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Allografts

Allografts refer to tissues or organs transplanted from one individual to another of the same species.
These transplants can be used to replace damaged or diseased body parts, such as bone, skin, or corneas.
Allografts offer a valuable alternative to autologous grafts, which use the patient's own tissues.
Researchers can optimize their allograft work by comparing protocols from the literature, preprints, and patents using the AI-driven platform PubCompare.ai.
This intelligent tool helps enhance reproducibility and accuracy, enabling users to find the best allograft products and procedures to advance their research.
Experienece the power of AI-assisted research with PubCompare.ai.

Most cited protocols related to «Allografts»

1
ACL Reconstruction Using CPC-Enhanced Allograft
Fourteen immature female 30kg Yorkshire pigs underwent unilateral ACL reconstruction using a bone-patellar tendon-bone allograft. ACL reconstruction with standard allograft (ACLR; control) was performed in 7 animals while the procedure was performed using the same allograft enhanced with CPC in 7 animals (E-ACLR; experimental). One animal in the control group was euthanized at the time of surgery due to a condylar fracture and was not included in the study. The study was 80% powered to detect an effect size of 2.
Following the induction of anesthesia and clinical examination of both knees, the knee was shaved, prepared with a surgical iodine solution and alcohol, and draped. An 8 cm incision was made at the medial border of the patellar tendon. The patella was retracted laterally without dislocating it from the trochlear groove. The fat pad was partially resected to expose the ACL, which was completely transected at the junction of the proximal and middle thirds of the ligament. ACL transection was verified by a positive Lachman exam.
The fresh frozen allografts were harvested from fourteen age, weight and gender matched donor knees. The entire patellar tendon, which was approximately 10 mm in width, was used. The bone blocks were trimmed to 7 mm diameter to allow for smooth graft passage through 8 mm osseous tunnels in the femur and tibia. The osseous tunnels were drilled to the insertion sites of the native ACL using a commercial drill guide system (Acufex Elbow Aimer, Smith & Nephew, Inc, Andover MA). Once the tunnels were completed, the graft was introduced intra-articularly through the arthrotomy. One bone block was passed into the femoral tunnel and rigidly fixed using a 6 mm bioabsorbable interference screw (CALAXO, Smith-Nephew, Andover, MA). In the standard ACLR group, the graft was then passed retrograde into the tibial tunnel, preconditioned using 20 cycles of firm manual tension, held in maximum manual tension, and secured in the tibia using another 6 mm interference screw. The tibial screw was inserted into the tibial tunnel at the distal end of the tunnel, and the screw was countersunk 3 mm below the cortical surface of the tibia (Fig. 1). In the E-ACLR group, a tubular collagen sponge (details below) was threaded onto the graft after femoral fixation. The graft was then pulled retrograde into the tibial tunnel, preconditioned, tensioned, and secured with another interference screw as described for the ACLR group. The concentrated platelets were added to the sponge to create the CPC.
The retinacula and subcutaneous tissues were closed with interrupted 2-0 Vicryl, and a 3-0 Vicryl subcuticular stitch was used to close the skin incision. The animals were allowed unrestricted weight bearing. Postoperative pain was controlled with narcotics. All animals were monitored closely after surgery for any signs of discomfort, lameness or weight loss. The pigs were euthanized after 15 weeks of healing. The knees were immediately harvested and frozen until mechanical testing.
Fleming B.C., Spindler K.P., Palmer M., Magarian E, & Murray M.M. (2009). COLLAGEN-PLATELET COMPOSITES IMPROVE THE BIOMECHANICAL PROPERTIES OF HEALING ACL GRAFTS IN A PORCINE MODEL. The American journal of sports medicine, 37(8), 1554-1563.
Publication 2009
Allografts Anesthesia Animals ARID1A protein, human Blood Platelets Bone and Bones Bones Collagen Condyle Cortex, Cerebral Drill Elbow Ethanol Femur Fracture, Bone Freezing Grafts Iodine Knee Ligaments Ligamentum Patellae Operative Surgical Procedures Pad, Fat Pain, Postoperative Patella Physical Examination Pigs Porifera Reconstructive Surgical Procedures Skin Subcutaneous Tissue Tibia Tissue Donors Trochlear Notch Vicryl Woman
2
Pediatric Burn Wound Management Protocol
All thermally injured children with burns over 30% of their total body surface area (TBSA) who required surgery and consented to an IRB-approved experimental protocol between 1998 and 2007, and were admitted to our burn unit and required at least one surgical intervention were included in this study. If needed, patients were resuscitated according to the Galveston formula with 5000 cc/m2 TBSA burned + 2000 cc/m2 TBSA lactated Ringer’s solution given in increments over the first 24 hours. Within 48 hours of admission, all patients underwent total burn wound excision and the wounds were covered with autograft. Any remaining open areas were covered with homograft. After the first operative procedure, patients were taken back to the operation theater when donor sites were healed. This procedure was repeated until all open wound areas were covered with autologous skin.
All patients underwent the same nutritional treatment according to a standardized protocol. The intake was calculated as 1500 kcal/m2 body surface + 1500 kcal/m2 area burn as previously published.13 (link)–15 (link) The nutritional route of choice in our patient population was enteral nutrition via a duodenal (Dobhof) or nasogastric tube. Parenteral nutrition was only given in rare instances if the patient could not tolerate tube feeds.
Patient demographics (age, date of burn and admission, sex, burn size and depth of burn) and concomitant injuries such as inhalation injury, sepsis, morbidity, and mortality were recorded. Sepsis was defined as a positive blood culture or pathologic tissue identifying the pathogen during hospitalization or at autopsy, in combination with at least 3 of the following: leucocytosis or leucopenia (>12,000 or <4,000), hyperthermia or hypothermia (>38.5 or <36.5°C), tachycardia (>150 BPM in children), refractory hypotension (systolic BP <90 mmHg), thrombocytopenia (platelets <50,000/mm3), hyperglycemia (serum glucose >240 mg/dl), and enteral feeding intolerance (residuals > 200 cc/hr or diarrhea > 1 L/day) as previously published.13 (link), 14 (link), 16 (link) We further determined time between operations as a measure for wound healing/re-epithelization. We propose that the time between operations was indicative when donor sites were healed and thereby allowed determination of wound healing.
Jeschke M.G., Chinkes D.L., Finnerty C.C., Kulp G., Suman O.E., Norbury W.B., Branski L.K., Gauglitz G.G., Mlcak R.P, & Herndon D.N. (2008). THE PATHOPHYSIOLOGIC RESPONSE TO SEVERE BURN INJURY. Annals of surgery, 248(3), 387-401.
Publication 2008
Allografts Autopsy Blood Culture Blood Platelets Body Surface Area Child Diarrhea Duodenum Enteral Nutrition Fever Glucose Hospitalization Hyperglycemia Inhalation Injuries Lactated Ringer's Solution Leukocytosis Leukopenia Parenteral Nutrition pathogenesis Patients Septicemia Serum Skin Systolic Pressure Thrombocytopenia Tissue Donors Tissues Transplantation, Autologous Treatment Protocols Tube Feeding Wounds
3
Bioactive Scaffold for ACL Repair
Institutional Animal Care and Use Committee approvals were obtained. Sixty four Yucatan mini-pigs in late adolescence (with closed tibial and femoral physes) [age (mean±SD): 15.0±0.95 months; weight: 58.6±7.9 kg] underwent ACL transection and were randomized to one of four experimental groups: 1) no treatment, 2) conventional ACL reconstruction with bone-patellar tendon-bone (BPTB) allograft,37 (link) 3) bio-enhanced ACL reconstruction with BPTB allograft using a bioactive scaffold,13 (link) and 4) bio-enhanced ACL repair using a bioactive scaffold of the same material and sutures (Fig. 1).25 (link) Half of the animals within each treatment group were allowed to heal for 6 and 12 months, respectively.
Murray M.M, & Fleming B.C. (2013). Use of a Bioactive Scaffold to Stimulate ACL Healing Also Minimizes Post-traumatic Osteoarthritis after Surgery. The American journal of sports medicine, 41(8), 1762-1770.
Publication 2013
Allografts Animals Bone and Bones Epiphyseal Cartilage Femur Institutional Animal Care and Use Committees Ligamentum Patellae Reconstructive Surgical Procedures Sutures Swine, Miniature Tibia Wound Healing
4
Optimized Islet Isolation Protocol
In compliance with federal regulations, islet isolations were performed from deceased donors (research/clinical) (n=94), split pancreas digestion (n=5), and chronic pancreatitis (n=150) pancreases. On arrival at the laboratory, the pancreas was trimmed, cannulated, and distended with tissue dissociation enzymes of various combinations. After ductal perfusion of the enzymes, the pancreas was digested using a modified Ricordi’s semi-automated method (31 (link)). The digested tissue was then purified by continuous iodixanol (OptiPrep™, Axis-Shield, Oslo, Norway) density gradient on a COBE-2991 cell processor.
Clinical pancreases were accepted following standard organ acceptance criteria and the Edmonton pancreas donor scoring algorithm was applied to each donor (32 (link)). In clinical allograft isolations, our University of Minnesota isolation protocol (17 (link)) was used for all isolations performed with EC-A (n=13) and EC-F (n=19). For clinical isolations performed with the NEM, 2 were performed with this protocol while the remaining 8 isolations were performed with the Clinical Islet Transplantation (CIT) Consortium islet isolation protocol. In all cases of allotransplantation, the liberated islets were first cultured in CMRL-1066 supplemented medium (Mediatech, Inc, Manassas, VA) for 36–72h before being transplanted.
Autologous islet isolations were performed following total pancreatectomy as described (33 (link)–35 (link)). The isolated islets were transplanted immediately after isolation.
Split pancreas digestions (n=5) were performed on research pancreases to study the potency of the NEM compared to EC-F (Table-1C). Each pancreas was split into two lobes, head/body and body/tail, and each portion was digested with either intact collagenase and ChNP (NEM) or intact collagenase and thermolysin (EC-F). Digestions were performed sequentially and each lobe received alternating enzyme treatments to reduce intra-pancreatic variability.
Balamurugan A.N., Loganathan G., Bellin M.D., Wilhelm J.J., Harmon J., Anazawa T., Soltani S.M., Radosevich D.M., Yuasa T., Tiwari M., Papas K.K., McCarthy R., Sutherland D.E, & Hering B.J. (2012). A new enzyme mixture to increase the yield and transplant rate of autologous and allogeneic human islet products. Transplantation, 93(7), 693-702.
Publication 2012
Allografts Clinical Protocols Collagenase Culture Media Digestion Donors Enzymes Epistropheus Head Hereditary pancreatitis Human Body iodixanol Islets of Langerhans Transplantation isolation Pancreas Pancreatectomy Perfusion Tail Thermolysin Tissues
5
Developing and Validating a Kidney Transplant Survival Prediction Model
We followed the TRIPOD (Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis) statement (supplementary methods) for reporting the development and validation of the multivariable prediction model.21 (link) We describe continuous variables by using means and standard deviations or medians and interquartile ranges. We compared means and proportions between groups by using Student’s t test, analysis of variance (Mann-Whitney test for mean fluorescence intensity), or the χ2 test (or Fisher’s exact test if appropriate). We used the Kaplan-Meier method to estimate graft survival. The duration of follow-up was from the patient’s risk evaluation (starting point) to the date of kidney allograft loss or the end of the follow-up (31 March 2018). For patients who died with a functioning allograft, allograft survival was censored at the time of death as a surviving or functional allograft.22 (link)
In the derivation cohort, we used univariable Cox regression analyses to assess the associations between allograft failure and clinical, histological, functional, and immunological factors measured at the patient’s risk evaluation (see above). We used the log graphic method to test hazard proportional assumptions. The factors identified in these analyses were thereafter included in a final multivariable model.
We confirmed the internal validity of the final model by using a bootstrap procedure, which involved generating 1000 datasets derived from resampling the original dataset and permitting the calculation of optimism corrected performance estimates.23 (link) We tested the centre effect in stratified analyses. We investigated potential non-linear relations between continuous predictors and graft loss by using fractional polynomial methods (see supplementary methods).
We assessed the accuracy of the prediction model on the basis of its discrimination ability and calibration performance. We evaluated the discrimination ability (the ability to separate patients with different prognoses) of the final model by using Harrell’s concordance index (C index) (see supplementary methods).24 (link) We assessed calibration (the ability to provide unbiased survival predictions in groups of similar patients) on the basis of a visual examination of the calibration plots by using the rms package in R. We used the SurvIDINRI package in R to calculate net reclassification improvement for censored survival data.25 (link)
26 (link) We then evaluated the external validity of the final model in the external validation cohorts, including discrimination tests and model calibration as mentioned above.
We calculated a risk prediction score (integrative box risk prediction score—iBox) for each patient according to the β regression coefficients estimated from the final multivariable Cox model. Allograft survival probabilities are given at three, five, and seven years after iBox risk evaluation. The seven year post-transplant iBox risk assessment was guided by the median follow-up after iBox risk assessment of 7.65 (interquartile range 5.39-8.21) years.
We used R version 3.2.1 foe all analyses and considered P values below 0.05 to be significant; all tests were two tailed. Details of the interpretation of important statistical concepts are given in the supplementary methods.
Loupy A., Aubert O., Orandi B.J., Naesens M., Bouatou Y., Raynaud M., Divard G., Jackson A.M., Viglietti D., Giral M., Kamar N., Thaunat O., Morelon E., Delahousse M., Kuypers D., Hertig A., Rondeau E., Bailly E., Eskandary F., Böhmig G., Gupta G., Glotz D., Legendre C., Montgomery R.A., Stegall M.D., Empana J.P., Jouven X., Segev D.L, & Lefaucheur C. (2019). Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study. The BMJ, 366, l4923.
Publication 2019
Allografts Diagnosis Discrimination, Psychology Fluorescence Grafts Graft Survival Health Risk Assessment Immunologic Factors Kidney Optimism Patients Prognosis Student

Most recents protocols related to «Allografts»

1
Generating KIF5B-RET Variant 1 Expressing Cell Lines
Not available on PMC !

Example 2

The DNA encoding the amino acid sequence of human KIF5B-RET variant 1 was placed in a lentivirus vector under a doxycycline-inducible promoter to maximize expression with a carboxyl-terminal FLAG epitope to facilitate immunodetection of the fusion by anti-FLAG antibodies. Lentiviral-mediated gene transduction was used to express KIF5B-RET in Ba/F3 cells, KIF5B-RET dependent cells were selected by IL-3 withdrawal and confirmed to express the KIF5B-RET fusion protein by immunoblot analysis. To generate Ba/F3 cells carrying V804 substitutions, WT KIF5B-RET Ba/F3 cells were mutagenized overnight with ENU and plated in 96-well plates for a period of 2 weeks in the presence of 6 concentrations of MKIs (ponatinib, regorafenib, cabozantinib, or vandetanib). The concentrations chosen ranged from 2×-64× the proliferation IC50 for each compound: 125 nM to 4 μmol/L cabozantinib, 20 to 640 nM ponatinib, and 250 nM to 8 μmol/L vandetanib. Genomic DNA was isolated from resistant clones, and Sanger sequencing was used to identify those that harbored substitutions. FIG. 3 shows antitumor activity of Compound 1 compared with cabozantinib in KIF5B-RET V804L Ba/F3 allografts.

US11872192B2. RET inhibitor for use in treating cancer having a RET alteration (2024-01-16). BLUEPRINT MEDICINES CORPORATION [US]. Inventors: Erica Evans Raab [US], Beni B. Wolf [US].
Full text: Click here
Patent 2024
Allografts Amino Acid Sequence Anti-Antibodies Biological Assay cabozantinib Cells Clone Cells Cloning Vectors Doxycycline Epitopes Genome Homo sapiens Immunoblotting KIF5B protein, human Lentivirus Mutagenesis ponatinib regorafenib Transduction, Genetic vandetanib
2
Allograft Transplantation for Osteochondral Defects
Arthrotomy for exposure was based on surgeon preference. Fresh osteochondral
tissue was obtained from JRF Ortho, using MRI for size matching. The tissue was
screened for absence of defects, aseptically harvested from donor knees, and
stored at 4°C in a proprietary solution. The corresponding sized allograft to
match the debrided osteochondral area of injury was prepared as described previously.30 (link)
 The matched allograft was compared with the DA estimated area of injury.
Large oblong osteochondral defects were treated with the previously described
snowman technique of interposing 2 dowel grafts.26 (link)
 No shell graft techniques were employed in patients in this study.
Concomitant knee pathology was also addressed.
Postoperatively, patients were allowed to immediately bear weight as tolerated in
a knee brace with crutch assistance, when concomitant procedures did not limit
weightbearing. Full active and passive knee range of motion was prescribed for
open-chain activity immediately and after brace removal with weightbearing.
Moulton S.G., Provencher M., Vidal A., Wiedrick J., Arnold K, & Crawford D. (2023). Application of 3D Modeling Software to Preoperative MRI for Prediction of Surface Area of Tissue Applied During Osteochondral Allograft Reconstruction of the Knee. Orthopaedic Journal of Sports Medicine, 11(3), 23259671231153132.
Publication 2023
Allografts Bears Braces Crutches Grafts Injuries Knee Patients Post Technique Surgeons Tissue Donors Tissues
3
Cytokine Profiling in Facial Allotransplants

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Publication 2023
Allografts Biological Assay Buffers Cytokine Enzyme-Linked Immunosorbent Assay Face IL10 protein, human IL17A protein, human Immunosuppressive Agents Interferon Type II Interleukin-1 beta Interleukin-12 Mus Pharmaceutical Preparations Radioimmunoprecipitation Assay Spleen Tissues Tumor Necrosis Factor-alpha
4
Postoperative Facial Allograft Rejection Study

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Publication 2023
Allografts Buffers Cefazolin Erythema Face IL10 protein, human Ketoprofen Mice, House Necrosis Saline Solution
5
Evaluating Facial Allograft Rejection

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Publication 2023
Allografts Buffers Face IL10 protein, human Lymphocyte Muscle Tissue Response, Immune Skin

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More about "Allografts"

Allotransplants are a valuable alternative to autologous grafts, where the patient's own tissues are used.
These transplanted tissues or organs, derived from another individual of the same species, can be utilized to replace damaged or diseased body parts such as bone, skin, or corneas.
Researchers can optimize their allograft work by comparing protocols from the scientific literature, preprints, and patents using the AI-driven platform PubCompare.ai.
This intelligent tool helps enhance the reproducibility and accuracy of allograft research, enabling users to find the best allograft products and procedures to advance their studies.
PubCompare.ai can be particularly useful when working with Matrigel, a commonly used extracellular matrix preparation derived from Engelbreth-Holm-Swarm (EHS) mouse sarcoma cells.
Similarly, the platform can assist in optimizing the use of TRIzol reagent, a popular solution for RNA extraction, as well as the application of DAPI (4',6-diamidino-2-phenylindole), a fluorescent stain that binds to DNA, and the RNeasy Mini Kit, a kit for purifying RNA.
The power of AI-assisted research with PubCompare.ai can be experienced across various stages of allograft development, from the initial protocol comparisons to the final data analysis using tools like GraphPad Prism 5, Prism 6, Prism 7, and Prism 8.
Furthermore, PubCompare.ai can be beneficial in research involving streptozotocin (STZ), a compound commonly used to induce diabetes in animal models, which may be relevant for studying the effects of allografts on diabetic conditions.
By leveraging the platform's intelligent protocol comparisons, researchers can optimize their allograft work and enhance the reproducibility and accuracy of their findings, ultimately advancing the field of allograft research and healthcare.