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> Chemicals & Drugs > Organic Chemical > 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide

4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide

4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide is a chemical compound with potential therapeutic applications.
It is a derivative of benzamide, containing a benzodioxole and imidazole moiety attached to a pyridine ring.
This molecule has been the subject of research in areas such as medicinal chemistry and drug discovery.
PubCompare.ai can help researchers optimize their studies on this compound by quickly locating and comparing protocols from literature, preprints, and patents to identify the best procedures and products for their needs, ensuring reproducible and accurate results in their research.

Most cited protocols related to «4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide»

1
hESC Differentiation to MS5 Cells
Cited 313 times
hESC cultures were disaggregated using accutase for 20 minutes, washed using hESC media and pre-plated on gelatin for 1 hour at 37°C in the presence of ROCK inhibitor to remove MEFs. The nonadherent hESC were washed and plated on matrigel at a density of 10,000–25,000 cells/cm2 on matrigel (BD) coated dishes in MEF conditioned hESC media (CM) spiked with 10 ng/mL of FGF-2 and ROCK-inhibitor. Ideal cell density was found to be 18,000 cells/cm2. The ROCK inhibitor was withdrawn, and hESC were allowed to expand in CM for 3 days or until they were nearly confluent. The initial differentiation media conditions included knock out serum replacement (KSR) media with 10 nM TGF-b inhibitor (SB431542, Tocris) and 500 ng/mL of Noggin (R&D). Upon day 5 of differentiation, the TGF-b inhibitor was withdrawn and increasing amounts of N2 media (25%, 50%, 75%) was added to the KSR media every two days while maintaining 500 ng/mL of Noggin. For MS5 induction, established methods previously reported were used22 (link).
Chambers S.M., Fasano C.A., Papapetrou E.P., Tomishima M., Sadelain M, & Studer L. (2009). Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nature biotechnology, 27(3), 275-280.
Publication 2009
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide accutase Cells Culture Media, Conditioned FGF10 protein, human Fibroblast Growth Factor 2 Gelatins Human Embryonic Stem Cells Hyperostosis, Diffuse Idiopathic Skeletal matrigel noggin protein Serum Transforming Growth Factor beta
2
Differentiation of Mouse A9 Organoids
Cited 69 times
Mouse A9 ES cells were cultured on Mitomycin C growth inactivated MEFs and passaged according to standard protocols53 . For the generation of mouse organoids, the organoid protocol was applied with the following modifications: cells were trypsinized and 2000 stem cells were plated in each well of an ultra-low binding 96-well plate in differentiation medium as described by Eiraku et al.20 (link) (Medium containing 10uM SB431542 but without Dkk-1). Subsequent steps were followed according to the human organoid method using identical media compositions, with the exception that for mouse tissues faster timing was used according to morphology. EBs were transferred to neural induction medium on day 4, embedded in matrigel droplets on day 6, and on day 9 transferred to the spinning bioreactor.
Lancaster M.A., Renner M., Martin C.A., Wenzel D., Bicknell L.S., Hurles M.E., Homfray T., Penninger J.M., Jackson A.P, & Knoblich J.A. (2013). Cerebral organoids model human brain development and microcephaly. Nature, 501(7467), 10.1038/nature12517.
Publication 2013
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide Bioreactors Cells Embryonic Stem Cells Homo sapiens matrigel Mitomycin Mus Organoids Stem Cells Tissues
3
Neural Induction and Differentiation of hESCs/iPSCs
Cited 66 times
hESCs or iPSCs were isolated from MEFs following dissociation to single cells with Accutase (Innovative Cell Technologies) by a 1 hr pre-plate on gelatin-coated dishes in hESC medium supplemented with 10 ng/ml FGF2 and 10 μM ROCK inhibitor (Calbiochem). The non-adherent pluripotent stem cells were harvested and plated on Matrigel (BD) coated 12-well plates in MEF-conditioned hESC medium with 10 ng/ml FGF2. Once the cell culture reached 95% confluence, neural induction was initiated by changing the culture medium to a culture medium that supports neural induction, neurogenesis and neuronal differentiation (referred to as 3N medium), a 1:1 mixture of N2- and B27-containing media. N2 medium: DMEM/F12, N2 (GIBCO), 5 μg/ml Insulin, 1mM L-Glutamine, 100 μm non-essential amino acids, 100 μM 2-mercaptoethanol, 50 U/ml Penicillin and 50 mg/ml Streptomycin; B27 medium: Neurobasal (Invitrogen), B27 with or without vitamin A (GIBCO), 200 mM Glutamine, 50 U/ml Penicillin and 50 mg/ml Streptomycin. 3N medium was supplemented with either 1 μm Dorsomorphin (Tocris) or 500 ng/ml mouse Noggin-CF chimera (R&D Systems), and 10 μm SB431542 (Tocris) to inhibit TGFβ signaling during neural induction 19 (link). Cells were maintained in this medium for 8-11 days, during which time the efficiency of neural induction was monitored by the appearance of cells with characteristic neuroepithelial cell morphology. Neuroepithelial cells were harvested by dissociation with Dispase and replated in 3N medium including 20 ng/ml FGF2 on poly-ornithine and laminin-coated plastic plates. After a further 2 days, FGF2 was withdrawn to promote differentiation. Cultures were passaged once more with Accutase, replated at 50,000 cells/cm2 on poly-ornithine and laminin-coated plastic plates in 3N medium and maintained for up to 100 days with a medium change every other day.
For quantitative RT-PCR, total RNA was isolated from three cultures at each timepoint (days 5, 10, 15, 20 and 25) (Trizol, Sigma). Total RNA was reverse-transcribed and used for quantitative RT-PCR with primers specific to Foxg1 and Tbr2 using the Applied Biosystems 7000 system. Semi-quantitative RT-PCR with primers for Emx1, Dlx1, Nkx2.1, HoxB4 and Isl1 was carried out according to standard techniques on first strand, random-primed cDNA generated from total RNA extracted from cultures grown in the presence or absence of purmorphamine.
Shi Y., Kirwan P., Smith J., Robinson H.P, & Livesey F.J. (2012). Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses. Nature neuroscience, 15(3), 10.1038/nn.3041.
Publication 2012
2-Mercaptoethanol 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide accutase Amino Acids, Essential Cardiac Arrest Cell Culture Techniques Cells Chimera Culture Media, Conditioned dispase DNA, Complementary dorsomorphin Fibroblast Growth Factor 2 Gelatins Glutamine Human Embryonic Stem Cells Hyperostosis, Diffuse Idiopathic Skeletal Induced Pluripotent Stem Cells Insulin Laminin matrigel Mus Nervousness Neuroepithelial Cells Neurogenesis Neurons NKX2-1 protein, human noggin protein Oligonucleotide Primers Ornithine Penicillins Pluripotent Stem Cells Poly A purmorphamine Reverse Transcriptase Polymerase Chain Reaction Streptomycin Transforming Growth Factor beta trizol Vitamin A
4
Neural Induction of Pluripotent Stem Cells
Cited 65 times
For dissociating intact colonies of pluripotent stem cells from the layer of DR4 feeders, hiPSCs were exposed to a low concentration of dispase (Invitrogen: 17105-041; 0.7 mg/ml) for ~30 min. Suspended colonies were subsequently transferred into ultra-low-attachment 100 mm plastic plates (Corning) in hiPSC medium without FGF2. For the first 24 h (day 0), the medium was supplemented with the ROCK inhibitor Y-27632 (EMD Chemicals). For neural induction, dorsomorphin (also known as compound C; Sigma 10 μM) and SB-431542 (Tocris, 10 μM) were added to the medium for the first five days. On the sixth day in suspension, the floating spheroids were moved to neural medium (NM) containing Neurobasal (Invitrogen: 10888), B-27 serum substitute without vitamin A (Invitrogen: 12587), GlutaMax (Invitrogen, 1:100), 100 U/ml penicillin and 100 μl streptomycin (Invitrogen). The NM was supplemented with 20 ng/ml FGF2 (R&D Systems) and 20 ng/ml EGF (R&D Systems) for 19 days with daily medium change in the first 10 days, and every other day for the subsequent 9 days. To promote differentiation of the neural progenitors into neurons, FGF2 and EGF were replaced with 20 ng/ml BDNF (Peprotech) and 20 ng/ml NT3 (Peprotech) starting at day 25, while from day 43 onwards only NM without growth factors was used for medium changes every four days.
Paşca A.M., Sloan S.A., Clarke L.E., Tian Y., Makinson C.D., Huber N., Kim C.H., Park J.Y., O’Rourke N.A., Nguyen K.D., Smith S.J., Huguenard J.R., Geschwind D.H., Barres B.A, & Paşca S.P. (2015). Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nature methods, 12(7), 671-678.
Publication 2015
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide dispase dorsomorphin Feeder Cell Layers Fibroblast Growth Factor 2 Growth Factor Human Induced Pluripotent Stem Cells Nervousness Neurons Penicillins Pluripotent Stem Cells Serum Streptomycin Vitamin A Y 27632
5
Neural Induction and Nociceptor Differentiation
Cited 58 times
Neural induction was performed as previously reported6 (link). Briefly, cells were rendered to single cells using accutase plated on gelatin for 30 minutes to remove MEFs. Non-adherent cells were collected and plated on matrigel treated dishes at a density of 20-40,000 cells/cm2 (link) in the presence of MEF-conditioned hESC media containing 10 ng/ml FGF-2 and 10 μM Y-27632. Neural differentiation was initiated when the cells were confluent using KSR media containing 820 ml of Knockout DMEM, 150 ml Knockout Serum Replacement, 1 mM L-glutamine, 100 μM MEM non-essential amino acids, and 0.1 mM β-mercaptoethanol. To inhibit SMAD signaling, 100nM LDN-193189 and 10 μM SB431542 were added on days 0 through 5. Cells were fed daily, and N2 media was added in increasing 25% increments every other day starting on day 4 (100% N2 on day 10). Nociceptor induction was initiated with the addition of the three inhibitors 3 μM CHIR99021, 10 μM SU5402, 10 μM DAPT on days 2 through 10. Cell passage to lower density can promote maturation of SOX10+ progenitors, and long-term culture media consisted of N2 containing 25ng/ml human-b-NGF, BDNF, and GDNF.
Chambers S.M., Qi Y., Mica Y., Lee G., Zhang X.J., Niu L., Bilsland J., Cao L., Stevens E., Whiting P., Shi S.H, & Studer L. (2012). Combined small molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nature biotechnology, 30(7), 715-720.
Publication 2012
1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol 2-Mercaptoethanol 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide accutase Amino Acids, Essential Cardiac Arrest Cells Chir 99021 Culture Media Culture Media, Conditioned Fibroblast Growth Factor 2 Gelatins Glial Cell Line-Derived Neurotrophic Factor Glutamine Homo sapiens Human Embryonic Stem Cells Hyperostosis, Diffuse Idiopathic Skeletal inhibitors LDN 193189 matrigel Nervousness Nociceptors Serum SOX10 Transcription Factor SU 5402 Y 27632

Most recents protocols related to «4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide»

1
Differentiation of Excitatory Neurons from iPSCs
The iPSC cultures were maintained in NutriStem hPSC XF Medium (Biological Industries, 01-0005). When iPSCs reached confluency, the cells were differentiated into excitatory neurons on Geltrex (ThermoFisher, A1413202) coated plates. Cells were maintained in N2/B27 media containing 485 mL Neurobasal medium (Life Technologies), 5 mL N2 (Gibco, 17502001), 5 mL Glutamax (ThermoFisher Scientific), 5 mL penicillin–streptomycin), 10 mL B27 supplement (Gibco, 17504044). For the first 7 days, the medium was supplemented with 10 μM SB431542 (Sigma-Aldrich, S4317), 1 μM dorsomorphin (Sigma-Aldrich, P5499) and 100 nM LDN193189 (Sigma-Aldrich, SML0559). On days 8–29, the N2/B27 media was changed daily, without supplementing the media with SB431542, dorsomorphin or LDN193189. On day 30, cells were transitioned in Brainphys Neuronal Medium (Stemcell Technologies, 05790) supplemented with B-27, with media change twice weekly. Methods for differentiation of cerebral organoids and extraction of RNA had been described in our previous studies [19 (link), 20 (link)].
Kathuria A., Lopez-Lengowski K., McPhie D., Cohen B.M, & Karmacharya R. (2023). Disease-specific differences in gene expression, mitochondrial function and mitochondria-endoplasmic reticulum interactions in iPSC-derived cerebral organoids and cortical neurons in schizophrenia and bipolar disorder. Discover Mental Health, 3(1), 8.
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Publication 2023
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide Biopharmaceuticals Cells dorsomorphin Induced Pluripotent Stem Cells LDN 193189 Neurons Organoids Penicillins Stem Cells Streptomycin
2
Differentiation of Excitatory Neurons from iPSCs
The iPSC cultures were maintained in NutriStem hPSC XF Medium (Biological Industries, 01-0005). When iPSCs reached confluency, the cells were differentiated into excitatory neurons on Geltrex (ThermoFisher, A1413202) coated plates. Cells were maintained in N2/B27 media containing 485 mL Neurobasal medium (Life Technologies), 5 mL N2 (Gibco, 17502001), 5 mL Glutamax (ThermoFisher Scientific), 5 mL penicillin–streptomycin), 10 mL B27 supplement (Gibco, 17504044). For the first 7 days, the medium was supplemented with 10 μM SB431542 (Sigma-Aldrich, S4317), 1 μM dorsomorphin (Sigma-Aldrich, P5499) and 100 nM LDN193189 (Sigma-Aldrich, SML0559). On days 8–29, the N2/B27 media was changed daily, without supplementing the media with SB431542, dorsomorphin or LDN193189. On day 30, cells were transitioned in Brainphys Neuronal Medium (Stemcell Technologies, 05790) supplemented with B-27, with media change twice weekly. Methods for differentiation of cerebral organoids and extraction of RNA had been described in our previous studies [19 (link), 20 (link)].
Kathuria A., Lopez-Lengowski K., McPhie D., Cohen B.M, & Karmacharya R. (2023). Disease-specific differences in gene expression, mitochondrial function and mitochondria-endoplasmic reticulum interactions in iPSC-derived cerebral organoids and cortical neurons in schizophrenia and bipolar disorder. Discover Mental Health, 3(1), 8.
Full text: Click here
Publication 2023
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide Biopharmaceuticals Cells dorsomorphin Induced Pluripotent Stem Cells LDN 193189 Neurons Organoids Penicillins Stem Cells Streptomycin
3
Structure-Based Molecular Docking of OVA with SARS-CoV-2 and TGF-β Receptors

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Publication 2023
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide Binding Sites inhibitors Ligands Phosphotransferases Proteins Radius SARS-CoV-2 TGFBR2 protein, human Transforming Growth Factor-beta Type II Receptor
4
Ovatodiolide's Anti-Fibrotic Potential

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Publication 2023
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide Bleomycin Dexamethasone epigallocatechin gallate GS-5734 Homo sapiens ovatodiolide remdesivir Sulfoxide, Dimethyl TGF-beta1 TGFB1 protein, human
5
Cryopreserved Hepatocyte Expansion Protocol
The cryopreserved human hepatocytes were plated on collagen type I-coated (Rat-tail collagen type I, Gibco) plate at a density of 1 × 105/cm2 in a modified liver expansion medium containing William’s E Medium supplemented with 2% B27 (without VA), 1% PS (All from Invitrogen), 50 ng/mL EGF, 20 ng/mL HGF (Both from Peprotech), 200 μM 2-phospho-L-ascorbic acid (pVc), 3 μM CHIR99021, 5 μM SB431542, 5 μM Lysophosphatidic acid (LPA), 0.5 μM Sphingosine-1-phosphate (S1P) (All from MCE), and 1% fetal bovine serum (FBS) (Gibco, US). After seeding for 7–10 days, expanded cells were passaged at a ratio of 1:2 after dissociation with Accutase (eBioscience). The expansion medium was changed every day. Hepatocyte donor information is shown in Table 1.
Shi J., Li G., Yuan X., Wang Y., Gong M., Li C., Ge X, & Lu S. (2023). Exploration and verification of COVID-19-related hub genes in liver physiological and pathological regeneration. Frontiers in Bioengineering and Biotechnology, 11, 1135997.
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Publication 2023
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide accutase Ascorbic Acid Cells Chir 99021 Collagen Type I Fetal Bovine Serum Hepatocyte Homo sapiens Liver lysophosphatidic acid sphingosine 1-phosphate Tail Tissue Donors

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2
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Sb431542 by Selleck Chemicals
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SB431542 is a small molecule inhibitor that selectively targets the transforming growth factor-beta (TGF-β) superfamily type I activin receptor-like kinases (ALK4, ALK5, and ALK7). It blocks the phosphorylation of SMAD2 and SMAD3, which are key mediators of the TGF-β signaling pathway.
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DMEM/F12 is a cell culture medium developed by Thermo Fisher Scientific. It is a balanced salt solution that provides nutrients and growth factors essential for the cultivation of a variety of cell types, including adherent and suspension cells. The medium is formulated to support the proliferation and maintenance of cells in vitro.
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More about "4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"

4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide, also known as BDB or benzodioxolbenzamide, is a chemical compound with promising therapeutic applications.
It is a derivative of benzamide, containing a benzodioxole and imidazole moiety attached to a pyridine ring.
This versatile molecule has been extensively studied in the fields of medicinal chemistry and drug discovery.
In addition to its primary structure, 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide shares similarities with other notable compounds, such as SB431542, a potent and selective inhibitor of the TGF-beta superfamily type I activin receptor-like kinases (ALK4, ALK5, and ALK7).
Similarly, the compound may interact with cell culture media components like DMEM/F12, GlutaMAX, Penicillin/streptomycin, FBS, N2 supplement, B27 supplement, and Non-essential amino acids, which are commonly used in research involving this molecule.
Researchers can optimize their studies on 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide by utilizing PubCompare.ai, an AI-driven platform that helps locate and compare protocols from literature, preprints, and patents.
This ensures reproducible and accruate results, leading to breakthroughs in the development of novel therapies based on this promising compound.