The largest database of trusted experimental protocols
> Anatomy > Body Part > Atrium, Right

Atrium, Right

The right atrium is one of the four chambers of the heart.
It receives deoxygenated blood from the superior and inferior vena cavae and pumps it into the right ventricle.
The right atrium is located in the upper right portion of the heart and is separated from the left atrium by the interatrial speptum.
It plays a crucial role in the cardiac cycle by facilitating the flow of blood through the heart.
Proper functioning of the right atruim is essential for maintaining effective cardiovascular activity.

Most cited protocols related to «Atrium, Right»

The dataset consists of short-axis and long-axis cine CMR images of 5,008 subjects (61.2 ±7.2 years, 52.5% female), acquired from the UK Biobank. The baseline characteristics of the UK Biobank cohort can be viewed in the data showcase at [16 ]. For short-axis images, the in-plane image resolution is 1.8 ×1.8 mm2 with slice thickness of 8.0 mm and slice gap of 2 mm. A short-axis image stack typically consists of 10 image slices. For long-axis images, the in-plane image resolution is 1.8 ×1.8 mm2 and only 1 image slice is acquired. Each cardiac cycle consists of 50 time frames. For both short-axis and long-axis views, the balanced steady-state free precession (bSSFP) magnitude images were used for analysis. Details of the image acquisition protocol can be found in [17 (link)].
Manual image annotation was undertaken by a team of eight observers under the guidance of three principal investigators and following a standard operating procedure [18 (link)]. For short-axis images, the LV endocardial and epicardial borders and the RV endocardial borders were manually traced at ED and ES time frames using the cvi42 software (version 5.1.1, Circle Cardiovascular Imaging Inc., Calgary, Alberta, Canada). For long-axis 2-chamber view (2Ch) images, the left atrium (LA) endocardial border was traced. For long-axis 4-chamber view (4Ch) images, the LA and the right atrium (RA) endocardial borders were traced.
In pre-processing, the CMR DICOM images were converted into NIfTI format. The manual annotations from the cvi42 software were exported as XML files and also converted into NIfTI format. The images and annotations were quality controlled to ensure that annotations cover both ED and ES frames and without missing slices or missing anatomical structures. For short-axis images, 4,875 subjects (with 93,500 annotated image slices) were available after quality control, which were randomly split into three sets of 3,975/300/600 for training/validation/test, i.e. 3,975 subjects for training the neural network, 300 validation subjects for tuning model parameters, and finally 600 test subjects for evaluating performance. For long-axis 2Ch images, 4,723 subjects were available after quality control, which were split into 3,823/300/600. For long-axis 4Ch images, 4,682 subjects were available, which were split into 3,782/300/600.
Publication 2018
Atrium, Left Atrium, Right Cardiovascular System Endocardium Epistropheus Heart Reading Frames Woman
To investigate transcriptome-wide associations between predicted gene expression and AF disease risk, we employed the method MetaXcan v0.3.5.12 MetaXcan extends the previous method PrediXcan69 to predict the association between gene expression and a phenotype of interest, using summary association statistics. Gene expression prediction models were generated from eQTL datasets using Elastic-Net to identify the most predictive set of SNPs. Only models that significantly predict gene expression in the reference eQTL dataset (FDR <0.05) were considered. Pre-computed MetaXcan models for the two available heart tissues (left ventricle and right atrial appendage) in the genotype-tissue expression project version 6p (GTEx)68 (link) were used to predict the association between gene expression and risk of AF. Summary level statistics from the combined ancestry meta-analysis were used as input. 4859 genes were tested for left ventricle and 4467 genes were tested for right atrial appendage. Bonferroni correction was applied to account for the number of genes tested across both tissues, resulting in a significance threshold of P < 5.36×10−6, calculated as 0.05/(4859 + 4467).
Publication 2018
Atrium, Right Auricular Appendage Gene Expression Genes Genotype Heart Left Ventricles Phenotype Single Nucleotide Polymorphism Tissues Transcriptome
All barcodes labelled in the global object as cardiomyocytes, fibroblasts and neural cells were selected for further subpopulation analyses. Additional cell population-specific filtering criteria were applied to nuclei as follows: cardiomyocyte counts (n_counts <12,500), genes (n_genes <4,000), mitochondrial genes (percent_mito <1%), ribosomal genes (percent_ribo <1%) and scrublet score (scrublet_score <0.25); FB mitochondrial genes (percent_mito <1%), ribosomal genes (percent_ribo <1%); neuronal cell genes (n_genes <4000), mitochondrial genes (percent_mito <1%), ribosomal genes (percent_ribo <1%). Total and CD45+ cells were excluded in the atrial and ventricular cardiomyocytes datasets and did not contribute to subpopulation analysis. No further filtering of FBs or neuronal cell total and CD45+ cells was applied. Cardiomyocytes and FBs were then further split into two groupings based on the region of origin: (1) left and right atrium, and (2) left and right ventricles, apex and interventricular septum.
Donor effects were aligned as described in step (1) above. For FB and neuronal cells, sources were aligned as described in step (3) above. Leiden clustering and UMAP visualization were performed for identifying subpopulations and visualization86 (link). Differentially expressed genes were calculated using the Wilcoxon rank sum test. Genes were ranked by score.
Publication 2020
Atrium, Right Cell Nucleus Cells Fibroblasts Genes Genes, Mitochondrial Heart Atrium Heart Ventricle Mitomycin Myocytes, Cardiac Neurons Population Group Reproduction Ribosomes Strains Tissue Donors Ventricles, Right Ventricular Septum
Mice were treated with 50ul of 1000U/ml s.c. heparin, and then euthanized with Isoflurane. The chest cavity was opened, the left atrium nicked, and the lungs perfused with 10ml of PBS through the right atrium. The trachea was then exposed, a small incision was made at its top, and an 18 gauge angiocath was inserted and secured. Lung was inflated with digestion solution containing 1.5mg/ml of Collagenase A (Roche) and 0.4mg/ml DNaseI (Roche) in HBSS plus 5% fetal bovine serum and 10mM HEPES. Trachea was tied off with 2.0 sutures. The heart and mediastinal tissues were carefully removed and the lung parenchyma placed in 5ml of digestion solution and incubated at 37°C for 30 minutes with gently vortexing every 8–10 minutes. Upon completion of digestion, 25ml of PBS was added; and the samples were vortexed at maximal speed for 30 seconds. The resulting cell suspensions were strained through a 70um cell strainer and treated with ACK RBC lysis solution.
Publication 2016
Atrium, Left Atrium, Right Cells Collagenase Digestion Fetal Bovine Serum Heart Hemoglobin, Sickle Heparin HEPES Isoflurane Lung Mediastinum Mus Neoplasm Metastasis Sutures Thoracic Cavity Tissues Trachea
The protocol was approved by the Washington University Animal Care and Use Committee. The isolated perfused canine right atrium,12 (link) as well as the experimental techniques,13 have been previously described in detail.
An expanded Materials and Methods section is available in the online data supplement at http://circres.ahajournals.org.
Publication 2009
Animals Atrium, Right Canis familiaris Dietary Supplements

Most recents protocols related to «Atrium, Right»

TTE was performed using a Philips Affiniti 50 ultrasound system (Philips Ultrasound, Bothell, WA, USA) equipped with QLAB cardiac analysis software and a 2–4 MHz sector cardiac transducer. TTE operators were university cardiologists with certification in TTE and trained in advanced echocardiography of critical care patients. Our evaluation protocol included examining the apical four-chamber image or, failing that, the subxiphoid four-chamber image if the first does not achieve sufficient quality. Echocardiographic images were recorded at a minimum rate of 30 frames per second, and stored in digital format.
For the generation of the contrast bubbles, we used the technique described by Lovering et al.10 (link) This technique requires a 20-gauge peripheral venous catheter or a central venous access and a three-way stopcock to which two 10 mL syringes are connected. One syringe contained 10 mL of saline and the other 1 mL of room air. Contrast bubbles were created by rapidly passing the solution from one syringe to another for at least 15 s, removing any residual macroscopic air prior to infusion through the patient's vein. These contrast bubbles are highly echogenic and are easily visualized in the right chambers after venous injection. The injection was considered successful if the entire right atrium was opacified with microbubble-induced contrast. Up to two successful contrast studies were performed on each patient.
Publication 2023
Atrium, Right Cardiologists Catheters Conditioning, Psychology Critical Care Echocardiography Heart Microbubbles Patients Reading Frames Saline Solution Syringes Transducers Ultrasonics Veins
Our study cohort included eight children aged 6–10 years who were hospitalised in the Affiliated Hospital of Southwest Medical University, China on June 2022. Four of the children were diagnosed by echocardiography as VSD without PAH (control group, n = 4) and the other four were diagnosed by echocardiography and right cardiac catheterisation as moderate or severe PAH secondary to VSD (PAH group, n = 4). A diagnosis of PAH by right-heart catheterisation was defined as a mean pulmonary arterial pressure >25 mmHg at rest, a pulmonary capillary wedge pressure <15 mmHg and a pulmonary vascular resistance of >3 Wood units. We excluded patients receiving targeted therapy for PAH and those diagnosed with other intracardiac malformations, such as patent ductus arteriosus, large atrial septal defect, or other related conditions, like congenital lung disease, bronchial asthma and congenital pulmonary vascular malformation.
During the cardiac operation, atrial appendage specimens were collected from all patients before cardiopulmonary bypass and blood samples were collected via the jugular vein before performing the midline sternotomy. The plasma and right atrial appendage specimens were then aliquoted and stored at −80°C until RNA extraction.
Publication 2023
Asthma Atrial Septal Defects Atrium, Right Auricular Appendage BLOOD Blood Vessel Cardiopulmonary Bypass Catheterizations, Cardiac Child Congenital Abnormality Congenital Disorders Echocardiography Jugular Vein Lung Lung Diseases Median Sternotomy Patent Ductus Arteriosus Patients Plasma Pulmonary Wedge Pressure Surgical Procedure, Cardiac Therapeutics Vascular Malformations
Between May 2001 and June 2022, 244 patients with sporadic cardiac myxomas underwent surgical resection at our institution. Among the 244 cases, 28 were RHMs (11.48%) and 216 were LHMs (88.52%). The clinical features of 28 RHM cases were then compared to those of 216 LHM cases. Of the 28 RHM cases, 26 were right atrial myxomas (RAMs) and 2 were right ventricular myxomas (RVMs). While the LHMs were all left atrial myxomas (LAMs), the left ventricular myxomas (LVMs) were not detected. The preoperative diagnosis of RHM was confirmed by transthoracic echocardiography (TTE); transesophageal echocardiography was performed for patients in whom the diagnosis was doubtful by TTE. A definitive diagnosis was determined based on the pathological results postoperatively. However, patients with a possible diagnosis of RHM on echocardiography who did not undergo surgery were excluded. Clinical and follow-up data were obtained from electronic medical records and follow-up surveys.
Publication 2023
Atrium, Left Atrium, Right Diagnosis Echocardiography Echocardiography, Transesophageal Heart Left Ventricles Myxoma Operative Surgical Procedures Patients Ventricles, Right
In 25 patients (25/28, 89.29%), RHMs were excised through median sternotomy under cardiopulmonary bypass using aortic and bicaval cannulation (cardiac arrest in 23, beating heart in 2). To prevent detachment of the mass and intra-operative embolization, we minimized movement and compression of the heart during the surgery. Right atriotomy was performed in all 25 patients; of these, 2 cases were RVM, and ventricular tumors were approached across the tricuspid valve in 1 patient and through an extra right ventriculotomy in the other patient. The basic principle of excision was the complete resection of the tumor and its attached sites. The attachment sites of RHM are listed in Table 1. All myxomas were excised completely. The defect of the atrial septum and right atrial free wall after myxoma resection was repaired with a bovine or autologous pericardial patch when needed. Transesophageal echocardiography was performed at the end of the procedure to assess the presence of a residual tumor or interatrial shunting after septal reconstruction.
Of the remaining 3 patients, 2 underwent total endoscopic robotic RAM resection with da Vinci Surgical System (Intuitive Surgical, Sunnyvale, Calif, USA), and 1 underwent total thoracoscopic surgery for RAM resection. Both robotic and thoracoscopic surgeries are minimally invasive procedures for which the peripheral cardiopulmonary bypass was established via right internal jugular venous cannulation and femoral arterial and venous cannulations. In both these procedures, RAM was excised via right atriotomy on the beating heart without aortic occlusion. The principles for myxoma resection were the same as those for conventional surgeries with median sternotomy.
Publication 2023
Aorta Arteries Atrial Septal Defects Atrium, Right Cannulation Cardiac Arrest Cardiac Tamponade Cardiopulmonary Bypass Cattle Dental Occlusion Echocardiography, Transesophageal Embolization, Therapeutic Endoscopy Femur Heart Heart Ventricle Jugular Vein Median Sternotomy Movement Myxoma Neoplasms Operative Surgical Procedures Patients Pericardium Reconstructive Surgical Procedures Residual Tumor Robotic Surgical Procedures Septum, Atrial Surgical Endoscopy Surgical Procedures, Thoracoscopic Valves, Tricuspid Veins
The recovery of DCD hearts by taNRP is represented in Fig. 1.

Donor systolic blood pressure during taNRP recovery of the heart in a rat model. The series of events is as follows. The decision is made to withdraw life sustaining treatment (WSLT). The onset of FWIT occurs when the systolic blood pressure <50 mmHg and therefore inadequate to properly perfuse the heart. The onset of death occurs when the heart first becomes asystolic. Death is confirmed after 5 min of complete absence of circulation. At this point the right atrium and the aorta are cannulated such that reperfusion can begin. The heart begins to beat shortly after.

Publication 2023
Aorta Atrium, Right Cardiac Arrest Heart Reperfusion Systolic Pressure

Top products related to «Atrium, Right»

Sourced in Australia, United States, United Kingdom, New Zealand, Germany, Japan, Spain, Italy, China
PowerLab is a data acquisition system designed for recording and analyzing physiological signals. It provides a platform for connecting various sensors and transducers to a computer, allowing researchers and clinicians to capture and analyze biological data.
Sourced in United States, Norway, United Kingdom, Japan, France, Canada, Germany, Belgium
The Vivid 7 is a high-performance ultrasound system designed for cardiovascular and general imaging applications. It features advanced imaging technologies and versatile capabilities to support comprehensive diagnostic assessments.
Sourced in United States, Germany, Switzerland, United Kingdom, Japan, China, Italy, France, Macao, Israel, Australia, Sao Tome and Principe, Canada, Spain, Netherlands, Czechia
Hyaluronidase is an enzyme used in laboratory settings. It functions by breaking down hyaluronic acid, a component of the extracellular matrix.
Sourced in United States, Canada, Germany, United Kingdom
Collagenase XI is a purified enzyme preparation derived from Clostridium histolyticum. It is used for the dissociation and dispersion of a variety of tissues, including connective tissue.
Sourced in United States, Norway, Japan, United Kingdom, Germany
The Vivid E9 is a diagnostic ultrasound system developed by GE Healthcare. It is designed to provide high-quality imaging for a wide range of clinical applications.
Sourced in United States
The Swan-Ganz catheter is a medical device used to measure various hemodynamic parameters, such as cardiac output, pulmonary artery pressure, and central venous pressure. It is a long, thin, flexible tube that is inserted into a vein and advanced into the pulmonary artery, allowing for the monitoring of cardiovascular function.
Sourced in United States, Germany, United Kingdom, China, Macao, Sao Tome and Principe, France, Japan, Switzerland, Israel, Spain, Australia, Italy, Canada
Collagenase type I is an enzyme used in laboratory settings to break down collagen, a structural protein found in various tissues. It is commonly used in cell isolation and tissue dissociation procedures.
Sourced in Australia, United States, United Kingdom, New Zealand, Germany, Japan, Canada
The PowerLab system is a versatile data acquisition hardware platform designed for laboratory research and teaching applications. It offers a range of input channels and signal conditioning options to accommodate a variety of experimental setups. The PowerLab system is capable of recording and analyzing various physiological signals, enabling researchers to capture and study relevant data for their studies.
Sourced in United States
The EPR-800 is a compact and versatile electron paramagnetic resonance (EPR) spectrometer designed for a wide range of applications. It offers high-performance capabilities and is suitable for various research and analytical tasks.
Sourced in United States, United Kingdom, Jersey, Germany, Japan, Switzerland, Canada, Australia, France
Collagenase type II is an enzyme used in cell and tissue culture applications. It is responsible for the breakdown of collagen, a structural protein found in the extracellular matrix. This enzyme is commonly used to facilitate the dissociation of cells from tissues during cell isolation and harvesting procedures.

More about "Atrium, Right"

The right atrium (RA) is one of the four major chambers of the heart.
It is responsible for receiving deoxygenated blood from the superior and inferior vena cavae and pumping it into the right ventricle (RV).
The RA plays a crucial role in the cardiac cycle by facilitating the flow of blood through the heart.
Proper functioning of the RA is essential for maintaining effective cardiovascular activity.
The RA is located in the upper right portion of the heart and is seperated from the left atrium (LA) by the interatrial septum.
Synonyms for the RA include right atriuim and upper right heart chamber.
Related terms and subtopics include the cardiac cycle, vena cavae (superior and inferior), right ventricle, interatrial septum, and cardiovascular function.
Abbreviations commonly used include RA and RV.
Techniques and tools used to study the RA include the PowerLab system, Vivid 7 and Vivid E9 echocardiography, Swan-Ganz catheterization, and the use of enzymes like hyaluronidase and collagenase (types I and II) for tissue dissociation and cell isolation.
The EPR-800 is an example of an electronic pressure recorder that can be used to measure RA pressures.