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Thyroid Cartilage

Thyroid Cartilage: The largest and most prominent of the laryngeal cartilages, located in the upper part of the larynx.
It is composed of two laminae that meet at an angle, forming the prominence known as the Adam's apple.
The thyroid cartilage plays a key role in phonation and protects the underlying vocal folds.
Researchers can optimize their thyroid cartilage studies by using PubCompare.ai to locate the best protocols from literature, preprints, and patents, enhancing reproducibility and accuracy for their research.

Most cited protocols related to «Thyroid Cartilage»

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Publication 2019
Anesthetics Animals Body Weight Buprenorphine Clavicle Cricoid Cartilage Euthanasia Formalin Grafts Hyoid Bone Ibuprofen Ketamine Ketoprofen Mice, House Mice, Inbred C57BL Muscle Tissue Ovum Implantation Respiratory Rate Sedatives Stridor Sutures Thyroid Cartilage Tissues Trachea Transplantation Transplant Recipients Xylazine
Figure 2A illustrates the in-laboratory multisensor setup consisting of the simultaneous acquisition of data from the following devices:

Acoustic microphone placed 10 cm from the lips (MKE104, Sennheiser, Electronic GmbH, Wennebostel, Germany).

Electroglottograph electrodes placed across the thyroid cartilage to measure time-varying laryngeal impedance (EG-2, Glottal Enterprises, Syracuse, NY, USA).

Accelerometer placed on the neck surface at the base of the neck (BU-27135; Knowles Corp., Itasca, IL, USA).

Airflow sensor collecting high-bandwidth aerodynamic data via a circumferentially vented pneumotachograph face mask (PT-2E, Glottal Enterprises).

Low-bandwidth air pressure sensor connected to a narrow tube inserted through the lips in the mouth (PT-25, Glottal Enterprises).

In particular, the use of the pneumotachograph mask to acquire the high-bandwidth oral airflow signal is a key step in calibrating/adjusting the vocal system model described in Section “Estimating Aerodynamic Properties from the Accelerometer Signal” so that aerodynamic parameters can be extracted from the accelerometer signal (Zañartu et al., 2013 (link)). All subjects wore the accelerometer below the level of the larynx (subglottal) on the front of the neck just above the sternal notch. When recorded from this location, the accelerometer signal of an unknown phrase is unintelligible. The accelerometer sensor used is relatively immune to environmental sounds and produces a voice-related signal that is not filtered by the vocal tract, alleviating confidentiality concerns because speech audio is not recorded.
The in-laboratory protocol requires subjects to perform the following speech tasks at a comfortable pitch in their typical speaking voice mode:

three cardinal vowels (“ah,” “ee,” “oo”) sustained at soft, comfortable, and loud levels;

first paragraph of the Rainbow Passage at a comfortable loudness level;

string of consonant-vowel pairs (e.g., “pae pae pae pae pae”).

The sustained vowels provide data for computing objective voice quality metrics such as perturbation measures, harmonics-to-noise ratio, and harmonic spectral tilt. The Rainbow Passage is a standard phonetically balanced text that has been frequently used in voice and speech research (Fairbanks, 1960 ). The string of /pae/ syllables is designed to enable non-invasive, indirect estimates of lung pressure (during lip closure for the /p/ when airway pressure reaches a steady state/equilibrates) and laryngeal airflow (during vowel production when the airway is not constricted) for a sustained vowel (Rothenberg, 1973 (link)). Figure 2B displays a snapshot of synchronized in-laboratory waveforms from the consonant-vowel task for a 28-year-old female music teacher diagnosed with vocal fold nodules.
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Publication 2015
Acoustics Air Pressure Face Females Glottis Laryngeal Prosthesis Larynx Lung Medical Devices Neck Oral Cavity Pressure Sound Speech Sternum Strains Thyroid Cartilage Vocal Cords
Animals were placed on an operating platform in the supine position. To prepare for surgery, the neck was shaved from the submentum to the chest. Local anesthesia (0.2% lidocaine) was administered at the surgical site and a midline incision was made from the hyoid bone to the sternal notch to expose the larynx and trachea. A tracheostomy was then created to provide a stable airway. The trachea was transected just proximal to the sternum and the lower portion of the trachea was suspended to the sternal fascia. A 3.5 cuffed endotracheal tube (Willy Rusch GmbH, Kernen, Germany) was inserted into the upper portion of the bisected trachea and positioned 2 cm below the glottal opening. The cuff of the endotracheal tube was inflated to seal off the trachea and deliver airflow. Continuous humidified airflow was delivered to the glottis heated at 37° C using a Gilmont Instruments flowmeter (GF-8522, Barrington, IL) and Conch Therm III humidifier (Hudson, RCI, Temecula, CA). A bilateral Isshiki type IV thyroplasty2 (link) was performed to simulate the action of the cricothyroid muscle. The thyroid cartilage and cricoid cartilage were sutured together using 3–0 Webcryl sutures (Patterson Veterinary, Saint Paul, MN) to approximate one another. Suture positioning provided increased lengthening and tension to the vocal folds, providing medial movement of the arytenoid cartilages and vocal fold approximation. Tenseness of the sutures was adjusted until there was audible phonation. Figure 1 is an image demonstrating the in vivo suture placement and approximation of the thyroid and cricoid cartilages.
The larynx was suspended using an 11-cm Hollinger-Tucker pediatric anterior commissure side-slotted laryngoscope (Karl Storz Endoscopy-America, Inc., El Segundo, CA). Three trials of vocal fold vibration were recorded using a 0-degree, 4.0-mm rigid endoscope coupled to a FASTCAM MC 2.1 high-speed camera (KayPENTAX, Montvale, NJ). The images were captured in black and white with 512 × 96 pixel resolution at a rate of 10,000 frames per second. To obtain acoustic measurements, three trials of phonation were recorded using a Perception 170 Condenser microphone (AKG, Vienna, Austria) positioned 10 cm from the opening of the laryngoscope. Uninterrupted, continuous phonation was recorded for approximately 10–20 seconds. Recordings were digitized using Computerized Speech Lab Model 4500 (KayPENTAX, Montvale, NJ). The most stable 1-second portion of the acoustic waveform was selected and analyzed to obtain mean vocal intensity sound pressure level (dB) and mean fundamental frequency (Hz) values. Following acoustic analyses, sound waveforms were edited using Cool Edit Pro v. 2.1 (Syntrillium Software, Phoenix, AZ, 2003). To improve visualization of the waveforms, signals were amplified and excessive noise was removed. Sound spectrograms were created for spectrographic feature analysis. In addition, three trials of airflow rate (ml/s) and subglottal pressure (cm H2O) were documented. At the end of the phonation procedure, humidified airflow was discontinued and the sutures between the thyroid and cricoid cartilages remained in place. The animals were sacrificed and larynges were harvested.
Publication 2015
Acoustics Animals Arytenoid Cartilage Chest Cricoid Cartilage Cricothyroid Muscle Endoscopes Endoscopy Fascia Flowmeters Glottis Hyoid Bone Laryngoscopes Larynx Lidocaine Local Anesthesia Movement MS 1-2 Muscle Rigidity Neck Operative Surgical Procedures Phocidae Phonation Pressure Reading Frames Sound Speech Sternum Sutures Thyroid Cartilage Thyroid Gland Trachea Tracheostomy Vibration Vocal Cords
The study population was composed of 6 head and neck cancer patients. These patients underwent a planning CT scan (CTplan) which was acquired prior to radiation, and a repeat CT scan (CTrep) which was acquired during the course of radiation. CTrep scans were performed 11 to 35 days (range) after the start of radiotherapy. The CT images were made with the patient in supine position on a multidetector-row spiral CT scanner (Somatom Sensation Open, 24 slice configuration; Siemens Medical Solutions, Erlangen, Germany). The acquisition parameters were: gantry un-angled, spiral mode, rotation time 0.5 s, 24 detector rows at 1.2 mm intervals, table speed 18.7 mm/rotation, reconstruction interval 2 mm at Kernel B30 and 120 kVp/195 mA. The matrix size was 512 × 512, with a pixel spacing of 0.97 × 0.97 × 2.0 mm in the x, y and z directions, respectively.
Five specialized head and neck radiation oncologists (R.S., A.N., H.B., O.C. and F.B.), all treating more than 50 head and neck patients per year, delineated five OARs on axial CT slices in all CT images. The radiation oncologist did not have clinical patient information additional to the CT scan. The OAR set included the spinal cord, the parotid and submandibular glands, the thyroid cartilage, and the glottic larynx. For one patient, the right parotid gland contained tumour infiltration and therefore the patient was excluded from analysis for this particular OAR beforehand. The total number of delineated structures was 410.
CTplan and CTrep were delineated under slightly different circumstances, since CTplan was made with contrast-enhancement (iodine containing contrast medium, intravenously applied) while CTrep was acquired without contrast enhancement. Furthermore, the CTplan scan was delineated from scratch and the CTrep scan was delineated using a template obtained from the delineated contours of the CTplan, which were propagated to CTrep after a rigid registration of CTrep to CTplan in each individual patient.
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Publication 2012
Cancer of Head and Neck CAT SCANNERS X RAY Glottis Head Iodine Muscle Rigidity Neck Neoplasms Parotid Gland Patients Radiation Oncologists Radionuclide Imaging Radiotherapy Reconstructive Surgical Procedures Spinal Cord Submandibular Gland Thyroid Cartilage Tomography, Spiral Computed X-Ray Computed Tomography
Each larynx was mounted on a barbed fitting connected to a custom built artificial lung chamber (Fig. 2). Airflow into the lung chamber was controlled with a pressure valve and directed first through two Concha Therm III humidifiers in series (Fisher & Paykel Healthcare Inc., Laguna Hills, CA) and an FMA-1601A airflow meter (Omega Engineering Inc., Stamford, CT). An ECM-88 microphone (Sony Electronics Inc., New York, NY) was positioned 15 cm above and 5 cm anterior to the larynx and an Ultima APX digital camera (Photron USA Inc., San Diego, CA) was mounted directly above to take photographs of the glottal areas. The pressure directly beneath the larynx was measured with a Heise 901 series digital pressure meter (Ashcroft Inc., Stratford, CT). The pressure and flow readings and the acoustic signal were recorded using custom Labview 7.1 software (National Instruments Corp., Austin, TX). A suture placed through the thyroid notch secured the thyroid cartilage anterior to an x-y-z stage. The arytenoid cartilage opposite to the thyroplasty window was adducted using a three-pronged probe on an x-y-z stage. Medialization thyroplasty was simulated by a probe 3 mm in diameter attached to a DFG60-0.5 force gauge (Omega Engineering Inc., Stamford, CT) on another x-y-z stage. The probe was advanced through the thyroplasty window to adduct the anterior, medial or posterior portion of the vocal fold. The probe was advanced just enough to allow the portion of the vocal fold it was medializing to lightly touch the opposite adducted vocal fold.
Publication 2009
Acoustics Arytenoid Cartilage austin Fingers Glottis Larynx Lung Pressure Sutures Thyroid Cartilage Thyroid Gland Thyroplasty Touch Vocal Cords

Most recents protocols related to «Thyroid Cartilage»

Participants in the modified group will receive the modified US-guided anterior SLNB in a supine position (figure 1A, B). The sniffing position may be required if the exposition of the anterior cervical region is unsatisfied. The probe will be placed in the transverse plane, over the thyroid cartilage (TC). Adjust the midline of the probe until TC is clearly identified in the middle of the screen. Then cephalad move the probe to look for the thyroid incisura notch (the disconnected part of TC) (figure 2A). US-guided out-of-plane injection will be performed in the midline targeting TH-Mb with a 22-gauge 50 mm nerve block needle.8 (link) After confirming the needle tip is in place (thyroid incisura notch anteriorly, TH-Mb posteriorly) and negative aspiration for air or blood, inject 6 mL of 2% lidocaine. The resistance while injecting should be small. Pushing down of TH-Mb and pre-epiglottis by lidocaine provides an early sign of a successful US-guided anterior SLNB (figure 2B).
Publication 2023
Blood Epiglottis Lidocaine Neck Needles Nerve Block Thyroid Cartilage Thyroid Gland
Occlusion has a significant effect on the characteristics of pulse waves at the carotid artery. However, these characteristics may also be influenced by several factors such as the condition of the patient. To understand the relationship between occlusion and the characteristics of pulse waves, other contributing factors were precluded from this study. For example, prior to commencing the measurements, all subjects avoided eating, exercising, and smoking for over 2 h. This was followed by resting in the supine position for 15 min in a quiet room at 25 °C. The cardiovascular function and vasomotor tone in the resting conditions were thus obtained19 (link),20 (link).
The schematic of the measurement condition is illustrated in Fig. 3. The pulse wave was measured at the skin surface by placing a piezoelectric ceramic transducer (MA40E7R, Murata Corp.) at the upper edge of the thyroid cartilage, the position where the strongest pulse wave could be sensed by a finger. We measured pulse waves in both the right and left common carotid arteries. The observed signal was amplified by 40 dB using a preamplifier (NF 5307) and was subsequently digitized using a 14-bit analog-to-digital converter (Keyence NR-500, NR-HA08, or using our prototype measurement system manufactured in collaboration with Proassist. Ltd.) with a sampling frequency of 1.0 kHz21 (link). In accordance with the characteristics of the sensor and the circuit system, the measured pulse wave corresponded to the differential (velocity) waveform in the low-frequency range. Thereafter, an average of the observed waves was obtained, and the DC component was eliminated to obtain the averaged differential pulse waveforms. Differential pulse waves (not integrated pulse waves) were consistently used in the measurement, feature extraction, and classification of the proposed method. Hereinafter, we use the word "pulse wave" to indicate "differential pulse wave" for simplicity.

Pulse wave measurement.

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Publication 2023
Cardiovascular Physiological Phenomena Common Carotid Artery Dental Occlusion Patients Pulse Rate Skin Thyroid Cartilage Transducers
Hematoxylin and Eosin (H&E) staining was performed using a previously established protocol for frozen tissues36 . Picrosirius Red staining was performed following manufacturer’s protocol (Abcam). Due to tissue fragility, the thyroid cartilage was removed on sections to produce cleaner stains (i.e., less folds) (Supplementary Fig. 7). CD11b staining was performed using the same protocol and antibody (Mouse Anti-Rabbit CD11b [Bio-Rad MCA802GA], 1:100 dilution) described previously15 (link) Briefly, sections were rehydrated with PBS and incubated with blocking buffer (PBS, 5% BSA, 5% milk, 5% FBS) for 30 min at room temperature. Next, the primary antibody was applied overnight at 4 °C and the slides were washed with PBS before applying the secondary antibody (AlexaFluor 488 Goat Anti-mouse) at a 1:1000 dilution for 1 h at room temperature. Finally, the slides were washed with PBS stained with DAPI, and mounted with Prolong Gold Antifade mountant. H&E and Picrosirius Red brightfield imaging was performed by the University of Virginia Biorepository and Tissue Research Facility (BTRF) core using a Hamatsu Slide scanner. Picrosirius Red polarized light imaging was performed using a LEICA Thunder microscope at the UVA Advanced Microscopy Facility. Polarized light image analysis was conducted using ImgeJ by separating the red and green channels, auto-thresholding each channel, and then measuring the percent area (Supplementary Fig. 12). For this analysis, the new tissue was cropped in each image to analyze the full area and the full right vocal fold was analyzed. Three 10X sections were analyzed for each of the rabbits that had new tissue formation (n = 4). Fiber alignment analysis was conducted using a previously published MATLAB method available on github29 (link),32 (link) with a square size of 100 and threshold of 10000 (Supplementary Fig. 13). Three 20X images from each vocal fold with new tissue were analyzed using the right vocal fold as a comparison. Three different sections were used for each rabbit (n = 4).
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Publication 2023
Buffers DAPI Eosin Fibrosis Freezing Goat Gold Hematoxylin Immunoglobulins ITGAM protein, human Light Mice, House Microscopy Milk, Cow's Oryctolagus cuniculus Rabbits Technique, Dilution Thyroid Cartilage Tissues Vocal Cords
The cardiometabolic risk indicators used in the present study were: body weight (kg), height (cm), BMI (kg/m2), neck circumference (cm), submandibular skinfold (cm), waist circumference (cm), calf circumference (cm), and waist-to-height ratio. Body weight and height were measured following the protocol of the World Health Organization [31 ], with the participants wearing light clothing and without shoes, using a 206 SECA model digital scale and a portable stadiometer, respectively. Neck, abdomen, and calf circumferences were measured using a 201-SECA-model inelastic measure tape. The measurement of the neck circumference was performed standing and in an upright position, with the head positioned in the Frankfort horizontal plane, placing the measure tape at the midpoint of the neck height [32 (link)]. Waist circumference was measured at the midpoint between the iliac crest and the last rib, at the end of the expiratory movement [31 ], while the calf circumference was measured in the widest section of the distance between the ankle and the knee, in the calf area [33 (link)]. The measurement of the submandibular fold was made by applying a Slim Guide caliper (Rosscraft, Surrey, Canada) previously validated [34 (link)], in a bipedal position and looking forward, at the point of the line that joins the thyroid cartilage and the chin, in an anteroposterior direction [35 (link)], as Figure 1 shows. The waist–height ratio (WC (cm)/height (cm)) was calculated based on the absolute values of the aforementioned measurements. The indicators used to quantify obesity were BMI and waist circumference, which have been established as easy-to-apply tools in clinical practice to assess cardiovascular risk in overweight or obese patients [36 (link)].
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Publication 2023
Abdomen Ankle Body Weight Chin Exhaling Fingers Head Iliac Crest Knee Joint Light Movement Neck Obesity Patients Thyroid Cartilage Waist Circumference
All children were forbidden to drink for 6 h and fasted for 8 h before operation. The general information of the patients were asked before surgery, including age, height and weight. The modified Mallampati classification (Class I–IV), mouth opening, thyromental distance, Upper lip bite test class, Hemifacial Microsomia, Modified Mallampati (Samsoon and Young) classification [7 (link)] was assessed by an anesthesiologist ignorant of the study while the patient was sitting with the mouth wide open and the tongue protruding without phonation. Mouth opening was measured as the difference between the upper and lower incisors at the midline in centimeters using a scale. Thyromental distance [8 (link)] was measured from the thyroid cartilage to inside of the mentum with neck extended, using a tape. Peripheral venous access was initiated in the operating room, a multifunctional monitor (Datex-Ohmeda S5, General Electric, Boston, MA, USA) to monitor basic vital signs such as electrocardiogram (ECG), non-invasive blood pressure (NIBP), end-tidal-carbon dioxide (EtCO2) and pulse oxygen saturation was set up.
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Publication 2023
Anesthesiologist Blood Pressure Carbon dioxide Child Chin Dental Occlusion Electricity Electrocardiogram Goldenhar Syndrome Incisor Neck Operative Surgical Procedures Oral Cavity Oxygen Saturation Patients Phonation Pulse Rate Signs, Vital Thyroid Cartilage Tongue Veins

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More about "Thyroid Cartilage"

The thyroid cartilage, also known as the laryngeal prominence or Adam's apple, is the largest and most prominent of the laryngeal cartilages.
It is located in the upper part of the larynx and is composed of two laminae that meet at an angle, forming the characteristic protrusion.
This cartilage plays a crucial role in phonation, or speech production, and also serves to protect the underlying vocal folds.
Researchers studying the thyroid cartilage can optimize their studies by utilizing tools like PubCompare.ai.
This AI-driven platform helps locate the best protocols from literature, preprints, and patents, enhancing the reproducibility and accuracy of the research.
By leveraging PubCompare.ai, researchers can ensure their thyroid cartilage studies are backed by the most reliable information, leading to more robust and impactful findings.
In addition to the thyroid cartilage, other key structures and technologies relevant to this area of research include the Aquilion 64 CT scanner, Wall-mounted stadiometer for height measurement, Wacom Cintiq Pro 13 for digital illustration, MATLAB for data analysis, the Leica EM MED20 cryo-ultramicrotome, Somatom Definition CT scanner, Nanoject III injector for microinjection, P1020 pipette, and SPSS version 18.0 for statistical analysis.
The use of Rompun, a veterinary anesthetic, may also be relevant in certain animal studies.
By incorporating these related terms, abbreviations, and technologies, researchers can broaden their understanding of the field and enhance the effectiveness of their thyroid cartilage studies.
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