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Ethylene Dichlorides

Ethylene Dichlorides are a class of organic compounds with the chemical formula C2H4Cl2.
They are widely used as solvents, intermediates in chemical synthesis, and in the production of other industrial chemicals.
Ethylene Dichlorides have a variety of applications, including the manufacture of vinyl chloride, the production of agricultural chemicals, and as degreasing agents.
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Most cited protocols related to «Ethylene Dichlorides»

The HMMM membrane patch
was constructed by placing two leaflets of short-tailed lipids at
the interface of water and 1,1-dichloroethane (DCLE), as described
in detail elsewhere.32 (link) The phosphatidylcholine
(PC) headgroup was selected for this study because of its relevance
to membrane composition of eukaryotic cells. The lipids used in the
membrane patch were constructed starting from palmitoyloleoylphosphatidylcholine
(POPC) molecule as a template and shortening its lipid tails to only
five carbons.32 (link) The HMMM membrane was then
assembled by use of Packmol software35 (link) by
constructing a DCLE box, with dimensions of 100 × 100 ×
10 Å3 and containing 5840 molecules of the organic
solvent, and placing 300 short-tailed PC lipids on its large faces,
with 150 lipids in each leaflet. The resulting structure was then
solvated with water by use of the SOLVATE plugin of VMD,36 yielding a system of ∼66 000 atoms.
The solvated membrane mimetic system was energy-minimized for 10 000
steps and simulated for 2 ns, by use of an NPnAT ensemble with constant area, and with a target normal pressure
and temperature of 1.0 atm and 310 K, respectively. A constant area
of 11 236 Å2 (106 × 106 Å2) was employed, yielding an area of ∼75 Å2/lipid (AL), which is ∼8% higher
than the experimental AL for POPC.37 (link) This was done to account for the area of the
membrane that would be occupied by the protein upon its insertion.
On the basis of our experience with several other peripheral proteins,
a mild increase (5–8%) in the area can significantly accelerate
the process. The resulting membrane was employed in all subsequent
simulations of membrane binding and dynamics of CYP3A4.
Publication 2013
1-palmitoyl-2-oleoylphosphatidylcholine Carbon Cytochrome P-450 CYP3A4 Ethylene Dichlorides Eukaryotic Cells Face Lipids Phosphatidylcholines Proteins Tissue, Membrane
Microarray was printed using PCR products prepared from plasmid clones of the NIA 7.4 K clone set (8 (link)) plus other ∼400 mouse oligos. PCR products were generated as described in Tanaka et al. (8 (link)). The PCR products were purified using NucleoFast PCR purification kit from Macherey Nagel (Duren, Germany), concentrated by vacuum centrifugation and redissolved in printing buffer (1 M Betaine, 10% Glycerol, 50 mM NaPO4, pH 7.5) at a concentration of 100 ng/µl. The PCR products were spotted in duplicates on polylysine coated slides using a Virtek SDDC-3 (Bio-Rad Laboratories, CA) equipped with quill-type steel pins (Telechem, Sunnyvale, CA). Spots were printed at a nominal centre-to-centre spacing of 200 µm. Printed slides were baked at 80°C for 2 h and blocked in succinic anhydride and 1,2 dichloroethane as described by Diehl et al. (9 (link)). The number of the print-tips used was 48. Details of the array design can be found on base platform GPL1961.
Publication 2006
2',5'-oligoadenylate Betaine Buffers Centrifugation Clone Cells Ethylene Dichlorides Exanthema Glycerin Microarray Analysis Mus Plasmids Polylysine Steel succinic anhydride Vacuum

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Publication 2014
alum, potassium Bath Cells Centrifugation Chloramphenicol Diffusion Dry Ice Ethylene Dichlorides Gentamicin Helminths Immunogenicity, Vaccine Infection Larva Lucite Mice, House Mus Neck Oxide, Ethylene Parasites Penicillins Range of Motion, Articular Resins, Plant Response, Immune Ring Chromosome 14 Syndrome Saline Solution Secondary Immunization Streptomycin Tissue, Membrane

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Publication 2012
1H NMR 2-hydroxyethyl methacrylate Acetone Acids bis(tert-butoxycarbonyl)oxide Dialysis Dowex Esterification Ethylene Dichlorides Freeze Drying Hydrochloric acid Ion Exchange Methacrylate Molar Resins, Plant Sodium Chloride Sodium Hyaluronate succinic anhydride Sulfoxide, Dimethyl tetrabutylammonium Vertebral Column
The chemical treatments with H-TFSI (0.02 M in 1, 2-dichloroethane), F4TCNQ (0.02 M in dichloromethane), and Magic Blue (0.02 M in dichloromethane) are carried out inside a nitrogen glovebox, and other treatments are carried out in the ambient atmosphere. Methanol is used as a solvent for all ionic salts for comparison. The chemical treatments were achieved by immersing the samples into concentrated solutions of the investigated chemicals (0.02 M) for 40 min.
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Publication 2021
Atmosphere Ethylene Dichlorides Ions Methanol Methylene Chloride Nitrogen Salts Solvents

Most recents protocols related to «Ethylene Dichlorides»

Not available on PMC !

Example 54

To a mixture of 1-methyl-3-{[4-(piperidin-4-yl)phenyl]amino}-5-(1,3-thiazol-2-yl)pyrazin-2-one (24 mg, 0.065 mmol) and 1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperidine-4-carbaldehyde (24 mg, 0.065 mmol) in 1,2-dichloroethane (1.0 mL) was added sodium triacetoxyborohydride (41 mg, 0.20 mmol). After 30 minutes, additional portions of 1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperidine-4-carbaldehyde (24 mg, 0.065 mmol) and sodium triacetoxyborohydride (41 mg, 0.20 mmol) were added. After 30 more minutes, water was added and the mixture was extracted twice with dichloromethane. The combined organic layers were concentrated then purified by preparative TLC eluted with 10% MeOH/DCM to provide 2-(2,6-dioxopiperidin-3-yl)-5-(4-{[4-(4-{[4-methyl-3-oxo-6-(1,3-thiazol-2-yl)pyrazin-2-yl]amino}phenyl)piperidin-1-yl]methyl}piperidin-1-yl)isoindole-1,3-dione (0.017 g, 35%).

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Patent 2024
Anabolism Ethylene Dichlorides Isoindoles Methylene Chloride piperidine Sodium

Example 51

[Figure (not displayed)]
1) Synthesis of Compound 52

[Figure (not displayed)]

In a dry single-necked flask, Compound 36-4 (300 mg), Compound 52-1 (129 mg), sodium carbonate (102 mg), 1,2-dichloroethane (2.1 mL), and water (0.9 mL) were added. After nitrogen purge, dichlorobis(triphenylphosphine)palladium (40 mg) was added, and the resulting mixture was refluxed at 100° C. and reacted for 16 h. The reaction mixture was concentrated, and the residue obtained from the concentration was purified successively by a preparative TLC plate and preparative HPLC method to obtain Compound 52. 1H NMR (400 MHz, CDCl3) δ ppm 9.52-9.55 (m, 1H), 8.93 (d, J=2.89 Hz, 1H), 7.98-8.04 (m, 2H), 7.92 (d, J=0.88 Hz, 1H), 7.86-7.91 (m, 1H), 7.59 (dd, J=9.91, 2.13 Hz, 1H), 6.60 (dd, J=2.89, 1.63 Hz, 1H), 3.20 (q, J=7.53 Hz, 2H), 1.73 (s, 5H), 1.67-1.77 (m, 1H), 1.50 (t, J=7.59 Hz, 3H). LCMS (ESI) m/z: 554 (M+1).

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Patent 2024
1H NMR Anabolism Ethylene Dichlorides High-Performance Liquid Chromatographies Lincomycin Nitrogen Palladium sodium carbonate triphenylphosphine

Example 4

[Figure (not displayed)]

2,2′-(1,2-Bis((E)-3-bromoacryloyl)hydrazine-1,2-diyl)diacetic acid (210 mg, 0.509 mmol) in dichloroethane (15 ml) was added (COCl)2 (505 mg, 4.01 mmol), followed by addition of 0.040 ml of DMF. After stirred at RT for 2 h, the mixture was concentrated and co-evaporated with dichloroethane (2×20 ml) and toluene (2×15 ml) to dryness to afford the title crude product (which is not stable) for the next step without further purification (245 mg, 107% yield). MS ESI m/z calcd for C10H9Br2Cl2N2O4 [M+H]+ 448.82, 450.82, 452.82, 454.82, found 448.60, 450.60, 452.60, 454.60.

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Patent 2024
Acids Anabolism Chlorides Diacetyl Ethylene Dichlorides hydrazine Toluene

Example 50

[Figure (not displayed)]
1) Synthesis of Compound 51

[Figure (not displayed)]

In a dry microwave tube, Compound 36-4 (500 mg), Compound 55-1 (564 mg), sodium carbonate (2M, 800 μL, an aqueous solution), 1,2-dichloroethane (7 mL), and water (3 mL) were added. After nitrogen purge, dichlorobis(triphenylphosphine)palladium (67 mg) was added, and the resulting mixture reacted at 140° C. for 10 min. The reaction mixture was concentrated, and the residue obtained from the concentration was purified successively by a preparative TLC plate and preparative HPLC method to obtain Compound 51. 1H NMR (400 MHz, CDCl3) δ ppm 8.28 (s, 2H), 8.08 (s, 1H), 8.03 (d, J=8.16 Hz, 1H), 7.99 (s, 1H), 7.86 (d, J=8.16 Hz, 1H), 7.51-7.55 (m, 1H), 3.23 (q, J=7.50 Hz, 2H), 1.69 (s, 6H), 1.51 (t, J=7.72 Hz, 3H). LCMS (ESI) m/z: 554 (M+1).

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Patent 2024
1H NMR Anabolism Ethylene Dichlorides High-Performance Liquid Chromatographies Lincomycin Microwaves Nitrogen Palladium sodium carbonate triphenylphosphine

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Publication 2023
Anabolism Argon asperazine cyclopropane Dimerization Ethylene Dichlorides Explosion Flushing naphtha Oxidants perchlorate Phocidae Rubber Salts Solvents Syringes Ultraviolet Rays Vacuum

Top products related to «Ethylene Dichlorides»

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1,2-dichloroethane is a colorless, volatile liquid chemical compound. It has the molecular formula C₂H₄Cl₂. The compound is commonly used as a solvent and an intermediate in the production of other chemicals.
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Chloroform is a colorless, volatile liquid with a characteristic sweet odor. It is a commonly used solvent in a variety of laboratory applications, including extraction, purification, and sample preparation processes. Chloroform has a high density and is immiscible with water, making it a useful solvent for a range of organic compounds.
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1,2-dichloroethane is a colorless, volatile liquid chemical compound. It has the chemical formula C2H4Cl2. The core function of 1,2-dichloroethane is as a solvent and intermediate in chemical synthesis.
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Sulfuric acid is a highly corrosive, colorless, and dense liquid chemical compound. It is widely used in various industrial processes and laboratory settings due to its strong oxidizing properties and ability to act as a dehydrating agent.
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Dichloroethane is a colorless, volatile liquid chemical used as a solvent and intermediate in the production of other chemicals. It has the molecular formula C2H4Cl2.
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1,2-dichloroethane is a colorless, volatile liquid commonly used as a chemical intermediate in industrial applications. It has the molecular formula C2H4Cl2. The core function of 1,2-dichloroethane is to serve as a chemical building block and solvent in various industrial processes.
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N,N-dimethylformamide is a clear, colorless liquid organic compound with the chemical formula (CH3)2NC(O)H. It is a common laboratory solvent used in various chemical reactions and processes.
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Dichloromethane is a clear, colorless, and volatile liquid commonly used as a laboratory solvent. It has a molecular formula of CH2Cl2 and a molar mass of 84.93 g/mol. Dichloromethane is known for its high solvent power and low boiling point, making it suitable for various laboratory applications where a versatile and efficient solvent is required.
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Methanol is a clear, colorless, and flammable liquid that is widely used in various industrial and laboratory applications. It serves as a solvent, fuel, and chemical intermediate. Methanol has a simple chemical formula of CH3OH and a boiling point of 64.7°C. It is a versatile compound that is widely used in the production of other chemicals, as well as in the fuel industry.
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Acetonitrile is a colorless, volatile, flammable liquid. It is a commonly used solvent in various analytical and chemical applications, including liquid chromatography, gas chromatography, and other laboratory procedures. Acetonitrile is known for its high polarity and ability to dissolve a wide range of organic compounds.

More about "Ethylene Dichlorides"

1,2-Dichloroethane, Chloroform, Sulfuric acid, Dichloroethane, N,N-dimethylformamide, Dichloromethane, Methanol, Acetonitrile