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Dander

Dander is a type of airborne particle composed of shed skin cells, hair, and other biological material.
It can be a common allergen, contributing to respiratory issues like asthma and allergies.
Dander is produced by a variety of animals, including cats, dogs, rodents, and birds.
Understanding the composition and dynamics of dander is crucial for managing allergies and developing effective treatment protocols.
PubCompare.ai can help reasearchers optimize thier dander research by locating the best protocols from literature, preprints, and patents, while ensuirng reproducibility and accuracy through AI-driven comparisons.

Most cited protocols related to «Dander»

Epigenetics and Childhood Asthma in Puerto Rico

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Publication 2018

Allergens Asthma Child Cockroaches Dander Dermatophagoides pteronyssinus Diagnosis Ethics Committees, Research Households Mice, House Nose Physicians Proteins Puerto Ricans Respiratory Rate Serum Urine Wheezing

Prospective Cohort Study of Childhood Atopy

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Publication 2007

Adenoviruses Allergens Alternaria Aspergillus Asthma Birth Cohort Child Chlamydophila pneumoniae Coronavirus 229E, Human Cough Dander Dermatophagoides pteronyssinus ECHO protocol Eczema Egg White Enterovirus Fever Fever, Hay Freezing Histamine Human Metapneumovirus Influenza Lolium Milk, Cow's Mycoplasma pneumoniae Nasopharynx Normal Saline Para-Influenza Virus Type 1 Para-Influenza Virus Type 3 Parent Physicians Picornaviridae Reverse Transcriptase Polymerase Chain Reaction Rhinorrhea Rhinovirus Saline Solution Signs and Symptoms, Respiratory Specimen Collection Test, Skin Wheezing

Eosinophil Activation in Allergic Asthma

The study protocol was approved by the University of Wisconsin-Madison Health Sciences Institutional Review Board. Informed written consent was obtained from subjects prior to participation. For studies of in vitro eosinophil activation, peripheral blood eosinophils were obtained from allergic subjects with and without mild asthma. Subjects with prescriptions for low doses of inhaled corticosteroids did not use their corticosteroids the day of the blood draw. Eosinophils were purified by negative selection as previously described [20 (link)]. Briefly, heparinized blood was diluted 1:1 in HBSS and was overlaid above Percoll (1.090 g/ml). After centrifugation at 700 × g for 20 min at room temperature, the mononuclear cells were removed from the plasma/percol interface and erythrocytes were eliminated from the cell pellet by hypotonic lysis. The remaining pellet was resuspended in 2% NCS in HBSS. Cells were then incubated with anti-CD16, anti-CD3, anti-CD14 and anti-Glycophorin-A beads from Miltenyi (San Diego, CA), and run through an AutoMACS (Miltenyi). Eosinophil preparations with purity > 99% and viability ∼98% were used the same day, ∼5 h after the blood draw.
For studies of in vivo eosinophil activation, bronchoscopy and bronchoalveolar lavage (BAL) were performed 48 h after segmental bronchoprovocation with an allergen (SBP-Ag) in subjects with mild asthma who were allergic to ragweed, dust mite, or cat dander allergens [20 (link)]. Eosinophils were purified, as previously described [12 (link)], from the BAL cell preparation (BAL EOS) and from peripheral blood (BBL EOS) of the same allergen-challenged subject. On the same day, eosinophils were also purified from peripheral blood of a control unchallenged subject (control EOS (Ctrl)).

Esnault S., Johansson M.W., Kelly E.A., Koenderman L., Mosher D.F, & Jarjour N.N. (2017). IL-3 Up-regulates and Activates Human Eosinophil CD32 and αMß2 Integrin Causing Degranulation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 47(4), 488-498.

Publication 2016

Adrenal Cortex Hormones Allergens Asthma BLOOD Bronchoscopy Cells Centrifugation Dander Dimercaprol Eosinophil Erythrocytes Ethics Committees, Research Glycophorin A Hemoglobin, Sickle Muromonab-CD3 Percoll Plasma Prescriptions Pyroglyphidae

Cytokine and Allergen Detection in Tissue Samples

Tissue samples were weighed and homogenized and the supernatants were harvested for later analysis [7 (link)]. The protein levels of cytokines and chemokines were detected by means of bio-plex suspension chip technology (BIO-RAD, Hercules, Ca) according to the manufacturer’s instructions. Total IgE and specific IgE levels to common airborne allergens were detected by the ImmunoCAP system (Phadia, Uppsala, Sweden). Specific IgE was determined for house dust mix (Hx2, Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blatella germanica), mould mix (Mx2, Penicillium notatum, Aspergillus fumigatus, Candida albicans and Alternaria), animal epidermal and protein mix (Ex1, Dander from cat, horse, cow and dog), tree pollen mix (Tx4, Oak, Elm, Maple leaf sycamore, Willow and Cottonwood), weed pollen mix (Wx5, Common Ragweed, Mugwort, Marguerite, Dandelion and Golded rod) and staphylococcus aureus enterotoxin A (SEA) and B (SEB) [2 (link), 7 (link), 8 (link)]. More information is provided in the Online Supplement.

Cao P.P., Zhang Y.N., Liao B., Ma J., Wang B.F., Wang H., Zeng M., Liu W.H., Schleimer R.P, & Liu Z. (2014). Increased local IgE production induced by common aeroallergens and phenotypic alteration of mast cells in Chinese eosinophilic, but not non-eosinophilic, chronic rhinosinusitis with nasal polyps. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44(5), 690-700.

Publication 2014

Acer Allergens Alternaria Animals Artemisia vulgaris Aspergillus fumigatus Candida albicans Chemokine Cytokine Dander Dermatophagoides farinae Dermatophagoides pteronyssinus Dietary Supplements DNA Chips Epidermis Equus caballus Fungus, Filamentous House Dust Penicillium chrysogenum Plant Leaves Pollen Populus fremontii Proteins Staphylococcal enterotoxin A Taraxacum Tissues Trees Willow

Maternal and Paternal IgE Profiling

Blood samples were obtained from both mothers and fathers during the first trimester of pregnancy. Serum total and allergen-specific IgE titers of mothers were analysed by a contract clinical laboratory by immunological assays. Serum total and allergen-specific IgE titers of mothers were assayed by ImmunoCAP (Thermo Fisher Scientific, Inc., Sweden). Specific titers were detected for the following allergens: Der p 1 (Dermatophagoides pteronyssinus), animal dander, Japanese cedar, birch, moth, and egg white. IgE levels were allocated into six classes: class 1 (0.35–0.69 UA/mL), class 2 (0.70–3.49 UA/mL), class 3 (3.5–17.49 UA/mL), class 4 (17.5–49.99 UA/mL), class 5 (50–99.99 UA/mL), and class 6 (≥100 UA/mL). Positive IgE sensitization to any allergen was defined as allergen-specific IgE ≥ 0.35 UA/mL to any of the allergens listed above. Total IgE titers were measured for the fathers using the same method.

Yamamoto-Hanada K., Yang L., Ishitsuka K., Ayabe T., Mezawa H., Konishi M., Shoda T., Matsumoto K., Saito H, & Ohya Y. (2017). Allergic profiles of mothers and fathers in the Japan Environment and Children’s Study (JECS): a nationwide birth cohort study. The World Allergy Organization Journal, 10(1), 24.

Publication 2017

Allergens Animals Betula BLOOD Clinical Laboratory Services Cryptomeria Dander Dermatophagoides pteronyssinus Dermatophagoides pteronyssinus antigen p 1 Egg White Fathers Mothers Moths Serum

Most recents protocols related to «Dander»

Seasonal and Perennial Allergic Conjunctivitis Study

Included patients were aged ≥18 years with a documented history of AC, a documented positive skin prick test and/or positive validated IgE test to perennial allergen (eg cat dander, dog dander, dust mites and/or cockroach) or to seasonal allergen (eg grass, ragweed, and/ or tree pollen) within 6 months before the study, or a positive skin prick test at Visit 1a and showing signs and symptoms of AC, ie tearing, itching and redness, that were likely to continue for the next weeks. The patients had to have a minimum score of 4 on a 0–10 numeric rating scale (0, no symptom; 10, very severe symptom) in at least one of three categories (ocular itching, ocular redness, and ocular tearing). The main exclusion criteria were a history of known contraindications or sensitivities to the use of the drug or any of its components; intraocular surgery or planned surgery during study participation and within 2 weeks after follow-up; ocular trauma in the 6 months before the study; clinical evidence of ocular herpes simplex or ocular herpes zoster infectious disease; or any clinically significant (CS) external ocular disease within 30 days before study start.

Kuna P., Jutel M., Pulka G., Tokarski S., Arranz P., Hernández G, & Fernández Hernando N. (2023). Safety and Tolerability of Bilastine 0.6% Ophthalmic Solution: An 8-Weeks Phase III Study. Clinical Ophthalmology (Auckland, N.Z.), 17, 735-746.

Publication 2023

Allergens Cockroaches Communicable Diseases Dander Erythema Eye Eye Injuries Herpes Zoster Ophthalmicus Hypersensitivity Keratitis, Herpetic Operative Surgical Procedures Patients Pharmaceutical Preparations Poaceae Pollen Pyroglyphidae Test, Skin Trees

Real-World Allergy Immunotherapy Survey

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Publication 2023

Animals Dander Dermatophagoides pteronyssinus Food Fungus, Filamentous Hymenoptera Venoms Hypersensitivity Life Experiences Patients Pollen Respiratory Rate

Serological Profiling of Common Allergens

The levels of total IgE and sIgE against Der-p, Der-f, and other common allergens such as dog dander in all serum samples were measured by a Pharmacia CAP fluorescence enzyme immunoassay system (ThermoFisher, Sweden) at week 0. The sIgE results are reported as kU/L, with a cut-off value of 0.35 kU/L and upper sIgE detection limit of 100 kU/L. Any sample with a sIgE level >100 kU/L was diluted and tested again. Serum Der-p sIgG4 levels were measured by a four-layer sandwich ELISA using methods that we had reported previously.¹² (link)

Su Q., Ren N., Feng M., Zeng X., Dong Y., Xian M., Shi X., Luo T., Liu G, & Li J. (2023). Specific immunoglobulin G4 correlates with Th2 cytokine reduction in patients with allergic asthma treated by Dermatophagoides pteronyssinus subcutaneous immunotherapy. The World Allergy Organization Journal, 16(1), 100715.

Publication 2023

Allergens Dander Enzyme-Linked Immunosorbent Assay Enzyme Immunoassay Fluorescence Serum

Pigeon Feather Allergen Extraction

The collected fresh pigeon feathers and dander were dissolved in phosphate-buffered saline (PBS, pH 7.4) at a concentration of 1:20 and thoroughly stirred for 24 h. Lyophilized protein powder from pigeon shedding materials of feathers and dander were prepared after filtering, removing water, and other operations and stored at 1–4°C for future use. The prepared lyophilized powder contained a large amount of active allergens.

Li Y., Lian Z., Li Q., Ding W., Wang W., Zhang L., Muhataer X., Zhou Y., Yang X, & Wu C. (2023). Molecular mechanism by which the Notch signaling pathway regulates autophagy in a rat model of pulmonary fibrosis in pigeon breeder’s lung. Open Medicine, 18(1), 20230629.

Publication 2023

Allergens Columbidae Dander Feathers Phosphates Powder Proteins Saline Solution

Predictors of Omalizumab Response in Severe Asthma

For all patients, demographic characteristics, severe asthma-related comorbidities (allergic rhinitis, chronic rhinosinusitis, and gastroesophageal reflux disease), asthma control test (ACT), asthma exacerbation that required at least three days of systemic corticosteroids, asthma treatment, fractional exhaled nitric oxide (FeNO) levels, pulmonary function (forced vital capacity, FEV₁), and blood test (eosinophil proportion, serum total IgE, and serum aeroallergen-specific IgE (ImmunoCAP^® total IgE and ImmunoCAP^® specific IgE, Phadia K.K., Tokyo, Japan)) results before and 52 weeks after omalizumab administration were extracted by reviewing medical records. Patients with allergic rhinitis were diagnosed by an otolaryngologist (M.S.) or pulmonologists (T.T., T.K., Y.K., M.T., K.Y., and A.N.) according to the guideline.19 (link) Pretreatment serum aeroallergen-specific IgEs were classified into the following five groups:20 (link) house dust; dust mite (Dermatophagoides); mold (mixed molds [Penicillium, Cladosporium, Aspergillus, Candida, and Alternaria] and Trichophyton); animal dander (cat dander, dog dander); pollen (Japanese cedar, mixed grass (orchard grass, vernal grass, Bermuda grass and timothy grass), and mixed weed (ragweed, mugwort, oxeye daisy, dandelion and goldenrod)). Positivity of serum aeroallergen-specific IgE was defined as ≥0.35 UA/mL.21 (link) In all patients, serum specific IgEs against house dust and house dust mite were tested. The major component of house dust is house dust mite, though it includes house dust mite, animal dander, and mold.
Demographic characteristics and other variables listed above were assessed at baseline. Response to omalizumab treatment was then assessed in all patients. Demographic characteristics and other variables, including the positive ratio of serum specific IgE of each subgroup, were next compared between responders and non-responders. Univariate and multivariate logistic regression analyses were finally performed to clarify the predictors of responsiveness to omalizumab. Treatment responsiveness to omalizumab was determined by physicians’ overall evaluation according to the GETE scale at 52 weeks.22 (link) GETE is a five-point scale: excellent (complete control of asthma), good (marked improvement), moderate (discernible, but limited improvement), poor (no appreciable change), and worsening (overall deterioration of asthma control). Patients with an “excellent” or “good” response were defined as responders.
This study was approved by the Ethics Committee of Nagoya City University (60-20-0174). Written informed consent was waived by the ethics committee due to the retrospective nature of this study. Instead, an opt-out document was posted on the hospital website to offer patients the opportunity to refuse participation.

Tajiri T., Suzuki M., Kutsuna T., Nishiyama H., Ito K., Takeda N., Fukumitsu K., Kanemitsu Y., Fukuda S., Umemura T., Ohkubo H., Maeno K., Ito Y., Oguri T., Takemura M., Yoshikawa K, & Niimi A. (2023). Specific IgE Response and Omalizumab Responsiveness in Severe Allergic Asthma. Journal of Asthma and Allergy, 16, 149-157.

Publication 2023

Adonis vernalis Adrenal Cortex Hormones Alternaria Animals Artemisia vulgaris Aspergillus Asthma Candida Cladosporium Cryptomeria Cynodon Dactylis Dander Dermatophagoides Dermatophagoides pteronyssinus Endodermophyton Eosinophil Ethics Committees Forced Vital Capacity Fractional Exhaled Nitric Oxide Fungus, Filamentous Gastroesophageal Reflux Disease Hematologic Tests House Dust Lung Natural Springs Omalizumab Otolaryngologist Patients Penicillium Phleum Physicians Poaceae Pollen Pulmonologists Rhinitis, Allergic Serum Solidago Taraxacum

Top products related to «Dander»

Immunocap by Thermo Fisher Scientific

Sourced in Sweden, United States, Germany, Denmark, France

The ImmunoCAP is a laboratory instrument used for in vitro allergen-specific IgE testing. It provides quantitative measurement of IgE antibodies to a wide range of allergens. The ImmunoCAP system utilizes fluorescent enzyme immunoassay technology to detect and measure IgE levels in patient samples.

Immunocap system by Thermo Fisher Scientific

Sourced in Sweden, United States, Germany, Denmark, United Kingdom

The ImmunoCAP system is a fully automated immunoassay analyzer used for the quantitative measurement of specific IgE antibodies in human serum or plasma. It provides accurate and reliable results for the in vitro diagnosis of allergic diseases.

Phadia 250 by Thermo Fisher Scientific

Sourced in Sweden, United States, Germany

The Phadia 250 is an automated immunoassay analyzer designed for in-vitro diagnostic testing. It is capable of processing a range of immunoassay tests, including those for allergy, autoimmunity, and infectious disease. The Phadia 250 provides reliable and efficient sample processing and analysis to support clinical decision-making.

Immunocap assay by Thermo Fisher Scientific

Sourced in Sweden, United States

The ImmunoCAP assay is a laboratory test designed to detect and measure specific antibodies in a person's blood. It is used to identify the presence and levels of immunoglobulin E (IgE) antibodies, which are associated with allergic responses. The ImmunoCAP assay provides quantitative results, allowing for the assessment of the patient's allergic sensitivity to various environmental and food-related allergens.

Immunocap 250 by Thermo Fisher Scientific

Sourced in Sweden, United States, Germany

The ImmunoCAP 250 is a fully automated lab equipment for the detection and quantification of specific IgE antibodies in patient samples. It utilizes fluorescence-enzyme immunoassay technology to provide reliable and standardized results for the diagnosis of allergies and related conditions.

Immunocap rapid test kit by Thermo Fisher Scientific

Sourced in United States

The ImmunoCAP Rapid test kit is an in vitro diagnostic tool used to detect and measure specific immunoglobulin E (IgE) antibodies in human serum or plasma. It provides a rapid, quantitative analysis of IgE levels, which is useful for the diagnosis and management of allergic conditions.

Diff quik stained cytospin slides by Siemens

Diff-Quik-stained cytospin slides are a type of laboratory equipment used to prepare and stain cellular samples for microscopic analysis. The slides are made using a centrifugation process that deposits cells onto the slide surface, which are then stained using the Diff-Quik staining method. The staining process highlights various cellular components, allowing for detailed examination and assessment of the sample.

Falcon tube by BD

Sourced in United States, Germany, United Kingdom, Switzerland

Falcon tubes are conical centrifuge tubes designed for a variety of laboratory applications. They are made of polypropylene and are available in different sizes, typically ranging from 15 to 50 milliliters. Falcon tubes are used for sample collection, storage, and processing in research and diagnostic laboratories.

Immunocap 100 by Thermo Fisher Scientific

Sourced in Sweden

The ImmunoCAP 100 is an automated instrument used for in vitro diagnostic testing. It is designed to perform quantitative and qualitative analysis of specific IgE antibodies in human serum or plasma samples.

Thimerosal by Merck Group

Sourced in United States, United Kingdom

Thimerosal is a preservative used in certain pharmaceutical and lab products. It is a mercury-containing organic compound that helps prevent the growth of microorganisms in these products.

What is dander and how does it impact health?

How can PubCompare.ai help with dander research?

PubCompare.ai allows you to screen protocol literature more efficiently and leverage AI to pinpoint critical insights. The platform can help researchers identify the most effective protocols related to dander for their specific research goals. PubCompare.ai's AI-driven analysis can highlight key differences in protocol effectiveness, enabling you to choose the best option for reproducibility and accuracy in your dander research.

What are the different types or variations of dander?

Dander can be produced by a variety of animals, including cats, dogs, rodents, and birds. Each type of animal dander has its own unique composition and characteristics that can impact allergic reactions and respiratory issues. Researchers need to understand these differences to develop targeted treatments and management strategies for dander-related health concerns.

What are some common applications or uses of dander research?

Dander research is crucial for understanding and managing allergies, asthma, and other respiratory conditions. Researchers may study the composition, distribution, and dynamics of dander to develop more effective allergen avoidance strategies, improved diagnostic tests, and novel therapeutic approaches. Additionlly, dander research can inform the design of ventilation systems, air purifiers, and other environmental controls to mitigate dander exposure.

How can PubCompare.ai help ensure the accuracy and reproducibility of dander research protocols?

PubCompare.ai's AI-driven platform allows researchers to quickly identify and compare the most effective dander research protocols from literature, preprints, and patents. By highlighting key differences in protocol effectiveness, the platform enables researchers to choose the best option for their specific needs, ensuring reproducibility and accuracy in their dander studies. This helps researchers save time, improve the quality of their work, and ultimately advance the field of dander research.

More about "Dander"

Dander is a common allergen that can contribute to respiratory issues like asthma and allergies.
It is composed of shed skin cells, hair, and other biological material, and is produced by a variety of animals, including cats, dogs, rodents, and birds.
Understanding the composition and dynamics of dander is crucial for managing allergies and developing effective treatment protocols.
Researchers can utilize the ImmunoCAP system, Phadia 250, and ImmunoCAP assay to accurately measure and analyze dander allergens.
The ImmunoCAP 250 and ImmunoCAP 100 are specialized instruments that can detect and quantify specific IgE antibodies to dander.
The ImmunoCAP Rapid test kit is another useful tool for quick and convenient dander allergy screening.
Dander samples can be collected using Falcon tubes and Diff-Quik-stained cytospin slides for further analysis.
The presence of Thimerosal, a preservative, may also be a consideration in some dander research protocols.
PubCompare.ai can help researchers optimize their dander research by locating the best protocols from literature, preprints, and patents, while ensuring reproducibility and accuracy through AI-driven comparisons.
By leveraging these tools and technologies, researchers can take their dander research to the next level and develop more effective allergy management strategies.