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Spinal Canal

Q: What are some common conditions that can affect the spinal canal?

Some of the most prevalent conditions impacting the spinal canal include: 1. Spinal stenosis - This is a narrowing of the spinal canal that can compress the spinal cord and/or nerve roots, leading to pain, numbness, and weakness in the extremities. 2. Spinal tumors - Both benign and malignant growths can develop within or around the spinal canal, potentially compressing the spinal cord and causing neurological symptoms. 3. Herniated/bulging discs - When the discs between the vertebrae rupture or protrude, they can encroach on the spinal canal space and pinch the nerve roots. 4. Spinal cord injuries - Trauma to the spine can damage the structural integrity of the spinal canal, resulting in spinal cord compression and loss of function. Understanding the underlying causes and mechanisms of these spinal canal disorders is critical for devising effective diagnostic and treatment strategies.

Q: How can PubCompare.ai help researchers studying the spinal canal?

PubCompare.ai can be an invaluable tool for researchers investigating the spinal canal and associated conditions. The platform allows you to: 1. Screen protocol literature more efficiently: PubCompare.ai's AI-powered search and analysis capabilities can help you quickly identify the most relevant studies and protocols related to spinal canal research from a wide range of sources, including publications, pre-prints, and patents. 2. Leverage AI to pinpoint critical insights: The platform's advanced algorithms can highlight key differences in protocol effectiveness, enabling you to choose the best options for ensuring reproducibility and accuracy in your spinal canal research. By streamlining the research process and providing data-driven insights, PubCompare.ai can assist you in identifying the most effective protocols and products related to the spinal canal, ultimately enhancing the quality and reliability of your findings.

Q: Are there different types or variations of the spinal canal?

While the spinal canal is a singular anatomical structure, there are some notable variations and subdivisions within it: 1. Cervical, thoracic, lumbar, and sacral regions: The spinal canal extends the length of the vertebral column, and its dimensions and characteristics can vary depending on the region (cervical, thoracic, lumbar, or sacral). 2. Central canal vs. lateral recesses: The central spinal canal houses the spinal cord, while the lateral recesses provide passageways for the exiting nerve roots. 3. Congenital abnormalities: In some individuals, the spinal canal may be narrower or malformed from birth, predisposing them to conditions like congenital spinal stenosis. Understanding these anatomical nuances is crucial for accurately diagnosing and treating spinal canal-related disorders, as well as for designing effective research protocols.

Q: What are some specific applications of spinal canal research?

Reserch on the spinal canal has a wide range of practical applications, including: 1. Improving diagnostic accuracy: Enhancing our understanding of spinal canal anatomy and pathology can lead to more precise imaging techniques and clinical assessments for conditions like stenosis and tumors. 2. Optimizing surgical interventions: Detailed knowledge of spinal canal dimensions and variations can help surgeons plan and execute procedures, such as decompression surgeries, more effectively. 3. Developing novel therapies: Investigating the underlying mechanisms of spinal canal disorders can pave the way for innovative treatment approaches, including pharmacological, regenerative, and minimally invasive options. 4. Enhancing rehabilitation outcomes: Understanding the impact of spinal canal conditions on neurological function can inform the development of more targeted and effective rehabilitation protocols. By leveraging the insights from spinal canal research, clinicians and researchers can improve patient outcomes and advance the field of spinal care.

Q: Can you describe a common typo or error that might occur in spinal canal research?

One common typo or error that can occur in spinal canal research is the misidentification of anatomical landmarks or structures. For example, researchers may accidentally confuse the central spinal canal with the lateral recesses, or they may mislabel the boundaries between the cervical, thoracic, and lumbar regions of the vertebral column. These types of mistakes can lead to inaccurate measurements, improper characterization of pathological changes, and ultimately, flawed conclusions. Careful attention to detail and cross-validation of findings are essential to minimize such errors in spinal canal research.

The spinal canal is a bony passage within the vertebral column that houses the spinal cord.
It extends from the foramen magnum at the base of the skull to the sacral hiatus at the lower end of the vertebral column.
The spinal canal protects the delicate spinal cord and nerve roots as they traverse the spine.
Conditions affecting the spinal canal, such as stenosis or tumors, can impact the function of the spinal cord and nerves, leading to neurological symptoms.
Understanding the anatomy and pathology of the spinal canal is critical for diagnosing and treating a variety of spinal disorders.
Researchers can leverage PubCompare.ai to streamline their exploration of spinal canal reserch, improving the reproducibility and accuracy of their findings.

Most cited protocols related to «Spinal Canal»

Defining Lumbar Muscle Regions of Interest

Detailed descriptions of the complex anatomy of lumbar paravertebral muscles and definitions regarding the spatial distribution of MFI on axial MRI are limited [37 –40 (link)]. Published images demonstrating investigators’ definition of ROI for these muscles predominantly depict the lower lumbar levels, with limited identification of separate muscles. Further, descriptions lack details towards acknowledging the complex three-dimensional structure that produces a changing spatial relationship observed across lumbar segmental levels. The lumbar paravertebral muscles typically examined in such studies include: multifidus (MF) as the largest lumbar spinotransverse muscles; erector spinae (ES) including lumbar longissimus and iliocostalis; and less frequently, psoas (including major and minor), and quadratus lumborum (see Fig. 1). This paper intentionally focuses on MF and ES as these are presumed to have the greatest clinical significance. However, other paravertebral muscles exist in the lumbar spine (e.g. the lumbar interspinales and intertransversarii, and thoracic semispinalis), yet they are generally not mentioned in descriptive investigations. This may relate to a lack of image resolution with available sequences, making it challenging to accurately delineate individual muscles from adjacent structures, and it therefore remains unclear how they should be treated when defining ROIs.Fig. 1

Axial E12 plastinated sections (a, c) and schematic illustrations (b, d) at approximately L1 (a, b) and L4 (c, d) highlighting anatomical structures at these vertebral levels. b, d Dotted lines and shading, Green - psoas major muscle; Blue – quadratus lumborum muscle; Purple – erector spinae muscles; Red – spinotransverse muscles. b round white dotted regions (bilateral) denote 12th rib. d square dotted box surrounds enlarged inset; round dotted circle indicates morphological feature of interest (ILB fatty ‘tent’). Legend: A – aorta; ES – erector spinae muscles; ESA – erector spinae aponeurosis; ILB – iliocostalis – longissimus boundary and indentation; ISL – interspinous ligament; IT – intertransversarii muscle; IVC – inferior vena cava; K – kidney; L – liver; P – psoas major muscle; QL – quadratus lumborum muscle; SAF – superior articular facet; SP – spinous process; SPC – spinal canal; SPT – spinotransverse muscle group; ZJ – zygapophysial joint

Our proposed method outlined in the results section, provides a foundational solution for the problem of how to measure muscles traversing the lumbar spine, and includes suggestions on operational characteristics for acquiring MR images. While we offer this starting point for a common methodology to facilitate accurate definition of lumbar muscle ROI, we are cognisant that the method is not a definitive end-point on ‘how to’. We hope that with time and new research findings these methods will be modified, expanded, and refined.

Crawford R.J., Cornwall J., Abbott R, & Elliott J.M. (2017). Manually defining regions of interest when quantifying paravertebral muscles fatty infiltration from axial magnetic resonance imaging: a proposed method for the lumbar spine with anatomical cross-reference. BMC Musculoskeletal Disorders, 18, 25.

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Publication 2017

Aorta Aponeurosis Facet Joint Interspinales Intertransversales Kidney Ligaments Liver Lumbar Region Multifidus Muscle Tissue Psoas Muscles Semispinalis Spinal Canal Spinous Processes Vena Cavas, Inferior Vertebra Vertebrae, Lumbar

Astrocyte Ribosome Profiling after Spinal Cord Injury

Two weeks after SCI, spinal cords of wild type control (GFAP-RiboTag) and STAT3-CKO (GFAP-STAT3CKO-RiboTag) mice were rapidly dissected out of the spinal canal. The central 3mm of the lower thoracic lesion including the lesion core and 1mm rostral and caudal were then rapidly removed and snap frozen in liquid nitrogen. Hemagglutinin (HA) immune-precipitation (HA-IP) of astrocyte ribosomes and ribosome-associated mRNA (ramRNA) was carried out as described^{26 (link)}. The non-precipitated flow through (FT) from each IP sample was collected for analysis of non-astrocyte total RNA. HA and FT samples underwent on-column DNA digestion using the RNase-Free Dnase Set (Qiagen) and RNA purified with the RNeasy Micro kit (Qiagen). Integrity of the eluted RNA was analyzed by a 2100 Bioanalyzer (Agilent) using the RNA Pico chip, mean sample RIN = 8.0±0.95. RNA concentration determined by RiboGreen RNA Assay kit (Life Technologies). cDNA was generated from 5ng of IP or FT RNA using the Nugen Ovation® 2 RNA-Seq Sytstem V2 kit (Nugen). 1 ug of cDNA was fragmented using the Covaris M220. Paired-end libraries for multiplex sequencing were generated from 300 ng of fragmented cDNA using the Apollo 324 automated library preparation system (Wafergen Biosystems) and purified with Agencourt AMPure XP beads (Beckman Coulter). All samples were analyzed by an Illumina NextSeq 500 Sequencer (Illumina) using 75-bp paired-end sequencing. Reads were quality controlled using in-house scripts including picard-tools, mapped to the reference mm10 genome using STAR^{60 (link)}, and counted using HT-seq^{61 (link)} with mm10 refSeq as reference, and genes were called differentially expressed using edgeR^{62 (link)}. Individual gene expression levels in the Figure 4e histogram are shown as mean FPKM (Mean fragments per kilobase of transcript sequence per million mapped fragments). Additional details of differential expression analysis are described in figure legends of Figure 4 and Extended Data Figures 3 and 4. Raw and normalized data have been deposited in NCBI’s Gene Expression Omnibus and are accessible through GEO Series accession number GSE76097 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE76097).

Anderson M.A., Burda J.E., Ren Y., Ao Y., O’Shea T.M., Kawaguchi R., Coppola G., Khakh B.S., Deming T.J, & Sofroniew M.V. (2016). Astrocyte scar formation aids CNS axon regeneration. Nature, 532(7598), 195-200.

Publication 2016

Astrocytes Biological Assay cDNA Library Deoxyribonuclease I Digestion DNA, Complementary DNA Chips Endoribonucleases Freezing Gene Expression Genes Glial Fibrillary Acidic Protein Hemagglutinin Immunoprecipitation Mus Nitrogen Ribosomes RNA, Messenger RNA-Seq Spinal Canal Spinal Cord STAT3 Protein

Histopathological Analysis of Spinal Cord and Brain

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Publication 2006

BLOOD Brain Cone-Rod Dystrophy 2 Eosin Formalin Inflammation Meninges Paraffin Spinal Canal Spinal Cord Syringes

Standardized Rodent Spinal Cord Injury Model

After making an incision on the skin, longitudinal incisions with approximately 2–3 mm depth were made on the left and right side of the spinous processes of the vertebrae T6-T12 using scalpel #10. The paravertebral muscles were then gently pulled away from the spine, without any further incision or damage to the muscles. With retractors holding the muscle aside, laminectomy was performed using a Zeiss operating microscope, by cutting and removing the lamina at T8 to expose the dorsal surface of the spinal cord. Stabilization clamps were placed at the posterior spinous processes of the vertebrae T6 and T12 to support the vertebral column during impact.
The exposed spinal cord was then contused at the thoracic vertebra T8 using the NYU-MASCIS (New York University - Multicenter Animal Spinal Cord Injury Study) weight-drop impactor11 (link). This device consists of a 10g rod with a flat circular impact surface of diameter 2mm, which is slightly less than that of the rodent spinal cord (body weight >200g) to clear the edges of the vertebral canal as the impactor hits the cord. This also ensures that the entire impact surface is in complete contact with the cord during the contusion, so that all the energy from the weight drop is transferred to the spinal cord parenchyma. This impactor rod was directed towards the midline of the exposed spinal cord and was released from a height of 6.25 mm (n=3), 12.5 mm (n=3), 25 mm (n=3) or 50 mm (n=3), producing more severe neurologic injuries with increasing height. The control group (n=3) underwent laminectomy only. The impactor device was connected to a software Impactor v. 7.0 on a computer, which displayed the impact trajectory curves using the impactor and vertebral position sensors and the cord contact sensor11 (link). It also computed the actual height, time and velocity of the impact. Only rats with <0.05% variation in these values were considered for this study.
After injury, the muscles were sutured in layers and the skin closed with metal wound clips. Gentamycin (5 mg/kg, intramuscular; Abbott Laboratories, North Chicago, IL) was administered immediately post-surgery and then daily for 7 days. The analgesic, Buprenex (0.3 mg/kg, subcutaneous; Reckitt Benckiser, Richmond, VI), was delivered post-surgery and daily for 2 days. After surgery, their bladders were expressed regularly with no complications or other infections to report. No sign of autotomy or autophagy were observed. The rats were maintained for 7 weeks after injury.

Agrawal G., Kerr C., Thakor N.V, & All A.H. (2010). Characterization of Graded MASCIS Contusion Spinal Cord Injury using Somatosensory Evoked Potentials. Spine, 35(11), 1122-1127.

Publication 2009

Analgesics Animals Autophagy Buprenex Clip Cone-Rod Dystrophy 2 Contusions Gentamicin Infection Injuries Laminectomy Medical Devices Metals Microscopy Muscle Tissue Operative Surgical Procedures Rattus norvegicus Rodent Skin Spinal Canal Spinal Cord Spinal Cord Injuries Spinous Processes Trauma, Nervous System Urinary Bladder Vertebra Vertebrae, Thoracic Vertebral Column Wounds

Abdominal Micro-CT Predicts Total Body Fat

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Publication 2009

Abdomen Abdominal Fat Adiposity Animals Autopsy Base of Skull Body Fat Body Regions Diet Epididymis Human Body Mesentery Mice, House Pad, Fat Radionuclide Imaging Spinal Canal Subcutaneous Fat Tibia Whole Body Imaging X-Ray Microtomography

Most recents protocols related to «Spinal Canal»

Spinal Cord Injury Pig Model

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Publication 2023

Anesthesia Animals Cells Copper Disinfection Fascia Gelatins Glutaral Hemostasis Ilium Infection Injuries Laminectomy Muscle Tissue Needles Normal Saline Operative Surgical Procedures Penicillins Phosphotungstic Acid Pigs Porifera Povidone Iodine Propofol Punctures, Lumbar Skin Spinal Canal Spinal Cord Telazol Transmission Electron Microscopy TSG101 protein, human Vertebra Western Blot Wounds Xylazine

The need for written consent from patients was waived because we ensured all the information and treatment records of the patients were kept anonymous by all researchers involved. Patients diagnosed with ZRN (course of disease < 1 month) with a clear history of zoster and hospitalized at the Guangdong Provincial Shenzhen People's Hospital (Ethics No. LL-KY-2022144-01) from May 2019 to December 2021 were included in this study. The inclusion criteria were: (1) patients diagnosed with ZRN with a clear history of zoster; (2) patients aged between 50 to 75 years; (3) patients with pain located in the T3-T12 spinal nerve distribution area; (4) patients with visual analogous scale (VAS) score ≥ 5, and; (5) ZRN patients only received medication 1 week prior to the study. The exclusion criteria were: (1) patients with a history of cancer, infection in the spinal canal or diabetes; (2) patients with systemic immune disease, impaired cardiac and pulmonary function or respiratory tract infection; (3) patients with presence of intercostal neuralgia but not caused by HZ, and; (4) patients with pain located beyond T3-T12 spinal nerve distribution area. In all, 90 patients were randomly allocated to group A, group B and group C, with 30 ones in each group.

Zhang Z.W., Zhao Y., Du T.Y., Zhang J., Wu Q, & Wang Z.Y. (2023). A clinical study of C arm-guided selective spinal nerve block combined with low-temperature plasma radiofrequency ablation of dorsal root ganglion in the treatment of zoster-related neuralgia. Frontiers in Neurology, 14, 1122538.

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Publication 2023

Diabetes Mellitus Disease Progression Heart Herpes Zoster Immune System Diseases Infection Lung Malignant Neoplasms Neuralgia Pain Patients Respiratory Tract Infections Spinal Canal Spinal Nerves

Transforaminal Endoscopic Discectomy Protocol

The lesioned intervertebral space was located by fluoroscopy, and the side with severe symptoms was the operative side.The syringe needle was oriented directly opposite to the lower edge of the lamina and the junction area of the spinous process root as observed on lateral fluoroscopic view. In the AP view, the needle was 1 cm lateral to the spinous process on the operative side. Markings were made 1 cm above or below this point. After transverse incisions were created for the portals, serial dilators were inserted followed by transparent cannulas over the dilators. Water influx was then connected to the endoscopic portal inserted via the viewing cannula. A radiofrequency probe was used to clean the soft tissue and stop bleeding, and the intervertebral space was exposed. A guiding rod was inserted and positioned under fluoroscopy. In the AP view, the endoscopic tube and the guiding rod intersected at the intervertebral space, and the guide rod was anchored at the lower edge of the upper vertebral lamina.Bilateral partial laminectomy and medial facetectomy were performed. The nerve root canal entrance and lateral recess were carefully expanded to achieve decompression. Then, decompression was performed across the dorsal side of the dural sac, and the herniated disc was simultaneously resected (Figure 1). After adequate hemostasis, the equipment was withdrawn, drainage tubes were placed, and the incision was closed.

Tan B., Yang Q.Y., Fan B, & Xiong C. (2023). Decompression via unilateral biportal endoscopy for severe degenerative lumbar spinal stenosis: A comparative study with decompression via open discectomy. Frontiers in Neurology, 14, 1132698.

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Publication 2023

Cannula Decompression Drainage Endoscopy Fluoroscopy Hemostasis Intervertebral Disk Displacement Laminectomy Needles Plant Roots Spinal Canal Spinous Processes Syringes Tissues Vertebral Arch

Vertebral Tumor Model and RFA

Two Bama miniature pigs were used to make vertebral tumor models. First, an electric grinding drill was used to grind along L1, L3, and L5 pedicle direction, and a quasi-circular cavity with a diameter of about 1.7cm was ground in the upper 1/3 of the vertebra to ensure the integrity of the surrounding bone. The adjacent erector spinae muscle was separated to form the adjacent muscle flap with blood supply, which was filled in the vertebra to construct the vertebral tumor model. RFA was performed on the vertebral tumor model. The ablation parameters were set as power 35W, temperature 70°C, needle length 1cm, and ablation time 20 minutes. Temperature measurement points were arranged in the spinal canal (posterior cortex of vertebra near spinal cord), nerve root foramen, and anterior edge of vertebral body, and thermocouples were used to monitor the temperature in real time.

Zhang C., Feng J., Liu Y., Zhang Y., Song W., Ma Y., Han X, & Wang G. (2023). Direct and indirect damage zone of radiofrequency ablation in porcine lumbar vertebra. Frontiers in Oncology, 13, 1138837.

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Publication 2023

A-A-1 antibiotic Bones Cortex, Cerebral Dental Caries Drill Electricity Muscle Tissue Needles Neoplasms Nervousness Pigs Spinal Canal Spinal Cord Surgical Flaps Tooth Root Vertebra Vertebrae, Thoracic Vertebral Body

Evaluating Radiofrequency Ablation in Pigs

Previous literature reported that the number of lumbar vertebrae in pigs was 6-7 (25 (link)). The experimental animal in this study was the Bama miniature pig, and each pig had six lumbar vertebrae. RFA was performed in L1, L2, L3, L4, and L5 vertebrae of six Bama miniature pigs, and L5 vertebra was not ablated as control group. The ablation parameters were set as power 35W, temperature 70 °C, active tip 1cm, and ablation time 20 minutes. Thermocouples were placed in the spinal canal, the pedicle hole, and the anterior edge of the vertebra to monitor the temperature in real time. MR imaging (GE, 3.0T discovery, MR750) was performed on 0, 7, and 14 days after RFA. The scanning sequences were T1-weighted and T2-weighted. In T1-weighted and T2-weighted images, the longest diameter of RFA was measured.
The three groups of pigs were euthanized at three separate time points, and then the lumbar vertebrae were taken out. A high-precision hard tissue slicer was used to cut the vertebrae to obtain a complete cross-section of the vertebral body. The thickness of the section was about 2 mm. The maximum diameter of ablation range of gross specimens was measured. Then the special embedding box was used for embedding, ethylene diamine tetraacetic acid (EDTA) was used for decalcification, and the decalcification of samples was observed regularly. Finally, HE and TUNEL were used to evaluate the range of RFA. According to the effective range of HE staining, the maximum diameter of RFA was measured.

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Publication 2023

Edetic Acid In Situ Nick-End Labeling Pigs Spinal Canal Tissues Vertebra Vertebrae, Lumbar Vertebral Body

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What are the main functions of the spinal canal?

The spinal canal is a bony passage within the vertebral column that serves two critical functions: 1) It houses and protects the delicate spinal cord, which is the main conduit for signals traveling between the brain and the rest of the body. 2) It provides a passageway for the nerve roots that branch out from the spinal cord to innervate the body's various organs and muscles. Maintaining the structural integrity and proper dimensions of the spinal canal is essential for the optimal functioning of the spinal cord and nerves.

What are some common conditions that can affect the spinal canal?

Some of the most prevalent conditions impacting the spinal canal include: 1. Spinal stenosis - This is a narrowing of the spinal canal that can compress the spinal cord and/or nerve roots, leading to pain, numbness, and weakness in the extremities. 2. Spinal tumors - Both benign and malignant growths can develop within or around the spinal canal, potentially compressing the spinal cord and causing neurological symptoms. 3. Herniated/bulging discs - When the discs between the vertebrae rupture or protrude, they can encroach on the spinal canal space and pinch the nerve roots. 4. Spinal cord injuries - Trauma to the spine can damage the structural integrity of the spinal canal, resulting in spinal cord compression and loss of function. Understanding the underlying causes and mechanisms of these spinal canal disorders is critical for devising effective diagnostic and treatment strategies.

How can PubCompare.ai help researchers studying the spinal canal?

PubCompare.ai can be an invaluable tool for researchers investigating the spinal canal and associated conditions. The platform allows you to: 1. Screen protocol literature more efficiently: PubCompare.ai's AI-powered search and analysis capabilities can help you quickly identify the most relevant studies and protocols related to spinal canal research from a wide range of sources, including publications, pre-prints, and patents. 2. Leverage AI to pinpoint critical insights: The platform's advanced algorithms can highlight key differences in protocol effectiveness, enabling you to choose the best options for ensuring reproducibility and accuracy in your spinal canal research. By streamlining the research process and providing data-driven insights, PubCompare.ai can assist you in identifying the most effective protocols and products related to the spinal canal, ultimately enhancing the quality and reliability of your findings.

Are there different types or variations of the spinal canal?

While the spinal canal is a singular anatomical structure, there are some notable variations and subdivisions within it: 1. Cervical, thoracic, lumbar, and sacral regions: The spinal canal extends the length of the vertebral column, and its dimensions and characteristics can vary depending on the region (cervical, thoracic, lumbar, or sacral). 2. Central canal vs. lateral recesses: The central spinal canal houses the spinal cord, while the lateral recesses provide passageways for the exiting nerve roots. 3. Congenital abnormalities: In some individuals, the spinal canal may be narrower or malformed from birth, predisposing them to conditions like congenital spinal stenosis. Understanding these anatomical nuances is crucial for accurately diagnosing and treating spinal canal-related disorders, as well as for designing effective research protocols.

What are some specific applications of spinal canal research?

Reserch on the spinal canal has a wide range of practical applications, including: 1. Improving diagnostic accuracy: Enhancing our understanding of spinal canal anatomy and pathology can lead to more precise imaging techniques and clinical assessments for conditions like stenosis and tumors. 2. Optimizing surgical interventions: Detailed knowledge of spinal canal dimensions and variations can help surgeons plan and execute procedures, such as decompression surgeries, more effectively. 3. Developing novel therapies: Investigating the underlying mechanisms of spinal canal disorders can pave the way for innovative treatment approaches, including pharmacological, regenerative, and minimally invasive options. 4. Enhancing rehabilitation outcomes: Understanding the impact of spinal canal conditions on neurological function can inform the development of more targeted and effective rehabilitation protocols. By leveraging the insights from spinal canal research, clinicians and researchers can improve patient outcomes and advance the field of spinal care.

Can you describe a common typo or error that might occur in spinal canal research?

One common typo or error that can occur in spinal canal research is the misidentification of anatomical landmarks or structures. For example, researchers may accidentally confuse the central spinal canal with the lateral recesses, or they may mislabel the boundaries between the cervical, thoracic, and lumbar regions of the vertebral column. These types of mistakes can lead to inaccurate measurements, improper characterization of pathological changes, and ultimately, flawed conclusions. Careful attention to detail and cross-validation of findings are essential to minimize such errors in spinal canal research.

More about "Spinal Canal"

The spinal canal is a crucial anatomical structure within the vertebral column, also known as the vertebral or spinal column.
This bony passage houses the delicate spinal cord, which is responsible for transmitting sensory and motor signals between the brain and the rest of the body.
The spinal canal extends from the foramen magnum at the base of the skull to the sacral hiatus at the lower end of the vertebral column, providing essential protection for the spinal cord and nerve roots as they traverse the spine.
Conditions affecting the spinal canal, such as spinal stenosis (narrowing of the canal) or spinal cord tumors, can have significant impacts on the function of the spinal cord and nerves, leading to a variety of neurological symptoms.
Understanding the intricate anatomy and potential pathologies of the spinal canal is critical for healthcare professionals in diagnosing and treating a wide range of spinal disorders, including herniated discs, spinal cord injuries, and neurodegenerative diseases.
Researchers can leverage tools like PubCompare.ai to streamline their exploration of spinal canal research, optimizing their search for relevant protocols, pre-prints, and patents.
This AI-driven platform can enhance the reproducibility and accuracy of research findings, allowing scientists to more effectively investigate topics related to the spinal canal and associated conditions.
When conducting spinal canal research, researchers may utilize various supplementary materials and techniques, such as B27 supplement for cell culture, DNase I for tissue dissociation, Collagenase D for enzymatic digestion, Glutamine as a nutrient, Trypsin for cell dissociation, MS-222 or Xylazine for anesthesia, AxioVision 4.8 software for microscopy, and Poly-L-lysine for cell adhesion.
By incorporating these specialized tools and methods, researchers can gain deeper insights into the complex structure and function of the spinal canal, ultimately leading to more reliable and impactful findings.