The cancer risk assessment for benzene, ethylbenzene, styrene, trichloroethylene, and tetrachloroethylene and the non-carcinogenic health risk assessment for all VOCs were performed using the EPA method [24 ,25 ]. After determining the concentration of pollutants, the adjusted air exposure concentration (EC, mg m
−3) was calculated in order to represent the duration of exposure through Equation (1), based on USEPA recommendations [25 ].
where C (mg m
−3) is the concentration of the considered compound in the collected personal air sample; ET (h day
−1) is the exposure time per day; EF (days year
−1) is the exposure frequency per year; ED (years) is the exposure duration; and AT (hours) is the average lifetime (
Table 1).
The hazard quotient (HQ) index was calculated to estimate the potential risk posed by the non-carcinogenic effects of the chemical compounds (Equation (2)). The total hazard quotient (THQ) is the sum of the individual HQs.
where RFC is the reference concentration for inhalation exposure (
Table 2).
The chronic daily intake (CDI) was calculated by:
where BW is the body weight (kg), IR is the inhalation rate (m
3 day
−1), and LT is the lifetime (day) (
Table 1).
If the lifetime risk of cancer (LTCR; Equation (4)) was less than or equal to one in a million (1 × 10
−6), it had no significant effects on human health, so cancer risk was negligible. A LTCR more than 1 × 10
−4 was established as “definite risk,” between 1 × 10
−4 and 1 × 10
−6 as “probable risk,” between 1 × 10
−5 and 1 × 10
−6 as “possible risk,” and less than 1 × 10
−6 as “negligible risk” for human health [27 ]. The cancer slop factor (CSF) for benzene, ethylbenzene, styrene, trichloroethylene, and tetrachloroethylene are shown in
Table 2 [10 (
link)].
Ghobakhloo S., Khoshakhlagh A.H., Morais S, & Mazaheri Tehrani A. (2023). Exposure to Volatile Organic Compounds in Paint Production Plants: Levels and Potential Human Health Risks. Toxics, 11(2), 111.