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Artery, Coronary

Artery, Coronary: The major blood vessels that supply the heart muscle with blood, nutrients, and oxygen.
Coronary arteries originate from the aorta and run along the surface of the heart, branching and penetrating the myocardium.
The right and left coronary arteries are the principal branches.
Coronary arteries and their smaller branches supply all the areas of the heart except for the atrial septum and the portion of the ventricular septum that lies immedietly beneath the atrial septum.

Most cited protocols related to «Artery, Coronary»

Improved Myocardial Infarction Modeling

Experiments were carried out according to National Institutes of Health Guidelines on the Use of Laboratory Animals and all procedures were approved by the Thomas Jefferson University Committee on Animal Care. A total of 497 (384 mice for MI and 113 for I/R) male 8-10 week old C57/B6 mice were used for this study. For the MI model, mice were subjected to permanent coronary artery ligation using either the new (N) method or the classical (C) method. Mice were randomly assigned to four groups: new method of MI (MI-N) or sham (S-N); classical method of MI (MI-C) or sham (S-C). There were 119 mice used for survival study. Some of the mice survived at the end of 28 days were also used for echocardiographic, hemodynamic and infarct size studies as indicated in each study. The rest of 232 mice survived from all kinds of 265 procedures (33 mice died) were used for 24h infarct size measurement (32 mice), Masson's trichrome stain (18 mice), arrhythmia analysis (28 mice), myeloperoxidase (MPO, 81) and TNFα (73) assays. In I/R model, mice were subjected to 30 min of myocardial ischemia followed by 24 hrs of reperfusion. Mice were divided into four groups also: new method of I/R (I/R-N, n=41) or sham (SI/R-N, n=16), classical method of I/R or sham I/R (I/R-C, n=40, SI/R-C, n=16, respectively). All animals were monitored after the surgery and received one dose (0.3mg/kg) of buprenophine within 6 hours post surgery and another dose was administered the following morning. No further analgesia was given thereafter.

Gao E., Lei Y.H., Shang X., Huang Z.M., Zuo L., Boucher M., Fan Q., Chuprun J.K., Ma X.L, & Koch W.J. (2010). A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse. Circulation research, 107(12), 1445-1453.

Publication 2010

Animals Animals, Laboratory Artery, Coronary Biological Assay Buprenorphine Cardiac Arrhythmia Echocardiography Hemodynamics Infarction Ligation Males Management, Pain Mice, House Myocardial Ischemia Operative Surgical Procedures Peroxidase Reperfusion trichrome stain Tumor Necrosis Factor-alpha

Genetic Variants and Cardiometabolic Traits

Association with BMI was tested as in stage 1, assuming an additive model. Logistic regression analysis was used to test for association with the risk of being overweight (defined as BMI ≥ 25 kg/m²) or obese (BMI ≥ 30 kg/m²), with adjustment for age, age2 (link), and sex, testing for SNP effects in an additive genetic model. Evidence for association between our replicating SNPs and type 2 diabetes15 (link), lipidlevels16 (link) and coronary artery disease17 (link),18 (link) was extracted from publicly available datasets. The effect of the replicating SNPs on expression of nearby genes was determined from publicly available eQTL GWA studies from lymphocytes42 (link) and brain tissue27 (link).

Willer C.J., Speliotes E.K., Loos R.J., Li S., Lindgren C.M., Heid I.M., Berndt S.I., Elliott A.L., Jackson A.U., Lamina C., Lettre G., Lim N., Lyon H.N., McCarroll S.A., Papadakis K., Qi L., Randall J.C., Roccasecca R.M., Sanna S., Scheet P., Weedon M.N., Wheeler E., Zhao J.H., Jacobs L.C., Prokopenko I., Soranzo N., Tanaka T., Timpson N.J., Almgren P., Bennett A., Bergman R.N., Bingham S.A., Bonnycastle L.L., Brown M., Burtt N.P., Chines P., Coin L., Collins F.S., Connell J.M., Cooper C., Smith G.D., Dennison E.M., Deodhar P., Elliott P., Erdos M.R., Estrada K., Evans D.M., Gianniny L., Gieger C., Gillson C.J., Guiducci C., Hackett R., Hadley D., Hall A.S., Havulinna A.S., Hebebrand J., Hofman A., Isomaa B., Jacobs K.B., Johnson T., Jousilahti P., Jovanovic Z., Khaw K.T., Kraft P., Kuokkanen M., Kuusisto J., Laitinen J., Lakatta E.G., Luan J., Luben R.N., Mangino M., McArdle W.L., Meitinger T., Mulas A., Munroe P.B., Narisu N., Ness A.R., Northstone K., O'Rahilly S., Purmann C., Rees M.G., Ridderstråle M., Ring S.M., Rivadeneira F., Ruokonen A., Sandhu M.S., Saramies J., Scott L.J., Scuteri A., Silander K., Sims M.A., Song K., Stephens J., Stevens S., Stringham H.M., Tung Y.C., Valle T.T., Van Duijn C.M., Vimaleswaran K.S., Vollenweider P., Waeber G., Wallace C., Watanabe R.M., Waterworth D.M., Watkins N., Witteman J.C., Zeggini E., Zhai G., Zillikens M.C., Altshuler D., Caulfield M.J., Chanock S.J., Farooqi I.S., Ferrucci L., Guralnik J.M., Hattersley A.T., Hu F.B., Jarvelin M.R., Laakso M., Mooser V., Ong K.K., Ouwehand W.H., Salomaa V., Samani N.J., Spector T.D., Tuomi T., Tuomilehto J., Uda M., Uitterlinden A.G., Wareham N.J., Deloukas P., Frayling T.M., Groop L.C., Hayes R.B., Hunter D.J., Mohlke K.L., Peltonen L., Schlessinger D., Strachan D.P., Wichmann H.E., McCarthy M.I., Boehnke M., Barroso I., Abecasis G.R, & Hirschhorn J.N. (2008). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature genetics, 41(1), 25-34.

Publication 2008

Artery, Coronary Brain Gene Expression Genome-Wide Association Study Obesity Single Nucleotide Polymorphism

Genomic Epidemiology of Cardiovascular Traits

Data from 62,266 participants from the following eleven studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium [3] (link) were included in this joint calling experiment and study descriptions were published previously: Age, Gene/Environment, Susceptibility-Reykjavik (AGES) Study [8] (link), Atherosclerosis Risk in Communities (ARIC) Study [9] (link), Cardiac Arrest Blood Study (CABS) [10] (link), Cardiovascular Health Study (CHS) [11] (link), [12] (link), Coronary Artery Risk Development in Young Adults (CARDIA) [13] (link), [14] (link), Multi-Ethnic Study of Atherosclerosis (MESA) [15] (link), Family Heart Study (FamHS) [16] (link), Framingham Heart Study (FHS) [17] (link), Health, Aging, and Body Composition (HABC) Study [18] (link), Jackson Heart Study (JHS) [19] , and the Rotterdam Study (RS) [20] –[23] (link). In addition, we genotyped 96 unrelated HapMap samples (48 CEU and 48 YRI) with each cohort and the list of sample IDs are available as a reference on the CHARGE exome chip public website.

Grove M.L., Yu B., Cochran B.J., Haritunians T., Bis J.C., Taylor K.D., Hansen M., Borecki I.B., Cupples L.A., Fornage M., Gudnason V., Harris T.B., Kathiresan S., Kraaij R., Launer L.J., Levy D., Liu Y., Mosley T., Peloso G.M., Psaty B.M., Rich S.S., Rivadeneira F., Siscovick D.S., Smith A.V., Uitterlinden A., van Duijn C.M., Wilson J.G., O’Donnell C.J., Rotter J.I, & Boerwinkle E. (2013). Best Practices and Joint Calling of the HumanExome BeadChip: The CHARGE Consortium. PLoS ONE, 8(7), e68095.

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Publication 2013

Artery, Coronary Atherosclerosis BLOOD Body Composition Cardiac Arrest Cardiovascular System DNA Chips Exome Genes Genome HapMap Heart Joints Susceptibility, Disease Young Adult

Quantifying Coronary Artery Calcium Using CT Scans

The methodology for acquisition and interpretation of the CAC scans, as well as the reproducibility of the readings, has been reported previously.^{14 (link)} Scanning centers assessed CAC using either an electron-beam CT scanner (Chicago, Los Angeles, and New York) or a multidetector CT system (Baltimore, St Paul, and Winston-Salem). All scanners were cardiac gated. Slice thickness was 3mm using the electron-beam CT scanners and 2.5 mm using the multidetector CT scanners. Each participant was scanned twice for CAC, which was measured during the same examination using the same site-specific scanners. CAC scans were read centrally at the MESA CT Reading Center and were brightness adjusted using a standard phantom to control for any scanner differences.^{15 (link)} In addition to the Agatston score, a volume score was also calculated.^{16 (link)} To qualify as a calcified plaque using CAC scoring, the plaque calcium density, measured in Hounsfield units, must be 130 Hu or higher. The Agatston scoring method for CAC measures each such discrete plaque area in square millimeters. Each discrete plaque area is then multiplied by 1, 2, 3, or 4, depending on the highest density measurement in Hu anywhere in the plaque. Plaques with a maximum density of 130 to 199 Hu are multiplied by 1, those with 200 to 299 Hu by 2, those with 300 to 399 by 3, and those with 400 Hu or greater by 4. These plaque-specific scores are then summed for all slices of the heart to give the Agatston score, which is thus an area score upweighted for increased plaque density. The participants received their Agatston score, were told that the presence of CAC represented hardening of the coronary arteries, and told of their amount of CAC (less than average, average, or greater than average).
The MESA database does not contain the individual area score for each participant. Thus, to calculate the individual area scores, the volume scores in cubic millimeters were divided by the appropriate slice thickness, 2.5 mm or 3 mm, resulting in the area score in square millimeters. The Agatston score was then divided by the area score and the quotient was the average CAC density score for each participant. The formula was: Agatston score/area score = density score. The density score thus ranged from 1 to 4 and reflected the average plaque density for all CT slices from that participant.

Criqui M.H., Denenberg J.O., Ix J.H., McClelland R.L., Wassel C.L., Rifkin D.E., Carr J.J., Budoff M.J, & Allison M.A. (2014). Calcium Density of Coronary Artery Plaque and Risk of Incident Cardiovascular Events. JAMA : the journal of the American Medical Association, 311(3), 271-278.

Publication 2014

Artery, Coronary Calcium CAT SCANNERS X RAY Cuboid Bone Dental Plaque Electrons Heart Multidetector Computed Tomography Radionuclide Imaging Sclerosis Senile Plaques

Subclinical CVD Risk in Rheumatoid Arthritis

The Evaluation of Subclinical Cardiovascular disease And Predictors of Events in Rheumatoid Arthritis Study (ESCAPE RA) is a cohort study of the prevalence, progression, and risk factors for subclinical CVD in men and women with RA. The ESCAPE RA study was designed with identical inclusion and exclusion criteria (except for the diagnosis of RA) to MESA, a population-based cohort study of subclinical CVD with similar objectives. The ESCAPE RA inclusion criteria were: fulfillment of American College of Rheumatology criteria for the classification of RA [18 (link)] of ≥ 6 months; and age 45 to 84 years. Medical records were reviewed for each participant to confirm diagnosis. Exclusion criteria were: prevalent CVD prior to enrollment (prior CVD was defined as self-reported or physician-diagnosed myocardial infarction, heart failure, coronary artery revascularization, angioplasty, peripheral vascular disease or procedures (excluding varicose vein procedures), implanted pacemaker or defibrillator devices, and current atrial fibrillation); weight exceeding 300 pounds (due to imaging equipment limitations); and CT scan of the chest within 6 months prior to enrollment (to limit radiation exposure).
Given the greater prevalence of RA in women, we set a recruitment goal of at least 40% males to enable gender-specific analyses, and recruited 195 patients from the Johns Hopkins Arthritis Center and by referral from community rheumatologists.
The study was approved by the Johns Hopkins Hospital Institutional Review Board and MESA, with all participants providing informed consent prior to enrollment. Enrollment occurred from October 2004 through May 2006.

Giles J.T., Szklo M., Post W., Petri M., Blumenthal R.S., Lam G., Gelber A.C., Detrano R., Scott WW J.r., Kronmal R.A, & Bathon J.M. (2009). Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of Atherosclerosis. Arthritis Research & Therapy, 11(2), R36.

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Publication 2009

Angioplasty Artery, Coronary Arthritis Atrial Fibrillation Cardiovascular Diseases Chest Congestive Heart Failure Defibrillators Disease Progression Ethics Committees, Research Gender Males Medical Devices Myocardial Infarction Pacemaker, Artificial Cardiac Patients Peripheral Vascular Diseases Physicians Radiation Exposure Rheumatoid Arthritis Rheumatologist Satisfaction Varices Woman X-Ray Computed Tomography

Most recents protocols related to «Artery, Coronary»

Hemodynamic Modeling and Validation in Coronary Arteries

Not available on PMC !

Example 1

Results from a method for patient-specific modeling of hemodynamic parameters in coronary arteries in accordance with one or more example embodiments of the disclosure were compared to real life results. In particular, invasively collected FFR data from 30 patients in 3 hospitals was compared to numerically calculated FFR values using one or more example embodiments of the disclosure. The statistical results for a total of 35 stenoses are summarized in the table below and in FIG. 25.

Sensitivity82.4%

Specificity88.9%

Positive Predictive Value87.5%

Negative Predictive Value84.2%

Accuracy85.7%

Area under ROC curve0.863

US11871995B2. Patient-specific modeling of hemodynamic parameters in coronary arteries (2024-01-16). HEMOLENS DIAGNOSTICS SP. Z.O.O. [PL]. Inventors: Andrzej Kosior [PL], Kryspin Mirota [PL], Wojciech Tarnawski [PL].

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Patent 2024

Artery, Coronary Hemodynamics Patients Stenosis

Invasive LV Pressure and CAD Evaluation

A total of 42 patients, who underwent LV catheterization for coronary angiography, were prospectively included. The invasive LV pressure was recorded. The LV dp/dt min, tau and LVEDP were averaged over 3–6 cardiac cycles. An LVEDP value of > 16 mmHg was defined as an elevated LV filling pressure [23 (link)]. The invasive values were measured by two researchers, who were blinded to the results of the MW measurements. All patients underwent coronary angiography with multiple projections. CAD was defined when the lumen was stenotic for more than 50% in one or more major epicardial coronary arteries [24 (link)].

Guo Y., Wang X., Yang C.G., Meng X.Y., Li Y., Xia C.X., Xu T., Weng S.X., Zhong Y., Zhang R.S, & Wang F. (2023). Noninvasive assessment of myocardial work during left ventricular isovolumic relaxation in patients with diastolic dysfunction. BMC Cardiovascular Disorders, 23, 129.

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Publication 2023

Angiography Artery, Coronary Catheterization Catheterizations, Cardiac Coronary Angiography Heart Patients Pressure Stenosis

Transcriptomic Analysis of Post-MI Mouse Heart

The RNA-seq data of GSE114695 from the GEO database in the present study were obtained. GSE114695 included the mouse left ventricle at 1 day (1 D) and 1 week (1 W) after MI or sham operation. MI was induced by permanent ligation of the left anterior descending coronary artery in 8-week-old male mice. A total of four sets of data were used in our study, including 1 D and 1 W after MI and then 1 D and 1 W after sham operation, and each set had three samples. The proportion of mapping of each sample was more than 80%, and the correlation in the group was better with no group outliers.
SRA Run files were converted to fastq format using NCBI SRA Tool fastq-dump. The raw reads were trimmed of low-quality bases, and clean reads were evaluated using FASTX-Toolkit (v.0.0.13; http://hannonlab.cshl.edu/fastx_toolkit/) and FastQC (http://www.bioinformatics.babraham.ac.uk/projects/fastqc).

Yang J., Yang M, & Sheng G. (2023). Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks. Open Medicine, 18(1), 20230657.

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Publication 2023

2'-deoxyuridylic acid Artery, Coronary Left Ventricles Ligation Males Mice, House RNA-Seq

Korean Acute Myocardial Infarction Registry

The study population was selected from the Korean Acute Myocardial Infarction Registry-National Institutes of Health (KAMIR-NIH) [10 (link)]. KAMIR-NIH is a nation-wide, prospective, multicenter, web-based observational cohort study aiming to develop a prognostic and surveillance index for patients with AMI. Patients who were hospitalized primarily for AMI and signed informed consents were consecutively enrolled from November 2011 to October 2015. This study was conducted according to the ethical guidelines of the Declaration of Helsinki. The study protocol was approved by the ethics committee at Chonnam National University Hospital, Republic of Korea (IRB No. CNUH-2011-172) and the institutional review boards of all participating hospitals approved the study protocol. Written informed consents were obtained from participating patients or legal representative. Data were collected by the attending physician with the assistance of a trained clinical research coordinator, via a web-based case report form in the clinical data management system of the Korea NIH. Patients, who died during index hospitalization, did not have hypertension, were prescribed neither ACEI nor ARB, or both ACEI and ARB at discharge, did not undergo echocardiographic study, and had incomplete clinical data, were excluded.
AMI was diagnosed when there was an evidence of myocardial necrosis (a rise and/or fall in cardiac biomarker, preferably cardiac troponin), and at least one of the following: (1) symptoms of ischemia, (2) new or presumed new significant ST-segment-T wave changes or a new left bundle branch block, (3) a development of pathologic Q waves in the electrocardiogram, (4) an imaging evidence of the new loss of viable myocardium or new regional wall motion abnormality, and (5) the identification of an intracoronary thrombus by angiography [11 (link)]. Hypertension was defined as values ≥140 mmHg of systolic BP (SBP) and/or ≥90 mmHg of diastolic BP (DBP) during the initial hospitalization [12 (link), 13 (link)]. Patients with a history of hypertension or antihypertensive treatment on the interview were also considered to have hypertension. Coronary reperfusion included reperfusion by percutaneous coronary intervention (PCI), thrombolysis, or coronary artery bypass graft (CABG), MI with non-obstructed coronary arteries (MINOCA) [3 (link)], and myocardial bridge. LV systolic function was evaluated by the echocardiographic study during the initial hospitalization.

Lee J.G., Joo S.J., Kim S.Y., Choi J.H., Boo K.Y., Hwang J.Y., Hur S.H, & Jeong M.H. (2023). Impact of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers on clinical outcomes in hypertensive patients with acute myocardial infarction. PLOS ONE, 18(3), e0281460.

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Publication 2023

Angiography Antihypertensive Agents Artery, Coronary Biological Markers Coronary Artery Bypass Surgery Echocardiography Electrocardiography Ethics Committees Ethics Committees, Research Fibrinolytic Agents Heart High Blood Pressures Hospitalization Ischemia Koreans Left Bundle-Branch Block Myocardial Infarction Myocardial Reperfusion Myocardium Patient Discharge Patients Percutaneous Coronary Intervention Physicians Pressure, Diastolic Reperfusion Systole Systolic Pressure Thrombus Troponin

Cardiovascular Procedure Risk Factors

Preoperative factors were collected, including age, sex, recent major cardiovascular procedure (within 3 months), coronary artery disease, cerebral vascular events, chronic lung disease, essential hypertension, dyslipidemia, liver cirrhosis, atrial fibrillation, type 2 diabetes mellitus, end-stage renal disease with dialysis (both hemodialysis and peritoneal dialysis), and regular use of antiplatelet or anticoagulant agents. The major cardiovascular procedures included coronary arterial bypass, coronary arterial angioplasty/stenting, cardiac valvular surgery, aortic surgery, and peripheral arterial surgery. Preoperative blood cell counts included white cell counts, differential counts (immature band form white cell) [15 (link)], platelet counts, the neutrophil-to-lymphocyte ratio (NLR) [16 (link)], and hemoglobin levels. Preoperative blood biochemistry results included serum levels of albumin, alanine aminotransferase (ALT), bilirubin, and creatinine. The coagulation test included the prothrombin time (PT) and was expressed by the international normalized ratio (INR). Preoperative shock status was defined as the requirement for vasopressors or inotropes. The types of AMI were determined by preoperative contrast CT scans.

Liu H.T., Lai C.Y., Liao J.J., Chen Y.J., Cheng S.B, & Wu C.C. (2023). Immediate postoperative parenteral anticoagulant therapy in patients with mesenteric ischemia after intestinal resection: a retrospective cohort study at a single institute. BMC Gastroenterology, 23, 56.

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Publication 2023

Angioplasty Angioplasty, Balloon, Coronary Anticoagulants Aorta Arteries Artery, Coronary Atrial Fibrillation Bilirubin BLOOD Cardiovascular System Cells Cerebrovascular Accident Coronary Arteriosclerosis Coronary Artery Bypass Surgery Creatinine D-Alanine Transaminase Diabetes Mellitus, Non-Insulin-Dependent Dialysis Disease, Chronic Dyslipidemias Essential Hypertension Hemodialysis Hemoglobin Inotropism International Normalized Ratio Kidney Failure, Chronic Leukocyte Count Liver Cirrhosis Lung Lung Diseases Lymphocyte Neutrophil Neutrophil Band Cells Operative Surgical Procedures Peritoneal Dialysis Platelet Counts, Blood Serum Albumin Shock Surgical Procedure, Cardiac Tests, Blood Coagulation Times, Prothrombin Vasoconstrictor Agents X-Ray Computed Tomography

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Hcaec by Lonza

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HCAECs are human coronary artery endothelial cells. They are a type of primary cell line derived from the endothelial lining of human coronary arteries. HCAECs are used in cell culture research to study the function and biology of the coronary artery endothelium.

Somatom definition flash by Siemens

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What are the main functions of the coronary arteries?

The coronary arteries are the blood vessels responsible for supplying the heart muscle (myocardium) with oxygen-rich blood, nutrients, and other essential substances. They originate from the aorta and branch out across the surface of the heart, penetrating the myocardium to deliver these vital resources to the heart tissue. The right and left coronary arteries are the principal branches that ensure the heart receives the blood flow it needs to function properly.

How do the coronary arteries differ from other blood vessels in the body?

Unlike most other blood vessels, the coronary arteries are unique in that they supply blood directly to the heart muscle itself, rather than to the rest of the body. This specialized function is critical, as the heart requires a constant supply of oxygenated blood to continue pumping and sustaining the body's circulation. The coronary arteries are also positioned on the surface of the heart, rather than running through the internal chambers or tissues.

What are some common conditions or issues that can affect the coronary arteries?

Coronary artery disease, or the buildup of plaque in the arteries, is one of the most prevalent issues that can impact the coronary arteries. This narrowing or blockage of the arteries can reduce blood flow to the heart, potentially leading to chest pain, heart attacks, and other serious cardiovascular problems. Coronary artery spasms, inflammation, and congenital abnormalities are some other conditions that can affect the proper functioning of the coronary arteries.

How can PubCompare.ai help researchers studying the coronary arteries?

PubCompare.ai's AI-powered platfrom can assist researchers studying the coronary arteries in several ways. First, it allows you to more efficiently screen the existing literature on protocols related to the coronary arteries. The platfrom's AI analysis can help pinpoint the most critical insights, enabling you to identify the most effective protocols for your specific research goals around the coronary arteries. This can improve reproducibility and accuracy in your studies. Furthemore, PubCompare.ai can help you compare the effectiveness of different protocols, so you can choose the best option for your coronary artery research needs.

What are some unique variations or types of coronary arteries that researchers should be aware of?

While the right and left coronary arteries are the main branches, there can be some natural variation in the specific anatomy and branching patterns of the coronary arteries. For example, some individuals may have an additional or accessiory coronary artery, or differences in the relative sizes and territories supplied by the right and left coronary arteries. Researchers should be mindful of these potential anatomical variations when designing studies or interpreting results related to the coronary arteries.

More about "Artery, Coronary"

Coronary arteries, also known as the heart's blood vessels, are the major conduits that supply the myocardium (heart muscle) with oxygen-rich blood, nutrients, and essential substances.
These vessels originate from the aorta, the largest artery in the body, and traverse the surface of the heart before branching and penetrating the myocardium.
The right and left coronary arteries are the principal branches, with their smaller offshoots ensuring comprehensive coverage of the heart's tissues, excluding the atrial septum and the portion of the ventricular septum immediately beneath it.
Proper functioning of the coronary arteries is crucial for maintaining the heart's health and performance.
Conditions like atherosclerosis, which can lead to the narrowing or blockage of these vessels, can have severe consequences, including myocardial infarction (heart attack) and other cardiovascular disorders.
Understanding the anatomy and physiology of the coronary arteries is essential for researchers and clinicians involved in the study and treatment of heart-related diseases.
In the context of medical research, various advanced imaging techniques, such as computed tomography (CT) scans using devices like the SOMATOM Definition Flash, Aquilion ONE, and LightSpeed VCT, have been employed to visualize and analyze the coronary arteries.
Additionally, animal models, such as those involving human coronary artery endothelial cells (HCAECs) and the use of pentobarbital sodium, have provided valuable insights into the mechanisms underlying coronary artery function and disease.
Techniqes like Trusquare tessellation (TTC) staining have also been utilized to assess myocardial damage and perfusion.
The integration of these advanced imaging and experimental tools, along with the ongoing research efforts, continues to expand our understanding of the coronary arteries and their role in cardiovascular health and disease.