Log In Sign up
The largest database of trusted experimental protocols
> Chemicals & Drugs > Amino Acid > ACE protein, human

ACE protein, human

Angiotensin-Converting Enzyme (ACE) is a key enzyme in the renin-angiotensin system, responsible for converting angiotensin I to the active vasoconstrictor angiotensin II.
ACE plays a crucial role in regulating blood pressure and fluid balance.
Researchers studying ACE proteins can leverage PubCompare.ai's AI-driven tools to streamline their workflow, locate the best research protocols, and identifie the most effective products for their experiments.
This cutting-edge platform helps scientists get better results from their ACE protein research by comparing published protocols and optimizing their approach.

Most cited protocols related to «ACE protein, human»

1
Mendelian Randomization Analysis of Antihypertensive Drugs
Cited 7 times
We conducted a two-sample Mendelian randomization analysis using summary data on SNPs from GWAS. We identified SNPs to proxy the protein targets of antihypertensive drugs on the basis that they mimicked the action of that drug on the target. For example, angiotensin-converting enzyme inhibitors work by inhibiting the enzyme angiotensin-converting enzyme. We therefore selected SNPs in the angiotensin-converting enzyme gene to use as a genetic proxy for the protein targets of this drug class. Effect sizes for these SNPs were then extracted from a GWAS of systolic blood pressure to estimate the instrument–exposure association.17 The instrument–outcome association was estimated using the effect sizes for these same SNPs from a GWAS of Alzheimer’s disease.18 (link) All data used were publicly available and mostly obtained from European ancestry populations [the exception being the Genotype-Tissue Expression (GTEx) project data—see below].
Walker V.M., Kehoe P.G., Martin R.M, & Davies N.M. (2019). Repurposing antihypertensive drugs for the prevention of Alzheimer’s disease: a Mendelian randomization study. International Journal of Epidemiology, 49(4), 1132-1140.
Full text: Click here
Publication 2019
ACE protein, human Alzheimer's Disease Angiotensin-Converting Enzyme Inhibitors Antihypertensive Agents Cardiac Arrest Drug Delivery Systems Enzymes Europeans Genes Genome-Wide Association Study Genotype Population Group Proteins Reproduction Single Nucleotide Polymorphism Systolic Pressure Tissues
2
Molecular Docking Analysis of pGlu Binding
Cited 5 times
The RCSB Protein Data Bank (www.rcsb.org) was employed to retrieve the 3D-crystal structure of phosphodiesterase 5A1 (PDE5A1) catalytic domain in complex with sildenafil (PDB ID: 2H42), 3D-crystal structure of human angiotensin-converting enzyme (ACE) docked with captopril (PDB ID: 1UZF), 3D-crystal structure of jack bean urease (JBU; PDB ID: 3LA4), and 3D-structure of pGlu (SDF file ID: PCA). PyRx docking software fitted with Autodock VINA (version 0.8, The Scripps Research Institute, La Jolla, CA, USA) was exploited to accomplish the molecular docking studies and to assess the binding modes of pGlu in the active sites of the above-mentioned enzymes.
To ascertain the optimal parameters for reliable docking analyses, sildenafil was extracted from the 3D-crystal structure of (PDB ID: 2H42) and further re-docked back into the crystal structure of the enzyme, while captopril was erased from the 3D-crystal structure of (PDB ID: 1UZF) and re-docked back into the enzyme. All optimal parameters, settings, calculations, protonation conditions, and the overall charges were tracked, as previously designated [28 (link),29 (link)]. Additionally, Zn+2 and Mg+2 ions were assigned during the processing of docking analysis for PDE5A1. All graphical presentations of the docked complexes were illustrated using Discovery studio visualizer version v19.1.0.18287 (BIOVIA, San Diego, CA, USA) [30 ].
Šudomová M., Hassan S.T., Khan H., Rasekhian M, & Nabavi S.M. (2019). A Multi-Biochemical and In Silico Study on Anti-Enzymatic Actions of Pyroglutamic Acid against PDE-5, ACE, and Urease Using Various Analytical Techniques: Unexplored Pharmacological Properties and Cytotoxicity Evaluation. Biomolecules, 9(9), 392.
Full text: Click here
Publication 2019
ACE protein, human Captopril Catalytic Domain Enzymes Homo sapiens Hydrolases, Phosphoric Diester Ions Sildenafil Urease
3
Sarcoidosis Cohort Identification Protocol
Cited 5 times

Protocol full text hidden due to copyright restrictions

Open the protocol to access the free full text link

Publication 2015
ACE protein, human Bacillus acidicola Calcium Diagnosis Ethnicity Fungi Granuloma Lymphadenopathy Mediastinum Patients Physicians Residency Sarcoidosis Sarcoidosis, Pulmonary Skin Tissues X-Rays, Diagnostic
4
SARS-CoV-2 Antibody Neutralization Assay
Cited 3 times
To determine the neutralizing activity of antibodies, we used a surrogate viral neutralization test (C-Pass GenScript sVNT, Piscataway NJ, USA) [17 (link),18 (link)]. Briefly, serum or plasma samples were diluted according to manufacturer’s instructions and incubated with soluble SARS-CoV-2 receptor-binding domain (RBD-HRP) antigen for 30 min, mimicking a neutralization reaction. Following incubation, samples were added to a 96-well plate coated with human ACE-2 protein. RBD-HRP complexed with antibodies were removed in a wash step. The reaction was developed with tetramethylbenzidine (TMB) followed by a stop solution allowing the visualization of bound RBD-HRP to the ACE2. Since this is an inhibition assay, color intensity was inversely proportional to the number of neutralizing antibodies present in samples. Data were interpreted by calculating the percent of inhibition of RBD-HRP binding. Samples with neutralization activity of ≥ 30% indicated the presence of SARS CoV-2 RBD-interacting antibodies capable of blocking the RBD–ACE2 interaction, thus inhibiting viral entry into host cells. While this assay measures the blocking activity of those antibodies, this activity is referred to throughout the text as “percentage of neutralization” for consistency and clarity.
Sariol C.A., Pantoja P., Serrano-Collazo C., Rosa-Arocho T., Armina-Rodríguez A., Cruz L., Stone E.T., Arana T., Climent C., Latoni G., Atehortua D., Pabon-Carrero C., Pinto A.K., Brien J.D, & Espino A.M. (2021). Function Is More Reliable Than Quantity to Follow Up the Humoral Response to the Receptor-Binding Domain of SARS-CoV-2-Spike Protein after Natural Infection or COVID-19 Vaccination. Viruses, 13(10), 1972.
Full text: Click here
Publication 2021
3,3',5,5'-tetramethylbenzidine ACE2 protein, human ACE protein, human Antibodies Antibodies, Blocking Antibodies, Neutralizing Biological Assay Cells Neutralization Tests Plasma Psychological Inhibition Receptors, Antigen SARS-CoV-2 Serum Virus Internalization
5
Evaluating Renin-Angiotensin System in Heart
Cited 3 times
The enzyme-linked immunosorbent assay (ELISA) kits for renin, angiotensin converting enzyme (ACE), chymase, angiotensin I (Ang I) and angiotensin II (Ang II) were obtained from Meimian (Wuhan, China). The primary antibodies against ACE, Chymase and angiotensin II type1 receptor (AT1R) were purchased from Abcam (Cambridge, UK), while those against Collagen I and Collagen III were provided by Bioss (Wuhan, China). Triphenyl tetrazolium chloride (TTC) staining kit was obtained from Sigma (Aldrich, St. Louis, USA). H&E and Masson staining kits were provided by Solarbio (Beijing, China). In situ apoptosis detection kit was obtained from Roche (New Jersey, USA). Goat anti-rabbit antibodies and DAB detection kit were purchased from ZSGB-BIO (Beijing, China). Toluidine blue (TB) staining kit was brought from LEAGENE (Huaibei, China). Acetonitrile and formic acid for ultra-performance liquid chromatography (UPLC) analysis were provided by Sigma. Tranilast capsules were brought from Pharmaceutical Company of China Pharmaceutical University (Nanjing, China).
Zhang X., Shao C., Cheng S., Zhu Y., Liang B, & Gu N. (2021). Effect of Guanxin V in animal model of acute myocardial infarction. BMC Complementary Medicine and Therapies, 21, 72.
Full text: Click here
Publication 2021
ACE protein, human acetonitrile Angiotensin I Angiotensin II Anti-Antibodies Antibodies Apoptosis Capsule CMA1 protein, human Collagen Collagen Type I Enzyme-Linked Immunosorbent Assay formic acid Goat Liquid Chromatography Pharmaceutical Preparations Rabbits Receptor, Angiotensin II Renin Tolonium Chloride tranilast triphenyltetrazolium chloride

Most recents protocols related to «ACE protein, human»

1
Quantitative RT-PCR Analysis of Mouse Gene Expression
Total RNA was reverse-transcribed using PrimeScript RT Master Mix (Clonetech) containing random hexamer and oligo (dT) primer. Alternatively, SMART MMLV Reverse Transcriptase (Clonetech) with oligo (dT) primer was used. Aliquots of the products were amplified using BioRad CFX96. The primers used for the mouse genes were as follows: Gapdh, 5′-GTT​GTC​TCC​TGC​GAC​TTC​AAC-3′ and 5′-CCA​GGG​TTT​CTT​ACT​CCT​TGG-3′; Rpl13a, 5′-GGC​TGA​AGC​CTA​CCA​GAA​AGT-3′ and 5′-TCT​TTT​CTG​CCT​GTT​TCC​GTA-3′; Aldh1a2, 5′-CAC​AGG​AGA​GCA​AGT​GTG​TGA-3′ and 5′-TAG​TTG​CAA​GAG​TTG​CCC​TGT-3′; Aldh1a1, 5′-GCA​CTC​AAT​GGT​GGG​AAA​GT-3′ and 5′-TTT​GGC​CAC​ACA​CTC​CAA​TA-3′; Aldh1a3, 5′-AAA​CCC​ACG​GTC​TTC​TCA​GAT-3′ and 5′-CTT​TGT​CCA​GGT​TTT​TGG​TGA-3′; Phex, 5′-GGG​TTT​ATC​CTT​GGC​TGA​GAC-3′ and 5′-AGG​TGA​ATG​CCT​CAA​GAT​GTG-3′; Postn, 5′- AAC​CAA​GGA​CCT​GAA​ACA​CG-3′ and 5′- GTG​TCA​GGA​CAC​GGT​CAA​TG-3′; Ptx3, 5′-CCT​GCT​TTG​TGC​TCT​CTG​GT-3′ and 5′-TCT​CCA​GCA​TGA​TGA​ACA​GC-3′; Cd143, 5′-CAG​TGT​CTA​CCC​CCA​AGC​AT-3′ and 5′-TTC​CAT​CAA​AGA​CCC​TCC​AG-3′; Adm, 5′-GTC​GTG​GGA​AGA​GGG​AAC​TAC-3′ and 5′-GGT​AGC​GTT​TGA​CAC​GAA​TGT-3′; Tie2, 5′-CAG​GCC​TGG​AAA​TAC​ATT​GAA-3′ and 5′-GGC​AGG​AGA​CTG​AGA​CCT​CTT-3′; Msln, 5′-AGT​CAG​GGA​GGT​TCT​GAG​GAG-3′ and 5′-AGG​GGT​CTC​TGG​AGA​TGT​GTT-3′; Lrrn4, 5′-TGA​GTT​CCT​TTG​GTC​CTT​GG-3′ and 5′-TAA​AGC​AGG​CTC​ACA​CAT​GG-3′; Upk3b, 5′-AGA​ATC​CCA​ACT​CCA​TTG​ACA​C-3′ and 5′-ATG​TAA​CGT​TTT​CCC​ATG​AAG​G-3′; Ccl19, 5′-CAC​CAC​ACT​AAG​GGG​CTA​TCA-3′ and 5′-TCT​TCT​GGT​CCT​TGG​TTT​CCT-3′; Col4a1, 5′-GAG​AGA​CAG​GAC​CCT​TTG​GAC-3′ and 5′-GGA​CAC​AGT​GGG​TCA​TCT​GTT-3′; Col14a1, 5′-CTG​CCC​ACA​CAG​CTA​GTG​AA-3′ and 5′-GCC​AGA​CCT​TCT​GTG​AGA​GG-3′; Cxcl12, 5′-GCT​CTG​CAT​CAG​TGA​CGG​TA-3′ and 5′-TAA​TTT​CGG​GTC​AAT​GCA​CA-3′; Cxcl13, 5′-TCT​GGA​AGC​CCA​TTA​CAC​AA-3′ and 5′-TTT​GTA​ACC​ATT​TGG​CAC​GA-3′; Cxcl16, 5′-TCC​GTG​AAC​TAG​TGG​ACT​GCT-3′ and 5′-GGA​AGA​GTG​GAG​TGC​TGA​GTG-3′; Ccl21, 5′-ATG​TGC​AAA​CCC​TGA​GGA​AG-3′ and 5′-TCC​TCT​TGA​GGG​CTG​TGT​CT-3′; Dpt, 5′-CCA​CTA​TGG​GGA​AGA​CAT​GG-3′ and 5′-CCT​TCA​CCC​GGA​CTT​CTG​TA-3′; Wt1, 5′- ACA​CCA​AAG​GAG​ACA​CAC​AGG-3′ and 5′- GCG​CAA​ACT​TTT​TCT​GAC​AAC-3′.
Yoshihara T, & Okabe Y. (2023). Aldh1a2+ fibroblastic reticular cells regulate lymphocyte recruitment in omental milky spots. The Journal of Experimental Medicine, 220(5), e20221813.
Full text: Click here
Publication 2023
5'-chloroacetamido-5'-deoxythymidine ACE protein, human ALDH1A1 protein, human ALDH1A2 protein, human CCL19 protein, human CCL21 protein, human CXCL12 protein, human CXCL13 protein, human GAPDH protein, human Genes Mice, Laboratory MSLN protein, human Oligonucleotide Primers Oligonucleotides Real-Time Polymerase Chain Reaction RNA-Directed DNA Polymerase
2
Bepridil Plasma Concentration Determinants
Correlations between bepridil dosage and its plasma concentration were analyzed using Spearman correlation coefficient analysis. Univariate analyses were performed as follows for continuous and categorical variables, respectively. Differences in continuous variables between the ≥800 ng/mL and < 800 ng/mL groups were analyzed using the Mann–Whitney U test as they followed a non-normal distribution. Categorical variables were compared using the chi-square test. Fisher’s exact test was selected to include one cell with an expected value of < 5 on a 2 × 2 contingency table. In the multivariate logistic regression analysis, the objective variable constituted plasma bepridil concentrations ≥800 ng/mL, whereas the explanatory variables included age, which reportedly influences plasma bepridil concentration [20 (link)], and factors that showed p <  0.05 in the univariate analysis. For enhanced clarity of clinical settings, when the continuous variables were included in the multivariate logistic regression model, the continuous variables were converted to categorical variables based on specified cut-off values. Specifically, the cut-off values for age and daily bepridil dose were the median values obtained considering all the eligible patients (Table 1). For Ccr, the cutoff value was Ccr ≤ 30 mL/min, which signifies severe renal impairment, and for LVEF, it was LVEF ≤50%, which indicates a reduced LVEF. Furthermore, the Hosmer–Lemeshow test was used to assess the goodness of fit of the multivariate logistic regression model (p > 0.05 was considered statistically significant). Multicollinearity was also evaluated using the variance inflation factor (VIF). To determine the number of concomitant drugs influencing the C/D ratio, the three groups were compared using the Kruskal–Wallis test, followed by Bonferroni correction for comparisons between groups. Statistical analyses were performed using SPSS Statistics version 27 (IBM Japan, Tokyo, Japan), and the significance level was set at p <  0.05.

Summary of patient data

Factorsn = 359
Sex (Male/Female)238/121
Age (years)71 (64, 79)d
Height (m)1.64 (1.55, 1.71)d
Body weight (kg)62.55 (54.68, 72.40)d
Body mass index (kg/m2)23.41 (21.15, 25.65)d
Serum creatinine (mg/dL)0.88 (0.74, 1.03)d
Ccr (mL/min)64.63 (47.56, 86.03)d
Daily dose of bepridil (mg/kg body weight)1.58 (1.24, 2.02)d
Period of bepridil treatment (day)356 (124, 1404)d
Plasma bepridil concentration (ng/mL)300 (157, 491)d
C/D ratio of bepridil (ng/mL) / (mg/day/kg)186 (108, 278)
LVEF (%)65.1 (59.1, 69.9)d
 HFrEFa, n (%)14 (3.9)
 HFmrEFb, n (%)28 (7.8)
 HFpEFc, n (%)317 (88.3)
Patient’s medical history, n (%)
 Coronary artery bypass graft3 (0.8)
 Graft replacement1 (0.3)
 Atrial fibrillation346 (94.3)
 Heart valve replacement or formation8 (2.2)
Concomitant drugs for HF and comorbidities, n (%)
 ACE inhibitor/ARB116 (32.3)
 β-blocker218 (60.7)
 Calcium-channel blocker98 (27.3)
 Statins111 (30.9)
 Diuretics89 (24.8)
 Antidiabetic drugs40 (11.1)
 Anticoagulant drugs286 (79.7)

ACE Angiotensin converting enzyme, ARB Angiotensin II receptor blocker, Ccr Creatinine clearance, C/D Concentration-to-dose, HFmrEF Heart failure with mid-range ejection fraction; HFpEF Heart failure with preserved ejection fraction, HFrEF Heart failure with reduced ejection fraction, LVEF Left ventricular ejection fraction

aLVEF< 40%

b40%≦LVEF< 50%

C50%≦LVEF

dEach value represents the median (25 to 75% percentile)

Asai Y., Arihara H., Omote S., Tanio E., Yamashita S., Higuchi T., Hashimoto E., Yamada M., Tsuji H., Kondo Y., Hayashi M, & Yamamoto Y. (2023). Effect of polypharmacy on plasma bepridil concentration in patients with heart failure: a multicenter retrospective study. Journal of Pharmaceutical Health Care and Sciences, 9, 10.
Full text: Click here
Publication 2023
ACE protein, human Angiotensin-Converting Enzyme Inhibitors Angiotensin II Receptor Antagonist Anticoagulants Antidiabetics Bepridil Body Weight Calcium Channel Cells Congestive Heart Failure Coronary Artery Bypass Surgery Creatinine Grafts Heart Atrium Heart Failure, Diastolic Heart Failure, Systolic Heart Valves Left Ventricles Males Patients Pharmaceutical Preparations Plasma Renal Insufficiency Woman
3
Multiscale Pharmacodynamic Modeling of RAAS
The systems pharmacology model was built in two consecutive phases. First, a largely empirical PKPD model with minimum parameterization was built to capture basic biological variations in the data. In practice, this entailed fitting a basic 1-, 2-, or 3-compartment model to the pharmacokinetics of benazeprilat, and then linking the PK to the RAAS biomarkers concentrations via various indirect and direct response models. Whenever possible we opted for direct over indirect effects models, and fewer compartments, to reduce the number of total estimated parameters during model fit.
Then, in an iterative fashion, model components were replaced with more mechanistic structures. To do this, we modeled the cascade of peptides which define the alternative and classical RAAS pathways. We also tested whether we could expand the mathematical model to include important biological systems such as the clearance of angiotensins via the liver vs. kidneys, non-specific plasma binding, first-pass metabolism, and site-specific metabolism. Some components and parameters of the model structure were arbitrarily fixed to literature or exploratory values to preserve fidelity to relevant biological systems. For example, our model equations were rewritten so that the production of AngII was always one-to-one proportional with catalysis of AngI via the angiotensin converting enzyme. The final model was refined through various arithmetic simplifications and parameter search optimizations to improve precision of parameter estimates as much as possible without comprising fit to experimental data. The significance of bodyweight, sex, sodium intake, and benazepril dose on parameters estimates was further evaluated using the automated Pearson’s correlation test and ANOVA method as implemented in Monolix 2020 R1.
Schneider B.K., Ward J., Sotillo S., Garelli-Paar C., Guillot E., Prikazsky M, & Mochel J.P. (2023). Breakthrough: a first-in-class virtual simulator for dose optimization of ACE inhibitors in translational cardiovascular medicine. Scientific Reports, 13, 3300.
Full text: Click here
Publication 2023
ACE protein, human Angiotensins benazepril benazeprilat Biological Markers Biopharmaceuticals Body Weight Catalysis Drug Kinetics Kidney Liver Metabolism neuro-oncological ventral antigen 2, human Peptides Plasma Sodium
4
Meta-analysis of ACE I/D Polymorphisms in Longevity
Due to nomenclature inconsistency among studies, we used I (insertion) and D (deletion) alleles as follows: The genotypes were referred to as homozygous insertion (II), heterozygous insertion/deletion (ID), and homozygous deletion (DD). The I and D polymorphisms were referred to as I/D. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) [53 (link)] and performed a meta-analysis as described [54 (link)] with updates described in PRISMA 2020 [55 (link)]. We performed a literature search to collect publications on ACE I/D polymorphisms in centenarians published before 25 May 2022. A total of 80 studies were obtained from the Human Genomic Aging Resource’s Longevity Map database, Scopus, PubMed, and Google Scholar using the keywords “ACE” OR “angiotensin-converting enzyme” AND “longevity” OR “centenarian” OR “nonagenarian” (subjects 90+ years). Studies of all languages were included. The titles and abstracts of each article were imported to Colandr [24 (link)], which uses AI and machine-learning algorithms to determine an article’s relevance based on text-based evidence. Of the 80 studies initially identified, 37 were excluded as duplicates. The remaining 43 articles were then screened in Colandr according to specified inclusion criteria.
Li L, & Murakami S. (2023). Artificial Intelligence-Assisted Meta-Analysis of the Frequency of ACE I/D Polymorphisms in Centenarians and Other Long-Lived Individuals. International Journal of Molecular Sciences, 24(4), 3411.
Full text: Click here
Publication 2023
ACE protein, human Alleles Centenarians Deletion Mutation Genetic Polymorphism Genome Genome, Human Genotype Heterozygote Homo sapiens Homozygote INDEL Mutation Manpower Nonagenarians
5
Preparation of Simulated Digestive Fluid
The reagents used to prepare the digestion solution, NaCl (S271-3), NaHCO3 (80500-300), CaCl2 (C614-3), and HCl (UN 1789), were purchased from Thermo Fisher Scientific (Hampton, VA, USA). The KCl (3040) and KH2PO4: monobasic crystal (4008-01) were acquired from J. T. Baker (Phillipsburg, NJ, USA), and KSCN (CAAA14318-22) and NH4Cl (CAAA12361-36) were supplied by VWR (Radnor, PA, USA). The NaH2PO4·H2O (84456-300), Na2SO4 (57361) and MgCl2.H2O (M-2670) were purchased from Anachemia, BDH and Sigma-Aldrich (Oakville, ON, Canada), respectively. The α-amylase (A3176), pepsin (P7000), lipase (L3126), bile (B8631), mucin from porcine stomach (Type III), pancreatin (P7545), angiotensin-converting enzyme from rabbit lungs (EC 3.4.15.1), its substrate N-hippuryl-His-Leu (HHL), as well as 1,4-dioxane, were supplied by Sigma-Aldrich (Oakville, ON, Canada). Bovine serum albumin (BSA) was acquired from Thermo Fisher Scientific (Hampton, VA, USA). The specific ACE inhibitor, enalapril, was supplied by Sigma-Aldrich (St. Louis, MO, USA). The α-amylase (E-BLAAM), protease (E-BSPRT), amyloglucosidase (E-AMGDF) and celite (G-CEL 100) were purchased from Megazyme International Ireland Ltd. (Wicklow, Ireland).
Vasconcelos M.M., Marson G.V., Rioux L.E., Tamigneaux E., Turgeon S.L, & Beaulieu L. (2023). In Vitro Bioaccessibility of Proteins and Bioactive Compounds of Wild and Cultivated Seaweeds from the Gulf of Saint Lawrence. Marine Drugs, 21(2), 102.
Full text: Click here
Publication 2023
ACE protein, human Amylase Angiotensin-Converting Enzyme Inhibitors Bicarbonate, Sodium Bile Celite Digestion Dioxanes Enalapril Endopeptidases Glucan 1,4-alpha-Glucosidase histidylleucine Lipase Lung Magnesium Chloride Mucins, Gastric Pancreatin Pepsin A Pigs potassium thiocyanate Rabbits Serum Albumin, Bovine Sodium Chloride

Top products related to «ACE protein, human»

1
Angiotensin converting enzyme by Merck Group
Sourced in United States
Angiotensin-converting enzyme is a lab equipment product that catalyzes the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. It is an important component in the renin-angiotensin system, which regulates blood pressure and fluid balance in the body.
2
Angiotensin converting enzyme from rabbit lung by Merck Group
Sourced in United States
Angiotensin converting enzyme from rabbit lung is a laboratory product that serves as a source of the angiotensin converting enzyme (ACE). ACE is an important enzyme involved in the regulation of blood pressure and fluid balance in the body.
3
Hippuric acid by Merck Group
Sourced in United States, France, Germany, Spain, Sweden, Switzerland, United Kingdom
Hippuric acid is a chemical compound used as a reference standard in analytical testing. It is a metabolite produced in the human body and is commonly used in analytical laboratories to validate and calibrate instrumentation for the detection and quantification of similar metabolites.
4
Captopril by Merck Group
Sourced in United States, Germany, United Kingdom, Ireland, Japan, China, Canada
Captopril is a laboratory equipment product used in the pharmaceutical industry. It is a peptidase inhibitor that acts as an angiotensin-converting enzyme (ACE) inhibitor. Captopril is used in the development and production of various pharmaceutical drugs.
5
Gallic acid by Merck Group
Sourced in United States, Germany, Italy, Spain, France, India, China, Poland, Australia, United Kingdom, Sao Tome and Principe, Brazil, Chile, Ireland, Canada, Singapore, Switzerland, Malaysia, Portugal, Mexico, Hungary, New Zealand, Belgium, Czechia, Macao, Hong Kong, Sweden, Argentina, Cameroon, Japan, Slovakia, Serbia
Gallic acid is a naturally occurring organic compound that can be used as a laboratory reagent. It is a white to light tan crystalline solid with the chemical formula C6H2(OH)3COOH. Gallic acid is commonly used in various analytical and research applications.
6
Dimethyl sulfoxide (dmso) by Merck Group
Sourced in United States, Germany, United Kingdom, China, Italy, Sao Tome and Principe, France, Macao, India, Canada, Switzerland, Japan, Australia, Spain, Poland, Belgium, Brazil, Czechia, Portugal, Austria, Denmark, Israel, Sweden, Ireland, Hungary, Mexico, Netherlands, Singapore, Indonesia, Slovakia, Cameroon, Norway, Thailand, Chile, Finland, Malaysia, Latvia, New Zealand, Hong Kong, Pakistan, Uruguay, Bangladesh
DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
7
Trolox by Merck Group
Sourced in United States, Germany, Italy, France, Spain, Brazil, India, Poland, Switzerland, Canada, China, New Zealand, United Kingdom, Chile, Macao, Mexico, Australia, Portugal, Czechia, Hungary, Japan, Belgium, Singapore, Argentina, Ireland, Sao Tome and Principe, Denmark, Thailand, Israel, Morocco, Cameroon
Trolox is a water-soluble vitamin E analog that functions as an antioxidant. It is commonly used in research applications as a reference standard for measuring antioxidant capacity.
8
α amylase by Merck Group
Sourced in United States, Germany, China, Italy, Poland, United Kingdom, India, France, Switzerland, Singapore, Spain, Sao Tome and Principe, Canada, Sweden, Australia
α-amylase is an enzyme commonly used in laboratory settings. It functions by catalyzing the hydrolysis of starch, glycogen, and related polysaccharides into smaller carbohydrate units such as maltose and glucose.
9
Fetal bovine serum (fbs) by Thermo Fisher Scientific
Sourced in United States, China, United Kingdom, Germany, Australia, Japan, Canada, Italy, France, Switzerland, New Zealand, Brazil, Belgium, India, Spain, Israel, Austria, Poland, Ireland, Sweden, Macao, Netherlands, Denmark, Cameroon, Singapore, Portugal, Argentina, Holy See (Vatican City State), Morocco, Uruguay, Mexico, Thailand, Sao Tome and Principe, Hungary, Panama, Hong Kong, Norway, United Arab Emirates, Czechia, Russian Federation, Chile, Moldova, Republic of, Gabon, Palestine, State of, Saudi Arabia, Senegal
Fetal Bovine Serum (FBS) is a cell culture supplement derived from the blood of bovine fetuses. FBS provides a source of proteins, growth factors, and other components that support the growth and maintenance of various cell types in in vitro cell culture applications.
10
Sodium nitrite by Merck Group
Sourced in United States, Germany, Italy, United Kingdom, Australia, India, China, Canada, Spain, Sao Tome and Principe, Portugal, Switzerland, France, Belgium, Poland, Chile
Sodium nitrite is a chemical compound with the formula NaNO2. It is a white to slightly yellowish crystalline solid that is commonly used in various laboratory and industrial applications.

More about "ACE protein, human"

Angiotensin-Converting Enzyme (ACE) is a crucial enzyme in the renin-angiotensin system, responsible for converting the inactive angiotensin I into the potent vasoconstrictor angiotensin II.
This enzymatic process plays a vital role in regulating blood pressure and fluid balance within the body.
ACE proteins have been extensively studied by researchers, who can leverage the powerful AI-driven tools offered by PubCompare.ai to streamline their workflow, locate the best research protocols, and identify the most effective products for their experiments.
This cutting-edge platform helps scientists optimize their approach and get better results from their ACE protein research.
The renin-angiotensin system, of which ACE is a key component, is a complex physiological pathway that regulates cardiovascular function and fluid homeostasis.
Angiotensin-converting enzyme (also known as peptidyl-dipeptidase A or kininase II) catalyzes the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor that contributes to the regulation of blood pressure.
In addition to its role in the renin-angiotensin system, ACE is also involved in the metabolism of other bioactive peptides, such as bradykinin, a vasodilator.
The balance between the vasoconstrictor and vasodilator effects of the renin-angiotensin system is crucial for maintaining healthy cardiovascular function.
Researchers studying ACE proteins can utilize PubCompare.ai's AI-driven tools to compare published protocols, identify the most effective experimental approaches, and optimize their research workflow.
This can include comparing the use of various substrates, inhibitors, and cofactors, such as hippuric acid, captopril, gallic acid, DMSO, Trolox, and α-amylase, to understand their impact on ACE activity and function.
By leveraging the power of PubCompare.ai, scientists can streamline their ACE protein research, locate the best protocols from literature, preprints, and patents, and ultimately get better results from their experiments.
This cutting-edge platform empowers researchers to make more informed decisions and advance our understanding of this crucial enzyme and its role in the renin-angiotensin system.