Protocol full text hidden due to copyright restrictions
Open the protocol to access the free full text link
>
Chemicals & Drugs
>
Biomedical or Dental Material
>
Polydioxanone
Polydioxanone
Polydioxanone is a biodegradable, synthetic polymer used in medical applications such as absorbable sutures, orthopedic fixation devices, and drug delivery systems.
It has excellent biocompatibility, mechanical strength, and can be tuned to control its degradation rate.
Researchers use polydioxanone to develop innovative treatments and technolgies, but identifying the best protocols from the literature can be challenging.
PubCompare.ai's AI-driven comparisons help optimize polydioxanone research by locating the most effective protocols, enhancing reproducibility and accuracy to ensure your studies are a sucess.
It has excellent biocompatibility, mechanical strength, and can be tuned to control its degradation rate.
Researchers use polydioxanone to develop innovative treatments and technolgies, but identifying the best protocols from the literature can be challenging.
PubCompare.ai's AI-driven comparisons help optimize polydioxanone research by locating the most effective protocols, enhancing reproducibility and accuracy to ensure your studies are a sucess.
Most cited protocols related to «Polydioxanone»
Abdominal Cavity
Abdominal Muscles
Alloderm
Anesthesia
Animals
Animals, Laboratory
Antibiotic Prophylaxis
Aponeurosis
Areola
Biopharmaceuticals
Bladder Detrusor Muscle
Cattle
Cells
Cephalexin
Creativity
Cyanoacrylates
Dermis
Eosin
Euthanasia
Fascia
Feces
Fibrosis
Grafts
Grasp
Hernia
Herniorrhaphy
Homo sapiens
Inflammation
Innovativeness
Ketamine
Light Microscopy
Mesothelium
Microtomy
Operative Surgical Procedures
Paraffin Embedding
Pathologic Neovascularization
Pathologists
Pentobarbital
Pericardium
Peritoneum
Permacol
Pharmaceutical Preparations
Pigs
Polydioxanone
Postoperative Care
Potassium Chloride
Prolene
Sterility, Reproductive
Subcutaneous Fat
Sutures
Swine, Miniature
Telazol
Tissues
Transversus Abdominis
Wall, Abdominal
Woman
Xylazine
Diagnosis
Epistropheus
Polydioxanone
A laparotomy, designed to mimic a sham ventral ovariectomy [13 (link)], was performed under isoflurane/oxygen anesthesia. Following shaving and disinfection, a 1-cm midline incision was made using a scalpel. Muscle layers were closed with polydioxanone suture 5-0 (Vicryl®; Ethicon, Somerville, NJ) and skin edges apposed using tissue glue (Vetbond®; 3M, St. Paul, MN). Rats (n = 6) were tested before, and 1 h, 4 h, 6 h and 12 h post-surgery.
Full text: Click here
Anesthesia
Bladder Detrusor Muscle
Disinfection
Isoflurane
Laparotomy
Operative Surgical Procedures
Ovariectomy
Oxygen
Polydioxanone
Rattus norvegicus
Skin
Sutures
Tissues
Vicryl
Protocol full text hidden due to copyright restrictions
Open the protocol to access the free full text link
Actins
Adipocytes
Adipoq protein, mouse
Albumins
Animals
Antibodies
Ascorbic Acid
Bath
Betadine
Biological Assay
Biological Markers
BLOOD
Brain
Buffers
Caimans
Cells
Centrifugation
Chemiluminescence
Chickens
Cloning Vectors
Clotrimazole
Cold Temperature
Colorimetry
Cre recombinase
Denervation
Deoxyribonuclease I
Diagnosis
Diet
Dissection
DNA, Complementary
Endoribonucleases
Enzyme-Linked Immunosorbent Assay
Ethanol
Euthanasia
Females
Food
Formalin
Freezing
Gene Expression
Genes
Glucose
Groin
growth hormone, bovine
Homozygote
Humidity
Hypothalamus
Immunoglobulins
Immunohistochemistry
Injections, Intraperitoneal
Insulin
Inverted Terminal Repeat
Isoflurane
Leptin
leptin receptor, human
leptin receptor, mouse
Lipids
Liver
Males
Malignant Neoplasms
Marmota
Mice, Inbred C57BL
Mice, Laboratory
Microdissection
MicroRNAs
Microscopy
MK 2206
Nitrocellulose
Obesity
Oligonucleotide Primers
Operative Surgical Procedures
Paraffin
Phosphorus
pitrilysin
Plasmids
Poly A
Polydioxanone
PPARGC1A protein, human
PTEN protein, human
Radioimmunoprecipitation Assay
Receptor, Leptin
Regulatory Elements, Transcriptional
Reverse Transcriptase Polymerase Chain Reaction
Reverse Transcription
RNA Interference
RNA Polymerase II
Saline Solution
Serum
Skin
Surgical Wound
Sutures
SYBR Green I
Sympathectomy
Technique, Dilution
Tissue, Adipose
Tissue, Membrane
Tissues
Transgenes
Triglycerides
UCP1 protein, human
Vertebral Column
Vinculin
Viral Genome
White Adipose Tissue
Mice were placed on a heating pad in the supine position. A 1 cm skin incision was made in the left subcostal area, followed by a 1 cm incision in the peritoneum to expose the liver. Using a cotton swab, the left lobe of the liver was moved outside the body and placed on a nonwoven absorbent fabric sheet for the injection or implantation. After the injection or surgical implantation, the liver was returned within the body, and the abdominal incision was closed in 2 layers with 5-0 polydioxanone absorbable thread (AD Surgical, Sunnyvale, CA, USA).
Full text: Click here
Abdomen
Gossypium
Human Body
Liver
Mice, Laboratory
Operative Surgical Procedures
Ovum Implantation
Peritoneum
Polydioxanone
Skin
Most recents protocols related to «Polydioxanone»
The first suture is a 4-0 poliglecaprone (Monocryl) between point A and the 12 o’clock point of the NAC. The second suture is a 3-0 polydioxanone (PDS II) between points B and C and the 6 o’clock point of the NAC (Fig. 4 D). Superior traction is applied to the ends of the second suture.3 (link),4 (link) This elevates the inferior vertical limb, which is then closed with deep interrupted 3-0 polydioxanone (PDS II) sutures.
The peri-areolar closure is completed with 4-0 poliglecaprone (Monocryl) deep interrupted sutures at the 3 and 9 o’clock positions, followed by four more sutures, halfway between these points. A 3-0 white polyester suture soaked in Betadine is then placed as a buried purse-string suture around the areola, which is then tightened around the areola marker.37 ,38 Placement of the purse-string suture also helps define the length of the vertical scar.
The patients are placed in a seated position. If necessary, tailor tacking is performed on the vertical inferior ellipse and any planned horizontal closure in the IMF. Usually, as the vertical incision is closed, the IMF establishes its own level, and a vertical incision continues onto the abdominal wall (Fig.4 E). Excess subcutaneous fat at the inferior end of the vertical incision can be reduced using liposuction or direct excision. If an IMF horizontal excision is performed, it is closed with deep 3-0 polydioxanone. The primary author prefers to evaluate the breast shape postoperatively performing a delayed horizontal excision after 6 months.
The final closure of the vertical and horizontal incision is completed with deep interrupted and subcuticular 4-0 poliglecaprone. The final periareolar closure is a subcuticular 4-0 poliglecaprone. The closure of the vertical incision is initiated 1 cm below the 6 o’clock position of the areola, to prevent areola creep3 (link) and distortion of the areola. Half-inch Steri strips are applied.
Xeroform gauze is placed on the areola with the nipple exposed, followed by gauze secured with Tegaderm. A soft postsurgical bra (Design Veronique) is applied but is optional.
The peri-areolar closure is completed with 4-0 poliglecaprone (Monocryl) deep interrupted sutures at the 3 and 9 o’clock positions, followed by four more sutures, halfway between these points. A 3-0 white polyester suture soaked in Betadine is then placed as a buried purse-string suture around the areola, which is then tightened around the areola marker.37 ,38 Placement of the purse-string suture also helps define the length of the vertical scar.
The patients are placed in a seated position. If necessary, tailor tacking is performed on the vertical inferior ellipse and any planned horizontal closure in the IMF. Usually, as the vertical incision is closed, the IMF establishes its own level, and a vertical incision continues onto the abdominal wall (Fig.
The final closure of the vertical and horizontal incision is completed with deep interrupted and subcuticular 4-0 poliglecaprone. The final periareolar closure is a subcuticular 4-0 poliglecaprone. The closure of the vertical incision is initiated 1 cm below the 6 o’clock position of the areola, to prevent areola creep3 (link) and distortion of the areola. Half-inch Steri strips are applied.
Xeroform gauze is placed on the areola with the nipple exposed, followed by gauze secured with Tegaderm. A soft postsurgical bra (Design Veronique) is applied but is optional.
Areola
Betadine
Breast
Cicatrix
Monocryl
Nipples
Patients
Polydioxanone
Polyesters
Silene
Sitting
Subcutaneous Fat
Suction Lipectomy
Sutures
Traction
Wall, Abdominal
Xeroform
The tensile strength, breaking elongation, Young’s modulus, and residual strain after 100% deformation of the P(3HB-co-16 mol% 4HB) monofilament sutures (USP 2.5-0), PDS® II (USP 3-0), and Monomax® (USP 2-0) were measured using a tensile testing machine (AGS-50 NX, Shimadzu Corporation, Kyoto, Japan). In the corresponding tests (n = 3), 120-mm-long fibers were fixed using a length of 10 mm above and below, and an assessment was performed at a 100-mm-distance between the chucks of the tensile testing machine using a tensile speed of 10 mm min−1. The residual strain (S100, %) was calculated from the tensile elongation recovery (R100, %) as S100 = 100% − R100. After the suture was stretched to a 100% strain (200 mm, which corresponds to two times the initial length or a 100 mm displacement length), it was contracted by moving the gripper at a constant speed until the pre-stretch length was reached. Assuming that the displacement length at the first time point of the second stretch (which is assumed to approximately equal the end point of the first stretch) is X100 mm, the tensile elongation recovery is given by R100 (%) = 100% × [200 − (X100 + 100)]/100.
In the cycle test (n = 1), both ends (10 mm) of the 120-mm-long suture were gripped, and the suture was stretched to a 50% strain at an initial length (chuck-to-chuck distance) of 100 mm at room temperature (23 °C) using a tensile speed of 20 mm min−1. The gripper was then moved to the original length at the same speed to shrink the suture. This procedure was repeated five times. Error analysis was performed with a confidence interval of 95% (95% CI).
In the cycle test (n = 1), both ends (10 mm) of the 120-mm-long suture were gripped, and the suture was stretched to a 50% strain at an initial length (chuck-to-chuck distance) of 100 mm at room temperature (23 °C) using a tensile speed of 20 mm min−1. The gripper was then moved to the original length at the same speed to shrink the suture. This procedure was repeated five times. Error analysis was performed with a confidence interval of 95% (95% CI).
Full text: Click here
Polydioxanone
S100 Proteins
Strains
Sutures
KSF was used as an index of knot unraveling difficulty28 (link),38 (link). P(3HB-co-16 mol% 4HB) (2.5-0), PDS® II (2-0, 3-0, 4-0), and LACLON® (2-0, 3-0, 4-0) sutures were wound around a 2.9-cm-diameter plastic tube, tightly tied with a surgical knot, and cut at the side opposite the knot to create a single thread. Both sides were attached to a tensile tester and pulled at a rate of 100 mm min−1. Multiple sets of 10 samples were prepared, and if one of the 10 samples had a knot untied, a single nodule was added above the surgical knot until no knot could be untied. KSF was defined as the number of single nodules added until all 10 knots could not be untied, i.e., denotes the number of knots required to maintain adequate ligation. No statistical processing was performed in this experiment.
Full text: Click here
Ligation
Operative Surgical Procedures
Polydioxanone
Sutures
Wounds
Five P(3HB-co-4HB) sutures (USP 2.5-0) and five PDS® II sutures (USP 4-0) were prepared, and their diameters were measured using a dial thickness gauge (Techlock Co., Ltd., SM-1201 L Model, scale interval = 0.001 mm). Measurements were performed in three locations (1/4, 1/2, and 3/4 of the total length), and the average was defined as the thread diameter. Surgical knots were prepared on an artificial skin sheet made of a soft elastomer and tightened using a force of 5 N (Standard Model Digital Force Gauge, ZTS-100 N, IMADA Co., Ltd.). Each knot (five samples in total) was photographed from above using a camera (DP 26, Olympus Co., Ltd.) attached to a stereomicroscope (SZX7, Olympus Co., Ltd.). The knot size (knot perimeter and area) was determined using an image analysis software (cellSens, Olympus Co., Ltd.) (Fig. 4 ) and expressed as the knot area and the knot area/thread diameter ratio. The knot area/thread diameter ratio was processed using the statistical software EZR version 4.0.4 (Saitama Medical Center, Jichi Medical University, Saitama City, Japan). The lack of normality in both groups was tested using the Shapiro–Wilk test. The Mann–Whitney test was then performed between the two groups, and p values of < 0.05 indicated significant differences.
Full text: Click here
allobarbital
Elastomers
Fingers
Operative Surgical Procedures
Perimetry
Polydioxanone
Skin, Artificial
Sutures
All animal procedures were approved by the Centers for Disease Control and Prevention (CDC) Institutional Animal Care and Use Committee. Macaques were housed at CDC under the care of CDC veterinarians in accordance with the Guide for the Care and Use of Laboratory Animals. All procedures were performed under anesthesia and all efforts were made to minimize discomfort including providing appropriate housing conditions, dietary supplements and ample enrichment opportunities.
Female rhesus macaques received subcutaneous injections of CAB ISFI (500 mg/mL) at two different locations in the upper back (0.5–1 mL per site). Briefly, anesthetized animals were placed in ventral recumbency position and the semi-aqueous ISFI suspension loaded in a 3 cc syringe was administered in the subcutaneous space using a 16 G needle. Digital pressure was briefly applied over the administration site after the needle was removed.
To assess the feasibility of implant removal and to measure the drug tail, ISFIs that remained palpable were surgically retrieved from two macaques at week 12 (RA-1097 and RA-1093; 2 implants each) and from one animal at week 14 (RH-42012; 1 implant recovered). Animals were placed in ventral recumbency and the implant locations were confirmed through digital palpation. A surgical scalpel was used to make a single dermal incision (~1 in.) over each implant. The ISFI material was carefully separated from surrounding connective tissue and recovered mostly intact using tweezers. The incision site was visually inspected for abnormalities and subsequently flushed with sterile saline prior to being closed with Polydioxanone Sutures. Animals were monitored weekly by attending vets to assess surgical sites for proper wound healing and to ensure no signs of local infection.
Female rhesus macaques received subcutaneous injections of CAB ISFI (500 mg/mL) at two different locations in the upper back (0.5–1 mL per site). Briefly, anesthetized animals were placed in ventral recumbency position and the semi-aqueous ISFI suspension loaded in a 3 cc syringe was administered in the subcutaneous space using a 16 G needle. Digital pressure was briefly applied over the administration site after the needle was removed.
To assess the feasibility of implant removal and to measure the drug tail, ISFIs that remained palpable were surgically retrieved from two macaques at week 12 (RA-1097 and RA-1093; 2 implants each) and from one animal at week 14 (RH-42012; 1 implant recovered). Animals were placed in ventral recumbency and the implant locations were confirmed through digital palpation. A surgical scalpel was used to make a single dermal incision (~1 in.) over each implant. The ISFI material was carefully separated from surrounding connective tissue and recovered mostly intact using tweezers. The incision site was visually inspected for abnormalities and subsequently flushed with sterile saline prior to being closed with Polydioxanone Sutures. Animals were monitored weekly by attending vets to assess surgical sites for proper wound healing and to ensure no signs of local infection.
Full text: Click here
Anesthesia
Animals
Animals, Laboratory
Congenital Abnormality
Connective Tissue
Dietary Supplements
Fingers
Infection
Institutional Animal Care and Use Committees
Macaca
Macaca mulatta
Needles
Operative Surgical Procedures
Palpation
Pharmaceutical Preparations
Polydioxanone
Pressure
Saline Solution
Sterility, Reproductive
Subcutaneous Injections
Surgical Wound
Sutures
Syringes
Tail
Veterinarian
Woman
Top products related to «Polydioxanone»
Sourced in United States, Sweden, Italy
The PDS II is a laboratory equipment product designed for precision dispensing. It features an adjustable digital display and can be used to accurately measure and dispense a variety of liquids and solutions. The core function of the PDS II is to provide precise volumetric control for various laboratory applications.
Sourced in United States, Germany, Brazil, France, Australia, Italy
Vicryl is a sterile, absorbable surgical suture material composed of a copolymer of glycolic acid and lactic acid. It is designed for use in general soft tissue approximation and/or ligation, including use in ophthalmic procedures.
Sourced in United States, Germany, Sweden
Monocryl is a synthetic, absorbable monofilament suture material used in general soft tissue approximation and/or ligation, including ophthalmic procedures. It is composed of a copolymer of glycolide and e-caprolactone.
Sourced in Germany, United States, United Kingdom, Italy, India, France, Spain, China, Australia, Poland, Sweden, Sao Tome and Principe, Switzerland, Belgium, Denmark, Canada, Macao, Brazil, Portugal, Pakistan, Singapore, Ireland, Czechia, Mexico
Dichloromethane is a clear, colorless, and volatile liquid commonly used as a laboratory solvent. It has a molecular formula of CH2Cl2 and a molar mass of 84.93 g/mol. Dichloromethane is known for its high solvent power and low boiling point, making it suitable for various laboratory applications where a versatile and efficient solvent is required.
Sourced in United States, Germany
3-0 Vicryl is a sterile, absorbable surgical suture made of a copolymer of glycolide and L-lactide. It is designed for use in general soft tissue approximation and/or ligation, including use in ophthalmic procedures.
Sourced in United States, Germany
Prolene is a surgical suture material manufactured by Johnson & Johnson. It is a monofilament, nonabsorbable suture made of polypropylene. Prolene is designed for use in general soft tissue approximation and/or ligation, including use in cardiovascular, ophthalmic, and neurological procedures.
Sourced in Japan
The 3-0 PDS II is a surgical suture product manufactured by Johnson & Johnson. It is a synthetic, absorbable monofilament suture made from polydioxanone. The suture is designed for general soft tissue approximation and/or ligation, including use in ophthalmic, cardiovascular, and neurological procedures.
Sourced in United States, Germany, United Kingdom
Vicryl Plus is a sterile, absorbable surgical suture material. It is composed of a copolymer made from glycolide and lactide, and is coated with an antimicrobial agent, triclosan, to aid in the reduction of surgical site infections.
Sourced in Germany
Diethyl acetate is a colorless, volatile organic compound with a characteristic fruity odor. It is a versatile solvent used in various laboratory applications, including as a reaction medium, extraction agent, and cleaning solvent. Diethyl acetate has a boiling point of approximately 77°C and a density of around 0.902 g/cm³ at 20°C.
Sourced in Germany, France, United States, United Kingdom, Canada, Italy, Brazil, Belgium, Cameroon, Switzerland, Spain, Australia, Ireland, Sweden, Portugal, Netherlands, Austria, Denmark, New Zealand
Rompun is a veterinary drug used as a sedative and analgesic for animals. It contains the active ingredient xylazine hydrochloride. Rompun is designed to induce a state of sedation and pain relief in animals during medical procedures or transportation.
More about "Polydioxanone"
Polydioxanone (PDO) is a versatile, biodegradable polymer that has become increasingly important in the medical field.
This synthetic material is renowned for its excellent biocompatibility, mechanical strength, and the ability to control its degradation rate, making it a popular choice for various applications.
One of the primary uses of PDO is in the creation of absorbable sutures, which are used in surgical procedures.
These sutures made from PDO offer several advantages, including the ability to gradually break down and be absorbed by the body, eliminating the need for removal.
This makes them particularly useful in delicate or hard-to-access areas, such as internal organs or deep tissues.
In addition to sutures, PDO is also utilized in the development of orthopedic fixation devices, such as screws, pins, and plates.
These devices can be used to stabilize broken bones or assist in the healing process of various musculoskeletal injuries.
The biodegradable nature of PDO allows the fixation devices to be gradually absorbed by the body, reducing the need for additional surgical procedures to remove them.
Another innovative application of PDO is in drug delivery systems.
The polymer can be engineered to control the release rate of various therapeutic agents, allowing for sustained and targeted drug delivery.
This is particularly beneficial in the treatment of chronic conditions or for delivering medications to specific areas of the body.
Researchers continue to explore the potential of PDO, constantly working to develop new and improved treatments and technologies.
However, identifying the most effective protocols from the vast body of literature can be a daunting task.
This is where tools like PubCompare.ai's AI-driven comparisons can be invaluable, helping researchers optimize their PDO studies by locating the best protocols and enhancing reproducibility and accuracy.
Whether you're working with PDO, Vicryl, Monocryl, or other related materials, PubCompare.ai can be your go-to resource for streamlining your research and ensuring your studies are a success.
Explore the power of AI-driven protocol comparisons and take your PDO research to new heights.
This synthetic material is renowned for its excellent biocompatibility, mechanical strength, and the ability to control its degradation rate, making it a popular choice for various applications.
One of the primary uses of PDO is in the creation of absorbable sutures, which are used in surgical procedures.
These sutures made from PDO offer several advantages, including the ability to gradually break down and be absorbed by the body, eliminating the need for removal.
This makes them particularly useful in delicate or hard-to-access areas, such as internal organs or deep tissues.
In addition to sutures, PDO is also utilized in the development of orthopedic fixation devices, such as screws, pins, and plates.
These devices can be used to stabilize broken bones or assist in the healing process of various musculoskeletal injuries.
The biodegradable nature of PDO allows the fixation devices to be gradually absorbed by the body, reducing the need for additional surgical procedures to remove them.
Another innovative application of PDO is in drug delivery systems.
The polymer can be engineered to control the release rate of various therapeutic agents, allowing for sustained and targeted drug delivery.
This is particularly beneficial in the treatment of chronic conditions or for delivering medications to specific areas of the body.
Researchers continue to explore the potential of PDO, constantly working to develop new and improved treatments and technologies.
However, identifying the most effective protocols from the vast body of literature can be a daunting task.
This is where tools like PubCompare.ai's AI-driven comparisons can be invaluable, helping researchers optimize their PDO studies by locating the best protocols and enhancing reproducibility and accuracy.
Whether you're working with PDO, Vicryl, Monocryl, or other related materials, PubCompare.ai can be your go-to resource for streamlining your research and ensuring your studies are a success.
Explore the power of AI-driven protocol comparisons and take your PDO research to new heights.