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Lip

Lip, the fleshy, movable fold of skin that forms the outer boundary of the mouth in humans and many animals.
Lipps play a crucial role in speech, swallowing, and facial expressions.
They are composed of muscle, connective tissue, and mucous membranes, and can be affected by various conditions such as cleft lip, cheilitis, and lip cancer.
Understanding the anatomy and function of the lip is important for medical professionals in fields like dentistry, plastic surgery, and speech therapy.
Resaerch into lip structure and dynamics can lead to advancements in prosthetics, reconstructive procedures, and speech rehabilitation.*

Most cited protocols related to «Lip»

Three prospective cohorts of individuals with signs and symptoms suggestive of SS have been recruited over the past 10 years by teams who are now members of the International SS Criteria Working Group. These include 1) the SICCA cohort, comprised of 3514 participants (including 1578 individuals who meet the ACR classification criteria for pSS) recruited from Argentina, China, Denmark, India, Japan, the UK and the USA (co-principal investigators (PIs): C. Shiboski and L. Criswell, at the University of California San Francisco); 2) the Paris-Sud cohort that includes 1011 participants (including 440 individuals who meet the AECG criteria for pSS) recruited in Paris, France (PI: X. Mariette at Paris-Sud University, Bicêtre hospital in Paris); and 3) the OMRF cohort, that includes 837 participants (including 279 individuals who meet the AECG criteria for pSS) evaluated at either the Sjögren’s Research Clinic at OMRF or the Sjögren’s Clinic in the University of Minnesota (PI: K. Sivils,OMRF).
These cohorts share several key characteristics that make them appropriate for criteria development: Inclusion criteria required that participants have signs and symptoms suggestive of SS, warranting a comprehensive work-up by a multi-disciplinary team of SS clinicians. In addition to symptom-related data, objective tests with respect to oral, ocular, and systemic/serological endpoints had been collected using similar procedures:

Oral tests: labial salivary gland (LSG) biopsy to identify focal lymphocytic sialadenitis (FLS) and focus score (FS)(26 (link)); UWS flow rates.(27 (link), 28 (link))

Ocular tests: OSS using lissamine green and fluorescein, and other ocular tests such as Schirmer test and tear break-up time. For the ocular staining test, the Paris-Sud cohort used the VBS,(29 (link)) while SICCA used the OSS,(30 (link)) and OMRF used both. The Paris-Sud cohort also used fluorescein and collected data on the individual OSS components, so it could be computed subsequently. Thus data from the Paris-Sud and OMRF cohorts could be analyzed to establish a conversion algorithm between both scores as follows: for lower scores, 1–3, the VBS was equal to the OSS, but VBS of 4, 5, or 6 were equivalent to OSS scores of 5, 6, or 7, respectively. For the clinical vignettes, the ocular staining test was expressed as the OSS ranging from 0 to 7 and above. A group of four ophthalmologists from France, the US, and the UK formed an ad-hoc working group that interpreted the analyses performed on the Paris-Sud data (ML and TML) and on the OMRF data (AR). Together, they derived the conversion algorithm between the OSS and the VBS described above. In addition, since the VBS of 4 (previously used in the AECG criteria) was equivalent to an OSS of 5, the group agreed to modify the OSS threshold to 5 in the new criteria set. This threshold has also been shown, as part of subsequent analyses of the SICCA data, to be more specific for diagnostic purposes than the previous score of 3 (data not shown).

Serological assays: including anti-SSA/B(Ro/La), ANA titers, RF, IgG, presence of complement C3 and C4.

Cohort PIs were each asked to provide a dataset that consisted of a random sample of 400 individuals with equal numbers of pSS cases and non-cases (using their own diagnostic definition), and without revealing case status in the dataset. The combined datasets thus comprised 1200 individuals with well-characterized data on the phenotypic features of SS. Clinical vignettes describing each individual’s relevant features in text form were computer-generated using a program written in R version 3.2.(31 ) Vignettes described each individual with respect to age, gender, reported symptoms, clinical signs, and provided test results including ANA titers, RF, IgG, C3, C4, anti-SSA(Ro), anti-SSB(La), OSS for each eye, Schirmer for each eye, whether or not the LSG biopsy revealed FLS, and a FS (supplemental Figure 1). Ocular symptoms were defined according to the AECG definition, as a positive response to at least one of the following questions: 1) Have you had daily, persistent, troublesome dry eyes for more than 3 months? 2) Do you have a recurrent sensation of sand or gravel in the eyes? 3) Do you use tear substitutes more than 3 times a day? Oral symptoms were defined as a positive response to at least one of the following questions: 1) Have you had a daily feeling of dry mouth for more than 3 months? 2) Do you frequently drink liquids to aid in swallowing dry food?
Publication 2016
Biological Assay Biopsy Complement 3 Diagnosis Dry Eye Eye Fluorescein Food Gender Lip Lymphocyte Ophthalmologists Phenotype Salivary Glands Sialadenitis Tears Vision Xerostomia
Mothers were asked to bring in at the time of the 7-year assessment a tooth the child had shed. In the present study, we used incisors that were free of obvious defects (caries, hypoplasias, fluorosis, cracks, extensive attrition) and prepared ~100–150 μm sections in an axial labio-lingual plane. Using light microscopy, we identified the neonatal line (NL), a histological feature formed in deciduous teeth at birth (see Supporting Information, Figure S1). With the NL as a reference point, we measured Mn levels (as 55Mn:43Ca) in mantle dentine immediately adjacent to the enamel-dentine junction (EDJ) with laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) (Figure 1, Supporting Information Table S1, and Arora et al. 2011 [17 (link)]). We normalized Mn measurements to 43Ca to account for intra- and inter-sample variations in mineralization. We confirmed that our sampling points were in mantle dentine by examining sections in polarized light where mantle dentine is clearly demarcated from circumpulpal dentine (Figure 1d).
We sampled mantle dentine at 30 equally spaced points adjacent to the EDJ from cusp tip to the cemento-enamel junction and calculated the area under the curve (AUC) of Mn levels across all the sampling points in prenatally formed mantle dentine to estimate cumulative Mn exposure in the prenatal period. Because floor dust and blood samples were collected during the second trimester, we also undertook analyses restricted to Mn levels in sampling points located in mantle dentine formed in the second trimester.
Publication 2012
Birth BLOOD Child Deciduous Tooth Dental Caries Dental Enamel Dentin Fluorosis, Dental hypoplasia Incisor Infant, Newborn Laser Ablation Light Light Microscopy Lip Mass Spectrometry Mothers Physiologic Calcification Plasma Tongue Tooth Tooth Attrition TP63 protein, human
One way to understand polygenic associations for a complex trait is if
the implicated genetic variants are in genes that comprise a biological pathway.
Gene-set analysis includes evaluation of genetic variants in genes that are
grouped based on their interacting role in biological pathways (biological
pathway analysis) and genes that share similar cellular functions (functional
gene-set analysis).
We used JAG (Joint Association of Genetic variants, http://ctglab.nl/software) to conduct gene-set analyses. This
method has previously been applied to the International Schizophrenia Consortium
data by Lips et al. 94 (link) JAG
tests for the association of specified gene-sets with schizophrenia as applied
to individual-level genotype data which tends to be more powerful than using
summary statistics. JAG constructs a test-statistic for each gene-set. JAG
includes both self-contained and competitive tests. These two approaches
evaluate different null hypotheses. Statistical significance
(Pself and
Pcomp) are determined using permutation. First, the
self-contained test evaluates the null hypothesis that a defined set of genes is
not associated with schizophrenia while accounting for the some of the
properties of the SNPs being studied (e.g., LD structure). Second, the
competitive test evaluates whether a specific set of genes has evidence for
stronger associations with schizophrenia than randomly selected sets of control
genes (with the latter matched to the former using the same effective number of
SNPs per gene-set). Thus, a competitive test is of the null hypothesis is that
these genes are not more strongly associated than a similar but
randomly-selected set of genes. That is, the comparison is more one to the
average degree of association across genes. The principal comparison is the
competitive test, and we present self-contained tests for completeness.
Competitive gene-set tests are more appropriate for a polygenic disease like
schizophrenia because they explicitly prioritize gene-sets that show a greater
average degree of association, over and above the polygenic background, rather
than prioritizing larger but more weakly-enriched gene-sets (as self-contained
tests would tend to do).
Publication 2013
Biopharmaceuticals Genes Genes, vif Genetic Diversity Genetic Testing Genotype Joints Lip Physiology, Cell Polygenic Traits Schizophrenia Single Nucleotide Polymorphism
In order to validate the CPQ instrument, which was carried out in its developers’ study [11 (link)], the respondents were asked to rate their oral health and the extent to which it affected their well-being. For each of these dimensions, five sub-items were worded in the following way: a) “How you would describe health status of the following oral parts: - teeth; - lips; - gum; - oral mucosa; - jaws or joints?” and b) “Over the last three months, how much has your overall life been affected by the conditions of the following oral parts: - teeth; - lips; - gum; - oral mucosa; - jaws or joints?” The responses were scored in the following way: with regard to oral health rating: (0) ‘excellent’; (1) ‘very good’; (2) ‘good’; (3) ‘fair’, and (4) ‘poor’; with regard to well-being: (0) ‘not at all’; (1) ‘very little’; (2) ‘somewhat’ (3) ‘a lot’; and (4) ‘very much’. The sum score of all sub-items for each dimension ran from 0 to 20.
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Publication 2019
Jaw Joints Lip Mouth Diseases Mucosa, Mouth Tooth

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Publication 2008
Asthma Confined Spaces Ethics Committees, Research Healthy Volunteers Homo sapiens Lip Oral Cavity Safety Student Vision Voluntary Workers Woman

Most recents protocols related to «Lip»

At the clinical visit, parents/carers and twins were instructed not to brush their teeth from 7 pm the previous evening until after the clinical visit and not to eat or drink in the half an hour before the appointment. Supra-gingival plaque biofilm samples were taken by a team of calibrated clinicians (registered dentist, oral health therapist or a supervised dental student) wearing sterile gloves. Oral biofilm samples were obtained using sterile Cultiplast® Tampone Swabs (LP Italiana, Milan, Italy). The labial/buccal surfaces and gingival margins of teeth in the maxillary and mandibular right-hand side were gently but thoroughly swabbed for 30 seconds per quadrant. The swab was inserted into a tube containing VMGII. The cotton tip was fully submerged, the wooden handle was broken so the swab was left in the media. The tube was sealed and placed directly on dry ice at collection. All samples were transferred to −80 °C freezer within 4 h of collection.
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Publication 2023
Biofilms Dental Plaque Dentist Dry Ice Gingiva Gossypium Lip Mandible Maxilla Neoplasm Metastasis Parent Sterility, Reproductive Students, Dental Tooth Twins
The Sehhaty application was launched under the umbrella of digital transformation initiatives by the Saudi MOH aiming to provide access to several healthcare services for individuals in the Kingdom. These services included consultations, PCR testing for SARS-CoV-2, booking COVID-19 vaccine appointments, and reporting COVID-19 vaccines side-effects through the option of manual entering and/or drop box option selection (16 ). Indeed, the Sehhaty application offers a checkbox option to report symptoms for the received vaccine. The following symptoms were available for users to select from in the following order: injection site itching, wheezing, fatigue, hoarseness, low fever, anxiety, fever above or below 39°C, heartburn, injection site swelling, headache, loss of consciousness, nausea, injection site redness, injection site pain, itchiness other than injection site, seizure, dizziness, difficulty or shortness of breath, sleep disruption, swelling of lips, face, and throat, and intensive care unit (ICU) admission. The study participants were provided with a checkbox list that included all of the aforementioned side-effects and were given the option to select from the list if they experienced any of them. Another helpful feature was the registration of the date and the start of symptoms, which allowed for filtering and limiting the studied side-effects to be within a window of 14 days post-vaccination (7 (link)). Participants' demographics data were collected and included: age, gender, nationality, region, COVID-19 vaccine type, the number of vaccine doses, date of vaccination, and date of ICU admission.
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Publication 2023
Anxiety COVID-19 Vaccines Dyspnea Erythema Face Fatigue Fever Gender Headache Heartburn Hoarseness Lip Nausea Pain Pharynx Pruritus SARS-CoV-2 Seizures Sleep Vaccination Vaccines
The study included all vaccinated female and male individuals in Saudi Arabia of any ethnicity, who were 12–96 years of age and spontaneously self-reported their side-effects through the Sehhaty app after receiving at least one dose of the three available COVID-19 vaccines: Pfizer–BioNTech (BNT162b2), Oxford–AstraZeneca (ChAdOx1-S), and/or Moderna (mRNA-1273) within 14 days of receiving COVID-19 vaccination over the period from 17th December 2020 to 31st December 2021 (7 (link)). The ICU records were considered post vaccine events if they happened within 14 days post COVID-19 vaccination. The exclusion criteria entailed individuals with wrong or missing data entry and/or misidentified unique IDs, individuals who are under 12 years or above 96 years old, those who did not receive COVID-19 vaccination, or who received COVID-19 vaccines other than Pfizer–BioNTech, Oxford–AstraZeneca or Moderna vaccines, and those who reported their side-effects outside of the 14-day window. We excluded those with pre-existing comorbidities and/or autoimmune diseases, as they could confound the results of the self-reported vaccines adverse events. The primary objective was to determine the patterns of minor side-effects: injection site (itchiness, pain, reaction, redness, swelling, and other), anxiety, dizziness, fever above or below 39°C, headache, hoarseness, itchiness other than injection site, loss of consciousness, nausea, heartburn, sleep disruption, and fatigue. In addition, we examined the pattern of reported major COVID-19 vaccine side-effects: seizures, shortness of breath, wheezing, swelling of lips, face, and throat, ICU admission, and loss of consciousness. The AEs were classified as local, systemic, or allergic, or as mild or moderate.
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Publication 2023
2019-nCoV Vaccine mRNA-1273 Anxiety Autoimmune Diseases BNT162B2 ChAdOx1 nCoV-19 COVID-19 Vaccines COVID 19 Dyspnea Erythema Ethnicity Face Fatigue Fever Headache Heartburn Hoarseness Lip Males Nausea Pain Pharynx Pruritus Seizures Sleep Vaccination Vaccine, Pfizer Covid-19 Vaccines Woman
Vital capacity and forced expiratory volume were analyzed using a spirometer, in accordance with the technical procedures, acceptability, and reproducibility criteria, in an air-conditioned room environment between 22ºC and 24ºC, according to the guidelines laid down by the American Thoracic Society/European Respiratory Society (Miller et al., 2005 (link)). The participants were instructed to avoid bulky meals and not smoke or drink alcoholic beverages, coffee, or tea on the day of the examination. During the test, the participants remained seated with the elbows, hips, and knees at 90º, applied the nose clip, and received instructions on the respective maneuvers before performing the procedures. The lips were adjusted to the mouthpiece to prevent air leakage. Deep inspiration was performed, followed by rapid and forced expiration for as long as possible. At the end of the maneuver, deep inspiration was performed again. During the maneuvers, constant and repetitive stimuli of the instructor responsible for the examination were important. A minimum of three and a maximum of five forced expiratory curves were obtained to measure the forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1) in L, and the relationship between these two variables (FEV1/FVC) as a percentage (%).
Publication 2023
Alcoholic Beverages Clip Coffee Coxa Dietary Fiber Europeans Exhaling Forced Vital Capacity Inhalation Joints, Elbow Knee Lip Nose Respiratory Rate Smoke Spirometry Vital Capacity Volumes, Forced Expiratory
On admission to the ICU, the patients’ oral health was assessed utilizing the modified Beck Oral Assessment Score (BOAS), consisting of 5 subscales: assessment of lips, mucosa and gingiva, tongue, teeth, and saliva. A higher score reflects dysfunction or tissue injury. BOAS scores range from 5 (no oral dysfunction) to 20 (severe dysfunction). A score greater than 5 is abnormal [22 (link), 23 (link)] (Additional file 1: Appendix A1).
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Publication 2023
Gingiva Injuries Lip Mucous Membrane Patients Saliva Tissues Tongue Tooth

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More about "Lip"

Discover the fascinating world of lips, the versatile and vital structures that play a crucial role in our daily lives.
Lips, also known as the labiae or labia, are the fleshy, movable folds of skin that form the outer boundary of the mouth in humans and many animals.
These intricate anatomical features are composed of muscle, connective tissue, and mucous membranes, and are essential for speech, swallowing, and facial expressions.
Lips are not just important for their functional capabilities but also for their aesthetic and social significance.
They can be affected by various conditions, such as cleft lip, cheilitis, and lip cancer, which can have significant impacts on an individual's physical and emotional well-being.
Understanding the anatomy and function of lips is therefore crucial for medical professionals in fields like dentistry, plastic surgery, and speech therapy.
Research into lip structure and dynamics has led to advancements in prosthetics, reconstructive procedures, and speech rehabilitation.
Techniques like TRIzol reagent extraction, FBS culture, Transbond XT adhesive, and DM2500 imaging have all contributed to our understanding of lip biology and function.
Additionally, tools like the Williams Colour-Coded Probe, Nano-Glo® Luciferase Assay Reagent, and NanoLuc luciferase have enabled researchers to study the complex molecular mechanisms underlying lip development and behavior.
Whether you're a medical professional, a researcher, or simply someone interested in the human body, the world of lips is a fascinating and ever-evolving field of study.
Explore the latest insights and techniques with the help of PubCompare.ai, the ultimate tool for scientific discovery and collaboration.
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