The largest database of trusted experimental protocols

Insecticides

Insecticides are chemical substances used to kill or repel insects, a group of arthropod animals that include flies, mosquitoes, moths, beetles, and other pests.
These compounds are widely used in agriculture, public health, and household settings to control insects that damage crops, transmit diseases, or cause other problems.
Insecticides can be derived from natural sources or synthesized in the laboratory, and they work through various mechanisms to disrupt insect physiology and behavior.
Effective insecticide selection and application is crucial for maximizing pest control while minimizing harm to non-target organisms and the environment.
Reserch into new and improved insecticide products and application methods is an active area of study.

Most cited protocols related to «Insecticides»

To construct the Healthcare Access and Quality (HAQ) Index, we first rescaled the log age-standardised risk-standardised death rate by cause to a scale of 0 to 100 such that the highest observed value from 1990 to 2015 was 0 and the lowest was 100. To avoid the effects of fluctuating death rates in small populations on rescaling, we excluded populations less than 1 million population from setting minimum and maximum values. Any location with a cause-specific death rate below the minimum or above the maximum from 1990 to 2015 was set to 100 or 0, respectively.
Because each included cause provided some signal on average levels of personal health-care access and quality, we explored four approaches to construct the HAQ Index: PCA, exploratory factor analysis, arithmetic mean, and geometric mean. Details on these four approaches are in the appendix (pp 7, 8, 21, 22). All four measures were highly correlated, with Spearman's rank order correlations exceeding rs=0·98. We selected the PCA-derived HAQ Index because it provided the strongest correlations with six other currently available cross-country measures of access to care or health-system inputs (table 2). Three indicators came from the GBD Study 2015: health expenditure per capita, hospital beds per 1000, and the UHC tracer intervention index, a composite measure of 11 UHC tracer interventions (four childhood vaccinations; skilled birth attendance; coverage of at least one and four antenatal care visits; met need for family planning with modern contraception; tuberculosis case detection rates; insecticide-treated net coverage; and antiretroviral therapy coverage for populations living with HIV).56 (link) Three indicators came from WHO (physicians, nurses, and midwives per 1000),57 the International Labour Organization,46 and the World Bank (coverage index based on diphtheria-pertussis-tetanus vaccine coverage, coverage of at least four antenatal care visits, and proportion of children with diarrhoea receiving appropriate treatment).45 All indicators had correlation coefficients greater than 0·60, and three exceeded 0·80 (health expenditure per capita, the UHC tracer index, and International Labour Organization formal health coverage).

Correlations between different constructions of the HAQ Index and existing indicators of health-care access or quality

Source and yearGeographies representedHAQ Index construction
PCA weightedEFA weightedGeometric meanMean
Health expenditure per capitaGBD 20151950·8840·8800·8540·864
Hospital beds (per 1000)GBD 20151950·7000·6830·6250·650
UHC tracer index of 11 interventionsGBD 20151880·8260·8200·8120·818
Physicians, nurses, and midwives per 1000WHO 2010730·7690·7550·7250·732
Proportion of population with formal health coverageILO 2010–11930·8080·7980·7730·781
Coverage index of three primary health-care interventionsWorld Bank 20151230·6010·5890·5570·570

The universal health coverage tracer index of 11 interventions included coverage of four childhood vaccinations (BCG, measles, three doses of diphtheria-pertussis-tetanus, and three doses of polio vaccines); skilled birth attendance; coverage of at least one and four antenatal care visits; met need for family planning with modern contraception; tuberculosis case detection rates; insecticide-treated net coverage; and antiretroviral therapy coverage for populations living with HIV. The World Bank coverage index included coverage of three interventions: three doses of diphtheria-pertussis-tetanus vaccine; at least four antenatal care visits; and children with diarrhoea receiving appropriate treatment. HAQ Index=Healthcare Access and Quality Index. PCA=principal components analysis. EFA=exploratory factor analysis. GBD=Global Burden of Disease. UHC=universal health coverage. ILO=International Labour Organization.

The appendix (pp 21, 22) provides final rescaled PCA weights derived from the first five components that collectively accounted for more than 80% of the variance in cause-specific measures. Colon and breast cancer had negative PCA weights, which implied higher death rates were associated with better access and quality of care; because this cannot be true we set these weights to zero in the final PCA-derived HAQ Index. The appendix (p 15) compares each geography's HAQ Index in 2015 with the log of its age-standardised risk-standardised mortality rates.
Full text: Click here
Publication 2017
Care, Prenatal Child Childbirth Colon Contraceptive Methods Diarrhea Head Insecticides Malignant Neoplasm of Breast Measles Midwife Nurses Physicians Poliovirus Vaccines Population Group Primary Health Care Quality of Health Care Tuberculosis Vaccination Vaccination Coverage Vaccine, Diphtheria-Pertussis-Tetanus
The study was conducted in Namawala and Idete villages, located in the Kilombero Valley (8.1°S and 36.6°E) in south-eastern Tanzania (Figure 1). These communities experience hyper endemic malaria transmission [25 (link)], mostly transmitted by large populations of mosquitoes from the Anopheles gambiae sensu lato complex (Diptera: Culicidae) [26 (link),27 ]. In this area, this species complex is represented by two morphologically identical, but behaviourally distinctive, sibling species: A. gambiae sensu stricto (hereafter referred to as A. gambiae) and Anopheles arabiensis. A third, locally important vector species is Anopheles funestus. The ecosystem is dominated by a low lying river valley, 150 km long and up to 40 km wide, which is inter-dispersed with villages and rice farms. Annual flooding occurs during the rainy season (December - May) when large tracts of aquatic habitat suitable for immature mosquitoes are formed.
The epidemiology of malaria in the study villages has been well characterised over the past 15 years [e.g. [21 (link),22 (link),28 (link)-34 (link)]. Extremely high transmission intensities were recorded during the 1990s [21 (link)]. Since 1997, various cost-sharing schemes for subsidizing and promoting bed nets, as well as home insecticide treatment kits have been implemented in an effort to alleviate the malaria burden. The crux of the various programmes has been the generic branding of recommended nets and insecticides products which were sold in line with a price-fixing scheme that reflected a public subsidy (34% of retail value at US $5). To improve access to vulnerable pregnant women and infants, a further subsidy (17% of retail value) was provided through the use of a voucher scheme. The pregnant women and mothers of young children who attended antenatal or immunisation clinics were entitled to a discount voucher.
The initial pilot programme, KINET, distributed bed nets within the Kilombero Valley and achieved remarkably high bed net coverage of all community members [16 (link),22 (link),25 (link),35 (link)-37 (link)]. Although all KINET distributed bed nets were pre-treated with 20 mg/m2 deltamethrin [37 (link)], by 2001, insecticide levels had fallen below 5% and most nets were in poor condition containing many holes [22 (link),38 (link)]. Various national-scale distribution programmes have been implemented, commencing with PSI's Social Marketing of Insecticide Treated Nets (SMITN) programme which was run at a regional-scale during 1998-2000 and a national-scale during 2000-02 and promoted the use of nets and standard insecticide treatment kits (KO Tab, Icon® and Fendona). The sequential programme was SMARTNET from 2002, which the Tanzanian National Voucher Scheme (TNVS) was built upon in 2004. SMARTNET ensured that all bed nets manufactured in Tanzania were co-packaged with longer-lasting insecticide treatment kits, which were registered for use from 2004 onwards (Initially: KO Tab 123, target dose: 25 mg deltamethrin/m2 [39 (link),40 (link)]; and from 2008: Icon® MAXX, target dose: 50 mg lambda-cyhalothrin/m2 [41 ]).
Full text: Click here
Publication 2010
Anopheles Anopheles gambiae Child Cloning Vectors Culicidae decamethrin Diptera Ecosystem Fendona Generic Drugs Infant Insecticides lambda-cyhalothrin Malaria Mothers Oryza sativa Population Group Pregnant Women Rain Rivers SELL protein, human SLC6A2 protein, human Transmission, Communicable Disease Vaccination
We introduced the blend into two experimental huts in which there were single human volunteers sleeping under non-insecticidal bed-nets, such that in each hut, the blend and the human volunteer were positioned four meters apart. Two light traps were set up to collect mosquitoes inside each hut: one of the light traps near the human volunteer, and the other near the blend. In another two experimental huts, we set up a similar arrangement with single human volunteers but without introducing the blend. Instead, a blank unbaited MM-X® was set up at a similar location as in the first two huts, and similarly two light traps were set up in these huts. The volunteers remained in the same huts but the synthetic blend was rotated between the huts every night so as to account for any positional bias on mosquito catches. Again, for each experimental night mosquitoes entering the huts were trapped between 7.00pm and 7.00am. The mosquitoes were sorted into different taxa and counted daily. These experiments were repeated for a total of sixteen nights.
Full text: Click here
Publication 2010
Culicidae Human Volunteers Insecticides Light SLC6A2 protein, human Voluntary Workers

Protocol full text hidden due to copyright restrictions

Open the protocol to access the free full text link

Publication 2015
Antigens Child Ethical Review Insecticides Malaria Parent Safety Thumb Transmission, Communicable Disease Visit, Home Visually Impaired Persons
Household surveys followed completion of the UCC and hang-up campaign in seven districts: two in the Southern zone (Nachingwea and Mtwara Urban), three in the Lake zone (Sengerema, Rorya and Chato) and two in the Coastal zone (Kisarawe and Rufij) (A–C, Figure 2). Surveys in the Southern zone were done in March and April 2011 (middle of the rainy season), in Lake zone in June 2011 (soon after the rainy season), and Coastal zone in October 2011 (dry season). While most of the previous household surveys were conducted in the dry season, evaluation of the UCC was done during different seasons, which can make it difficult to compare data between zones due to seasonality of net hanging. The objective of the surveys was to assess household ITN ownership and use for different age and risk groups. ITN use is defined as the percentage of a given population group that slept under an ITN the night before the survey.
A total of 887, 592 and 580 households were surveyed in the Lake, Southern and Coastal zones, respectively. The zones were selected in line with the sub-national NATNETS surveys for which provision had been made in the NMCP M&E Plan 2008–2013. Districts within a zone were chosen based on the availability of baseline data from the 2008 NATNETS national survey (Marchant T, Bruce J, Nathan R, Mponda H, Sedekia Y, Hanson K: Monitoring and Evaluation of the Tanzanian National Net Strategy, Report on 2008 NATNETS Household, Facility services and Facility users surveys, unpublished). Sampling at district level was done by selecting 10 clusters (villages) with the selection probability proportional to the size of the village. Within each village, one sub-village was chosen using simple random sampling. Afterwards, 30 households were chosen in each selected sub-village by using a modified EPI-type sampling procedure resulting in a total of 300 households per district. Design of the questionnaire was primarily guided by the U5CC household survey tool and focused on household ownership and use of ITNs among different risk groups (under-fives, pregnant women, all household members). As in the standard Malaria Indicator Survey questionnaires, an ITN was defined as: 1) a factory-treated net that does not require any further treatment (LLIN), or 2) any net that has been soaked with insecticide within the past 12 months [14 ]. Additional questions were added to capture several process indicators specific to the UCC (e g, awareness of the UCC or indicators related to the UCC registration and issuing procedure) (Nathan R, Sedekia Y: Monitoring and Evaluation of the Tanzanian National Net Strategy, Universal Coverage Campaign, Household Survey Report- Coastal zone, Lake and Southern zones, unpublished).
An equity ratio, defined as the value for the lowest wealth quintile divided by the value for the highest wealth quintile, was used to assess equity across socio-economic quintiles. Relative wealth was estimated as an index derived from a combination of the household head’s education, housing conditions, asset ownership of the household and whether the house was rented or not. Weights for the variables were derived using principal components analysis, leading to a continuous variable. Households were then divided into quintiles according to the value of their score, ranging from the poorest (quintile 1) to the least poor (quintile 5) [15 (link)].
Full text: Click here
Publication 2013
Awareness Head of Household Households Insecticides Malaria N-methylchlorphentermine Population at Risk Population Group Pregnant Women Rain Sleep

Most recents protocols related to «Insecticides»

Example 5

The effects of AST on P. falciparum transmission to Anopheles gambiae mosquitoes was analyzed. AST was added to 15-day cultured P. falciparum-infected blood at concentrations from 0.1 to 3 μM and fed to An. gambiae using a standard membrane feeding assay (SMFA). The number of oocysts in mosquito midguts was counted on day 7 post-infection. AST completely inhibited malaria transmission at 3 μM (FIG. 4A) suggesting that AST effectively blocks transmission. Most of currently available antimalarial drugs and candidate drugs in clinical development require 5 μM or higher for complete inhibition of P. falciparum transmission in SMFAs. These results demonstrate that AST is at least as effective as current drugs. In contrast, no dead mosquitoes were observed, suggesting that AST has no or little insecticidal activity. The EC50 of AST in blocking the transmission of the sexual-stage P. falciparum to mosquitos, defined as the concentration of a compound that inhibits 50% of infection intensity (the number of oocysts per mosquito) compared to that of the compound-free control, was 0.34 μM.

Advantageously, AST significantly inhibits Plasmodium falciparum transmission to Anopheles gambiae mosquitoes compared to that of PT and MSO (FIG. 4B).

Full text: Click here
Patent 2024
Anopheles gambiae Antimalarials Biological Assay BLOOD Cardiac Arrest Culicidae Infection Insecticides Malaria Oocysts Pharmaceutical Preparations Plasmodium falciparum Psychological Inhibition Tissue, Membrane Transmission, Communicable Disease

Example 32

Etofenprox and β-caryophyllene were tested for efficacy against 3- to 5-day old adult Aedes aegypti. For the following concentrations 3% β-caryophyllene, 0.002 μg/mosquito of etofenprox, and 0.002 μg/mosquito of etofenprox with 3% β-caryophyllene, at 1 hour we obtained 13%, 83%, and 87% knockdown respectively. At 24 hours we obtained 3%, 53%, and 77% mortality respectively. The CO2 control and acetone standard both had 0% knockdown at 1 hour, and 0% mortality at 24 hours. Results are shown in Table 22.

TABLE 22
Efficacy of β-caryophyllene, etofenprox, and a combination of
both against adult, virgin, female Aedes aegypti mosquitoes.
% MORTALITY
ACTIVE INGREDIENTCONCENTRATIONAFTER 24 HRS
β-CARYOPHYLLENE3%77
ETOFENPROX0.002 μg53
OBS.*CALC.**
β-CARYOPHYLLENE + 3% + 0.002 μg9389.19
ETOFENPROX
*Obs. = observed efficacy
**Calc. = efficacy calculated using Colby (1967) formula
Since the actual insecticidal kill rate exceeds the calculated value, then the action of the combination is super-additive or a synergistic effect is present.

Full text: Click here
Patent 2024
Acetone Adult Aedes beta-caryophyllene Culicidae ethofenprox Females Insecticides

Example 31

Etofenprox and farnesene were tested for efficacy against 3- to 5-day old adult Aedes aegypti. For the following concentrations 3% farnesene, 0.002 μg/mosquito of etofenprox, and 0.002 μg/mosquito of etofenprox with 3% farnesene, at 1 hour we obtained 7%, 83%, and 60% knockdown respectively. At 24 hours we obtained 13%, 53%, and 50% mortality respectively. The CO2 control and acetone standard both had 0% knockdown at 1 hour, and 0% mortality at 24 hours. Results are shown in Table 21.

TABLE 21
Efficacy of farnesene, etofenprox, and a combination of both
against adult, virgin, female Aedes aegypti mosquitoes.
% MORTALITY
ACTIVE INGREDIENTCONCENTRATIONAFTER 24 HRS
FARNESENE3%13
ETOFENPROX0.002 μg53
OBS.*CALC.**
FARNESENE + 3% + 0.002 μg5059.11
ETOFENPROX
*Obs. = observed efficacy
**Calc. = efficacy calculated using Colby (1967) formula
Since the calculated insecticidal kill rate exceeds the observed value, then the action of the combination is antagonistic.

Full text: Click here
Patent 2024
Acetone Adult Aedes antagonists Culicidae ethofenprox Farnesenes Females Insecticides

Example 18

Dinotefuran and β-caryophyllene were tested for efficacy against 4- to 6-day old adult Aedes aegypti. For the following concentrations 3% β-caryophyllene, 0.06 μg/mosquito of dinotefuran, and 0.06 μg/mosquito of dinotefuran with 3% β-caryophyllene, at 1 hour we obtained 3%, 50%, and 100% knockdown respectively. At 24 hours we obtained 3%, 47%, and 100% mortality respectively. The CO2 control and acetone standard both had 0% knockdown at 1 hour, and 0% mortality at 24 hours. Results are shown in Table 9.

TABLE 9
Efficacy of β-caryophyllene, dinotefuran, and a combination of
both against adult, virgin, female Aedes aegypti mosquitoes.
% MORTALITY
ACTIVE INGREDIENTCONCENTRATIONAFTER 24 HRS
β-CARYOPHYLLENE3%3
DINOTEFURAN0.06 μg47
OBS.*CALC.**
β-CARYOPHYLLENE + 3% + 0.06 μg10048.59
DINOTEFURAN
*Obs.= observed efficacy
**Calc. = efficacy calculated using Colby (1967) formula
Since the actual insecticidal kill rate exceeds the calculated value, then the action of the combination is super-additive or a synergistic effect is present.

Full text: Click here
Patent 2024
Acetone Adult Aedes beta-caryophyllene Culicidae dinotefuran Females Insecticides

Example 22

Permethrin and linolenic acid were tested for efficacy against 4- to 6-day old adult Aedes aegypti. For the following concentrations 3% linolenic acid, 0.0004 μg/mosquito of permethrin, and 0.0004 μg/mosquito of permethrin with 3% linolenic acid, at 1 hour we obtained 7%, 93%, and 77% knockdown respectively. At 24 hours we obtained 60%, 70%, and 63% mortality respectively. The CO2 control had 0% knockdown at 1 hour, and 0% mortality at 24 hours. The acetone standard had 3% knockdown at 1 hour, and 7% mortality at 24 hours. Results are shown in Table 13.

TABLE 13
Efficacy of linolenic acid, permethrin, and a combination of both
against adult, virgin, female Aedes aegypti mosquitoes.
% MORTALITY
ACTIVE INGREDIENTCONCENTRATIONAFTER 24 HRS
LINOLENIC ACID3%60
PERMETHRIN0.0004 μg70
OBS.*CALC.**
LINOLENIC ACID + 3% + 0.0004 μg6388
PERMETHRIN
*Obs. = observed efficacy
**Calc. = efficacy calculated using Colby (1967) formula
Since the calculated insecticidal kill rate exceeds the observed value, then the action of the combination is antagonistic.

Full text: Click here
Patent 2024
Acetone Adult Aedes antagonists Culicidae Females Insecticides Linolenic Acid Permethrin

Top products related to «Insecticides»

Sourced in United States, Germany, China
Deltamethrin is a laboratory-grade synthetic pyrethroid insecticide. It is used as a standard reference compound in analytical applications, particularly for the detection and quantification of pyrethroids in environmental and food samples.
Sourced in United States, Austria, Japan, Cameroon, Germany, United Kingdom, Canada, Belgium, Israel, Denmark, Australia, New Caledonia, France, Argentina, Sweden, Ireland, India
SAS version 9.4 is a statistical software package. It provides tools for data management, analysis, and reporting. The software is designed to help users extract insights from data and make informed decisions.
Sourced in United States, Germany, United Kingdom, Italy, China, Japan, France, Canada, Sao Tome and Principe, Switzerland, Macao, Poland, Spain, Australia, India, Belgium, Israel, Sweden, Ireland, Denmark, Brazil, Portugal, Panama, Netherlands, Hungary, Czechia, Austria, Norway, Slovakia, Singapore, Argentina, Mexico, Senegal
Triton X-100 is a non-ionic surfactant commonly used in various laboratory applications. It functions as a detergent and solubilizing agent, facilitating the solubilization and extraction of proteins and other biomolecules from biological samples.
Sourced in United States, Germany, United Kingdom, Israel, Canada, Austria, Belgium, Poland, Lao People's Democratic Republic, Japan, China, France, Brazil, New Zealand, Switzerland, Sweden, Australia
GraphPad Prism 5 is a data analysis and graphing software. It provides tools for data organization, statistical analysis, and visual representation of results.
Sourced in United States, Austria, Canada, Belgium, United Kingdom, Germany, China, Japan, Poland, Israel, Switzerland, New Zealand, Australia, Spain, Sweden
Prism 8 is a data analysis and graphing software developed by GraphPad. It is designed for researchers to visualize, analyze, and present scientific data.
Sourced in Germany, United States, United Kingdom, Sweden, China, Sao Tome and Principe, Italy
Imidacloprid is a chemical compound used in laboratory equipment. It functions as an insecticide, targeting the nervous system of insects. The core purpose of Imidacloprid is to provide a means of pest control in controlled laboratory environments.
Sourced in United States, Germany, Switzerland
Permethrin is a synthetic pyrethroid compound commonly used as an insecticide and acaricide. It acts as a contact and stomach poison for a wide range of insects and arthropods. Permethrin is primarily used in agricultural, industrial, and public health applications to control pests.
Sourced in United States, Germany, United Kingdom, China, Italy, Sao Tome and Principe, France, Macao, India, Canada, Switzerland, Japan, Australia, Spain, Poland, Belgium, Brazil, Czechia, Portugal, Austria, Denmark, Israel, Sweden, Ireland, Hungary, Mexico, Netherlands, Singapore, Indonesia, Slovakia, Cameroon, Norway, Thailand, Chile, Finland, Malaysia, Latvia, New Zealand, Hong Kong, Pakistan, Uruguay, Bangladesh
DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
Sourced in Switzerland
Actellic® 300CS is a concentrated suspension formulation containing 300 g/L of the active ingredient pirimiphos-methyl, an organophosphate insecticide. The product is designed for professional use in the control of a variety of insect pests.
Sourced in United States, Austria, Japan, Belgium, United Kingdom, Cameroon, China, Denmark, Canada, Israel, New Caledonia, Germany, Poland, India, France, Ireland, Australia
SAS 9.4 is an integrated software suite for advanced analytics, data management, and business intelligence. It provides a comprehensive platform for data analysis, modeling, and reporting. SAS 9.4 offers a wide range of capabilities, including data manipulation, statistical analysis, predictive modeling, and visual data exploration.

More about "Insecticides"

Insecticides are a crucial tool in agriculture, public health, and household settings, used to control insect pests that damage crops, transmit diseases, or cause other problems.
These chemical substances, which can be derived from natural sources or synthesized in the laboratory, work through various mechanisms to disrupt insect physiology and behavior.
The selection and application of effective insecticides is crucial for maximizing pest control while minimizing harm to non-target organisms and the environment.
Research into new and improved insecticide products and application methods, such as those utilizing compounds like Deltamethrin, Imidacloprid, and Permethrin, is an active area of study.
Effective insecticide research requires accurate and reproducible protocols, which can be enhanced through the use of AI-driven tools like PubCompare.ai.
These innovative comparison tools can help researchers locate the best insecticide protocols from literature, pre-prints, and patents, and identify the most effective products and methods to streamline their research and development efforts.
In addition to chemical insecticides, other tools like SAS version 9.4, GraphPad Prism 5, and Prism 8 software can be utilized to analyze and interpret data from insecticide studies.
The use of surfactants like Triton X-100 and solvents like DMSO can also be important in insecticide formulations and applications.
Overall, the field of insecticide research and development is a dynamic and constantly evolving area, with a focus on balancing effective pest control with environmental and human health considerations.
By leveraging the latest tools and technologies, researchers can strive to enhance the accuracy, reproducibility, and impact of their work in this critical domain.