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Selenium

Selenium is a essential trace mineral that plays a crucial role in human health and development.
It is involved in various physiological processes, including antioxidant defense, thyroid function, and immune system regulation.
Selenium deficiency has been linked to an increased risk of certain diseases, such as cardiovascular disease, cancer, and cognitive decline.
Optimizing selenium levels through dietary intake or supplementation may offer protective benefits.
Researchers utilize selenium compounds and selenium-dependent proteins in a wide range of applications, including as biomarkers, therapeutic targets, and tools for investigating cellular processes.
This MeSH term provides a comprehensive overview of selenium's biological functions and its relevance to medical and scientific research.

Most cited protocols related to «Selenium»

1
Efficient Solvent Accessible Surface Area
Cited 91 times

Calculations. Both S&R and L&R are pretty straightforward to implement, and both require first determining which atoms are in contact, and then calculating the overlap between each atom and its neighbors. Finding contacts is done using cell lists, which means the contact calculation is an
O(
N) operation. Both algorithms then treat each atom independently, making also the second part of the calculation
O(
N). In addition, this second part is trivially parallelizable.
For L&R, instead of slicing the whole protein in one go, each atom is sliced individually. The L&R calculation is thus parameterized by the number of slices per atom, i.e. small atoms have thinner slices than large atoms.
The Fibonacci spiral gives a good approximation to an even distribution of points on the sphere (
Swinbank & Purser, 2006 (link)), allowing efficient generation of an arbitrary number of S&R test points. The cell lists provide the first of the two lattices in the double cubic lattice optimization for this algorithm (
Eisenhaber
et al., 1995), the second lattice (for the test points) is not implemented in FreeSASA, for now.
The correctness of the implementations was tested by first inspecting the surfaces visually. In the two atom case, results were verified against analytical calculations. Another verification came from comparing the results of high precision SASA calculations using the two independent algorithms. In addition, using the L&R algorithm gives identical results to NACCESS when the same resolution and atomic radii are used.
Radius assignment. An important step of the calculation is assigning a radius to each atom. The default in FreeSASA is to use the
ProtOr radii by
Tsai
et al. (1999). The library recognizes the 20 standard amino acids (plus Sec and Pyl), and the standard nucleotides (plus a few nonstandard ones). Tsai
et al. do not mention phosphorus and selenium; these atoms are assigned a radius of 1.8 and 1.9 Å respectively.
By default, hydrogen atoms and HETATM records are ignored in Protein Data Bank (PDB) files. If included, the library recognizes three common HETATM entries: the acetyl and NH
2 capping groups, and water, and assigns ProtOr radii to these. Otherwise the van der Waals radius of the element is used, taken from the paper by
Mantina
et al. (2009). For elements outside of the 44 main group elements treated by Mantina
et al., or if completely different radii are desired, users can provide their own configuration.
Users can specify their own atomic radii either through the API or by providing a configuration file. The library ships with a few sample configuration files, including one that provides a subset of the NACCESS parameterization, and one with the default ProtOr parameters. In addition, scripts are provided to automatically generate ProtOr configurations from PDB CONECT entries, such as those in the Chemical Component Dictionary (
Westbrook
et al., 2015). These can then be appended to the default configuration.
, & Mitternacht S. (2016). FreeSASA: An open source C library for solvent accessible surface area calculations. F1000Research, 5, 189.
Full text: Click here
Publication 2016
Amino Acids cDNA Library Cells Cuboid Bone Hydrogen Nucleotides Phosphorus Proteins Radius Sasa Selenium
2
Maintaining Human Embryonic Stem Cells
Cited 68 times
Human ES cells (H1 and H9) were usually maintained in specific media on Matrigel-coated tissue culture plates32 (link). Cells were passaged routinely with EDTA as described previously13 (link). Briefly, cells were washed twice with PBS/EDTA medium (0.5 mM EDTA in PBS, osmolarity 340 mOsm), then incubated with PBS/EDTA for 5 minutes at 37°C. PBS/EDTA was removed, and cells were washed off swiftly with a small volume of corresponding media.
E8 media composition: Media contained DMEM/F12, L-ascorbic acid-2-phosphate magnesium (64 mg/l), sodium selenium (14 µg/l), FGF2 (100 µg/l), insulin (19.4 mg/l), NaHCO3 (543 mg/l) and transferrin (10.7 mg/l), TGFβ1(2 µg/l) or NODAL (100 µg/l). Osmolarity of all media was adjusted to 340 mOsm at pH7.4. All the media were stored at 4°C, and were used within 2 weeks of production. L-ascorbic acid-2-phosphate magnesium is the stable form of L-ascorbic acid in cell culture.
Chen G., Gulbranson D.R., Hou Z., Bolin J.M., Ruotti V., Probasco M.D., Smuga-Otto K., Howden S.E., Diol N.R., Propson N.E., Wagner R., Lee G.O., Antosiewicz-Bourget J., Teng J.M, & Thomson J.A. (2011). Chemically defined conditions for human iPS cell derivation and culture. Nature methods, 8(5), 424-429.
Publication 2011
Ascorbic Acid Bicarbonate, Sodium Edetic Acid Fibroblast Growth Factor 2 Human Embryonic Stem Cells Insulin L Forms magnesium ascorbate-2-phosphate matrigel Osmolarity Selenium Sodium TGF-beta1 Tissues Transferrin
3
EBOV Glycoprotein Structural Characterization
Cited 40 times
T42V/T230V GP33-632Δmuc was transiently expressed in HEK293T cells with an N-terminal haemaglutinin tag for purification via affinity chromatography. GP was natively deglycosylated using PNGaseF and complexed with a SeMet-containing KZ52 antibody, and the resulting trimeric GP-Fab complex was purified by size exclusion chromatography. Crystals were grown in 8.5% (w/v) PEG 10,000, 0.1 M Tris-HCl pH 8.5, 0.4 M sodium acetate and 10% (v/v) PEG 200 and diffracted to 3.4 Å resolution. Phases were obtained by combination of the Fab selenium anomalous signal and molecular replacement using an independently determined structure of the uncomplexed KZ52 Fab as a search model. Interpretable electron density maps with clear secondary structural elements and solvent boundaries were obtained after NCS-averaged density modification. The structure was refined to final Rwork and Rfree values of 26.2% and 30.2%, respectively. Atomic coordinates and structure factors for the reported crystal structure have been deposited with the Protein Data Bank under accession code 3CSY.
Lee J.E., Fusco M.L., Hessell A.J., Oswald W.B., Burton D.R, & Saphire E.O. (2008). Structure of the Ebola virus glycoprotein bound to a human survivor antibody. Nature, 454(7201), 177-182.
Publication 2008
Cells Chromatography, Affinity Electrons Gel Chromatography Immunoglobulins Microtubule-Associated Proteins Selenium Sodium Acetate Solvents Tromethamine
4
Evaluating CRANK Protein Structure Determination
Cited 30 times
Here, we test the new methods described above on a wide range of real SAD, MAD and SIRAS merged diffraction data sets. For our tests, only the intensities or structure-factor amplitudes, along with the sequence for a protein monomer, the number of substructure atoms expected per monomer and the f′ and f′′ values for the substructure atoms were input. CRANK used AFRO and CRUNCH2 for substructure detection, BP3 for substructure phasing and SOLOMON with MULTICOMB for density modification. Three cycles of Buccaneer iterated with REFMAC were used for automated model building with iterative refinement. The default options or parameters were used in all programs. The defaults set by CRANK depend upon the particular experiment: for SAD data, AFRO uses the multivariate |FA| value calculation and MULTICOMB uses the multivariate SAD function for phase combination in density modification, while Buccaneer uses the SAD function implemented in REFMAC. For SIRAS data, AFRO calculates |FA| from either the anomalous signal or using isomorphous differences by determining which signal is greater. BP3 uses the uncorrelated SIRAS function described previously (Pannu et al., 2003 ▶ ) and SOLOMON uses MLHL phase combination in MULTICOMB, while Buccaneer uses the multivariate SIRAS function in REFMAC. Finally, for MAD data AFRO chooses the wavelength with the greatest anomalous signal and calculates multivariate FA values from it. Similar to SIRAS data, SOLOMON uses MLHL phase combination in MULTICOMB to perform density modification and Buccaneer uses the MLHL likelihood function in REFMAC for model refinement.
In the test cases below, the previous version of CRANK, version 1.3, is tested with the current version, version 1.4. The main differences between the two versions are the development version of AFRO that calculates multivariate |FA| values given SAD data and the use of MULTICOMB for phase combination in density modification, which were both introduced in version 1.4.
In total, we report results from 116 real data sets from several different sources listed in Appendix A. The data sets cover a wide range of resolutions (from 0.94 to 3.29 Å) and anomalous scatterers, including selenium, sulfur, chloride, sulfate, manganese, bromide, calcium and zinc. Of the 116 data sets, 63 are MAD data sets, 46 are SAD data sets and seven are SIRAS data sets.
Pannu N.S., Waterreus W.J., Skubák P., Sikharulidze I., Abrahams J.P, & de Graaff R.A. (2011). Recent advances in the CRANK software suite for experimental phasing. Acta Crystallographica Section D: Biological Crystallography, 67(Pt 4), 331-337.
Full text: Click here
Publication 2011
Amino Acid Sequence Bromides Calcium Chlorides Manganese Methamphetamine Selenium Sulfates, Inorganic Sulfur Zinc
5
Speciation of Urinary Arsenic by HPLC-ICPMS
Cited 26 times
The remainder of the thawed urine sample was filtered through a 0.2 μm Nylon filter (Whatman GmbH, Dassel, Germany) into a 250 μL polypropylene crimp vial (Agilent Technologies). This filtered sample was analysed directly by anion-exchange HPLC/ICPMS. Additionally, a portion (90 μL) of the filtered sample was removed from the HPLC vial and 10 μL of H2O2 were added, to convert any trivalent- and thio-arsenicals to their pentavalent and/or oxygenated forms, and the mixture was allowed to stand for at least two hours at a temperature > 23°C before analysis by anion-exchange HPLC/ICPMS.
The anion-exchange HPLC conditions (identical for both non-oxidised and oxidised urine samples) were: PRP-X100 column (4.6 mm × 150 mm, 5 μm particles; Hamilton Company, Reno USA) at 40°C with a mobile phase of 20 mM aqueous phosphoric acid adjusted with aqueous ammonia to pH 6 at a flow rate of 1 mL min−1. Injection volume was 20 μL. A carbon source (1% CO2 in argon) was introduced directly to the plasma, as previously described for selenium,14 (link) to provide a 4-5-fold increase in sensitivity. The CO2 was introduced via the T-piece of the high matrix sample introduction kit and the optional gas was set to 0.17 L min−1. Under these chromatographic conditions, As(III) elutes near the void volume, very close to AB and most other cationic arsenic species. This void-volume peak was assigned as AB + As(III) in the non-oxidised sample, and as AB in the oxidised sample (Fig. 1), based on the premise that AB is the only arsenic cation found in significant quantities in urine (see below).15 The total iAs content [As(III) + As(V)] was obtained from the As(V) peak in the oxidised sample. For all HPLC runs, peaks were quantified against the respective standard. Calibration was usually performed in the range 0.10 to 20.0 μg As L−1 (six-point calibration curve); limit of detection was 0.1 μg As L−1 for iAs [As(V) peak], MA, DMA and AB, and the intra-assay coefficient of variation was better than 5 % for all species.
The premise that AB was essentially the only cationic arsenic species in the urine samples was tested by performing cation-exchange HPLC/ICPMS on 188 samples that had shown a significant peak at the void volume during anion-exchange HPLC/ICPMS of the oxidized samples. A Zorbax 300-SCX column (4.6 mm × 150 mm, 5 μm particles; Agilent Technologies) at 30°C was used with a mobile phase of 10 mM pyridine at pH 2.3 (adjusted with formic acid) at a flow rate of 1.5 mL min−1. The injection volume was 10 μL. ICPMS was used as a detector with the settings described above for anion-exchange HPLC/ICPMS.
Scheer J., Findenig S., Goessler W., Francesconi K.A., Howard B., Umans J.G., Pollak J., Tellez-Plaza M., Silbergeld E.K., Guallar E, & Navas-Acien A. (2012). Arsenic species and selected metals in human urine: validation of HPLC/ICPMS and ICPMS procedures for a long-term population-based epidemiological study. Analytical methods : advancing methods and applications, 4(2), 406-413.
Publication 2012
Ammonia Anions Argon Arsenic Arsenicals Biological Assay Carbon Chromatography formic acid High-Performance Liquid Chromatographies Hypersensitivity Nylons Peroxide, Hydrogen Phosphoric Acids Plasma Polypropylenes pyridine Selenium Urination Urine

Most recents protocols related to «Selenium»

1
Silicic Acid and Micronutrients for Health
Not available on PMC !

Example 5

    • Daily oral administration of 5 mg of bioavailable silicic acid in the form of choline-stabilized orthosilicic acid (ch-OSA®), wherein silicic acid is stabilized with choline chloride, for instance in the form of a capsule.
    • Daily administration of a tablet containing 200 mg vitamin C, 150 microgram selenium, 10 mg zinc, 1 mg copper.

US11878031B2. Silicic acids for use in the treatment of periodontitis (2024-01-23). Bio Minerals N.V. [BE]. Inventors: Mario Remi Yvonne Calomme [BE], Kathleen Jozef Ingrid Suzanne Van Hoof [BE].
Full text: Click here
Patent 2024
Acids Administration, Oral Ascorbic Acid Capsule Choline Choline Chloride Copper Periodontitis Selenium Silicic acid Tablet Zinc
2
Silicic Acid and Mineral Supplementation Protocol
Not available on PMC !

Example 6

    • Daily oral administration of 5 mg of bioavailable silicic acid in the form of choline-stabilized orthosilicic acid (ch-OSA®), wherein silicic acid is stabilized with choline chloride, for instance in the form of a capsule;
    • Daily administration of 1000 mg calcium, 6 microgram vitamin D, 50 microgram vitamin K, preferably in two formulations, such as tablets;
    • Daily administration of 200 mg vitamin C, 100 microgram selenium, 10 mg zinc, 1 mg copper, 0.5 mg boron, 200 mg magnesium, for instance in the form of a single formulation, such as a tablet.

    • 6 months oral administration of 10 mg of a bioavailable silicon compound per day, which bioavailable silicon compound is in the form of choline-stabilized orthosilicic acid (ch-OSA®), wherein silicic acid is stabilized with choline chloride; 10 mg bioavailable silicon is preferably administered as two dosage units, each containing 5 mg bioavailable silicon, for instance as a tablet;
    • mouth rinsing with chlorhexidine 1% solution twice daily during 4 weeks.

It is herein preferable, that the administration of the bioavailable silicic acid and the mouth rinsing start simultaneously.

US11878031B2. Silicic acids for use in the treatment of periodontitis (2024-01-23). Bio Minerals N.V. [BE]. Inventors: Mario Remi Yvonne Calomme [BE], Kathleen Jozef Ingrid Suzanne Van Hoof [BE].
Full text: Click here
Patent 2024
Acids Administration, Oral Ascorbic Acid Boron Calcium, Dietary Capsule Chlorhexidine Choline Choline Chloride Copper Magnesium Periodontitis Selenium Silicic acid Silicon Tablet Vitamin D Vitamin K Zinc
3
Silicic Acid and Bone Health Supplement Protocol
Not available on PMC !

Example 11

    • 12 months oral administration of 10 mg of bioavailable silicic acid per day in the form of choline-stabilized orthosilicic acid (ch-OSA®), wherein silicic acid is stabilized with choline chloride, preferably in the form of two dosage units, such as capsules.
    • Daily administration of 1000 mg calcium, 6 microgram vitamin D, 50 microgram vitamin K, preferably in the form of two dosage units, such as tablets.
    • Daily administration of 200 mg vitamin C, 100 microgram selenium, 10 mg zinc, 1 mg copper, 0.5 mg boron, 200 mg magnesium, preferably in the form of a table.
    • irrigating the periodontal pockets and cleaning the implants with chlorhexidine 1% solution
    • mouth rinsing with chlorhexidine 1% solution twice daily during 4 weeks.

US11878031B2. Silicic acids for use in the treatment of periodontitis (2024-01-23). Bio Minerals N.V. [BE]. Inventors: Mario Remi Yvonne Calomme [BE], Kathleen Jozef Ingrid Suzanne Van Hoof [BE].
Full text: Click here
Patent 2024
Acids Ascorbic Acid Boron Calcium, Dietary Capsule Chlorhexidine Choline Choline Chloride Copper Dosage Forms Ergocalciferol Magnesium Patient Care Management Peri-Implantitis Periodontal Pocket Selenium Silicic acid Vitamin K Zinc
4
Diurnal Phosphorus Rhythms in Laying Hens
Hy-Line Brown laying hens were fed with a regular diet (corn-soybean meal-based; containing 0.32% non-phytate phosphorus (NPP); Table 1) start from 35 weeks of age. On the last day of age 40 weeks, a total of 60 hens that laid eggs between 07:30−08:30 were randomly selected to evaluate the daily phosphorus rhythms. Of them, 45 hens were euthanized for sample collection, and the other 15 hens were used to study the feed intake and calcium/phosphorus excretion rhythms. For sample collection, the 45 hens were sampled according the oviposition cycle: at oviposition, at 6, 12, 18 h post-oviposition, and at the next oviposition, respectively, with 9 hens sampled at each of the time point. The following samples were collected: blood (for serum), uterine (stored at −80 ℃, for Western-blotting analysis), femur (in 4% paraformaldehyde, for histological analysis) and kidney (stored at −80 ℃, for Western-blotting analysis). For the other 15 hens, the feed intake was recoded and the excreta was collected at the following intervals: from oviposition to 6 h post-oviposition, from 7 to 12 h post-oviposition, from 13 to 18 h post-oviposition, from 19 h post-oviposition to the next oviposition.

Composition and nutrient concentrations of basal diet (%, unless noted, as-is basis)

ItemLow phosphorusRegular phosphorus
Ingredients
 Corn56.6956.69
 Soybean meal25.7725.77
 Distillers dried grains with solubles4.004.00
 Calcium carbonate9.739.04
 Dicalcium phosphate-1.15
 Soybean oil1.511.51
 Sodium chloride0.260.26
 DL-Methionine0.180.18
 Choline chloride0.150.15
 Montmorillonite0.710.25
 Premix111
 In total100.00100.00
Nutrient levels
 Metabolizable energy, kcal/kg (calculated)2,6002,600
 Crude protein (calculated)16.516.5
 Total phosphorus (calculated/analyzed)0.34/0.340.53/0.49
 Non-phytate phosphorus (calculated)0.140.32
 Calcium (calculated/analyzed)3.50/3.473.50/3.52

1Provided per kilogram of diet: manganese 60 mg, copper 8 mg, zinc 80 mg, iodine 0.35 mg, selenium 0.3 mg, vitamin A 8000 IU, vitamin E 30 mg, vitamin K3 1.5 mg, thiamine 4 mg, riboflavin 13 mg, pantothenic acid 15 mg, nicotinamide 20 mg, pyridoxine 6 mg, biotin 0.15 mg, folic acid 1.5 mg, and cobalamin 0.02 mg

Yan J., Wang J., Chen J., Shi H., Liao X., Pan C., Liu Y., Yang X., Ren Z, & Yang X. (2023). Adjusting phosphate feeding regimen according to daily rhythm increases eggshell quality via enhancing medullary bone remodeling in laying hens. Journal of Animal Science and Biotechnology, 14, 17.
Full text: Click here
Publication 2023
Biotin BLOOD Calcium, Dietary calcium phosphate Cereals Choline Copper Corn Flour Corns Diet Eggs Feed Intake Femur Folic Acid Iodine Kidney Manganese Niacinamide Nutrients Oviposition Pantothenic Acid paraform Phosphorus Phytate Proteins Pyridoxine Riboflavin Selenium Serum Sodium sodium phosphate Soybean Flour Soybeans Specimen Collection Thiamine Uterus Vitamin A Vitamin B12 Vitamin E Vitamin K3 Western Blot Zinc-80
5
Culturing Human Vulval CAFs and SCC Cells
Human vulval CAFs are described in Gaggioli et al., 2007 (link). CAFs were cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented with 10% Fetal Bovine Serum (FBS) and 1% insulin–transferrin–selenium (Invitrogen, no. 41400–045) and 100  U/ml penicillin, and 100  μg/ml streptomycin. Human vulval SCC cell line A431 cells were grown in DMEM supplemented with 10% FBS, 100  U/ml penicillin, and 100  μg/ml streptomycin. For ROCK inhibitor treatment cells were treated with 10 µM Y27632.
Kato T., Jenkins R.P., Derzsi S., Tozluoglu M., Rullan A., Hooper S., Chaleil R.A., Joyce H., Fu X., Thavaraj S., Bates P.A, & Sahai E. (2023). Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma. eLife, 12, e76520.
Full text: Click here
Publication 2023
Cell Lines Cells Conotruncal Anomaly Face Syndrome Eagle Fetal Bovine Serum Homo sapiens Insulin Penicillins Selenium Streptomycin Transferrin Vulva Y 27632

Top products related to «Selenium»

1
Insulin transferrin selenium by Thermo Fisher Scientific
Sourced in United States, United Kingdom, Germany, Japan, China, Canada, France, Macao, Belgium, Switzerland, Netherlands, Australia
Insulin-transferrin-selenium is a complex of insulin, transferrin, and selenium. It is used as a cell culture supplement to promote cell growth and proliferation in vitro.
2
Fetal bovine serum (fbs) by Thermo Fisher Scientific
Sourced in United States, China, United Kingdom, Germany, Australia, Japan, Canada, Italy, France, Switzerland, New Zealand, Brazil, Belgium, India, Spain, Israel, Austria, Poland, Ireland, Sweden, Macao, Netherlands, Denmark, Cameroon, Singapore, Portugal, Argentina, Holy See (Vatican City State), Morocco, Uruguay, Mexico, Thailand, Sao Tome and Principe, Hungary, Panama, Hong Kong, Norway, United Arab Emirates, Czechia, Russian Federation, Chile, Moldova, Republic of, Gabon, Palestine, State of, Saudi Arabia, Senegal
Fetal Bovine Serum (FBS) is a cell culture supplement derived from the blood of bovine fetuses. FBS provides a source of proteins, growth factors, and other components that support the growth and maintenance of various cell types in in vitro cell culture applications.
3
Dexamethasone (dex) by Merck Group
Sourced in United States, Germany, United Kingdom, China, Japan, Italy, Sao Tome and Principe, Macao, France, Australia, Switzerland, Canada, Denmark, Spain, Israel, Belgium, Ireland, Morocco, Brazil, Netherlands, Sweden, New Zealand, Austria, Czechia, Senegal, Poland, India, Portugal
Dexamethasone is a synthetic glucocorticoid medication used in a variety of medical applications. It is primarily used as an anti-inflammatory and immunosuppressant agent.
4
Penicillin streptomycin by Thermo Fisher Scientific
Sourced in United States, Germany, United Kingdom, China, Canada, France, Japan, Australia, Switzerland, Israel, Italy, Belgium, Austria, Spain, Gabon, Ireland, New Zealand, Sweden, Netherlands, Denmark, Brazil, Macao, India, Singapore, Poland, Argentina, Cameroon, Uruguay, Morocco, Panama, Colombia, Holy See (Vatican City State), Hungary, Norway, Portugal, Mexico, Thailand, Palestine, State of, Finland, Moldova, Republic of, Jamaica, Czechia
Penicillin/streptomycin is a commonly used antibiotic solution for cell culture applications. It contains a combination of penicillin and streptomycin, which are broad-spectrum antibiotics that inhibit the growth of both Gram-positive and Gram-negative bacteria.
5
Dmem f12 by Thermo Fisher Scientific
Sourced in United States, United Kingdom, Germany, China, France, Japan, Canada, Australia, Italy, Switzerland, Belgium, New Zealand, Spain, Denmark, Israel, Macao, Ireland, Netherlands, Austria, Hungary, Holy See (Vatican City State), Sweden, Brazil, Argentina, India, Poland, Morocco, Czechia
DMEM/F12 is a cell culture medium developed by Thermo Fisher Scientific. It is a balanced salt solution that provides nutrients and growth factors essential for the cultivation of a variety of cell types, including adherent and suspension cells. The medium is formulated to support the proliferation and maintenance of cells in vitro.
6
Streptomycin by Thermo Fisher Scientific
Sourced in United States, United Kingdom, Germany, China, France, Canada, Australia, Japan, Switzerland, Italy, Belgium, Israel, Austria, Spain, Netherlands, Poland, Brazil, Denmark, Argentina, Sweden, New Zealand, Ireland, India, Gabon, Macao, Portugal, Czechia, Singapore, Norway, Thailand, Uruguay, Moldova, Republic of, Finland, Panama
Streptomycin is a broad-spectrum antibiotic used in laboratory settings. It functions as a protein synthesis inhibitor, targeting the 30S subunit of bacterial ribosomes, which plays a crucial role in the translation of genetic information into proteins. Streptomycin is commonly used in microbiological research and applications that require selective inhibition of bacterial growth.
7
Selenium by Merck Group
Sourced in United States, Germany, Macao, China
Selenium is a laboratory equipment used for analytical applications. It is a chemical element with the atomic number 34. Selenium serves as a critical component in various analytical instruments and techniques.
8
Dulbecco modified eagle medium (dmem) by Thermo Fisher Scientific
Sourced in United States, China, United Kingdom, Germany, France, Australia, Canada, Japan, Italy, Switzerland, Belgium, Austria, Spain, Israel, New Zealand, Ireland, Denmark, India, Poland, Sweden, Argentina, Netherlands, Brazil, Macao, Singapore, Sao Tome and Principe, Cameroon, Hong Kong, Portugal, Morocco, Hungary, Finland, Puerto Rico, Holy See (Vatican City State), Gabon, Bulgaria, Norway, Jamaica
DMEM (Dulbecco's Modified Eagle's Medium) is a cell culture medium formulated to support the growth and maintenance of a variety of cell types, including mammalian cells. It provides essential nutrients, amino acids, vitamins, and other components necessary for cell proliferation and survival in an in vitro environment.
9
Penicillin by Thermo Fisher Scientific
Sourced in United States, United Kingdom, Germany, China, France, Canada, Japan, Australia, Switzerland, Italy, Israel, Belgium, Austria, Spain, Brazil, Netherlands, Gabon, Denmark, Poland, Ireland, New Zealand, Sweden, Argentina, India, Macao, Uruguay, Portugal, Holy See (Vatican City State), Czechia, Singapore, Panama, Thailand, Moldova, Republic of, Finland, Morocco
Penicillin is a type of antibiotic used in laboratory settings. It is a broad-spectrum antimicrobial agent effective against a variety of bacteria. Penicillin functions by disrupting the bacterial cell wall, leading to cell death.
10
Epidermal growth factor (egf) by Thermo Fisher Scientific
Sourced in United States, United Kingdom, Germany, China, Canada, France, Italy, Japan, Israel, Switzerland, Australia, Macao, Belgium, Spain, Denmark, Jersey
EGF is a lab equipment product from Thermo Fisher Scientific. It is a recombinant human Epidermal Growth Factor (EGF) protein. EGF is a growth factor that plays a role in cell proliferation and differentiation.

More about "Selenium"

Selenium (Se) is an essential trace mineral that plays a vital role in human health and development.
It is involved in various physiological processes, including antioxidant defense, thyroid function, and immune system regulation.
Selenium deficiency has been linked to an increased risk of certain diseases, such as cardiovascular disease, cancer, and cognitive decline.
Optimizing selenium levels through dietary intake or supplementation may offer protective benefits.
Researchers utilize selenium compounds and selenium-dependent proteins in a wide range of applications, including as biomarkers, therapeutic targets, and tools for investigating cellular processes.
Selenium is often used in combination with other key nutrients and compounds in cell culture media, such as insulin-transferrin-selenium (ITS) and fetal bovine serum (FBS), as well as dexamethasone, penicillin/streptomycin, and DMEM/F12 media.
These components work together to support cell growth, differentiation, and survival.
Streptomycin, a common antibiotic, is also sometimes used in cell culture to prevent bacterial contamination.
By understanding the role of selenium and its interactions with other essential elements, researchers can optimize their cell culture protocols and experiments to gain deeper insights into cellular processes and develop new therapeutic approaches.
Leveraging the power of AI-driven tools like PubCompare.ai can help scientists quickly locate relevant protocols and products, and identify the best strategies for their selenium-related research.