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Amphiregulin

Q: What are some common challenges in working with Amphiregulin?

Researchers working with Amphiregulin may face challenges in identifying the most effective protocols and experimental methods from the vast array of available literature. Selecting the right reagents, cell lines, and experimental conditions can be time-consuming and prone to inconsistencies, potentially impacting the reproducibility and accuracy of your research.

Q: Are there different variations or types of Amphiregulin?

While Amphiregulin is primarily a single protein, there can be variations in its structure, modifications, and expression patterns depending on the cell type, tissue, and physiological or pathological conditions. Researchers may need to consider these nuances when designing experiments and interpreting results related to Amphiregulin.

Amphiregulin is a member of the epidermal growth factor (EGF) family of proteins.
It is involved in cell proliferation, differentiation, and survival.
Amphiregulin binds to and activates the EGF receptor, triggering intracellular signaling cascades that regulate various cellular processes.
It plays a role in the development and homeostasis of multiple tissues, including the skin, intestine, and mammary gland.
Dysregulation of Amphiregulin has been implicated in the pathogenesis of certain cancers and inflammatory disorders.
Researchers studying Amphiregulin can optimize their work using PubCompare.ai, an AI-powered platform that enhances reproducibility and accuarcy by helping locate the best protocols from literature, preprints, and patents, and discover the most reliable methods and products to advance their Amphiregulin research with ease.

Most cited protocols related to «Amphiregulin»

Plasmid-based EGFR Ligand Shedding Assay

Cited 12 times

Plasmids encoding AP-tagged EGFR ligands were constructed by inserting partial cDNAs for human TGFα, amphiregulin, epiregulin, EGF, betacellulin, and HB-EGF into the 3′ end of human placental AP cDNA on a pRc/CMV-based expression vector pAlPh. pAlPh contains an NH₂-terminally located HB-EGF signal sequence. In all cases, the junction between AP and the EGFR ligand was placed next to the membrane-proximal EGF repeat. Release of the AP module into the culture supernatant thus requires cleavage at the COOH-terminal cleavage site. It should be noted that the results obtained with AP-tagged EGFR ligands corroborate previous results that TGFα, HB-EGF, and amphiregulin are cleaved by ADAM17 (Peschon et al., 1998 (link); Merlos-Suarez et al., 2001 (link); Sunnarborg et al., 2002 (link); Jackson et al., 2003 (link)). This validates the use of AP tags to measure ectodomain shedding for these substrates. In addition, the use of an AP tag has been independently validated using the TNF family members TNFα and TRANCE/OPGL (Zheng et al., 2002 (link); Chesneau et al., 2003 (link)). This strongly suggests that an AP tag, which provides a sensitive and quantitative means of measuring ectodomain shedding, should not interfere with the shedding properties of the other EGFR ligands tested here.

Sahin U., Weskamp G., Kelly K., Zhou H.M., Higashiyama S., Peschon J., Hartmann D., Saftig P, & Blobel C.P. (2004). Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. The Journal of Cell Biology, 164(5), 769-779.

Publication 2004

ADAM17 protein, human Amphiregulin Betacellulin Cloning Vectors Cytokinesis DNA, Complementary EGFR protein, human Epiregulin Family Member Heparin-binding EGF-like Growth-Factor Homo sapiens Ligands Placenta Plasmids Signal Peptides Tissue, Membrane TNFSF11 protein, human Transforming Growth Factor alpha

Luminal Epithelial Cell Co-culture Assay

Cited 6 times

CD271^low/MUC1^high primary luminal epithelial cells were seeded at 6000 cells/cm² on confluent fibroblast feeders of CD105^high/CD26^low and CD105^low/CD26^high cells, respectively, in modified breastoid base medium without HEPES [9 (link)] (DMEM/F-12, 1:1), 1 μg/ml hydrocortisone (Sigma-Aldrich), 9 μg/ml insulin (Sigma-Aldrich), 5 μg/ml transferrin (Sigma-Aldrich), 5.2 ng/ml Na-Selenite (BD Industries), 100 μM ethanolamine (Sigma-Aldrich), 20 ng/ml basic fibroblast growth factor (PeproTech), 5 nM amphiregulin (R&D Systems), with the addition of 10 μM Y-27632 (Axon Medchem), 1.8 × 10⁻⁴ M adenine (Sigma Aldrich) and the serum replacement B27 (20 μl/ml, Life Technologies) [6 (link)]. hMSC feeders cultured under similar conditions were used for comparison.
To determine whether luminal progenitors and differentiated cells responded differently to co-culture, FACS-sorted CD166 (ALCAM)^high/laminin receptor 67LR^high (EpCAM^high/CD166^high/LNR67^high) or CD166^high (EpCAM^high/CD90^low/CD166^high) differentiated luminal cells versus 67LR^low (EpCAM^high/CD166^low/LNR67^low) or CD166^low (EpCAM^high/CD90^low/CD166^low) progenitors [6 (link)] were confronted with either CD105^high/CD26^low or CD105^low/CD26^high cells under similar conditions. Epithelial structure formation was observed for up to three weeks by phase contrast microscopy and photographed (Leica DM IL).

Morsing M., Klitgaard M.C., Jafari A., Villadsen R., Kassem M., Petersen O.W, & Rønnov-Jessen L. (2016). Evidence of two distinct functionally specialized fibroblast lineages in breast stroma. Breast Cancer Research : BCR, 18, 108.

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Publication 2016

Activated-Leukocyte Cell Adhesion Molecule Adenine Amphiregulin Axon Cells Coculture Techniques Epithelial Cells Ethanolamine Fibroblast Growth Factor 2 Fibroblasts HEPES Hydrocortisone Insulin Laminin Receptor Microscopy, Phase-Contrast Phenobarbital Selenite Serum Transferrin Y 27632

Multi-parameter Analysis of Lung Immune Cells

Cited 5 times

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Publication 2019

alpha HML-1 Amphiregulin anti-IgM Antibodies Antibodies, Anti-Idiotypic Antigen T Cell Receptor, beta Chain Cardiac Arrest CD44 protein, human Cells Collagenase Cytokine Deoxyribonucleases Euthanasia Flow Cytometry gamma-delta T-Cell Receptor Goat Hematopoietic System Hybridomas IL17A protein, human Immunoglobulins Interferon Type II Interleukin-17F ITGAM protein, human Lung MAG protein, human Mucolipidosis Type IV Mus Nodes, Lymph Protein Transport Protoplasm RORC protein, human Spleen Tissues Transcription Factor Tumor Necrosis Factor-alpha

3D Mammary Organoid Embedding in Preassembled Collagen

Cited 5 times

Fibrillar collagen I, the most abundant structural protein in mammary glands, plays an important role in normal development as well as in breast cancer. Our previous studies have demonstrated that collagen I induces a conserved response of protrusive invasion in both normal and tumor organoids [23 (link)]. This section describes how to properly prepare preassembled collagen I and embed mammary organoids in a 3D gel.

Use a plate with a glass bottom for time-lapse imaging.

Use 20-30 μL of neutralized collagen to make a thin underlay on the cover glass of the well at room temperature (Fig. 5e). The underlay helps the top collagen/organoid suspension attach better to the cover glass.

Incubate the plate with the underlays at 37 °C until ready for plating.

Preincubate the neutralized collagen I solution (used for the top gel) at 4 °C for 60–120 min for preassembly [24 (link)] (seeNote 14). The collagen I solution will turn cloudy and fibrous (Fig. 5d_1–6) (seeNote 15), a state we term preassembled collagen I.

Set up the tissue culture hood in preparation for plating (Fig. 4a).

Set the heating block to 37 °C, and place the plate on top, in direct contact with the block (Fig. 4b–c′) (seeNote 10).

Always keep the collagen I solution on ice. Add the desired amount of preassembled collagen I to the organoid pellet in a microcentrifuge tube. Since collagen I is quite viscous, first pipette up and down slowly a few times to coat the tip and ensure an accurate volume.

Keep the tube on ice or in a cold block. Resuspend the organoid pellet gently to avoid introducing air bubbles. Do not try to take up the entire volume into the pipette tip while mixing.

Plate the appropriate volume of collagen/organoid suspension (see table in Subheading 3.4) on top of the underlay (Fig. 5e′). Pipette up and down to resuspend the organoids before plating each sample, and pipette out only until the first stop.

Keep the plate on the heating block for several minutes to allow further gelation before returning it to the incubator (seeNote 16).

Incubate the plate at 37 °C, 5 % CO₂, for 45–60 min. After gelation, collagen I fibrils are visible under the microscope at 10× and 40× (Fig. 5f-f′).

Gently add pre-warmed organoid medium supplemented with growth factor to the wells. A variety of growth factors may be used, including EGF ligands (EGF, TGF-α, amphiregulin, heregulin, neuregulin), FGF ligands (FGF2, FGF7), and HGF. We most commonly use 2.5 nM FGF2.

Add sterile water or PBS to the empty wells to prevent desiccation.

Label the wells. Return the plate to the incubator.

If the plate will be used for DIC imaging, use a glass plate cover for better image quality.

Nguyen-Ngoc K.V., Shamir E.R., Huebner R.J., Beck J.N., Cheung K.J, & Ewald A.J. (2015). 3D Culture Assays of Murine Mammary Branching Morphogenesis and Epithelial Invasion. Methods in molecular biology (Clifton, N.J.), 1189, 135-162.

Publication 2015

Amphiregulin Breast Breast Carcinoma Cold Temperature Collagen Collagen Type I Desiccation FGF7 protein, human Fibroblast Growth Factor 2 Fibrosis Growth Factor Ligands Mammary Gland Microscopy Neoplasms Neuregulins Organoids Proteins Sterility, Reproductive TGFA protein, human Tissues Viscosity

Profiling MET and EGFR Alterations in NSCLC

Cited 5 times

MET and EGFR gene copy numbers were evaluated by FISH; a CEP7 centromere probe (Abbott Molecular) was used as a control. High-level MET amplification was defined as tight gene clusters of ≥ 15 copies in ≥ 10% of tumor cells, or a MET: CEP7 ratio of ≥2. A cutoff of ≥5 copies of MET/ cell was predefined as the criterion for FISH-positive status (FISH⁺), based on prior prognostic data supporting this cutoff in NSCLC (4 (link)). Tumors were considered EGFR FISH⁺ based on a scoring system used in multiple clinical studies (19 (link)). Further details are included in the Supplementary Methods section.
DNA and RNA were isolated from macrodissected tissue to enrich for tumor content. EGFR and KRAS mutations were evaluated using the DxS Genotyping Kit. MET exon 14 variants were evaluated by Surveyor nuclease digestion and detection by WAVE analysis (Transgenomics, Inc.). A polymorphism at position N375S of MET was evaluated by pyrosequencing on the Pyromark Q24 (11 (link)). Expression of MET, HGF, EGFR, amphiregulin (AREG), and epiregulin (EREG) mRNA transcripts was evaluated by qRT-PCR on the Biomark platform (Fluidigm). The primer/probes used for profiling are shown in Supplementary Table S2 and further details are included in the Supplementary Methods section.

Koeppen H., Yu W., Zha J., Pandita A., Penuel E., Rangell L., Raja R., Mohan S., Patel R., Desai R., Fu L., Do A., Parab V., Xia X., Januario T., Louie S.G., Filvaroff E., Shames D.S., Wistuba I., Lipkind M., Huang J., Lazarov M., Ramakrishnan V., Amler L., Phan S.C., Patel P., Peterson A, & Yauch R.L. (2014). Biomarker Analyses from a Placebo-Controlled Phase II Study Evaluating Erlotinib ± Onartuzumab in Advanced Non–Small Cell Lung Cancer: MET Expression Levels Are Predictive of Patient Benefit. Clinical cancer research : an official journal of the American Association for Cancer Research, 20(17), 4488-4498.

Publication 2014

Amphiregulin Cells Centromere Digestion EGFR protein, human Epiregulin Exons Fishes Genes Genetic Polymorphism K-ras Genes Mutation Neoplasms Non-Small Cell Lung Carcinoma Oligonucleotide Primers RNA, Messenger Tissues

Most recents protocols related to «Amphiregulin»

Transcriptional Analysis of Neuromuscular Genes

RNA from GCM was extracted using TRIzol (Invitrogen) and purified with PureLink RNA columns (Life Technologies). RNA samples were treated with DNase I, and reverse transcription was performed with High-Capacity cDNA Reverse Transcription Kit (Life Technologies). Real-time PCR was performed using the TaqMan Gene expression assay (Applied Biosystems) following the manufacturer’s instructions, on cDNA specimens in triplicate, using 1× Universal PCR Master Mix (Life Technologies) and 1× mix containing specific receptors probes (Life Technologies). Relative quantification was calculated from the ratio between the cycle number (Ct) at which the signal crossed a threshold set within the logarithmic phase of the given gene and that of the reference β-actin gene (4310881E; Life Technologies). Mean values of the triplicate results for each animal were used as individual data for 2-ΔCt statistical analysis. The following is the list of probes used: nicotinic cholinergic receptor, gamma subunit (AChRγ) (CHRNG; Mm00437419_m1; Life Technologies), epsilon subunit (AChRε) (CHRNE; Mm00437411_m1; Life Technologies), alpha subunit (AChRα1) (CHRNA1; Mm00431629_m1; Life Technologies), beta subunit (AChRβ1) (CHRNB1; Mm00680412_m1; Life Technologies), delta subunit (AChRδ) (CHRND; Mm00445545_m1; Life Technologies), tumour necrosis factor alpha (TNF-alpha) (Mm00443258_m1; Life Technologies), insulin-like growth factor 1 (IGF1) (Mm00439560_m1; Life Technologies), CD4 (Mm00442754_m1; Life Technologies), forkhead box P3 (FOXP3) (Mm00475162_m1; Life Technologies), amphiregulin (Mm00437583_m1; Life Technologies), CD11c (Mm00498701_m1; Life Technologies), interferon-γ (IFNγ) (Mm01168134_m1; Life Technologies), transforming growth factor-β1 (Mm01178820_m1; Life Technologies), CD8a (Mm01182107_g1; Life Technologies), MyoD1 (Mm00440387_m1; Life Technologies), MyoG (Mm00446194_m1; Life Technologies), and Tmem8c (Mm00481256_m1; Life Technologies).

Margotta C., Fabbrizio P., Ceccanti M., Cambieri C., Ruffolo G., D’Agostino J., Trolese M.C., Cifelli P., Alfano V., Laurini C., Scaricamazza S., Ferri A., Sorarù G., Palma E., Inghilleri M., Bendotti C, & Nardo G. (2023). Immune-mediated myogenesis and acetylcholine receptor clustering promote a slow disease progression in ALS mouse models. Inflammation and Regeneration, 43, 19.

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Publication 2023

Actins Amphiregulin Animals Biological Assay Deoxyribonuclease I DNA, Complementary Gamma Rays Gene Expression Genes Glycoprotein Hormones, alpha Subunit IGF1 protein, human Interferon Type II MYOD1 protein, human Nicotinic Receptors Protein Subunits Real-Time Polymerase Chain Reaction Reverse Transcription TGF-beta1 trizol Tumor Necrosis Factor-alpha

Quantification of Biomarkers in Samples

IL-9, EGFR, AREG, and HIF-1α levels were measured by commercial enzyme-linked immunosorbent assay (ELISA) kits purchased from R&D Systems (Minneapolis, MN, USA), including Human IL-9 DuoSet ELISA (Catalog Number: DY209-05), Human EGFR DuoSet ELISA (Catalog Number: DY231), Human Amphiregulin DuoSet ELISA (Catalog Number: DY262), and Human/Mouse Total HIF-1 alpha/HIF1A DuoSet IC ELISA (Catalog Number: DYC1935-2). Briefly, 100 µL of samples or standards were added to the wells of plates and incubated for 2 h at room temperature. The plates were washed five times. One hundred microliters of the detection antibodies were added to each well and incubated for 2 h at room temperature. The plates were washed five times. One hundred microliters of streptavidin-horseradish peroxidases were added to each well and incubated at room temperature for 20 min. The plates were washed five times. One hundred microliters of substrate solutions were added to each well and incubated at room temperature for 20 min. Fifty microliters of stop solutions were added to each well. The optical density of each well was determined using a microplate reader set to 450 nm.

Li Y., Li L., Zhang W, & Gao Y. (2023). Amphiregulin/epidermal growth factor receptor/hypoxia-inducible factor-1α pathway regulates T helper 9 and T cytotoxic 9 cell response in adult patients with infectious mononucleosis. Biomolecules and Biomedicine, 23(1), 63-72.

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Publication 2023

Amphiregulin Antibodies AREG protein, human EGFR protein, human Enzyme-Linked Immunosorbent Assay HIF1A protein, human Homo sapiens Horseradish Peroxidase Mus Streptavidin Vision

Microinjection of Oocytes with Regulators

Oocytes still enclosed in the cumulus cells (CEOs) were injected with 12.5 ng/μl Il7-RL, Thumpd1-RL, or Tpx2-RL and 12.5 ng/µl of polyadenylated FL using a FemtoJet Express programmable microinjector with an Automated Upright Microscope System (Leica, DM4000B). Injected CEOs were pre-incubated for 3 h in culture medium supplemented with 2 μM milrinone, and then cultured in milrinone-free medium supplemented with 100 nM amphiregulin. After 16 h, the CEOs were denuded, collected in lysis buffer and frozen. Luciferase activities in the oocyte extracts were measured using a dual-luciferase reporter assay kit (Promega), and luminescence was detected with a SpectraMax L luminometer (Molecular Devices). Data are reported as ratios of RL and FL.

Takahashi N., Franciosi F., Daldello E.M., Luong X.G., Althoff P., Wang X, & Conti M. (2023). CPEB1-dependent disruption of the mRNA translation program in oocytes during maternal aging. Nature Communications, 14, 416.

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Publication 2023

Amphiregulin Biological Assay Buffers Cells Culture Media Cumulus Cells Freezing Luciferases Luminescence Medical Devices Microscopy Milrinone Oocytes Promega TPX2 protein, human

Quantitative RT-PCR Analysis of Inflammatory and Lung Markers

After the treatment period, treated cells or rat lung tissues were subjected to RNA isolation using RNAiso plus as described earlier (Andugulapati et al. 2020 (link)). Briefly, RNA was isolated using the TRIzol–chloroform method and total RNA was quantified using nano-drop. Isolated RNA (1 μg) was subjected to cDNA synthesis using a prime script cDNA synthesis kit as per the manufacturer’s instructions. Specified primers [IL-6, IL-1β, TNF-α, IL-8, CCL2, CCL3, CCL7, CXCL1, alveolar pulmonary stretch (amphiregulin), CC16, vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule (ICAM-1), and reference markers (GAPDH, β2M, and β-actin)] were designed using Primer-3 software and the respective sequences are shown in Table S1. RT-qPCR was carried out using SYBR green mix and the differences in mRNA expression of the specified genes were calculated as the fold change using the formula 2-^ΔΔct and data were expressed as mean ± SEM.

Jangam A., Tirunavalli S.K., Adimoolam B.M., Kasireddy B., Patnaik S.S., Erukkambattu J., Thota J.R., Andugulapati S.B, & Addlagatta A. (2023). Anti-inflammatory and antioxidant activities of Gymnema Sylvestre extract rescue acute respiratory distress syndrome in rats via modulating the NF-κB/MAPK pathway. Inflammopharmacology, 31(2), 823-844.

Publication 2023

Actins Amphiregulin Anabolism CCL2 protein, human CCL3 protein, human CCL7 protein, human Cells Chloroform CXCL1 protein, human DNA, Complementary GAPDH protein, human Gene Expression Intercellular Adhesion Molecules Interleukin-1 beta Lung Oligonucleotide Primers RNA, Messenger SYBR Green I Tissues trizol Tumor Necrosis Factor-alpha Vascular Cell Adhesion Molecule-1

Investigating Cisplatin-Induced Oxidative Stress

Cisplatin (cDDP), vitamin E (VitE) and hydralazine (Hlz) were obtained from Sigma (St. Louis, MO, USA) and 4μ8cα was purchased from Millipore (Burlington, MA, USA). MK2206, an AKT inhibitor, was purchased from Selleck (Shanghai, China). Intracellular reactive oxygen species (ROS) were detected via 2′,7′‐dichlorofluorescin diacetate (DCFDA) staining (Thermo Scientific, Waltham, MA, USA). Moreover, 4,4‐difluoro‐1,3,5,7,8‐pentamethyl‐4‐bora‐3a,4a‐diaza‐s‐indacene (BODIPY 493/503) was obtained from Thermo Scientific, and 4‐hydroxy‐trans‐2‐nonenal (4‐HNE)‐protein adducts in the indicated cells were detected through competitive enzyme‐linked immunosorbent assays (ELISAs) (Abcam, Cambridge, UK). Primary antibodies (Abs) against amphiregulin (AREG) (AB‐262‐NA) and basic fibroblast growth factor (bFGF) (AF‐233‐NA) were obtained from R&D Systems (Minneapolis, MN, USA).

Jia X., Wang G., Wu L., Pan H., Ling L., Zhang J., Wen Q., Cui J., He Z., Qi B., Zhang S., Luo L, & Zheng G. (2023). XBP1‐elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR‐22/lncRNA/KAT6B‐dependent NF‐κB signalling. Clinical and Translational Medicine, 13(1), e1166.

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Publication 2023

4,4-difluoro-1,3,5,7,8-pentamethyl-4-bora-3a,4a-diaza-s-indacene 4-hydroxy-2-nonenal Amphiregulin Antibodies Cells Cisplatin dichlorofluorescin Enzyme-Linked Immunosorbent Assay Fibroblast Growth Factor 2 Hydralazine MK 2206 Proteins Protoplasm Reactive Oxygen Species Vitamin E

Top products related to «Amphiregulin»

Amphiregulin by R&D Systems

Sourced in United States, United Kingdom

Amphiregulin is a growth factor that belongs to the epidermal growth factor (EGF) family. It is a soluble protein that can bind to and activate the EGF receptor, promoting cell proliferation and differentiation.

Duoset elisa kit by R&D Systems

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DuoSet ELISA kits are laboratory reagent kits used for the quantitative measurement of specific proteins in a variety of sample types. The kits include a matched antibody pair and other necessary reagents to perform a sandwich enzyme-linked immunosorbent assay (ELISA). The assay measures the concentration of the target analyte in the sample.

Rneasy mini kit by Qiagen

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The RNeasy Mini Kit is a laboratory equipment designed for the purification of total RNA from a variety of sample types, including animal cells, tissues, and other biological materials. The kit utilizes a silica-based membrane technology to selectively bind and isolate RNA molecules, allowing for efficient extraction and recovery of high-quality RNA.

Human amphiregulin quantikine elisa kit by R&D Systems

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The Human Amphiregulin Quantikine ELISA Kit is a quantitative sandwich enzyme immunoassay designed for the measurement of human amphiregulin levels in cell culture supernates, serum, and plasma.

Rneasy plus mini kit by Qiagen

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The RNeasy Plus Mini Kit is a product from Qiagen designed for the purification of total RNA from a variety of sample types. It utilizes a silica-membrane-based technology to effectively capture and purify RNA molecules.

Gefitinib by Selleck Chemicals

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Gefitinib is a tyrosine kinase inhibitor used in laboratory research. It functions by inhibiting the epidermal growth factor receptor (EGFR) tyrosine kinase.

Phorbol myristate acetate (pma) by Merck Group

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Diff quick by Siemens

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Diff-Quick is a set of staining solutions used for rapid differential staining of blood smears and other cytological samples. It is a quick and easy-to-use staining method that allows for the identification of different cell types, such as red blood cells, white blood cells, and platelets, in a sample. The Diff-Quick staining procedure involves three steps: fixation, staining, and rinsing. The stained samples can then be examined under a microscope for analysis.

What is Amphiregulin and what are its key functions?

Amphiregulin is a member of the epidermal growth factor (EGF) family of proteins. It plays a crucial role in cell proliferation, differentiation, and survival. Amphiregulin binds to and activates the EGF receptor, triggering intracellular signaling cascades that regulate various cellular processes. It is involved in the development and homeostasis of multiple tissues, including the skin, intestine, and mammary gland. Dysregulation of Amphiregulin has been implicated in the pathogenesis of certain cancers and inflammatory disorders.

What are some common challenges in working with Amphiregulin?

How can PubCompare.ai help optimize Amphiregulin research?

PubCompare.ai allows you to screen protocol literature more efficiently and leverage AI to pinpoint critical insights. The platform's AI-driven analysis can help researchers identify the most effective protocols related to Amphiregulin for their specific research goals. By highlighting key differences in protocol effectiveness, PubCompare.ai enables you to choose the best option for reproducibility and accuracy, ultimately enhancing the quality and progress of your Amphiregulin studies.

Are there different variations or types of Amphiregulin?

What are some specific applications of Amphiregulin research?

Amphiregulin research has applications in various fields, such as developmental biology, regenerative medicine, and cancer biology. Studying Amphiregulin can provide insights into the regulation of tissue homeostasis, wound healing, and the mechanisms underlying certain cancers and inflammatory disorders. The findings from Amphiregulin research can contribute to the development of novel therapeutic strategies and diagnostic tools.

More about "Amphiregulin"

Epidermal Growth Factor, EGF, EGFR, Cell Proliferation, Cell Differentiation, Cell Survival, Tissue Development, Homeostasis, Cancer, Inflammation, DuoSet ELISA, RNeasy Mini Kit, Human Amphiregulin Quantikine ELISA Kit, RNeasy Plus Mini Kit, Gefitinib, PMA, Diff-Quick