Carcinoma of the Head and Neck Squamous Cell Carcinoma of the Mouth
3
Biodistribution of Fluorescent Aptamer in Mice

Protocol full text hidden due to copyright restrictions

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Publication 2023
BLOOD Brain Descending Aorta Drainage Fluorescence Freezing Gravity Heart Ketamine Kidney Liver Lung Microscopy Mus Nitrogen Oropharynxs Plasma Retention (Psychology) Reverse Transcriptase Polymerase Chain Reaction Spleen Sucrose Tissues Trachea Xylazine
4
Assessing Lung Injury and Inflammation in Mice

Protocol full text hidden due to copyright restrictions

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Publication 2023
Albumins Anesthesia Animals Cytokine Diet Eosin Eucalyptus Food Histones Inhalation Injections, Intraperitoneal Injuries Institutional Animal Care and Use Committees Isoflurane Ketamine Lung Lung Injury Males Mice, Inbred C57BL Mus Obstetric Delivery Oropharynxs physiology Rivers Rodent Saline Solution Smoke Tissue Harvesting Xylazine
5
Upscaling Cervical Cancer Screening and Treatment for WLWH in Tanzania
This is a before-and after study to evaluate the impact and feasibility of upscaling CC screening and treatment services for WLWH attending a rural referral CTC in Tanzania. The main objective is to evaluate the uptake by WLWH attending screening after implementation of HPV testing on a self-sampled cervico-vaginal smear, compared to a retrospective cohort screened by VIA. HPV testing has been implemented in a bundle with: a) a smartphone integrating a mobile colposcope (EVA system, Mobile ODT, Israel) for digital enhancement of VIA examination with cervix magnification and second look/quality control; b) thermal ablation in place of cryotherapy (thus avoiding the need for replenishing nitrogen gas cartridges); and c) LEEP.
We adopted an uncontrolled before-and-after design to compare proportion of WLWH attending screening before and after implementing mentioned interventions. A sub-study with cross-sectional design aims to explore diagnostic performance of two novel tests: the first, QuantiGene-Molecular-Profiling-Histology (QG-MPH), is based on transcriptomic biomarker analysis, while the second is a serological assay to detect antibodies against HPV16-L1 [29 (link)], either with a qualitative (Prevo-Check®) or quantitative (PT Monitor®) approach (Table 1. Supplementary material Annex A1 and A2). Further objectives are to determine the adherence to recommendations after screening, to assess the prevalence of HPV genotype-specific infection as well as other co-infections, and to assess feasibility, acceptability and costs of the new implemented screening and treatment plan.

Novel assays

TestNameTargetDescription
Lateral Flow Assay (LFA)PT Monitor® (Abviris GmbH, Germany)HPV16-L1 AbBlood-based (serum) competitive immunoassay assessing the presence of epitope-specific antibodies against HPV16-L1. Elevated levels of these antibodies are associated with the presence of HPV16-induced cancer or pre-cancer. A quantitative readout is possible with an optical table-top reader (aLF reader by Qiagen, Germany). CE-marked IVD
Rapid Lateral Flow Assay (rLFA)Prevo-Check® (Abviris GmbH, Germany)HPV16-L1 AbQualitative (yes/no) output of LFA (PT Monitor®) in form of rapid capillary point-of-care test with a cut-off of HPV16-L1 Ab > 1000 ng/ml. CE-IVD-marked for the detection of HPV16-induced anal and oropharyngeal cancers
Probe-based RNA AssayHPV and dysplasia test – QuantiGene-Molecular-Profiling-Histology (QG-MPH)mRNA of HPV oncogenes and cellular biomarkers

Cell-based. Quantitative detection of HPV16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82 and cellular biomarkers, correlating with severity of a dysplastic lesion. The emergence and strength of biomarkers define the lesion stage. The QuantiGene 2.0 platform (ThermoFisher) is used

2 Experimental molecular IVD, Charité-University Hospital Berlin, DE (WO2020/161285 A1)

Di Salvo I., Mnzava D., Nicoletti G.J., Senkoro E., Ndege R.C., Huang D.J., Makunja N.T., Kassiga G.I., Kaufmann A.M., Weisser M, & Kind A.B. (2023). Upscaling cervical cancer screening and treatment for women living with HIV at a rural referral hospital in Tanzania: protocol of a before-and-after study exploring HPV testing and novel diagnostics. BMC Health Services Research, 23, 234.
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Publication 2023
Antibodies Anus Biological Assay Biological Markers Capillaries Cells Cervix Uteri Coinfection Colposcopes Cryotherapy Epitopes Gene Expression Profiling Genotype Human papillomavirus 16 Immunoassay Malignant Neoplasms Nitrogen Oncogenes Oropharynxs Papillomavirus Infections, Human Point-of-Care Testing RNA, Messenger Second Look Surgery Serum Tests, Diagnostic Vaginal Smears

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1
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The QIAamp Viral RNA Mini Kit is a laboratory equipment designed for the extraction and purification of viral RNA from various sample types. It utilizes a silica-based membrane technology to efficiently capture and isolate viral RNA, which can then be used for downstream applications such as RT-PCR analysis.
2
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3
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The Allplex™ 2019-nCoV Assay is a real-time RT-PCR test designed for the qualitative detection of SARS-CoV-2 nucleic acid. The test targets three viral genes: E gene, RdRp gene, and N gene.
4
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More about "Oropharynxs"

The oropharynx, also known as the middle pharynx or oropharyngeal region, is a crucial part of the upper respiratory and digestive systems.
This area, located behind the mouth, plays a vital role in swallowing, breathing, and speech.
Researchers studying the oropharynx can gain insights into a variety of physiological and pathological processes, including respiratory function, swallowing disorders, and infectious diseases.
To optimize oropharynx research, scientists can utilize advanced tools and techniques.
For example, the QIAamp Viral RNA Mini Kit and RNeasy Mini Kit can be used for efficient extraction and purification of viral RNA from oropharyngeal samples.
FLOQSwabs and ESwab collection systems can provide high-quality specimens for analysis.
The Allplex™ 2019-nCoV Assay and Xpert Xpress SARS-CoV-2 tests can be employed for the detection of SARS-CoV-2 in oropharyngeal samples.
Furthermore, animal models, such as C57BL/6J mice, can be utilized to study the oropharyngeal region and its functions in a controlled environment.
The Cobas 6800 system, a fully automated molecular testing platform, can be employed for high-throughput analysis of oropharyngeal samples.
By leveraging these tools and techniques, researchers can enhance the quality and reliability of their oropharynx studies, leading to a better understanding of the physiological and pathological processes associated with this crucial anatomical region.
PubCompare.ai, an innovative AI-driven platform, can further assist in optimizing oropharynx research by surfacing relevant literature, preprints, and patents, and providing AI-powered comparisons to identify the most reproducible and accurate methods.