Log In Sign up
The largest database of trusted experimental protocols
> Chemicals & Drugs > Amino Acid > Parathyroid Hormone

Parathyroid Hormone

Parathyroid Hormone: A polypeptide hormone secreted by the parathyroid glands that regulates calcium and phosphate metabolism in the body.
It plays a crucial role in maintaining proper bone structure and calcium levels in the blood.
Parathyroid hormone is essential for the homeostatic control of calcium and phosphate, and its dysregulation can lead to various metabolic disorders, such as hyperparathyroidism and hypoparathyroidism.
Researchers utilize advanced tools like PubCompare.ai to streamile their parathyroid hormone studies and identify the most effective research protocols from the literature, preprints, and patents.

Most cited protocols related to «Parathyroid Hormone»

1
Serum Biomarkers of Vitamin D Metabolism
Cited 21 times
Baseline blood samples were frozen at −80°C and stored for later analysis. 25(OH)D, serum calcium, albumin, and levels of parathyroid hormone (PTH) were measured in the Massachusetts General Hospital (MGH) clinical laboratories. 25(OH)D2 and 25(OH)D3 levels were measured by liquid chromatography–tandem mass spectrometry (LC-MS), with interassay coefficients of variation (CVs) of 9.1% for 25(OH)D2 and 8.6% for 25(OH)D3. Total 25(OH)D level was calculated as the sum of 25(OH)D2 level and 25(OH)D3 level. Intact PTH was measured by electrochemiluminescense immunoassay on the Cobas E160 automated analyzer (Roche Diagnostics, Indianapolis, IN, USA). The interassay CV for intact PTH measurement was 4.2%. Calcium and albumin levels were measured by dye-based photometric assays on an automated analyzer.
DBP was measured in duplicate by commercial enzyme-linked immunosorbent assay (ELISA; Cat. No. DVDBP0, R&D Systems, Minneapolis, MN, USA) according to the manufacturer's instructions. The assay was conducted after diluting serum samples 1:2000 in Calibrator Diluent RD6-11 (Part No. 895489, R&D Systems). The interassay CV was 8.5% at a concentration of 40 µg/mL. The assay recovered between 93% and 110% of a 100- to 200-µg/mL dose of exogenous DBP added to human serum samples containing between 25 and 200 µg/mL of endogenous DBP. The manufacturer reports no significant cross-reactivity with human albumin, vitamin D3, or α-fetoprotein.
In a subset of patients in whom adequate serum was available (n = 45), total 1,25(OH)2D3 was measured by LC-MS/MS in the Mayo Clinic Medical Laboratories (Rochester, MN, USA).
Powe C.E., Ricciardi C., Berg A.H., Erdenesanaa D., Collerone G., Ankers E., Wenger J., Karumanchi S.A., Thadhani R, & Bhan I. (2011). Vitamin D–Binding Protein Modifies the Vitamin D–Bone Mineral Density Relationship. Journal of Bone and Mineral Research, 26(7), 1609-1616.
Full text: Click here
Publication 2011
Albumins alpha-Fetoproteins Biological Assay BLOOD Calcifediol Calcium Cholecalciferol Clinical Laboratory Services Cross Reactions Diagnosis Enzyme-Linked Immunosorbent Assay Freezing Homo sapiens Immunoassay Liquid Chromatography Parathyroid Hormone Patients Photometry Serum Serum Albumin, Human Tandem Mass Spectrometry
2
Targeted Metabolomic Profiling of Plasma
Cited 15 times
LC-MSmass spectrometry (LC-MS/MS) is increasingly used in clinical settings for quantitative assay of small molecules and peptides such as vitamin D, serum bile acid and parathyroid hormone under Clinical Laboratory Improvement Amendments environments with high sensitivities and specificities34 . In this study, targeted metabolomic analysis of plasma samples was performed using the Biocrates Absolute-IDQ P180 (BIOCRATES, Life Science AG, Innsbruck, Austria). This validated targeted assay allows for simultaneous detection and quantification of metabolites in plasma samples (10 µL) in a high-throughput manner. The methods have been described in detail35 ,36 . The plasma samples were processed as per the instructions by the manufacturer and analyzed on a triple-quadrupole mass spectrometer (Xevo TQ-S, Waters Corporation, USA) operating in the MRM mode. The measurements were made in a 96-well format for a total of 148 samples, and seven calibration standards and three quality control samples were integrated in the kit. Briefly, the flow injection analysis tandem mass spectrometry (MS/MS) method was used to quantify a panel of 144 lipids simultaneously by multiple reaction monitoring. The other metabolites are resolved on the UPLC and quantified using scheduled MRMs. The kit facilitates absolute quantitation of 21 amino acids, hexose, carnitine, 39 acylcarnitines, 15 sphingomyelins, 90 phosphatidylcholines and 19 biogenic amines. Data analysis was performed using the MetIQ software (Biocrates), and the statistical analyses included the nonparametric Kruskal-Wallis test with follow-up Mann-Whitney U-tests for pairwise comparisons using the STAT pack module v3 (Biocrates). Significance was adjusted for multiple comparisons using Bonferroni’s method (P < 0.025). The abundance is calculated from area under the curve by normalizing to the respective isotope labeled internal standard. The concentration is expressed as nmol/L. Human EDTA plasma samples spiked with standard metabolites were used as quality control samples to assess reproducibility of the assay. The mean of the coefficient of variation (CV) for the 180 metabolites was 0.08, and 95% of the metabolites had a CV of <0.15.
Mapstone M., Cheema A.K., Fiandaca M.S., Zhong X., Mhyre T.R., MacArthur L.H., Hall W.J., Fisher S.G., Peterson D.R., Haley J.M., Nazar M.D., Rich S.A., Berlau D.J., Peltz C.B., Tan M.T., Kawas C.H, & Federoff H.J. (2014). Plasma phospholipids identify antecedent memory impairment in older adults. Nature medicine, 20(4), 415-418.
Publication 2014
acylcarnitine Amino Acids Bile Acids Biogenic Amines Biological Assay Carnitine Clinical Laboratory Services Edetic Acid Ergocalciferol Flow Injection Analysis Hexoses Homo sapiens Hypersensitivity Isotopes Lipid A Parathyroid Hormone Peptides Phosphatidylcholines Plasma Serum Spectrometry Sphingomyelins Tandem Mass Spectrometry
3
pH-Sensitive Fluorescent Protein Assays
Cited 12 times
Excitation scans were generated using a Deltascan dual-wavelength fluorimeter from Photon Technology International (PTI; Birmingham, NJ) and the associated Felix software. Standard HEK293 cells were plated on 10 cm dishes and transiently transfected with 5 µg each of the soluble forms of GFP2, pHluorin and pHluorin2 using Fugene HD (Roche, Indianapolis, IN). Forty-eight hours post transfection, cells were washed with Hank’s Balanced Salt solution lacking calcium and magnesium ions and containing 2 mM EDTA. Cells were lifted from the plates using the same solution after a 10 minute incubation at 37°C and placed in a quartz cuvette with a stir bar. Excitation scans were performed between wavelengths 370 nm to 490 nm with the emission set at 510 nm. For the pH clamp experiments, cells were resuspended in a buffer containing 140 mM potassium chloride, 10 mM sodium phosphate with molar ratios of mono- and dibasic forms appropriate for the given pH and 30 mM nigericin (EMD Biosciences, Gibbstown, NJ). For the florescence plate reader studies, black, 96-well plates (Perkin-Elmer, Boston, MA) were loaded with 25,000 cells per well from the transfections described above and analyzed with dual excitation at 405 nm/8 nm and 485 nm/25 nm with a 535 nm/25 nm emission filter in an EnVision plate reader (Perkin-Elmer, Boston, MA). The narrow bandwidth of the 405 nm filter of 8 nm reduces the relative florescence compared to the larger bandwidth of the 485 nm filter. Despite this effect, the 405/485 nm ratios are still responsive to changes in intracellular pH.
For the hPTH1R endocytosis studies, HEK293 cells were sparsely plated into culture slides and transiently transfected with 100 ng of the hPTH1R-pHluorin2 construct using Fugene HD. Forty-eight hours post-transfection, cells were treated with either vehicle (acetic acid) or 100 nM parathyroid hormone containing amino acids 1 to 34 for 20 minutes. Cells were fixed with 3.7% paraformaldehyde and analyzed by confocal microscopy using a Radiance 2100 confocal microscope and the associated LaserSharp 2000 software (Bio-Rad Laboratories, Inc., Hercules, CA).
, & Mahon M.J. (2011). pHluorin2: an enhanced, ratiometric, pH-sensitive green florescent protein. Advances in bioscience and biotechnology (Print), 2(3), 132-137.
Publication 2011
Acetic Acid Amino Acids Buffers Calcium Cells Edetic Acid Endocytosis FuGene HEK293 Cells Hyperostosis, Diffuse Idiopathic Skeletal Ions Magnesium Microscopy, Confocal Molar Nigericin paraform Parathyroid Hormone PHluorin Potassium Chloride Protoplasm Quartz Radionuclide Imaging Sodium Chloride sodium phosphate Transfection
4
Measuring Vitamin D and Related Biomarkers
Cited 11 times
Blood samples drawn at the examination were stored at −80°C. Levels of total 25-hydroxyvitamin D (D2 and D3) were measured with the use of tandem mass spectrometry (interassay coefficient of variation, 8.6%). Levels of vitamin D– binding protein were measured by means of a commercial enzyme-linked immunosorbent assay (R&D Systems) that uses two monoclonal antibodies in a sandwich format (interassay coefficient of variation, 7.2%). Levels of intact parathyroid hormone were measured with the use of the Elecsys Parathyroid Hormone Immunoassay (Modular Analytics E170, Roche Diagnostics) (interassay coefficient of variation, 2.5%). Calcium levels were corrected for the participant's albumin level as follows: corrected calcium = (measured calcium in mg per deciliter) + [0.8 × (4.0 − serum albumin in g per deciliter)].
Powe C.E., Evans M.K., Wenger J., Zonderman A.B., Berg A.H., Nalls M., Tamez H., Zhang D., Bhan I., Karumanchi S.A., Powe N.R, & Thadhani R. (2013). Vitamin D–Binding Protein and Vitamin D Status of Black Americans and White Americans. The New England journal of medicine, 369(21), 1991-2000.
Publication 2013
Albumins BLOOD Calcifediol Calcium Diagnosis Enzyme-Linked Immunosorbent Assay Immunoassay Monoclonal Antibodies Parathyroid Hormone Serum Albumin Tandem Mass Spectrometry Vitamin D-Binding Protein
5
Nationwide Vitamin D Status in Germany
Cited 7 times
A population based study throughout a whole country is very complicated and expensive. Therefore we decided to involve GPs since their patients can be considered as approximately representative for the whole population. In total, 264 GP practices were contacted by the sponsor’s sales forces (Rottapharm|Madaus, Madaus GmbH), and recruited participants randomly throughout Germany. They received study sampling kits consisting of study information including questionnaires, blood sampling material and transportation material ready to be sent.
A central laboratory analyzed 25(OH)D, parathyroid hormone, calcium, alkaline phosphatase, creatinine, gamma-GT, phosphate. Subjects had to fill in a simple questionnaire giving their age, sex, living situation, previous falls or fractures within the last 12 mo, skin type, vitamin D-supplementation or stay in a lower-latitude country during the last 6 weeks before blood sampling, acute or chronic diseases, medications of the last 6 weeks. To ensure well balanced age groups and sex distribution, each center had to recruit one patient to each of the following predefined sex/age categories: male/female and age categories 20–39, 40–49, 50–59, 60–69, 70–79 and ≥ 80 y.
The trial was performed between February 26 and May 25, 2007. Forty-eight percent of the blood samples were collected between February 26, 2007 and March 24, 2007.
Blood sampling was geographically distributed throughout Germany. The allocation to the different regions, identified by postal code, and the respective number of subjects per region is shown in Table 3.
During routine blood sampling from otherwise unselected patients regardless of the actual reason for consultation they were asked to give blood (approximately 10 ml) for the study. After sampling, blood was processed according to the instructions of the central laboratory (Spranger Laboratories) and sent to the laboratory the same day. Table 1 shows the laboratory methods used. The laboratory was certified by an external quality assessment scheme for the relevant testing including 25(OH)D.
Finally out of the 264 participating physicians’ practices 176 sent back filled in questionnaires and laboratory data. Laboratory data were available for a total of 1,409 subjects and questionnaires from 1,352 subjects of whom 616 were male, 730 female and 7 subjects without gender information. After compiling laboratory data and filled in questionnaires complete data sets could be evaluated from 1,340 subjects. This final population consisted of 613 men and 727 women, mean age 57.6 y (Min. 19.0, Max. 99.0, SD 18.00, median 59.0). Table 2 shows mean age and number of subjects and their distribution per decades. Out of 1,290 subjects giving information whether they were institutionalized or not, 7 were institutionalized (1 man and 6 women).
Ringe J.D, & Kipshoven C. (2012). Vitamin D-insufficiency: An estimate of the situation in Germany. Dermato-endocrinology, 4(1), 72-80.
Publication 2012
Age Groups Alkaline Phosphatase BLOOD Calcium, Dietary Creatinine Disease, Chronic Females Fracture, Bone gamma-Glutamyl Transpeptidase Gender Parathyroid Hormone Patients Pharmaceutical Preparations Phosphates Physicians Skin Vitamin D Woman

Most recents protocols related to «Parathyroid Hormone»

1
Calvarial Bone Resorption Assay
Calvariae from 5-d-old wild-type or DKO mice were isolated aseptically, cleaned, and cultured for 16 h at 37°C in 0.5 ml of BGJb medium (Life Technologies) containing 1 mg/ml BSA (fraction V; Sigma-Aldrich; Moxon et al., 2015 (link)). Half calvariae were transferred to fresh medium with 0.1 μM parathyroid hormone (H-4835.0005; Bachem) in the presence or absence of an anti–galectin-3 monoclonal antibody (sc-32790L; Santa Cruz) or an anti-Lrp1 monoclonal antibody (MA1-27198; Thermo Fisher Scientific), and cultured for an additional 5 d. Culture supernatant was collected for bone resorption marker CTX-I level detection using RatLaps CTX-I EIA kit (AC-06F1; Immunodiagnostic Systems). The half calvariae were either fixed for immunostaining with an anti-TRAP polyclonal antibody (sc-30833; Santa Cruz), an anti–galectin-3 monoclonal antibody (#125401; Biolegend; clone M3/38), or an anti-V-type proton pump-3 (Vpp3) polyclonal antibody (ab200839; Abcam) as describe above or snap-frozen for TRAP activity assay.
Zhu L., Tang Y., Li X.Y., Kerk S.A., Lyssiotis C.A., Sun X., Wang Z., Cho J.S., Ma J, & Weiss S.J. (2023). Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption. The Journal of Cell Biology, 222(4), e202206121.
Publication 2023
Antibodies, Anti-Idiotypic Biological Assay Bone Resorption Calvaria Clone Cells Freezing Galectin 3 Immunodiagnosis Immunoglobulins Monoclonal Antibodies Mus Parathyroid Hormone Physiotens Protons
2
Vitamin D Status Assessment Protocol
Blood samples from participants (10 mL) were withdrawn by venipuncture in completely aseptic conditions through a puncture of an antecubital vein. Samples were left in a plain tube for 30–60 minutes to allow for spontaneous clotting at room temperature. They were then centrifuged at 3000 rpm for 10 minutes to achieve serum separation. The obtained sera were frozen immediately at -80 °C for future analysis, and the serum calcium, phosphate, and alkaline phosphatase were measured using standard analytical techniques (BECKMAN COULTER). The serum VD was measured by chemiluminescent microparticle immunoassay (CMIA; ARCHITECT, Abbott, USA). The general consensus on VD deficiency, as suggested by Endocrine Society Guidelines, is that deficiency exists when serum 25(OH)D levels are ≤20 ng/mL, insufficiency when they are 21 to 29 ng/mL, and sufficiency when they are 30–100 ng/mL.10 (link) Serum parathyroid hormone (PTH) was estimated using a chemiluminescent immunoassay technique (BECKMAN COULTER, ACCESS immunoassay systems). Lab technicians were blinded to the study outcomes.
Al Nozha O.M., El Tarhouny S., Taha I., Sultan I., Abdu Allah A.M., Hammoda M.A., Elmehallawy G., Elmehallawy Y., Eysawi E.A, & Desouky M.K. (2023). Association Between Vitamin D Level and Z-Score Changes of Bone Density in College-Age Saudi Girls: A Cross-Sectional Study. International Journal of General Medicine, 16, 865-874.
Publication 2023
Alkaline Phosphatase Asepsis BLOOD Calcium, Dietary Cell-Derived Microparticles Freezing Immunoassay Parathyroid Hormone Phosphates Serum System, Endocrine Venipuncture
3
Metabolic Markers in Dialysis Patients
Blood samples were collected after overnight fasting while continuing PD treatment, and relevant indicators were determined using standardized equipment and procedures, including serum albumin, AST, ALT, triglyceride, total cholesterol, low-density lipoprotein, high-density lipoprotein, phosphorus, calcium, sodium, potassium, parathyroid hormone, urea nitrogen, creatinine, uric acid, glycosylated hemoglobin, fasting blood glucose, high-sensitivity C-reactive protein (hsCRP), and hemoglobin. To rule out cognitive decline secondary to nutritional or endocrine changes, thyroid hormone levels in the blood were measured by standard laboratory methods. Dialysis adequacy was defined based on total Kt/V and creatinine clearance (Ccr).
Zhu X., Jing R., Li X., Zhang W., Tang Y, & Liu T. (2023). Left ventricular hypertrophy, carotid atherosclerosis, and cognitive impairment in peritoneal dialysis patients. BMC Cardiovascular Disorders, 23, 127.
Full text: Click here
Publication 2023
BLOOD Blood Glucose Calcium, Dietary Cholesterol C Reactive Protein Creatinine Dialysis Disorders, Cognitive Hemoglobin Hemoglobin, Glycosylated High Density Lipoproteins Low-Density Lipoproteins Nitrogen Parathyroid Hormone Phosphorus Potassium Serum Albumin Sodium System, Endocrine Thyroid Hormones Triglycerides Urea Uric Acid
4
Quadriceps Tendon Rupture in Uremia Patients
This retrospective study was approved by our Institutional review board and patients were recruited under informed consent. Between Jan 2014 and Dec 2018, ten uremia patients with SHPT suffered from complete QRTs at our Institution. Of these patients, two patients were lost at follow-up and so eight patients were included in this study. None of the patients had a history of steroid and fluoroquinolone administration.
Table 1 summarizes the patient characteristics of those included in this study. The median age of the patients was 38 ± 9.93 years. Males were more often affected than females (7:1). The average BMI was 21.95 ± 2.11 kg/m2, and the average period of hemodialysis was 5.38 ± 2.07 years. The mean time from the injury to QT repair was 14.13 ± 14.35 weeks. Six patients presented with simultaneous bilateral QTRs and one patient showed a unilateral QTR. One patient presented a QT and contralateral patellar tendon rupture but had a four-month interval between the lesions. The mechanism of injury in both bilateral and unilateral QTR was most commonly a slip or fall on a flat surface (four patients). This was followed by falls on stairs (two patients) and injuries resulting from falling from a bicycle (one patient). Also one patient was injured by sudden exertion whilst trying to stand up from squatting (Table 1).
Laboratory findings showed increased intact parathyroid hormone (iPTH), serum phosphorus, and alkaline phosphatase (ALP) in all patients (Table 2). x-ray imaging revealed severe and generalized osteoporosis and showed patella baja. Calcifications were observed in the ruptured ends of the tendon in all patients. MRI revealed the quadricep tendons presented an avulsion-like rupture at their osteotendinous junction.
Wu S., Wang H., Zhu Y, & Fu W. (2023). A retrospective case series of the treatment of spontaneous quadriceps tendon rupture in patients with uremia and secondary hyperparathyroidism. Frontiers in Surgery, 10, 961188.
Full text: Click here
Publication 2023
Alkaline Phosphatase Ethics Committees, Research Females Fluoroquinolones Fracture, Avulsion Hemodialysis Injuries Ligamentum Patellae Males Osteoporosis Parathyroid Hormone Patella Patients Phosphorus Physiologic Calcification Radiography Serum Steroids Tendons Uremia
5
CKD Patients: Creatinine vs. Cystatin C
This was a single-center retrospective cross-sectional study. We used outpatient clinic data from the Clinical Data Warehouse system of Konyang University Hospital between January 2019 and February 2022. We collected the data of adult patients (≥ 19 years old) diagnosed with CKD grade 3 or 4 as defined by the Kidney Disease: Improving Global Outcomes guideline (eGFRCr categories of grade 3: 30–59 ml/min/1.73 m2, grade 4: 15–29 ml/min/1.73 m2)34 . Serum Cr, CysC, inorganic phosphorus, calcium, and PTH levels were tested on the same day (n = 835).
We excluded patients taking phosphate-binding agents (sevelamer, lanthanum, calcium-based phosphate binder) or PTH-lowering agents (calcitriol, cinacalcet) (n = 56), those with a history of cancer (n = 9), and those with a difference between eGFRCr and eGFRCysC > 15 ml/min/1.73 m2 (n = 131). Therefore, 639 patients were enrolled in this study and divided into low- and high-difference groups based on the median value of |eGFRCr-eGFRCysC|: < 6.353 ml/min/1.73 m2 and ≥ 6.353 ml/min/1.73 m2, respectively (Fig. 5).

Study design. Of the 835 patients with CKD grades 3 and 4 based on the eGFRCr, 196 were excluded according to the exclusion criteria, and 639 were finally included. Patients were divided into two groups based on a median |eGFRCr-eGFRCysC| of 6.353 ml/min/1.73 m2. CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; eGFRCr, eGFR based on creatinine; eGFRCysC, eGFR based on cystatin C; PTH, parathyroid hormone.

This study was performed in accordance with the Declaration of Helsinki, and was approved by the Institutional Review Board of Konyang University Hospital (KYUH 2022-10-003). The need to obtain informed patient consent was waived by the Institutional Review Board of Konyang University Hospital (KYUH 2022-10-003) because the patient data were extracted in an anonymized form.
Min B., Yun S.R., Yoon S.H., Kim J.D., Hwang W.J., Hwang W.M, & Park Y. (2023). Comparison of the association intensity of creatinine and cystatin C with hyperphosphatemia and hyperparathyroidism in patients with chronic kidney disease. Scientific Reports, 13, 3855.
Full text: Click here
Publication 2023
Adult Calcitriol Calcium calcium phosphate Chronic Kidney Diseases Cinacalcet Creatinine EGFR protein, human Ethics Committees, Research Glomerular Filtration Rate Kidney Diseases Lanthanum Malignant Neoplasms Parathyroid Hormone Patients Phosphates Phosphorus Post-gamma-Globulin Serum Sevelamer

Top products related to «Parathyroid Hormone»

1
Advia 1800 by Siemens
Sourced in Germany, United States, United Kingdom, Japan, Denmark
The ADVIA 1800 is a clinical chemistry analyzer designed for use in medical laboratories. It is capable of performing a wide range of common clinical chemistry tests on patient samples. The ADVIA 1800 automates the analysis process, providing efficient and accurate results to support patient diagnosis and treatment.
2
Cobas e601 by Roche
Sourced in Germany, Switzerland, United States, China, Sweden, United Kingdom, Japan, Canada
The Cobas e601 is an automated immunochemistry analyzer used for in vitro diagnostic testing. It is designed to perform a wide range of immunoassay tests, including those for hormones, tumor markers, and infectious diseases. The Cobas e601 utilizes electrochemiluminescence technology to provide accurate and reliable results.
3
Cobas integra 800 by Roche
Sourced in Switzerland, Germany, United States, Japan
The Cobas Integra 800 is a fully automated, high-throughput clinical chemistry analyzer designed for use in medical laboratories. It is capable of performing a wide range of clinical chemistry tests on a variety of sample types. The Cobas Integra 800 utilizes advanced technology to provide accurate and reliable results, with the ability to handle a high volume of samples efficiently.
4
Cobas e411 by Roche
Sourced in Germany, Switzerland, United States, Japan, United Kingdom, Denmark, France, Poland
The Cobas e411 is a compact and fully automated immunoassay analyzer designed for clinical laboratory settings. It is capable of performing a wide range of immunoassay tests, including those for hormones, therapeutic drug monitoring, and infectious disease markers. The Cobas e411 is known for its reliability, ease of use, and efficient throughput.
5
Immulite 2000 by Siemens
Sourced in Germany, United States, United Kingdom, Italy, Spain, Japan
The Immulite 2000 is an automated immunoassay analyzer designed for in vitro diagnostic testing. It is capable of performing a variety of immunoassay tests, including those for hormones, proteins, and other analytes. The system utilizes chemiluminescent technology for detection and provides automated sample handling, reagent management, and result reporting.
6
Electrochemiluminescence system by Roche
Sourced in Germany, Switzerland
The Roche electrochemiluminescence system is a laboratory instrument designed for sensitive and accurate detection and quantification of various analytes in biological samples. The system utilizes electrochemical principles to generate luminescent signals, which are then measured and interpreted to provide analytical results.
7
Cobas e411 analyzer by Roche
Sourced in Germany, Switzerland, United States, Japan, France
The Cobas e411 analyzer is a fully automated, random-access immunoassay analyzer designed for clinical diagnostics. It is capable of performing a variety of immunoassay tests to aid in the diagnosis and monitoring of various medical conditions.
8
Cobas 8000 by Roche
Sourced in Switzerland, Germany, United States, Japan, France, Italy, China, United Kingdom, Sweden
The Cobas 8000 is a modular, automated in-vitro diagnostic system designed for high-throughput clinical chemistry and immunochemistry testing. It is used to perform a wide range of laboratory tests, including those for chemistry, immunoassay, and electrolyte analysis. The Cobas 8000 is capable of processing a large volume of samples efficiently and accurately.
9
Elecsys 2010 by Roche
Sourced in Germany, Switzerland, United States, United Kingdom, France, Norway, Japan
The Elecsys 2010 is an automated immunoassay analyzer used for the in vitro determination of various analytes in biological samples. It is designed for high-throughput testing and offers precise and reliable results.
10
Advia centaur by Siemens
Sourced in Germany, United States, United Kingdom, Spain, Ireland, Australia, Italy, Austria
The ADVIA Centaur is a fully automated, random-access immunoassay analyzer designed to perform a wide range of immunoassay tests. It is capable of processing multiple sample types, including serum, plasma, and urine. The instrument uses chemiluminescent technology to detect and quantify analytes in the samples.

More about "Parathyroid Hormone"

Parathyroid hormone (PTH) is a crucial polypeptide hormone secreted by the parathyroid glands.
It plays a vital role in regulating calcium and phosphate metabolism in the body, maintaining proper bone structure and calcium levels in the bloodstream.
PTH is essential for the homeostatic control of these crucial minerals, and its dysregulation can lead to various metabolic disorders, such as hyperparathyroidism and hypoparathyroidism.
Researchers often utilize advanced tools like PubCompare.ai to streamline their studies on parathyroid hormone.
This AI-driven platform allows them to identify the most effective research protocols from the literature, preprints, and patents, optimizing their investigations.
The ADVIA 1800, Cobas e601, Cobas Integra 800, Cobas e411, Immulite 2000, Roche electrochemiluminescence system, Cobas e411 analyzer, Cobas 8000, and Elecsys 2010 are some of the advanced analyzers and systems used in parathyroid hormone testing and research.
By leveraging the insights gained from the MeSH term description, researchers can better understand the critical role of PTH in maintaining calcium and phosphate homeostasis.
This knowledge, combined with the capabilities of tools like PubCompare.ai, can help streamline the research process and identify the most effective protocols for studying parathyroid hormone and its related metabolic conditions.
With the right tools and understanding, researchers can advance the field of parathyroid hormone studies and contribute to the development of improved diagnostic and treatment methods.