Analysis of variance was used to determine statistical significance except where an alternative test is specified. Statistical significance was accepted at P < 0.05.
Human Follicle Stimulating Hormone
It stimulates the growth and development of follicles in the ovary, as well as the production of estrogen in females.
In males, hFSH stimulates the Sertoli cells in the testes, which are responsible for supporting and nourishing the developing sperm cells.
Research on hFSH is important for understanding and treating various reproductive disorders, such as infertility, polycystic ovary syndrome, and hypogonadism.
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Most cited protocols related to «Human Follicle Stimulating Hormone»
Analysis of variance was used to determine statistical significance except where an alternative test is specified. Statistical significance was accepted at P < 0.05.
Ten patients were not eligible for inclusion and two patients withdrew consent prior to commencing the study protocol (Fig.
A zero-inflated Poisson regression (ZIP) was used to assess the primary endpoint, with treatment and country as fixed factors and age as a covariate. The primary endpoint was evaluated in all randomized patients (intent-to-treat [ITT] population) as well as in those who did not have any major protocol violations (according-to-protocol [ATP] population). The safety analysis included all randomized patients who received at least 1 dose of r-hFSH (Ovaleap® or Gonal-f®). A stratified post-hoc analysis of clinical and ongoing pregnancy rates by baseline and post-baseline characteristics was also performed.
Secondary endpoints, presented only for the ITT population, were assessed using descriptive statistics (eg, mean ± SD, median, and range). Stratified odds ratios and related P-values on secondary endpoints were calculated using Mantel-Haenszel tests. Since resultant P-values were regarded as supportive only, no adjustment for multiple testing was made.
Most recents protocols related to «Human Follicle Stimulating Hormone»
Example 20
Fertility—Progesterone is one of the most important hormones for pregnancy with myriad functions from ensuring implantation of the egg into a healthy uterine wall, to ensuring embryo survival and prevention of immune rejection of the developing baby. Many other hormones act in concert with progesterone, like Follicular Stimulating Hormone (FSH) and Luteinizing Hormone (LH) and can be used to assess optimal fertility windows on a monthly basis. And in fact an over dominant production of estrogen can lead to progesterone deficiency and thus difficulty getting or staying pregnant. It is important that women not only monitor FSH and LH to determine optimal fertility for getting pregnant, but ensure that sufficient levels or progesterone are being produced to ensure pregnancy and viability of the fetus. A study from the British Medical Journal, 2012, demonstrated that a single progesterone level test can help discriminate between viable and nonviable pregnancies. Among women who had an ultrasound, 73 percent had nonviable pregnancies. But among women with progesterone levels below 3 to 6 nanograms per milliliter, the probability of a nonviable pregnancy rose to more than 99 percent (Gallos L et al. British Medical J, 2012).
Perimenopause—Monitoring hormone levels during the menopausal transition may help women better understand important changes in their body and allow them to make more informed decisions about health, diet, and lifestyle. According to Hale G E (Best Pract Res Clin Obstet Gynaecol, 2009), data from endocrine studies on women throughout the menopausal transition show changes in levels of steroid hormones and gonadotropins (Progesterone, Estrodiol, LH, FSH and AMH) and follicle-stimulating hormone undergoes the first detectable change while menstrual cycles remain regular. Erratic and less predictable changes in steroid hormones follow, especially with the onset of irregular cycles. Later serum hormone studies on the inhibins and anti-Mullerian hormone established that diminishing ovarian follicle number contributes to the endocrine changes with advancing reproductive age.
Many fertility issues revolve around genetic, anatomical or other disorders that may either prevent a woman from becoming pregnant and/or staying pregnant. Some of these disorders include hormonal imbalances, diabetes, a short or insufficient cervix, and acute or chronic infections. A cascade of genes has been implicated in the occurrence of getting and staying pregnant. These genes have been studied using genotyping, gene expression, and proteomic analysis to assess a woman's ability to stay pregnant.
In some embodiments the disclosed device focuses on detecting levels of Progesterone, LH, FSH, Estrodiol, AMH, genotyping, gene expression through RNA and methylome sequencing, qPCR and proteomic analysis for fertility and menopause management from menstrual blood or cervicovaginal fluid.
We advised obese women to participate in a weight management program for 3 to 6 months before undergoing their first IVF/ICSI cycle. Women were divided into 2 groups according to the weight loss goal of 5%: weight reduction group A (≥weight loss goal of 5%) and control group A (
In all participants fasting, peripheral venous blood samples were taken from an antecubital vein between 08.00 and 10.00 a.m. Serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), TSH, and fT4 levels were measured on the same day with suprapubic pelvic ultrasonography. Samples were separated by centrifugation and stored protected from light at -80 C until analysis. Competitive electro-chemiluminescence immunoassays on the cobas® 6000 analyzer (Roche Diagnostics, Rotkreuz, Switzerland) were used to quantify serum LH, FSH, and E2. The lowest limits of detection were 0.1 mIU/mL for LH, 0.1 mIU/mL for FSH, and 18.4 pmol/L for E2. Serum TSH and fT4 levels were analyzed with Beckman Coulter DxI 800 Access® immunoassay system (Beckman Coulter, USA).
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More about "Human Follicle Stimulating Hormone"
It plays a crucial role in regulating reproductive function in both males and females.
In females, hFSH stimulates the growth and development of follicles in the ovary, as well as the production of estrogen.
In males, hFSH stimulates the Sertoli cells in the testes, which are responsible for supporting and nourishing the developing sperm cells.
Optimizing hFSH research is essential for understanding and treating various reproductive disorders, such as infertility, polycystic ovary syndrome (PCOS), and hypogonadism.
Gonal-F, TCM-199, Cetrotide, Ovidrel, Ovitrelle, and Menopur are some of the key pharmaceutical products and cell culture media used in hFSH research and reproductive medicine.
FBS (Fetal Bovine Serum) is a commonly used supplement in cell culture media, while Pregnyl is a medication containing human chorionic gonadotropin (hCG), which can be used in conjunction with hFSH to stimulate ovulation and support early pregnancy.
By utilizing the powerful tools and insights provided by PubCompare.ai, researchers can optimize their hFSH studies, enhance reproducibility, and identify the most effective protocols and products.
PubCompare.ai's AI-driven comparisons and comprehensive literature analysis can help researchers stay at the forefront of this critical field of study, ultimately leading to improved understanding and treatment of reproductive disorders.