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Meniscus, Medial

The meniscus, medial is a crescent-shaped fibrocartilage structure located in the knee joint.
It plays a crucial role in load distribution, shock absorption, and joint stability.
This vital structure can be affected by various injuries and degenerative conditions, making its study and understanding crucial for advancements in orthopedics and sports medicine.
PubCompare.ai's AI-powered platform offers an effeicient way to locate the most reliable and reproducible protocols from literature, preprints, and patents, empowering researchers to optimize the reproducibility of their meniscus, medial-related studies.

Most cited protocols related to «Meniscus, Medial»

1
Cross-species Comparative Knee Anatomy

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Publication 2011
Adolescents, Female Animals Animal Structures Anterior Cruciate Ligament Arm, Upper Bones Canis familiaris Capsule Cattle Collateral Ligaments Condyle Dissection Domestic Sheep Epistropheus Euthanasia Fascia Females Femur Flushing Fracture Fixation Freezing Goat Homo sapiens Horns Human Body Institutional Animal Care and Use Committees Joints Knee Ligaments Ligamentum Patellae Menisci, Lateral Meniscus Meniscus, Medial New Zealand Rabbits Pad, Fat Passive Range of Motion Patella Posterior Cruciate Ligament Rabbits Reproduction Skin Steel Tibia Tissue, Adipose Tissues Woman
2
Knee Joint Histology Protocol

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Publication 2015
Condyle Fast Green Femur Formalin Knee Joint Meniscus, Medial Paraffin Embedding Posterior Horn of Spinal Cord Proteoglycan safranine T Tibia Tissues Zinc
3
Meniscus Tissue Sampling Protocol

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Publication 2017
Bone Marrow Cartilage Collateral Ligaments Edema Ethics Committees, Research Fibrosis Gender Horns Index, Body Mass Injuries Knee Knee Replacement Arthroplasty Ligaments Meniscectomy Meniscus Meniscus, Medial Necrosis Osteogenesis Patients Strains Synovial Membrane X-Rays, Diagnostic
4
Identifying ACL Retear Risk Factors
Data from this 2002–2008 cohort database were used to identify risk factors for ACL retear. This study was reviewed and approved by each participating site’s respective institutional review board, and all subjects provided written informed consent prior to data collection. Subjects were selected from an ongoing prospective cohort study, enrolled between 2002 and 2008, which was designed to identify risk factors for patient outcomes and risk of ACL retear. Subjects who had a primary ACLR with no history of contralateral knee surgery with 2-year follow-up data were included in the cohort (Figure 1). Subjects who underwent a multiligament reconstruction or had a hybrid autograft + allograft ACLR were excluded from the analysis. Patient age, sex, BMI, smoking status, Marx activity score (37 (link)) at time of index surgery, graft type (bone- patellar tendon-bone [BTB] autograft, hamstring autograft, allograft), sport played after ACLR, full thickness lateral meniscus tear at the time of ACLR, full thickness medial meniscus tear at the time of ACLR, and consortium site were evaluated to determine their contribution to both ipsilateral retear and contralateral ACL tear.
Kaeding C.C., Pedroza A.D., Reinke E.K., Huston L.J, & Spindler K.P. (2015). Risk Factors and Predictors of Subsequent ACL Injury in either Knee after ACL Reconstruction: Prospective Analysis of 2488 Primary ACL Reconstructions from the MOON Cohort. The American journal of sports medicine, 43(7), 1583-1590.
Publication 2015
Allografts Anterior Cruciate Ligament Tear Bone and Bones Ethics Committees, Research Grafts Hybrids Knee Ligamentum Patellae Menisci, Lateral Meniscus, Medial Operative Surgical Procedures Patients Reconstructive Surgical Procedures Tears Transplantation, Autologous
5
Detailed Anatomical Mapping of Medial Collateral Ligaments
The insertion sites of the sMCL and dMCL were identified from their bony insertions of the femur and tibia (Fig. 1A). Three anatomic landmarks on the femur (ME = medial epicondyle, MGT = medial gastronomies tubercle, MAT = medial adductor tubercle) were specified as references for later measurements (Fig. 1B)[11 (link)]. The sMCL and dMCL were separated by a bursa in all cadaveric knees. The sMCL was carefully separated from the dMCL without damaging the dMCL during the dissection. The anterior part of the sMCL was vertically aligned but the posterior part was oblique (Fig. 2A). Unlike the anterior part, the posterior part of the sMCL was found firmly attached to the medial meniscus (Fig. 3)[13 ]. The dMCL, which consisted of a proximal portion (meniscofemoral ligament - MFL) and distal portion (meniscotibial ligament - MTL), was relative thinner compared to the sMCL (Fig. 4A). The pes anserinus tendons (sartorius, gracilis, and semitendinosus tendon) were detached from their tibial attachments during dissection. A fine-point marker was used to outline the location of the medial structures of the knee.
The outlines of the insertion sites of each ligament were then digitized using a 3D digitizing system which has a reported accuracy of 0.3 mm (MicroScribe G2LX; Immersion Technologies, San Jose, CA, USA). The digitized points were imported into solid modelling software (Rhinoceros; Robert McNeel and Associates, Seattle, WA, USA) to calculate the areas of the insertion sites and the centroids of the insertion areas. These values were calculated by using the inbuilt functions ("Area" and "AreaCentroid") of the Rhinoceros software.
In this study, we first determined the insertion areas of the sMCL and dMCL on the femur and tibia (Fig. 1A). We then measured the distances between the centroids of the insertion areas to determine the length of the ligament [11 (link)]. Joint line was determined according to the previous definitions of Laprade et al. [11 (link)], where the edge of the articular cartilage surface of the medial femoral condyle was defined as the femoral joint line and the medial tibial plateau as the tibial joint line. All measurements were performed according to a sequence of eight steps (Fig. 5).
Liu F., Yue B., Gadikota H.R., Kozanek M., Liu W., Gill T.J., Rubash H.E, & Li G. (2010). Morphology of the medial collateral ligament of the knee. Journal of Orthopaedic Surgery and Research, 5, 69.
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Publication 2010
Anatomic Landmarks Bones Cartilages, Articular Condyle Dissection Femur Gracilis Muscle Immersion Joints Knee Ligaments Meniscus, Medial Semitendinosus Tendon Synovial Bursa Tendons Tibia

Most recents protocols related to «Meniscus, Medial»

1
Peptide Therapy for Post-Traumatic OA
Not available on PMC !

Example 4

Amino acid sequences of region-A are 100% homologous between human and mouse. In order to further establish the in vivo activity of the peptides for use according to the invention, representative peptides may be tested in a well-accepted model for post-traumatic OA, the DMM model. The medial meniscus may be destabilized in 12 weeks old C57BL/6 mice. One week after DMM induction, peptides may be administered intra-articularly by twice-weekly injections as described previously. Dose may be based on intra-articular BMP-7 studies in which weekly injections of 250 ng BMP-7 in a rat knee joint (in 100 μl) showed favorable outcomes. As 10 μl can be injected in an OA mouse joint an equivalent amount of 25 ng peptide in this volume may be injected per knee joint. An amount of 2.5 and 0.25 ng peptide may also be tested in 2 additional groups to determine the pharmacological potency of the peptide. Saline injections may be used as controls. The sample size of this experiment is advantageously 8 mice per group. Animals may be sacrificed at consecutive time points after start of peptide treatment (2, 4, 8 weeks). Knee joints may be processed for (immuno)histochemical analyses and OARSI scoring (Safranin-O; modified Pritzker).

US11872264B2. Method for the treatment or prevention of osteoarthritis (2024-01-16). Chondropeptix B.V. [NL]. Inventors: Tim Johannes Maria Welting [NL], Marjolein Maria Johanna Caron [NL].
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Patent 2024
Aftercare Amino Acid Sequence Animals Bone Morphogenetic Protein 7 Homo sapiens Joint Loose Bodies Joints Knee Joint Meniscus, Medial Mice, House Mice, Inbred C57BL Peptides safranine T Saline Solution
2
Surgical Induction of Osteoarthritis in Rats
Rats were anesthetized with 4% isoflurane. The right knee was shaved, aseptically prepared with 90% alcohol, and exposed for surgery. For all groups, the same surgical approach was performed according to the standard incision performed in arthroplasty, prosthesis placement, and treatment of severe OA procedures in humans. This approach was also carried out in a previous experiment by this research group (Filho et al., 2021 (link)). It involves an anterior surgical approach to the knee, followed by medial parapatellar arthrotomy and lateral patellar dislocation, allowing access to the medial compartment of the knee of the animals (INSALL, 1971 (link)).
In OA groups, a meniscectomy of the medial meniscus was performed. Complete resection of the medial meniscus of the right hind limb was performed with a cold scalpel blade. In the Sham group, only the surgical approach was performed, without meniscectomy, followed by incision closure in two planes. There was no access to the lateral compartment of the joint and no additional ligament resection in any of the procedures. The central ligaments of the knee (anterior and posterior cruciate) and collateral ligaments (lateral and medial) were preserved. After reducing the patellar dislocation, the surgical incisions were closed in two planes with mono nylon sutures.
da Silva L.A., Thirupathi A., Colares M.C., Haupenthal D.P., Venturini L.M., Corrêa M.E., Silveira G.D., Haupenthal A., do Bomfim F.R., de Andrade T.A., Gu Y, & Silveira P.C. (2023). The effectiveness of treadmill and swimming exercise in an animal model of osteoarthritis. Frontiers in Physiology, 14, 1101159.
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Publication 2023
Animals Arthroplasty Collateral Ligaments Common Cold Ethanol Hindlimb Homo sapiens Isoflurane Joints Knee Ligaments Meniscectomy Meniscus, Medial Nylons Operative Surgical Procedures Patellar Dislocation Prosthesis Implantation Rattus norvegicus Surgical Wound Sutures
3
Return to Play After ACL Injury in Elite Soccer
After receiving ethics committee approval for the study protocol, we conducted a retrospective review of consecutive elite United European Football Association (UEFA) professional soccer players with a complete ACL injury who underwent ACLR at our institution. All patients underwent surgery by the senior author (C.F.) between September 2018 and May 2022. Patients with multiligamentous injuries and revision ACLR and those who had not returned to sport at the time of data collection were excluded. All patients had belonged on the first team of elite UEFA leagues (Bundesliga, Serie A, Premier League) during the ACL rupture.
All demographic and anthropometric characteristics—age, height, weight, body mass index, position, injury history, affected side, RTP time, minutes played per season (MPS), and MPS as a percentage of playable minutes—before and after ACLR were retrieved from medical records and publicly available media-based platforms: Transfermarkt (https://www.transfermarkt.com), uefa.com,fifa.com, official team websites, injury reports, official team press releases, personal websites, and professional statistical websites. These methods have commonly been used in similar research.10 ,20
Concomitant injuries to menisci, cartilage, and collateral ligaments were extracted from our clinical database.
The overall RTP rate was defined as the percentage of players, among all the injured players in the study, who were able to play in at least 1 game at a professional level after ACLR. RTP time was defined as the number of days from ACL injury to the first match appearance. The mean MPS and MPS% were calculated for the preinjury season as well as the first 3 postoperative seasons for all applicable players. The first season after ACLR, with a minimum of 4 months of competition, was defined as the first season of return to sport. The second and third seasons after ACLR, regardless of the amount of time played, represented the seasons after the first season post-ACLR. Players were noted who moved to a lower league according to UEFA country ranking during the same seasons or stopped their careers for any reason during the observation period. Complications after ACLR were documented.
The RTP times were compared with respect to player age (<25 vs ≥25 years), field position, absence of cartilage and meniscal tears, lateral and medial meniscal repair, type of graft, and presence of lateral extra-articular tenodesis (LET).
Farinelli L., Abermann E., Meena A., Ueblacker P., Hahne J, & Fink C. (2023). Return to Play and Pattern of Injury After ACL Rupture in a Consecutive Series of Elite UEFA Soccer Players. Orthopaedic Journal of Sports Medicine, 11(3), 23259671231153629.
Publication 2023
Anterior Cruciate Ligament Injuries Cartilage Collateral Ligaments Ethics Committees Grafts Index, Body Mass Injuries Joints Meniscus Meniscus, Medial Operative Surgical Procedures Patients Tears Tenodesis
4
Experimental Osteoarthritis Model: DMM and E.G. Treatment
Based on previous reports, we used an experimental model with surgical destabilization of the medial meniscus (DMM), which exhibits severe cartilage degradation and cartilage damage characteristic of OA.24 (link) The medial meniscus tibial ligament of C57BL/6 mice was made unstable during DMM surgery. In the sham group, no joint tissue was manipulated during surgery. We divided the mice into five groups at random: Sham group; DMM group; E.G. low group (E.G. L group); E.G. medium group (E.G. M group) and E.G. high group (E.G. H group). According to animal dose conversion table, we then determined the dose of the experimental group. After OA modeling, mice in E.G. high group received E.G. treatment at a dose of 1.17 g/kg/day orally for 12 consecutive weeks. Ratio of high, medium and low-dose groups is 4:2:1. Physiological saline was administered orally to mice in both the sham and DMM groups.
Wang P., Xu J., Sun Q., Ge Q., Qiu M., Zou K., Ying J., Yuan W., Chen J., Zeng Q., Cui Q., Jin H., Zhang C, & Li F. (2023). Chondroprotective Mechanism of Eucommia ulmoides Oliv.-Glycyrrhiza uralensis Fisch. Couplet Medicines in Knee Osteoarthritis via Experimental Study and Network Pharmacology Analysis. Drug Design, Development and Therapy, 17, 633-646.
Publication 2023
Animals Cartilage Joints Ligaments Meniscus, Medial Mice, House Mice, Inbred C57BL Operative Surgical Procedures physiology Saline Solution Tibia Tissues
5
Osteoarthritis Rat Model and Isorhy Treatment
The destabilized medial meniscus (DMM) model was used to mimic OA. 15 four-week-old male Sprague Dawley rats (200–250 g) were correctly partitioned into three portions: Normal group, OA group (surgery; normal saline treatment on the Monday of every week from the 5th to the 8th week after surgery) and OA + Isorhy group (surgery; 50 μM Isorhy treatment on the first day of every week from the 5th to the 8th week after surgery). After 4 weeks of drug treatment, all animals were euthanized through CO2 induction. Then the rats had been processed without debridement of the knee specimens and fixed using 4% paraformaldehyde for two days. This study was conducted according to the NIH guidelines (NIH Pub No 85-23, revised 1996) and the Chinese Regulations for the Management of Laboratory Animals, and followed the Guide for the Care and Use of Laboratory Animals published by the National Institutes of Health (NIH) in 2011, which has already been permitted through the ethics committee of the Second Affiliated Hospital of Jiaxing University.
Jiang J., Li J., Xiong C., Zhou X, & Liu T. (2023). Isorhynchophylline alleviates cartilage degeneration in osteoarthritis by activating autophagy of chondrocytes. Journal of Orthopaedic Surgery and Research, 18, 154.
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Publication 2023
Aftercare Animals Animals, Laboratory Chinese Debridement Ethics Committees, Clinical Knee Males Meniscus, Medial Normal Saline Operative Surgical Procedures paraform Pharmaceutical Preparations Rats, Sprague-Dawley Rattus norvegicus

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More about "Meniscus, Medial"

The medial meniscus is a crescent-shaped fibrocartilage structure located within the knee joint.
This vital component plays a crucial role in load distribution, shock absorption, and joint stability.
Understanding the medial meniscus is essential for advancements in orthopedics and sports medicine, as it can be affected by various injuries and degenerative conditions.
Researchers exploring the medial meniscus may utilize a range of animal models, such as C57BL/6 mice, Lewis rats, and others, to study its structure, function, and pathologies.
Pharmacological agents like Rompun, Tamoxifen, Zoletil 50, and Buprenorphine may be employed to facilitate research procedures.
Additionally, advanced imaging techniques, such as 3D Bioplotter, and data analysis software, like SAS version 9.4, can provide valuable insights into the medial meniscus and its related conditions.
PubCompare.ai's innovative AI-powered platform offers an efficient way for researchers to locate the most reliable and reproducible protocols from literature, preprints, and patents, empowering them to optimize the reproducibility of their medial meniscus-related studies.
This platform can help researchers identify the best methods and techniques, ensuring their research is backed by the most reliable and reproducible approaches.
By leveraging the insights and tools available, researchers can advance our understanding of the medial meniscus, leading to improved diagnostic, treatment, and rehabilitation strategies for conditions affecting this crucial knee joint structure.