Since paralyzed users of neural prostheses cannot generate overt arm movements an observation based algorithm training methodology can be used, as in previous animal studies8 (link) and clinical trials10 (link). We tested the ReFIT-KF algorithm with observation based training, replacing the native arm movement stage of algorithm training with an observation stage (Fig. 5b ).
Observation-based decode models were built with both of the monkey’s arms comfortably restrained along his side. A previously recorded arm-controlled experimental block of 500 center-out and back trials was shown to the monkey while in this posture. The kinematics of this recording were derived from a arm-controlled session from Monkey L. To help keep the monkey engaged in the task, he was rewarded when the computer-controlled cursor acquired and held the target for 500 ms.
Under this experimental context, the neural data recorded during these observation sessions and the previously recorded cursor kinematics served as the training data to build the initial decode model. This resulting model was then run online and used as training data to build the ReFIT-KF decoder. Little to no arm movement was visually noted during both observational blocks and decoding blocks.
Performance of ReFIT-KF based control during these sessions, as measured by the Fitts’ law metric, was roughly equivalent to performance on sessions that initially trained from arm movement data.
Observation-based decode models were built with both of the monkey’s arms comfortably restrained along his side. A previously recorded arm-controlled experimental block of 500 center-out and back trials was shown to the monkey while in this posture. The kinematics of this recording were derived from a arm-controlled session from Monkey L. To help keep the monkey engaged in the task, he was rewarded when the computer-controlled cursor acquired and held the target for 500 ms.
Under this experimental context, the neural data recorded during these observation sessions and the previously recorded cursor kinematics served as the training data to build the initial decode model. This resulting model was then run online and used as training data to build the ReFIT-KF decoder. Little to no arm movement was visually noted during both observational blocks and decoding blocks.
Performance of ReFIT-KF based control during these sessions, as measured by the Fitts’ law metric, was roughly equivalent to performance on sessions that initially trained from arm movement data.