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Ferumoxytol

Ferumoxytol is a superparamagnetic iron oxide nanoparticle used as a magnetic resonance imaging contrast agent and for the treatment of iron deficiency anemia.
It is composed of a core of iron oxide surronded by a semi-syynthetic carbohydrate coating.
Ferumoxytol has been shown to be effective in visualizing and quantifying various pathological processes, including tumor vascularity, inflammation, and organ perfusion.
It is also used to manage iron deficieny anemia, particularly in patients with chronic kidney disease.
Researchers can leverage PubCompare.ai's AI-driven protocol comparison tool to easily locate and compare Ferumoxytol-related protocols from the literature, preprints, and patents, helping to identify the best approaches for reproducibility and furthering Ferumoxytol research.

Most cited protocols related to «Ferumoxytol»

1
Ferumoxytol-enhanced Longitudinal Mouse MRI
All animal experiments were conducted in accordance with the Northeastern University Division of Laboratory Animal Medicine and Institutional Animal Care and Use Committee The same quadrature 300 MHz, 30 mm Mouse MRI coil was used for all in vivo work (Animal Imaging Research, LLC, Holden, Massachusetts, USA). Healthy anesthetized Swiss Webster mice (n = 5) received a one-time intravenous bolus injection of 0.4–0.8 mg ferumoxytol for a starting blood pool concentration of 100–200 μg/mL (diluted to 4 mg/mL in phosphate-buffered saline) and were imaged longitudinally after injection (0, 2, and 4 h). Precontrast images were also acquired. Given the assumption that blood in mice is about 7% of body weight, for a 50-g mouse an initial yield of 115–230 μg/mL was predicted. This is similar to clinical concentrations where an injection of 510 mg produces a blood concentration of about 100 μg/mL for a total blood volume in the average adult human of 5 L.
A single UTE protocol was used for all images. To establish the UTE protocol, the following parameters were fixed: FOV = 3 × 3 × 3 cm3; matrix mesh size = 200 × 200 × 200; TE = 13 μs; TR = 4 ms; and θ = 20°. TR was slightly higher than the optimal value because of hardware and memory constraints. We analyzed a 50-mL cylindrical phantom filled with 5 mM CuSO4 to determine the k-trajectories for image reconstruction.
Gharagouzloo C.A., McMahon P.N, & Sridhar S. (2014). Quantitative Contrast-Enhanced MRI with Superparamagnetic Nanoparticles Using Ultrashort Time-to-Echo Pulse Sequences. Magnetic resonance in medicine, 74(2), 431-441.
Publication 2014
Adult Animals, Laboratory BLOOD Blood Volume Body Weight Ferumoxytol Institutional Animal Care and Use Committees Memory Mice, House Mouse, Swiss Pharmaceutical Preparations Phosphates Saline Solution
2
Ferumoxytol Relaxivity in Biosamples
To account for any biological variability, a total of six units of fresh (no older than 42 days) human packed red blood cells (RBC) and 12 compatible units of human plasma were obtained from the local blood bank. Six units of plasma were combined to obtain an averaged plasma sample. The residual six units of plasma where mixed with the six units of compatible RBC to reconstitute whole blood.
Ferumoxytol was diluted in 30 mL sample tubes of saline (n=5), human plasma (n=5) and human whole blood (n=5) at five gradually increasing concentrations within the range typically used in clinical imaging (1/2048 [0.26 mM], 1/1024 [0.52 mM], 1/512 [1.05 mM], 1/256 [2.1 mM], 1/128 [4.2 mM]). The 15 sample tubes were sealed and then placed in an MR compatible water bath at 37°C for 20 minutes before imaging in the MR-scanner. To avoid settling of particles or cells, samples were inverted gently every 15–20 minutes.
Knobloch G., Colgan T., Wiens C.N., Wang X., Schubert T., Hernando D., Sharma S.D, & Reeder S. (2018). Relaxivity of ferumoxytol at 1.5T and 3.0T. Investigative radiology, 53(5), 257-263.
Publication 2018
Bath Biopharmaceuticals BLOOD Cells Erythrocytes Ferumoxytol Homo sapiens Plasma Saline Solution
3
Simulating Subvoxel Artery Visualization with Ferumoxytol
With higher concentrations of ferumoxytol, it is expected that the susceptibility of the artery will increase as will its visibility using SWI and QSM. Using simulations, the ability of visualizing subvoxel arteries with different concentrations of ferumoxytol was studied. Magnitude and phase images of 2D cylinders were simulated with B0 = 7T, with TE = 10 ms and 20 ms, FA = 10°, and TR = 24 ms. The dose of ferumoxytol was varied from 0.1 mg/kg to 4 mg/kg, with a step size 0.1 mg/kg. The body weight was assumed to be 60 kg and the blood volume 4700 mL. The main field direction was set to be perpendicular to the long axis of the cylinder. The regions inside and outside the cylinder were assumed to be arterial blood and white matter, respectively. The susceptibility and the T2* of the blood with a certain ferumoxytol concentration were predicted using the relationships found from phantom studies, while the T1 was calculated using the relationship found from literature.25 (link) Subvoxel cylinders were simulated by first creating high resolution data and then cropping the center of k-space, and the radii of the cylinders in the final magnitude and phase images ranged from 0.02 to 0.625 pixels.
Additionally, four voxel aspect ratios (in-plane to through-plane) were simulated, including 1:1, 1:2, 1:4, and 1:8, by collapsing the complex data. Each simulation setting was repeated 10 times with Gaussian noise added, such that the SNR in the magnitude was 10:1 (this matches the SNR measured from the in vivo data collected on Volunteer 3, see Table 1 for the imaging parameters). For generating conventional SWI data, the susceptibility weighting masks were generated using the simulated phase images; for generating tSWI data, susceptibility weighting masks were created using QSM data and multiplied into the magnitude images, following the procedures described in Liu et al12 (link); while for QSM, a truncated k-space division algorithm was used.11 (link) The contrast-to-noise ratios (CNRs) of the cylinder in magnitude, phase, SWI, tSWI, and QSM were measured as
CNR=|sin−sout|/σout where sin and sout are the signal intensities inside and outside the cylinders, and σout is the noise in the background. Then the CNRs were averaged over the 10 independent repetitions. Assuming that the CNR must be at least 3:1 for an artery to be detectable, according to the Rose criterion,26 the minimum diameters of the arteries detected using different types of images were determined for each ferumoxytol concentration.
Liu S., Brisset J.C., Hu J., Haacke E.M, & Ge Y. (2017). Susceptibility Weighted Imaging and Quantitative Susceptibility Mapping of the Cerebral Vasculature Using Ferumoxytol. Journal of magnetic resonance imaging : JMRI, 47(3), 621-633.
Publication 2017
Arteries BLOOD Blood Volume Epistropheus Ferumoxytol Radius Susceptibility, Disease Voluntary Workers White Matter
4
Intravital Imaging of Tumor PD-1 Dynamics
Intravital microscopy was performed in dorsal skin-fold window chambers installed on DPE-GFP or GREAT mice inoculated with MC38-H2B-mApple tumors. Mouse macrophages and/or vasculature were labeled with Pacific Blue ferumoxytol and dextran, respectively. AF647-aPD-1 (200 μg) was delivered i.v. and its tumor distribution was observed using an Olympus FluoView FV1000MPE confocal imaging system (Olympus America), as described previously (44 (link)). Pacific Blue, GFP/YFP, mApple, and AF647 were imaged sequentially using 405, 473, 559, and 635 nm lasers and BA430-455, BA490-540, BA575-620, BA575-675 emission filters with DM473, SDM560, and SDM 640 beam splitters, all sourced from Olympus America. Time lapse images were acquired continually over the first hour following AF647-aPD-1 injection, after which the mice were allowed to recover before subsequent imaging.
Arlauckas S.P., Garris C.S., Kohler R.H., Kitaoka M., Cuccarese M.F., Yang K.S., Miller M.A., Carlson J.C., Freeman G.J., Anthony R.M., Weissleder R, & Pittet M.J. (2017). In vivo imaging reveals a tumor-associated macrophage mediated resistance pathway in anti-PD-1 therapy. Science translational medicine, 9(389), eaal3604.
Publication 2017
Alexa Fluor 647 Dextran Ferumoxytol Intravital Microscopy Macrophage Mus Neoplasms Skin
5
Ferumoxytol Treatment of Biofilms
The biofilms were topically treated twice daily by placing them in 2.8 ml of ferumoxytol (1 mg ml−1) in 0.1 M NaOAc (pH 4.5) or vehicle-control (buffer only) for 10 min as described in Supplementary Fig. 4a. At the end of the experimental period (43 h), the ferumoxytol and vehicle treated biofilms were placed in 2.8 ml of 1% H2O2 or buffer for 5 min. After H2O2 exposure, the biofilms were removed and homogenized by sonication as described above; the sonication procedure provides optimum dispersal and maximum recoverable counts in our biofilm model without killing bacterial cells19 (link). The homogenized suspension was subjected to microbiological and biochemical methods19 (link),27 (link). The total number of viable cells in each of the treated biofilms was determined by colony forming units (CFU), while insoluble extracellular polysaccharides was extracted and quantified using colorimetric assays19 (link),27 (link).
Liu Y., Naha P.C., Hwang G., Kim D., Huang Y., Simon-Soro A., Jung H.I., Ren Z., Li Y., Gubara S., Alawi F., Zero D., Hara A.T., Cormode D.P, & Koo H. (2018). Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity. Nature Communications, 9, 2920.
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Publication 2018
Bacteria Biofilms Buffers Colorimetry Ferumoxytol Peroxide, Hydrogen Polysaccharides

Most recents protocols related to «Ferumoxytol»

1
Multimodal Labeling of Neural Stem Cells
NSCs were labeled using VMI-Trac Duo (Visicell Medical Inc., La Jolla, CA), a proprietary nanoparticle formulation that labels cells with ferumoxytol and a near-infrared (NIR) dye that, according to the manufacturer’s protocol, together enable cell tracking through optical imaging and MRI. Treated cells were washed to remove unincorporated nanoparticles, fixed with 4% paraformaldehyde, and examined by Prussian Blue staining and fluorescence microscopy.
Athertya J.S., Akers J., Sedaghat S., Wei Z., Moazamian D., Dwek S., Thu M, & Jang H. (2023). Detection of iron oxide nanoparticle (IONP)-labeled stem cells using quantitative ultrashort echo time imaging: a feasibility study. Quantitative Imaging in Medicine and Surgery, 13(2), 585-597.
Publication 2023
Cells ferric ferrocyanide Ferumoxytol Microscopy, Fluorescence paraform Trachea
2
Multiparametric MRI for Tumor and Macrophage Imaging
Multiparametric MRI was performed on a 9.4 T horizontal bore small animal NMR scanner (BioSpec 94/ 20 USR, Bruker BioSpin GmbH, Ettlingen, Germany) with a four-channel phased-array surface receiver coil. MR imaging included a standard RARE T2-w and T1-w post-Gd-contrast sequence to monitor tumor volume (T2-w parameters: 2D sequence, 0.078 mm in-plane resolution, TE: 33 ms, TR: 2500 ms, flip angle: 90°, acquisition matrix: 200 × 150, number of averages: 2, slice thickness: 0.7 mm, duration: 2 min 53 s; T1-w parameters: 2D sequence, 0.1 mm in-plane resolution, TE: 6 ms, 1000 TR: ms, flip angle: 90°, acquisition matrix: 256 × 256, number of averages: 2, slice thickness: 0.5 mm, duration: 5 min). Further functional MRI included diffusion tensor imaging (parameters: 2D EPI sequence, 30 diffusion gradient directions, 0.125 mm in-plane resolution, TE: 20 ms, TR: 3400 ms, flip angle: 90°, acquisition matrix: 96 × 96, number of averages: 1, slice thickness: 0.7 mm, duration: 7 min 56 s) and multi-gradient echo imaging (MGE parameters: 3D sequence, 0.1 mm in-plane resolution, TE: 2.57 ms, TR: 73.43 ms, flip angle: 20°, acquisition matrix: 200 × 200, number of averages: 2, slice thickness: 0.1 mm, duration: 22 min 7 s). As contrast agent 0.2 mmol/kg Dotarem (Guerbet) was administered i.v. to assess BBB integrity with T1-w. MGE imaging was used for macrophage tracking using the ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle ferumoxytol (Feraheme; AMAG Pharmaceuticals Inc.). Imaging was performed before and 24 h after ferumoxytol (dose of 30 mg/kg).
For all MRI procedures, animals were anesthetized with 3% isoflurane. Anesthesia was maintained with 1–1.5% isoflurane. Animals were kept on a heating pad to maintain constant body temperature, and respiration was monitored externally during imaging with a breathing surface pad controlled by a LabVIEW program developed in house (National Instruments Corporation).
Turco V., Pfleiderer K., Hunger J., Horvat N.K., Karimian-Jazi K., Schregel K., Fischer M., Brugnara G., Jähne K., Sturm V., Streibel Y., Nguyen D., Altamura S., Agardy D.A., Soni S.S., Alsasa A., Bunse T., Schlesner M., Muckenthaler M.U., Weissleder R., Wick W., Heiland S., Vollmuth P., Bendszus M., Rodell C.B., Breckwoldt M.O, & Platten M. (2023). T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles. Nature Communications, 14, 771.
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Publication 2023
Anesthesia Animals Body Temperature Cell Respiration Contrast Media Diffusion Dotarem ECHO protocol Feraheme ferumoxtran-10 Ferumoxytol fMRI Isoflurane Macrophage Multiparametric Magnetic Resonance Imaging Pharmaceutical Preparations
3
Magnetic Retrieval of Kidney Stone Fragments
Human kidney stone fragments obtained from lithotripsy (calcium phosphate (CaP), calcium oxalate monohydrate (COM), calcium oxalate dihydrate (COD), uric acid, and struvite) were separated by size. Fragments (10–15 mg by dry weight) were rehydrated with normal saline (0.9% NaCl) and incubated with ferumoxytol (AMAG Pharmaceuticals, Waltham, MA) alone or with ferumoxytol and 0.5% chitosan. Low molecular weight chitosan (50,000–190,000 Da, 75–-85% deacetylated) was purchased from Sigma Aldrich and dissolved in 1% v/v acetic acid to a concentration of 0.5% w/v, pH adjusted to pH 4.5, and stored at 4 °C.
Stone fragments incubated with ferumoxytol alone were submerged in 475 µL of normal saline to simulate the aqueous environment of ureteroscopy. Twenty five microliters of ferumoxytol (30 mg iron/mL) was pipetted on top of the stones, avoiding mixing. The stones and ferumoxytol were incubated together at 37 °C for 3 min. The magnetic wire was then inserted into the solution and withdrawn. Any stone fragments which remained attached to the magnetic wire were removed and allowed to air dry for 24 h. The dried fragments were weighed, and the capture efficiency was determined as the dry weight of the captured fragments divided by the starting stone dry weight.
Stone fragments incubated with ferumoxytol, and chitosan were submerged in 425 µL of normal saline at room temperature. Twenty five microliters of 30 mg/mL ferumoxytol was pipetted on top of the stones, avoiding mixing. Immediately after, 50 µL of 0.5% w/v chitosan was pipetted into the layer of ferumoxytol and stone and agitated with the tip of the pipet to form a chitosan-ferumoxytol (CF) hydrogel. Immediately after, the magnetic wire was introduced to retrieve the hydrogel-coated stones. Captured fragments were similarly dried and weighed. In contrast to excess ferumoxytol alone, the excess CF hydrogel was also attracted to the magnetic wire. When calculating capture efficiencies for stones captured with CF hydrogel, 0.9 mg was subtracted from the dry weight to account for the maximum dry weight of the CF hydrogel. n ≥ 3 for all groups.
Magnetic retrieval of kidney stone fragments with larger superparamagnetic nanoparticles and beads. Stone fragments were hydrated by mixing with 50 µL of normal saline. The excess fluid was removed. Twenty five microliters of iron oxide nanoparticles (7 nm: ferumoxytol (30 mg iron/mL) (AMAG Pharmaceuticals, Waltham, MA); 50–100 nm: SuperMag Carboxyl Beads (10 mg/mL) (Ocean NanoTech, San Diego, CA)) or beads (1 µm: DynaBeads MyOne Carboxylic Acid (10 mg/mL) (Thermo Fisher Scientific, Waltham, MA); 3–4.5 µm MonoMag Carboxyl Beads (30 mg/mL) (Ocean NanoTech, San Diego, CA)) at their stock solution was pipetted on top of the stones. The stones were then incubated at 37 °C for 3 min. Four hundred fifty microliters of normal saline was added to the solution. The magnetic wire was then inserted into the solution and withdrawn. Any stone fragments which remained attached to the magnetic wire were removed and allowed to air dry for 24 h. The dried fragments were weighed, and the capture efficiency was determined as the dry weight of the captured fragments divided by the starting stone dry weight.
Ge T.J., Roquero D.M., Holton G.H., Mach K.E., Prado K., Lau H., Jensen K., Chang T.C., Conti S., Sheth K., Wang S.X, & Liao J.C. (2023). A magnetic hydrogel for the efficient retrieval of kidney stone fragments during ureteroscopy. Nature Communications, 14, 3711.
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Publication 2023
Acetic Acid Calcium Oxalate Dihydrate (1:1) calcium phosphate Calculi Carboxylic Acids Chitosan Edema Ferumoxytol Homo sapiens Iron Iron Oxide Nanoparticles Kidney Calculi Lithotripsy Monohydrate, Calcium Oxalate Normal Saline PEGDMA Hydrogel Pharmaceutical Preparations Struvite Ureteroscopy Uric Acid
4
SEM Analysis of Stone Fragments
Stone fragments were captured as described above with either ferumoxytol or CF hydrogel. Dried fragments were mounted with carbon tape onto stainless steel pin studs (Ted Pella Inc., Redding, CA). Samples were coated with Au/Pd (60:40 ratio) or with carbon (15 micron thickness) for energy-dispersive X-ray analysis (EDX), and observed with an Apreo S LoVAC SEM (Thermo Fisher Scientific, Waltham, MA) and Quantax XFlash 6 system (Bruker, Billerica, MA).
Ge T.J., Roquero D.M., Holton G.H., Mach K.E., Prado K., Lau H., Jensen K., Chang T.C., Conti S., Sheth K., Wang S.X, & Liao J.C. (2023). A magnetic hydrogel for the efficient retrieval of kidney stone fragments during ureteroscopy. Nature Communications, 14, 3711.
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Publication 2023
Calculi Carbon Ferumoxytol PEGDMA Hydrogel Radiography Stainless Steel
5
Urothelial Exposure to Biomedical Materials
All studies were done with prior approval from the Stanford University and Palo Alto Veterans Affairs Healthcare Institutional Review Boards. Informed consent was provided by the patients from whom the human samples were obtained from. Human urothelium was obtained from fresh nephrectomy specimens. Nephrectomy specimens with suspicion for urothelial carcinoma were not used. The ureter and renal pelvis were excised and placed on Telfa moistened with normal saline, and flattened with a circular grid to create individual wells. Each area of urothelium was exposed to either PBS (negative control), ferumoxytol, chitosan, or the CF hydrogel, and incubated at 37 °C for 1 or 30 min. The urothelium was then gently rinsed with normal saline and fixed in formalin for 24 h. Tissue samples were embedded in paraffin and stained with hematoxylin & eosin or Prussian blue (Histo-Tec Laboratory, Hayward, CA). Samples were observed with a Keyence BZ-X810 optical microscope (Keyence, Osaka, Japan). Experiments were performed in triplicate.
Ge T.J., Roquero D.M., Holton G.H., Mach K.E., Prado K., Lau H., Jensen K., Chang T.C., Conti S., Sheth K., Wang S.X, & Liao J.C. (2023). A magnetic hydrogel for the efficient retrieval of kidney stone fragments during ureteroscopy. Nature Communications, 14, 3711.
Full text: Click here
Publication 2023
Carcinoma, Transitional Cell Chitosan Eosin Ethics Committees, Research ferric ferrocyanide Ferumoxytol Formalin Homo sapiens Light Microscopy Nephrectomy Normal Saline Paraffin Embedding Patients PEGDMA Hydrogel Pelvis, Renal Tissues Ureter Urothelium Veterans

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Tim trio by Siemens
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The Tim Trio is a versatile laboratory equipment that serves as a temperature-controlled magnetic stirrer. It features three independent stirring positions, allowing simultaneous operation of multiple samples. The device maintains a consistent temperature range to ensure accurate and reliable results during experimental procedures.
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Lsr 2 flow cytometer by BD
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The BD LSR II flow cytometer is a laboratory instrument designed to analyze and sort cells or particles in a fluid sample. It utilizes laser technology to detect and measure various properties of the cells or particles, providing data on their size, granularity, and fluorescent characteristics.
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Accustain iron stain kit by Merck Group
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The Accustain Iron Stain Kit is a laboratory product used for the detection and visualization of iron deposits in biological samples. It provides a simple and reliable method for staining iron-containing compounds, which can be useful in various research and diagnostic applications.
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Gadavist by Bayer
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Gadavist is a gadolinium-based contrast agent used in magnetic resonance imaging (MRI) procedures. It is designed to enhance the visualization of certain structures and abnormalities within the body during the MRI imaging process.
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Magnevist is a gadolinium-based contrast agent used in magnetic resonance imaging (MRI) procedures. It is designed to enhance the visualization of internal body structures and improve the diagnostic capabilities of MRI scans.
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Ferumoxytol by Takeda Pharmaceuticals
Sourced in Japan
Ferumoxytol is an iron-based laboratory reagent used for various applications in research and development. It is a superparamagnetic iron oxide nanoparticle that can be used as a contrast agent for magnetic resonance imaging (MRI) studies or as a tool for cell labeling and tracking. The core function of Ferumoxytol is to provide a means for visualizing and studying biological systems through its magnetic properties.
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Eclipse 2e200u by Nikon
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More about "Ferumoxytol"

Ferumoxytol, a superparamagnetic iron oxide nanoparticle, has emerged as a versatile tool in the field of medical imaging and anemia management.
Commonly referred to as SPION (superparamagnetic iron oxide nanoparticles), this contrast agent is utilized in magnetic resonance imaging (MRI) to visualize and quantify various pathological processes, such as tumor vascularity, inflammation, and organ perfusion.
Beyond its imaging applications, Ferumoxytol is also employed in the treatment of iron deficiency anemia, particularly in patients with chronic kidney disease.
This dual functionality makes Ferumoxytol a valuable resource for healthcare professionals and researchers alike.
To optimize Ferumoxytol research, researchers can leverage the power of AI-driven protocol comparison tools like PubCompare.ai.
This innovative platform allows users to easily locate and compare Ferumoxytol-related protocols from the literature, preprints, and patents, helping to identify the best approaches for reproducibility and advancing Ferumoxytol research.
In the realm of flow cytometry, Ferumoxytol can be used in conjunction with instruments like the BD LSR II flow cytometer and the LEGENDplex™ Human Th Panel (13-plex) with V-bottom Plate and the LEGENDplex™ Human Inflammation Panel (13-plex) to study immune responses and cellular dynamics.
Furthermore, Ferumoxytol research can be supported by complementary tools such as the Accustain Iron Stain Kit, which enables the visualization of iron-containing cells, and the LS25 MACS column, which facilitates the magnetic separation and isolation of Ferumoxytol-labeled cells.
For a more comprehensive understanding of Ferumoxytol, researchers may also explore the properties and applications of other contrast agents like Gadavist and Magnevist, which share some similarities with Ferumoxytol in terms of magnetic resonance imaging.
By leveraging the insights and tools available, researchers can unlock the full potential of Ferumoxytol and drive advancements in medical imaging, anemia management, and beyond.
The Nikon-Eclipse 2E200U microscope, with its high-quality imaging capabilities, can also be employed to visualize and analyze Ferumoxytol-related samples and experiments.
Explore the versatile applications of Ferumoxytol and embark on a journey of discovery with the support of cutting-edge technologies and AI-powered research tools.