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Linolenic Acid

Linolenic Acid: A polyunsaturated fatty acid found in various plant oils, such as flaxseed, walnut, and canola oil.
It is an essential omega-3 fatty acid with important roles in human health, including anti-inflammatory effects and potential benefits for cardiovascular and neurological functions.
Researchers can optimize their Linolenic Acid studies using PubCompare.ai, an AI-driven platform that enhances reproducibility and acuracy by helping locate optimal protocols from literature, preprints, and patents, while leveraging smart comparisons to identify the best products and approaches.
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Most cited protocols related to «Linolenic Acid»

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Publication 2012
2-Mercaptoethanol Adult Germline Stem Cells Cells DyeCycle Violet Fibroblast Growth Factor 2 Formaldehyde Glial Cell Line-Derived Neurotrophic Factor Glutamine Haploid Cell HEPES Homo sapiens Human Embryonic Stem Cells Human Induced Pluripotent Stem Cells Insulin Linoleic Acid Linolenic Acid Lysine Mus NRG1 protein, human Oleic Acid Palmitic Acid palmitoleic acid Parent Penicillins Poly A Putrescine Selenite, Sodium Serum Albumin, Bovine Stains stearic acid Streptomycin Transferrin
Three segregating populations were used for mapping. CDC Bethune/Macbeth (BM) is comprised of 243 F6-derived recombinant inbred lines (RILs). The two parents are current varieties termed ‘conventional’ oilseed types because they contain 55–57 % linolenic acid, a “standard” amount for oilseed flax varieties. E1747/Viking (EV) received from S. Knapp (University of Georgia, USA) consists of 90 F6-derived RILs generated from a cross between the low linolenic acid line E1747 and the European fibre flax variety Viking. SP2047/UGG5-5 (SU) is an F1-derived doubled haploid (DH) population of 78 individuals. SP2047 is a solin breeding line characterized by its 2–4 % linolenic acid content and yellow seeds while UGG5-5 is a “high-lin” line with 65–70 % linolenic acid (Banik et al. 2011 (link); Cloutier et al. 2011 (link)).
Genomic DNA was extracted from lyophilized leaf tissue (~100 mg fresh) of individual seedlings of all the segregating and parental lines of the three mapping populations using the DNeasy 96 plant kit according to manufacturer’s instructions (Qiagen Inc, Toronto, ON, Canada). The genomic DNA was quantified by fluorometer and re-suspended to a final concentration of 6 ng/μl. Amplification of template DNA with SSR primers was performed in 384–well plates in a final volume of 10 μl. The amplification products were resolved on an ABI 3130xl Genetic analyzer (Applied Biosystems, Foster City, CA, USA) and scored for segregation of parental alleles at each SSR locus. A total of five SNPs and seven genes (fad2A, fad2B, fad3A, fad3B, dgatA, dgatB and ysc1) were also positioned on the maps (Cloutier et al. 2011 (link)). Protocols and primer information for SSR markers Lu4 to Lu1193, Lu2097 to Lu2300 and Lu2331 to Lu3291 were previously described (Cloutier et al. 2009 (link), 2011 (link), 2012 (link)). In addition, SSR markers Lu2001 to Lu2096 were from previously published reports (Roose-Amsaleg et al. 2006 (link); Deng et al. 2010 (link), 2011 ) while Lu2301 to Lu2330 were designed from scaffold 505 of the flax WGS sequence assembly (http://www.phytozome.net), as previously described (Cloutier et al. 2009 (link), 2012 (link)). References for individual markers of the consensus map are listed (Supplementary Table S1).
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Publication 2012
Alleles Europeans Fibrosis Flax Genes Genome Linolenic Acid Microtubule-Associated Proteins Oligonucleotide Primers Parent Plant Embryos Plant Leaves Plants Population Group Seedlings Single Nucleotide Polymorphism Tissues
5-LOX inhibition was evaluated by following the linoleic acid oxidation at 234 nm, according to a previously reported procedure [14 (link)]. Equal volumes of extract solution (20 µL) and 5-LOX (EC 1.13.11.12) from Glycine max (100 U/mL) were pre-incubated with 200 µL of phosphate buffer (0.1 M, pH 9), at room temperature for 5 min, on a 96 well-plate. The reaction was started by the addition of 20 µL of linolenic acid (4.18 mM in ethanol) and followed for 3 min at 234 nm (Multiskan ASCENT, Massachusetts, MA, USA). Results correspond to the mean ± SEM of three independent assays, each performed in triplicate. Quercetin was used as positive control.
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Publication 2019
Biological Assay Buffers Ethanol Linoleic Acid Linolenic Acid Phosphates Psychological Inhibition Quercetin Soybeans
Dietary n3 and n6 fatty acids intakes were obtained from two 24 h dietary recall interviews. The two interviews were collected in-person in the mobile examination center (MEC) and by telephone 3 to 10 days later, respectively. Because linolenic acid includes primarily “alpha-linolenic acid” (n3) and lesser amounts of “gamma-linolenic acid” (n6) [41 (link)] and there was not a detailed classification of linolenic acid in NHANES, we categorized linolenic acid into n3 fatty acid. Thus, in our analyses, n3 fatty acid contained linolenic acid (18:3), stearidonic acid (18:4), eicosatetraenoic acid (20:5), clupanodonic acid (22:5), and docosahexaenoic acid (22:6), and n6 fatty acid contained linoleic acid (18:2) and arachidonic acid (20:4). The average daily dietary n3, n6 fatty acids were calculated according to the U.S. Department of Agriculture’s Dietary Research Food and Nutrition Database for Dietary Studies [42 ] and were adjusted to the body weight. Dietary n3, n6 fatty acids intake and n6:n3 ratio were divided into tertiles.
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Publication 2019
(all-Z)-7, 10, 13, 16, 19-docosapentaenoic acid Acids, Omega-6 Fatty alpha-Linolenic Acid Arachidonic Acid Body Weight Diet Docosahexaenoic Acids Eicosatetraenoic Acids Fatty Acids Food gamma Linolenic Acid Linoleic Acid Linolenic Acid Mental Recall Omega-3 Fatty Acids stearidonic acid
Linear programming models were developed to design diets with reduced GHGE and subjected to a set of nutritional constraints, while remaining as close as possible to the mean diet of the French adult population. The impact of the GHGE constraint on food choices, nutritional quality and cultural acceptability was evaluated by incrementally decreasing diet-related GHGE. Three levels of nutritional exigencies were defined by increasingly stringent nutritional constraints. The cultural acceptability dimension was considered through the objective function by minimizing departure from the mean observed diet. In addition, acceptability constraints on food quantities and energy were used in all models to ensure that the modelled diets remained within the range of diets actually consumed by the general French adult population. All linear programming models were run using the statistical software package SAS version 9·4. The characteristics of the linear programming models (objective function and constraints) are summarized in Table 1.

Constraints in the FREE, MACRO and ADEQ scenarios

WomenMenFREEMACROADEQReference
Nutritional constraints
Proteins (% of total energy)10–20appliedapplied(33)
Carbohydrates (% of total energy)50–75appliedapplied(34)
Fats (% of total energy)20–35appliedapplied(35)
Linolenic acid (% of total energy)>0·5applied(35)
Linoleic acid (% of total energy)2·5–9·0applied(35)
EPA+DHA (g/d)>0·25applied(35)
PUFA (% of total energy)6–11applied(35)
SFA (% of total energy)<10applied(7)
Cholesterol (mg/d)<300applied(7)
Free sugars (% of total energy)<10applied(7)
Na (mg/d)1500–23651500–2759applied(37)
Fibre (g/d)>30>30applied(36)
Ca (mg/d)≥900≥900applied(36)
Cu (mg/d)≥1·5≥2applied(36)
Fe (mg/d)≥16≥9applied(36)
Iodine (mg/d)≥150≥150applied(36)
Mg (mg/d)≥360≥420applied(36)
P (mg/d)≥750≥750applied(36)
K (mg/d)≥3100≥3100applied(36)
Se (µg/d)≥50≥60applied(36)
Vitamin A (µg/d)600–1600800–1800applied(36)
Thiamin (mg/d)≥1·1≥1·3applied(7)
Riboflavin (mg/d)≥1·5≥1·6applied(7)
Niacin (mg/d)≥11≥14applied(7)
Vitamin B12 (µg/d)≥2·4≥2·4applied(7)
Pantothenic acid (mg/d)≥5≥5applied(7)
Vitamin B6 (mg/d)≥1·5≥1·8applied(7)
Folic acid (µg/d)≥300≥330applied(7)
Vitamin C (mg/d)≥110≥110applied(7)
Vitamin D (µg/d)≥5≥5applied(7)
Vitamin E (mg/d)≥12≥12applied(7)
Zn (mg/d)≥10≥12applied(7)
Total energy (kcal/d)Equal to the total energy of the mean observed diet*appliedappliedapplied
Cultural acceptability constraints
Total weight80–120 % of total weight of the mean observed dietappliedappliedapplied
Foods, food groups and subgroups<90th percentile, calculated on the mean observed diet,appliedappliedapplied
Environmental constraints
Total dietary GHGEIncremental reduction (10 %) from level in the observed dietappliedappliedapplied

FREE; no nutritional constraints; MACRO, constraints on macronutrients only; ADEQ, constraints on all nutrients; GHGE, greenhouse gas emissions.

8109 kJ/d (1938 kcal/d) for women, 10 891 kJ/d (2603 kcal/d) for men.

Calculated for men and women separately.

For foods, non-consumers excluded; for food subgroups and groups, non-consumers included.

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Publication 2016
Adult Ascorbic Acid Carbohydrates Cholesterol Cobalamins Diet Ergocalciferol Fats Fibrosis Folic Acid Food Greenhouse Gases Iodine Linoleic Acid Linolenic Acid Macronutrient Niacin Nutrients Pantothenic Acid Polyunsaturated Fatty Acids Proteins Riboflavin Sugars Thiamine Vitamin A Vitamin B6 Vitamin E Woman

Most recents protocols related to «Linolenic Acid»

Example 22

Permethrin and linolenic acid were tested for efficacy against 4- to 6-day old adult Aedes aegypti. For the following concentrations 3% linolenic acid, 0.0004 μg/mosquito of permethrin, and 0.0004 μg/mosquito of permethrin with 3% linolenic acid, at 1 hour we obtained 7%, 93%, and 77% knockdown respectively. At 24 hours we obtained 60%, 70%, and 63% mortality respectively. The CO2 control had 0% knockdown at 1 hour, and 0% mortality at 24 hours. The acetone standard had 3% knockdown at 1 hour, and 7% mortality at 24 hours. Results are shown in Table 13.

TABLE 13
Efficacy of linolenic acid, permethrin, and a combination of both
against adult, virgin, female Aedes aegypti mosquitoes.
% MORTALITY
ACTIVE INGREDIENTCONCENTRATIONAFTER 24 HRS
LINOLENIC ACID3%60
PERMETHRIN0.0004 μg70
OBS.*CALC.**
LINOLENIC ACID + 3% + 0.0004 μg6388
PERMETHRIN
*Obs. = observed efficacy
**Calc. = efficacy calculated using Colby (1967) formula
Since the calculated insecticidal kill rate exceeds the observed value, then the action of the combination is antagonistic.

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Patent 2024
Acetone Adult Aedes antagonists Culicidae Females Insecticides Linolenic Acid Permethrin

Example 6

Linolenic acid at concentrations of 1%, 5%, 10%, and 20% was tested for efficacy against 4- to 6-day old adult Aedes aegypti. At 1 hour we obtained 0%, 27%, 40%, and 93% knockdown, respectively. At 24 hours we obtained 3%, 33%, 83%, and 93% mortality, respectively. The CO2 control had 0% knockdown at 1 hour, and 7% mortality at 24 hours. The acetone standard had 0% knockdown at 1 hour, and 0% mortality at 24 hours. These data suggest that relatively high rates of linolenic acid exposure by contact, leads to mosquito mortality.

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Patent 2024
Acetone Adult Aedes Culicidae Insecticides Linolenic Acid

Example 33

We tested etofenprox+linolenic acid for efficacy against 3- to 5-day old adult Aedes aegypti. For the following concentrations 3% linolenic acid, 0.002 μg/mosquito of etofenprox, and 0.002 μg/mosquito of etofenprox with 3% linolenic acid, at 1 hour we obtained 0%, 83%, and 0% knockdown respectively. At 24 hours we obtained 3%, 53%, and 7% mean mortality respectively. The CO2 control and acetone standard both had 0% knockdown at 1 hour, and 0% mean mortality at 24 hours. Results are shown in Table 23.

TABLE 23
Efficacy of linolenic acid, etofenprox, and a combination of
both against adult, virgin, female Aedes aegypti mosquitoes.
CONCEN- % MORTALITY
ACTIVE INGREDIENT TRATION AFTER 24 HRS
LINOLENIC ACID 3%  3
ETOFENPROX 0.002 μg 53
OBS.* CALC.**
LINOLENIC ACID + 3% + 0.002 μg 754.41
ETOFENPROX
*Obs. = observed efficacy
**Calc. = efficacy calculated using Colby (1967) formula
Since the calculated insecticidal kill rate exceeds the observed value, then the action of the combination is antagonistic.

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Patent 2024
Acetone Adult Aedes antagonists Culicidae ethofenprox Females Insecticides Linolenic Acid

Example 27

We tested pyrethrin+linolenic acid for efficacy against 4- to 6-day old adult Aedes aegypti. For the following concentrations 3% linolenic acid, 0.002 μg/mosquito of pyrethrin, and 0.002 μg/mosquito of pyrethrin with 3% linolenic acid, at 1 hour we obtained 17%, 90%, and 50% knockdown respectively. At 24 hours we obtained 7%, 57%, and 37% mean mortality respectively. The CO2 control and acetone standard both had 0% knockdown at 1 hour, and 0% mean mortality at 24 hours. Results are shown in Table 17.

TABLE 17
Efficacy of linolenic acid, pyrethrin, and a combination of both
against adult, virgin, female Aedes aegypti mosquitoes.
% MORTALITY
ACTIVE INGREDIENTCONCENTRATIONAFTER 24 HRS
LINOLENIC ACID3%7
PYRETHRIN0.002 μg57
OBS.*CALC.**
LINOLENIC ACID + 3% + 0.002 μg3760.01
PYRETHRIN
*Obs. = observed efficacy
**Calc. = efficacy calculated using Colby (1967) formula
Since the calculated insecticidal kill rate exceeds the observed value, then the action of the combination is antagonistic.

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Patent 2024
Acetone Adult Aedes antagonists Culicidae Females Insecticides Linolenic Acid Pyrethrins

Example 1

Variety 18GG0453L has shown uniformity and stability for all traits, as described in the following variety description information. The variety has been increased with continued observation for uniformity.

Table 1 provides data on morphological, agronomic, and quality traits for 18GG0453L. When preparing the detailed phenotypic information, plants of the new 18GG0453L variety were observed while being grown using conventional agronomic practices.

TABLE 1
Variety Descriptions based on Morphological,
Agronomic and Quality Trait
CHARACTERSTATE (Score)
Yield (bu/ac)32.94
SEED
Erucic acid content (%)0.01
Glucosinolate content11.37
Seed coat colorBlack (1)
SEEDLING
cotyledon widthWide (7)
seedling growth habitMedium to Upright (6)
Stem anthocyanin intensityAbsent (1)
LEAF
leaf lobesStrong Lobing (7)
number of leaf lobes4
leaf margin indentationMedium (5)
leaf margin shapeSharp (3)
leaf widthMedium (5)
leaf lengthMedium to Long (6)
petiole lengthMedium to Long (6)
PLANT GROWTH AND FLOWER
Time to flowering50.8
(number of days from planting
to 50% of plants showing one
or more open flowers)
Plant height at maturity (cm)125.8
Flower bud locationTouching to Slight Overlap (6)
Petal colorMedium Yellow (3)
Anther fertilityShedding Pollen (9)
Petal spacingTouching to Slight Overlap (6)
PODS AND MATURITY
Pod type
Pod lengthLong (7)
Pod widthMedium (5)
Pod angleHorizontal to Semi-Erect (3)
Pod beak lengthLong (7)
Pedicle lengthLong (7)
Lodging resistanceFair to Good
Time to maturity (no. days97.6
from planting to physiological
maturity)
HERBICIDE TOLERANCE
GlufonsinateTolerant
GlyphosateSusceptible
ImidazolinoneSusceptible
QUALITY CHARACTERISTICS
Oil content % (whole dry seed48.89
basis)
Protein content (percentage,47.24
whole oil-free dry seed basis)
Total saturated fats content6.35
Glucosinolates (μm total11.37
glucosinolates/gram whole
seed, 8.5% moisture basis)
Seed Chlorophyll2% higher than the WCC/RRC checks
Shatter Score (1 = poor;5.5
9 = best)
Acid Detergent Fibre (%)19.24
Total Saturated Fat (%)6.35
Oleic Acid - 18:1 (%)63.1
Linolenic Acid - 18:3 (%)8.89
Sclerotinia tolerance (% of40.16
susceptible check)
Blackleg (% of Westar)29.76

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Patent 2024
Acids Anthocyanins Beak Character Chlorophyll Cotyledon Detergents erucic acid Fertility Fibrosis Glucosinolates glyphosate Herbicides Immune Tolerance Linolenic Acid Oleic Acid Phenotype physiology Plant Leaves Plants Pollen Proteins Saturated Fatty Acid Sclerotinia Stem, Plant Tracheophyta

Top products related to «Linolenic Acid»

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Linolenic acid is a polyunsaturated fatty acid found in various plant oils, such as flaxseed, soybean, and canola oil. It is a key component of cell membranes and plays a role in various biological processes.
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Linoleic acid is an unsaturated fatty acid that is a key component of many laboratory reagents and test kits. It serves as a precursor for the synthesis of other lipids and plays a role in various biochemical processes. The core function of linoleic acid is to provide a reliable and consistent source of this essential fatty acid for use in a wide range of laboratory applications.
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Oleic acid is a long-chain monounsaturated fatty acid commonly used in various laboratory applications. It is a colorless to light-yellow liquid with a characteristic odor. Oleic acid is widely utilized as a component in various laboratory reagents and formulations, often serving as a surfactant or emulsifier.
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Stearic acid is a saturated fatty acid with the chemical formula CH3(CH2)16COOH. It is a white, odorless, and waxy solid at room temperature. Stearic acid is commonly used as a laboratory reagent and has various industrial applications.
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Palmitic acid is a saturated fatty acid with the chemical formula CH3(CH2)14COOH. It is a colorless, odorless solid at room temperature. Palmitic acid is a common constituent of animal and vegetable fats and oils.
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Palmitoleic acid is a monounsaturated fatty acid. It is a naturally occurring compound found in various plant and animal sources. The core function of palmitoleic acid is to serve as a building block for cell membranes and as a potential signaling molecule in biological processes.
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Arachidonic acid is a polyunsaturated fatty acid that serves as a precursor for the synthesis of eicosanoids, a class of bioactive lipid mediators. It is an important component of cell membranes and plays a role in various physiological processes.
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Ascorbic acid is a chemical compound commonly known as Vitamin C. It is a water-soluble vitamin that plays a role in various physiological processes. As a laboratory product, ascorbic acid is used as a reducing agent, antioxidant, and pH regulator in various applications.
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Bovine serum albumin (BSA) is a common laboratory reagent derived from bovine blood plasma. It is a protein that serves as a stabilizer and blocking agent in various biochemical and immunological applications. BSA is widely used to maintain the activity and solubility of enzymes, proteins, and other biomolecules in experimental settings.
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Methanol is a clear, colorless, and flammable liquid that is widely used in various industrial and laboratory applications. It serves as a solvent, fuel, and chemical intermediate. Methanol has a simple chemical formula of CH3OH and a boiling point of 64.7°C. It is a versatile compound that is widely used in the production of other chemicals, as well as in the fuel industry.

More about "Linolenic Acid"

Linolenic acid, also known as alpha-linolenic acid (ALA), is an essential omega-3 fatty acid that plays a crucial role in human health.
Found abundantly in various plant oils like flaxseed, walnut, and canola oil, this polyunsaturated fatty acid has been extensively studied for its anti-inflammatory properties and potential benefits for cardiovascular and neurological functions.
Researchers can optimize their studies on linolenic acid using PubCompare.ai, an AI-driven platform that enhances the reproducibility and accuracy of scientific research.
PubCompare.ai helps researchers locate optimal protocols from the vast literature, preprints, and patents, while leveraging smart comparisons to identify the best products and approaches.
In addition to linolenic acid, other related fatty acids like linoleic acid (an omega-6 fatty acid), oleic acid, stearic acid, and palmitic acid play important roles in human health and nutrition.
Ascorbic acid, also known as vitamin C, is another essential nutrient that has been studied for its synergistic effects with fatty acids.
Bovine serum albumin (BSA) is a commonly used protein in scientific experiments, often utilized as a stabilizer or carrier for various compounds, including fatty acids.
Methanol, on the other hand, is a solvent that may be used in the extraction and analysis of linolenic acid and other lipids.
By leveraging the powerful tools and features of PubCompare.ai, researchers can discover the future of scientific research and optimize their linolenic acid studies for enhanced reproducibility, accuracy, and impactful outcomes.