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Fibula

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Most cited protocols related to «Fibula»

The UF hybrid 1-year, 5-year, and 10-year phantoms were developed in part from the patient CT images used for the construction of the UF paediatric voxel phantom series (Lee et al., 2006 (link)) and in part from newer CT datasets obtained from Shands Children's Hospital at the University of Florida (see Table 1). These phantoms were constructed using modeling procedures and organ identification lists given previously for the UF newborn and 15-year hybrid phantoms (Lee et al., 2007 (link); Lee et al., 2008 (link)). The naming convention for the UF phantom series begins with the identifier UFH (University of Florida Hybrid), followed by the reference phantom age in years (00, 01, 05, 10, 15, and AD for adult), and then the phantom gender (M for male and F for female). The combined gender specification MF refers to the pair of male and female phantoms at the younger ages (newborn, 1-year, 5-year, and 10-year) where all internal organ anatomy is identical with the exception of the sex organs.
As shown in Table 1, original CT images used for the 4-year and 11-year UF voxel phantoms were reprocessed in this study for constructing hybrid phantoms representing the ICRP 89 reference 5-year and 10-year child. Patient CT image logbooks were reviewed under IRB-approved and HIPAA-compliant protocols to find the best candidates for reference phantom construction. Based on subject sex and age, a series of image sets were selected and then reviewed by the Chief of Paediatric Radiology at Shands Children's Hospital for abnormal patient anatomy (JW). All patients were scanned in a supine position with the arms raised to be out of the x-ray beam, and thus supplemental image sets were required to provide NURBS models for the skeleton of the extremities. Accordingly, separate arm bones (humerus, ulna, radius and hand bones) and leg bones (femur, patella, fibula, tibia and foot bones) were segmented from high-resolution CT images of an 18-year male cadaver and subsequently rescaled and attached to all phantoms of the series beyond the newborn. A total of 820 and 1099 images of the 18-year-old male cadaver CT datasets were semi-automatically segmented for construction of arm and leg models, respectively. Another supplementary image set was that of the cervical spine of a 15-year female patient. This image set, acquired at 0.75-mm slice thickness, yielded a far more discriminating view of the vertebral bodies and processes of the cervical spine than could be realized in existing 5-mm and 6-mm CT image sets used for the torso anatomy. Consequently, the resulting patient-specific cervical spine polygon mesh model was resized accordingly and inserted within the skeletal anatomy of all phantoms of the UF series older than the newborn.
Publication 2009
Adult Arm Bones Bones of Feet Cadaver Cervical Vertebrae Child Conferences Femur Fibula Hand Bones Humerus Hybrids Infant, Newborn Inpatient Leg Bones Males Neck Patella Patients Radiography Radius Skeleton Spinous Processes Tibia Torso Ulna Vertebral Body Woman
Before data collection, patients’ skin over the vastus lateralis was shaved, rubbed with abrasive skin prep, and cleaned with alcohol to improve the electrode–skin contact and minimize skin impedance. Bipolar, disposable, pre-gelled Ag/AgCl surface electrodes with 20 mm distance between electrode centers were placed on the belly of the vastus lateralis. The exact placement of the electrodes followed the recommendations by Surface Electromyography for the Non-Invasive Assessment of Muscles (SENIAM 2008 ). The reference electrode was placed over the proximal end of the fibula of the same leg. Signals were analog filtered at 10–500 Hz (with first order filter at lower cutoff frequency and sixth order filter at higher cutoff frequency), amplified 2000× and sampled at 1 kHz using a TeleMyo 900 telemetric hardware system (Noraxon USA, Inc., Scottsdale, AZ, baseline noise < 1 uV RMS, Common Mode Rejection min. 85 dB through 10–500 Hz operating range).
EMG signals were recorded as each of 17 subjects performed one near-maximal voluntary isometric contractions, starting with 1 s of rest interval to establish baseline. The raw signals were visually inspected and the pre-contraction portions of the baseline as well as the steady portions of the EMG burst were identified. The baseline and the EMG burst from each recorded signal was then used to construct 17 reference EMG signals by adjoining the baseline and the burst portion at a known onset time t0 (see Fig. 1). Length of the EMG baseline, EMG burst, and position of the true onset t0 varied for all reference signals. The known, true onset times, t0, were used as a reference to quantify the accuracy of estimated onset times t1 identified by three onset detection methods.

Construction of the reference signal. From the raw signal (top panel), a portion of the baseline and a portion of the EMG burst was selected (middle panel) and re-joined at the known onset time t0 (bottom panel). To demonstrate the importance of signal conditioning, the baseline in this example contains fluctuations in the signal amplitude. These fluctuations were not associated with the muscle contraction

The precise EMG onset was not known in the experimental signals recorded from old adults during gait. In these trials, we determined the onset time, t0, by visual detection because computerized techniques should detect EMG onset close to the onset time selected by individuals with EMG expertise (Staude et al. 2001 (link)).
SNR of the reference signals was calculated to test the influence of signal quality on onset detection accuracy. The SNR of the signals was defined as: where A is RMS amplitude. All data analysis was performed in MATLAB (MathWorks, Natick, MA).
Publication 2010
Adult Ethanol Fibula Gels Isometric Contraction Muscle Tissue Patients Skin Surface Electromyography Telemetry Vastus Lateralis
The apparatus and protocol for dynamically loading the mouse tibia/fibula have been reported previously [12,13,27,29,32] . In brief, the flexed knee and ankle joints are positioned in concave cups; the upper cup, into which the knee is positioned, is attached to the actuator arm of a servo-hydraulic loading machine (Model HC10; Zwick Testing Machines Ltd., Leominster, UK) and the lower cup to a dynamic load cell. The tibia/fibula is held in place by a low level of continuous static “pre-load”, onto which is superimposed higher levels of intermittent “dynamic” load.
In the present study, 2.0 N was used as the static “pre-load” which was held for 400 s according to the original protocol [12] (link). The 11.5 N of “dynamic” load was superimposed onto the 2.0-N static “pre-load” in a series of 40 trapezoidal-shaped pulses (0.025 s loading, 0.050 s hold at 13.5 N and 0.025 s unloading) with a 10-s rest interval between each pulse. Strain gauges attached to the medial surface of the tibial shaft of similar 19-week-old female C57BL/6 mice showed that at a proximal/middle site (37% of the bone's length from its proximal end) a peak load of 13.5 N engendered approximately 1400 microstrain [29] (link).
Although a peak load of 12.0 N can induce significant osteogenic responses in both cortical and trabecular bone [27] (link), we selected a higher peak load (13.5 N) which was sufficient to induce woven bone formation in the loaded tibia [29] (link). Woven bone is generally seen in areas where the strain-related stimulus is high. Sample et al. [30] (link) reported that it was at the “high” level of peak load that dynamic loading of the ulna resulted in (re)modelling responses in other bones that were not loaded. By using a loading regimen that stimulated woven bone formation, we sought to provide a stringent test for the presence of regional or systemic influences on mechanically adaptive (re)modelling in bones other than those being loaded.
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Publication 2010
Acclimatization ARID1A protein, human Bones Cancellous Bone Cortex, Cerebral Fibula Joints, Ankle Knee Joint Mice, Inbred C57BL Mus Osteogenesis Pulse Rate Pulses Strains Tibia Tibial Fractures Trapezoid Bones Treatment Protocols Ulna Vision Woman
Left tibias were brought to room temperature before testing and kept hydrated in calcium-buffered saline until the test was complete. Bones were tested in the ML direction (medial surface in tension) in four-point bending (Admet eXpert 450 Universal Testing Machine; Norwood, MA, USA). The fibula was carefully removed from each bone using a scalpel, and the bones were positioned with the TFJ aligned with the outside edge of one loading roller, preloaded to 0.5 N, preconditioned for 15 s (2 Hz, mean load of 2 ± 2 N), and monotonically tested to failure in displacement control at a rate of 0.025 mm/s. Load and deflection were recorded, from which structural strength (yield and ultimate forces), stiffness (slope of the linear portion of the force versus displacement curve), and deformation (yield deformation, postyield deformation, and total deformation) were determined.(11 (link),31 (link))
Bones were visually monitored during testing, and the point of fracture initiation was measured relative to the proximal end. A subset of geometric properties at the fracture site was obtained from μCT data (IAP and the distance from the centroid to the tensile surface of the bone, c). Together with the load and deflection data, IAP and c were used to map force and displacement (structural-level properties dependent on bone structural organization) into stress and strain (predicted tissue-level properties) from standard beam-bending equations for four-point bending:

In these equations, F is the force, d is the displacement, a is the distance from the support to the inner loading point (3 mm), and L is the span between the outer supports (9 mm). The yield point was calculated using the 0.2% offset method based on the stress-strain curve. The modulus of elasticity was calculated as the slope of the linear portion of the stress-strain curve.
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Publication 2008
ADMET Bones Calcium, Dietary Fibula Fracture, Bone Morphogenesis Saline Solution Strains Surface Tension Tibia Tissues
A 3D non-linear finite element (FE) knee model was developed from the computed tomography (CT) and MRI images of a healthy 36-year-old male subject.23 (link),24 The contours of the bony structures (including the femur, tibia, fibula, and patella) and the soft tissues (the ligaments and menisci) were reconstructed from the CT and MRI images, respectively. This computational knee joint model has been established and validated in previous studies.23 (link),24 The bony structures were modelled as rigid bodies.25 (link) All major ligaments were modelled with non-linear and tension-only spring elements.26 (link),27 (link) The force-displacement relationship based on the functional bundles in the actual ligament anatomy is shown in Table I.28 (link)The forces across the components of the knee joint were calculated as follows:
f(ε)={kε24ε1,0εε1k(εε1),ε>2ε10,ε<0
ε=ll0l0
l0=lrεr+1
where f(ε) is the current force, k is the stiffness, ε is the strain, and ε1 is assumed to be constant at 0.03. The ligament bundle slack length l0 can be calculated by the reference bundle length lr and the reference strain εr in the upright reference position.
Contact conditions were applied between the femoral component, PE insert, and the patellar button in TKA. The coefficient of friction between the PE material and metal was chosen to be 0.04 for consistency with previous explicit FE models.24 ,29 (link) Contact was defined using a penalty-based method with a weighting factor. As a result, contact forces were defined as a function of the penetration distance of the master into the slave surface. The PE insert and patellar button were modelled as an elastoplastic material (Table II).24 The femoral and tibial components were fully bonded to the femur and tibia bone models, respectively. All implant components were modelled as linear elastic isotropic materials (Table II).24 Surgical simulation for TKA was performed by two experienced surgeons (Y-GK and KKP). A neutral position FE model was developed according to the following surgical preferences: default alignment for the femoral component rotation was parallel to the transepicondylar axis with the coronal alignment perpendicular to the mechanical axis and the sagittal alignment at 3° flexion with a 9.5 mm distal medial resection. To develop the malrotation models, ten different malrotation cases were considered with respect to the neutral position: neutral, internal and external 2°, 4°, 6°, 8° and 10° malrotations (Fig. 1). The tibial default alignment was rotated 0° to the anteroposterior axis, the coronal alignment was 90° to the mechanical axis, and the sagittal alignment was 5° of the posterior slope with an 8 mm resection below the highest point of the lateral plateau. The implant used was the Genesis II Total Knee System (Smith & Nephew, Inc., Memphis, Tennessee).
To evaluate the effect of internal and external malrotation on the femoral component of the TKA model, the stance-phase gait and squat loading conditions were applied to both the tibiofemoral and PF joint motions.30 (link)-32 (link, link) The FE model was analysed using ABAQUS software (version 6.11; Simulia, Providence, Rhode Island). The results for the maximum contact stress on the PE insert were assessed, and the patellar button pressure and collateral ligament forces were evaluated in both internal and external malrotation conditions.
Publication 2016
A-factor (Streptomyces) Bones Collateral Ligaments Enslaved Persons Epistropheus factor A Femur Fibula Friction Healthy Volunteers Human Body Intestinal Malrotation, Familial Joints Knee Knee Joint Ligaments Males Meniscus Metals Muscle Rigidity Operative Surgical Procedures Patella Pressure Strains Surgeons Tibia Tissues X-Ray Computed Tomography

Most recents protocols related to «Fibula»

The bilateral ST36 acupoints, located on the posterolateral aspect of the knee approximately 2 mm below the fibular head, were selected for EA in our study. The mice were acupunctured by a pair of stainless needles in ST36 acupoints at a depth of 2–3 mm on bilateral hind limbs. An electrical stimulator (G6805-2A; Shanghai Huayi Medical Instrument Co., Ltd., Shanghai, China) was used in the experiment and stimulation was sustained for 30 min every day. For the SEA group, the mice underwent the same process without an electrical current. Mice were placed in a stimulus fixator for 30 min/day for 1 week before the experiment to eliminate constraint pressure.
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Publication 2023
Acupuncture Points Electricity Fibula Head Knee Mice, House Needles Pressure
The surgical procedure involving the distal femoral tumor was as follows. The incision was located on the inner side of the thigh, and the puncture channel was removed. The quadriceps femoris tendon was preserved, the femoral artery and vein were dissociated, and the intermediate femoral muscle and part of the medial femoral muscle were removed together with the tumor. The proximal osteotomy line was 3 cm away from the tumor and the distal osteotomy line was 0.5 to 2 cm away from the epiphyseal line. In 1 patient with a tumor focus of approximately 30 cm in length and close to the epiphysis of the proximal and distal ends of the femur, the proximal osteotomy line was 0.5 cm away from the epiphysis of the greater and lesser trochanter and the distal osteotomy line was 2 cm away from the epiphysis. No tumor was identified in the proximal and distal medullary cavity specimens. The tumor and soft tissue on the surface of the tumor bone and in the medullary cavity were removed, the reactive bone was removed and only the normal bone cortex was retained. Liquid nitrogen was inactivated for 30 minutes and then rewarmed for 40 minutes. The fibula with the vascular pedicle was harvested, and the length was 2 to 3 cm longer than the tumor segment. The vascularized fibula was inserted into the femur and anastomosed with the branch of the deep femoral artery, and then fixed with double plates. In 1 case the femoral inactivated bone had a large curve and as the vascularized fibula could not be sleeved into the femoral medullary cavity, the inactivated bone was cut longitudinally. We first implanted the fibula. Then, the 2 halves of the femoral cortex were caged back to wrap the fibula, bound with a steel wire, and fixed with 2 steel plates (Fig. 1). An anterior medial tibial incision was used for proximal tibial tumors, and the puncture channel was removed at the same time. Osteotomy was performed at a distance of 3 cm from the tumor at the distal end and 0.5 to 2 cm from the epiphyseal line. The patellar ligament can be retained in part or completely. The process of tumor bone treatment was similar to that in the femur. The ipsilateral vascularized fibula was inserted into the tibial medullary cavity by pushing or rotating the fibula segment in 2 patients, and the contralateral vascularized fibula was embedded into the autologous bone and then vascular anastomosis was performed in 1 patient. After the placement of a single tibial plate, the medial gastrocnemius myocutaneous flap was rotated to cover the proximal tibia, and then the patellar ligament was reconstructed (Fig. 2).
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Publication 2023
Blood Vessel Bones CM 2-3 Compact Bone Cortex, Cerebral Dental Caries Epiphyses Femoral Artery Femoral Neoplasms Femur Fibula Lesser Trochanter Ligamentum Patellae Medulla Oblongata Muscle, Gastrocnemius Muscle Tissue Myocutaneous Flap Neoplasms Neoplasms, Bone Nitrogen Operative Surgical Procedures Osteotomy Patients Punctures Quadriceps Femoris Soft Tissue Neoplasms Steel Surgical Anastomoses Tendons Thigh Tibia Veins
We positioned the patient in lateral decubitus, with a tourniquet positioned
proximally to the thigh. The surgical drape allowed visualization of the entire
leg starting from the knee to control the foot and ankle rotation during
arthrodesis. We chose a lateral, transmalleolar approach by resecting the distal
portion of the fibula and using it as a graft.
After osteotomy in the fibula, we obtained complete access to the ankle and
subtalar joints. The joints were prepared under direct visualization by
resecting the cartilage of both surfaces with osteotomes, followed by bone
perforations with Kirschner 2.0 wires.
The ankle and hindfoot were positioned with 90 degrees of dorsiflexion in
correlation to the tibia, 5 degrees of the calcaneus valgus, external rotation
of 10 to 15 degrees, provisionally fixating with Kirshner 2.0 wires, taking care
not to be in the possible path of the screws or nail.
Publication 2023
Calcaneus Cartilage Fibula Foot Grafts Joints Joints, Ankle Kirschner Wires Knee Joint Nails Osteotomy Patients Surgical Drapes Thigh Tibia Tourniquets
According to the Enneking stage, stage IB was found in 2 cases, stage IIA in 2 cases and stage IIB in 15 cases. Malawer I and II resection operations were performed in 3 and 16 cases, respectively. After successful general anaesthesia, the patients were placed in a semi-supine position with the affected limb elevated by 45˚. According to the Malawer I excision method (8 (link)), a longitudinal incision was made, and the proximal fibula along with 2-3 cm of normal diaphysis were removed. Simultaneously, a complete excision of the thin muscle sleeve around the perimeter, including the insertion of the lateral collateral ligament, was conducted. The common peroneal nerve and its motor nerve branches were preserved. Finally, the upper tibiofibular joint was excised through the capsular joint. Using the ditto incision for Malawer II excision, the resected proximal fibular tumour and its distal 2-3 cm normal diaphysis, the lateral muscle septum, common peroneal nerve and anterior tibial artery were excised (8 (link)). The superior tibiofibular joint was excised laterally through the knee joint. Gastrocnemius muscle flap transposition was required to repair the defect after tumour resection. The incision included the previous biopsy channel and 2-3 cm of the tissue at the edge. During surgical excision, the continuity of the biceps femoris tendon and lateral collateral ligament, as well as the continuity of the lateral deep fascia and the iliotibial band, were retained as much as possible. Using the rivet and non-absorbable nylon thread, the biceps femoris tendon and the insertion point of the lateral collateral ligament were closely sutured through the perforation of the lateral tibial condylar cortex. Small holes were made in the lateral cortex of the tibial condyle, the rivet and non-absorbable nylon suture were used to reconstruct the insertion point of the biceps femoris and lateral collateral ligament.
Patients with Malawer I resection underwent rehabilitation exercises of knee flexion and extension at 3 weeks post-surgery, whereas patients with Malawer II resection had to delay exercise for 2-3 weeks. Foot sagging was caused by common peroneal nerve resection. Ankle braces were used to assist walking exercise at 6 weeks post-surgery.
Publication 2023
Biceps Femoris Biopsy Braces CM 2-3 Condyle Cortex, Cerebral Diaphyses DMBT1 protein, human External Lateral Ligament Fascia Fibula General Anesthesia Joint Capsule Joints Joints, Ankle Knee Joint Muscle, Gastrocnemius Muscle Tissue Neoplasms Nervousness Neurectomy Nylons Operative Surgical Procedures Patients Perimetry Peroneal Nerve Rehabilitation Surgical Flaps Sutures Tendons, Biceps Femoris Tibia Tibial Arteries, Anterior Tissues
The endplates in the TA muscle are not sharply demarcated and are distributed along the whole muscle by staining longitudinal cryosections for cholinesterase (7 (link)). Despite the staining motor point demarcation, other descriptions, using an electrophysiological analysis, found the main motor point located at the proximal third of the TA muscle belly (8 (link)). Botter et al. (9 (link)) found another minor motor point located distally and laterally between the middle and the distal third. The main motor point could be localized by Buchthal et al. (1 (link)) tracing a line between the tibial bone tuberosity at the knee down to a median line between the two malleoli; the limit between the upper and the middle third is the reference point and (2 (link)) tracing a line between the fibular head and the medial malleolus; the limit between the upper and the middle third is the reference point (10 (link)).
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Publication 2023
Bones Butyrylcholinesterase Cryoultramicrotomy Fibula Head Knee Joint Muscle Tissue Tibia

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More about "Fibula"

Discover optimized research protocols for the fibula, a key component of the lower leg, with PubCompare.ai's innovative AI-driven platform.
Easily locate relevant protocols from scientific literature, preprints, and patents, while utilizing advanced AI-based comparisons to identify the best protocols and products.
Streamline your fibula research with PubCompare.ai's powerful tool, making it easier than ever to explore this crucial anatomical structure.
The fibula, also known as the calf bone, is a long, slender bone located on the lateral (outer) side of the lower leg.
It plays an important role in weight-bearing, ankle stability, and the attachment of various muscles and ligaments.
Researchers studying the fibula may utilize advanced imaging techniques like VivaCT 40, Skyscan 1172, SkyScan 1176, DS7AH, μCT40, and μCT100 to analyze its structure and function.
Fibula research can involve a wide range of topics, including bone health, fracture healing, biomechanics, and the development of innovative treatment strategies.
Researchers may culture fibular cells in DMEM medium and use MATLAB software for data analysis.
Understanding the fibula's role in the musculoskeletal system is crucial for advancements in orthopedics, sports medicine, and rehabilitation.
PubCompare.ai's AI-driven platform is designed to streamline the fibula research process, helping scientists quickly identify the most relevant and optimized protocols from a vast pool of scientific resources.
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