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4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate

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Most cited protocols related to «4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate»

Work on the Brain Imaging Data Structure began at a meeting of the INCF Neuroimaging Data Sharing Task Force (wiki.incf.org/mediawiki/index.php/Neuroimaging_Task_Force) held at Stanford University on January 27–30th 2015. While a flexible solution using the PROV W3C model (http://www.w3.org/TR/prov-overview/) was first investigated, it was acknowledged that this technology would be only viable if tools were in place to write the associated metadata. Since experimental data are obtained from multiple tools, a solution accessible to most neuroimaging researchers was designed. An initial draft was heavily inspired by the data structure used by the OpenfMRI database, but soon evolved beyond backward compatibility. After the initial draft was formed, a series of discussions and public calls for feedback were conducted. Feedback was solicited over Twitter, by presenting BIDS and distributing informational pamphlets at conferences (INCF, SfN), as well as by sending emails to SPM, FSL, Freesurfer, MRTrix, Slicer, Nipy, and HCP mailing lists (reaching over 5,000 researchers). Further refinement of the standard was facilitated by a meeting held during the OHBM conference in Honolulu in June 2015. The discussion over the standard involved domain researchers, computer scientists, MRI physicists, methods developers (FSL, SPM, Slicer, Nipy, PyMVPA, C-PAC, nilearn and aa), data curators (OpenfMRI, FCP/INDI, HCP, NKI, SchizConnect, ABIDE, DataLad, and BIRN) and database developers (COINS, LORIS, XNAT, NiDB and SciTran). The first Release Candidate was published on September 21st 2015 along with 22 example datasets, online and command line validation tools (https://github.com/INCF/bids-validator), and a converter from OpenfMRI standard (https://github.com/INCF/openfmri2bids). The standard became official (version 1.0.0) with the publication of this manuscript and we expect to update and extend it through future releases (see Supplementary File 1). We encourage everyone to provide feedback on the standard as well as suggestion for new features and support for more data types. Proposed changes will be discussed publicly trying to accommodate the needs of the community. To facilitate this process we have created the http://bids.neuroimaging.io website.
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Publication 2016
4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate ARID1A protein, human Brain Conferences Genus Loris indicine-N-oxide Patient Discharge
MRIQC is an open-source project, developed under the following software engineering principles. 1) Modularity and integrability: MRIQC implements a nipype [23 ] workflow (see Fig 4) to integrate modular sub-workflows that rely upon third party software toolboxes such as FSL [24 (link)], ANTs [25 ] and AFNI [26 (link)]. 2) Minimal preprocessing: the workflow should be as minimal as possible to estimate the IQMs. 3) Interoperability and standards: MRIQC is compatible with input data formatted according to the Brain Imaging Data Structure (BIDS, [27 (link)]) standard, and the software itself follows the BIDS Apps [28 (link)] standard. For more information on how to convert data to BIDS and run MRIQC, see Blocks 3 and 4 in S1 File respectively. 4) Reliability and robustness: the software undergoes frequent vetting sprints by testing its robustness against data variability (acquisition parameters, physiological differences, etc.) using images from the OpenfMRI resource. Reliability is checked and tracked with a continuous integration service.
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Publication 2017
4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate Ants Brain CTSB protein, human physiology
To kickstart the repository of BIDS Apps, a four-day long coding sprint was organized at Stanford University in August 2016. Leading neuroimaging methods and workflow developers were invited to learn about BIDS, Docker, and Singularity. In addition, the sprint was advertised on the Stanford Center for Reproducible Neuroscience and Twitter, and outreach was performed during the 2016 OHBM Meeting in Geneva. The workshop consisted of one day of training; during the remaining three days, hands-on support was provided by experienced Docker developers.
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Publication 2017
4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate CTSB protein, human Maritally Unattached
To reach young adults who had smoked recently, we paid for advertising using Facebook’s Advertising (Ad) program over 13 months from 2010 Feb 28 to 2011 Apr 4. Our campaign involved creating advertisements that appeared on the pages of our target audience meeting the criteria of age (18-25), location (United States or California), language (English), and tobacco- and/or marijuana-related keywords that appeared in their Facebook profiles through listed interests, activities, education and job titles, pages they like, or groups to which they belong (eg, “cigarette,” “nicotine,” “blunt,” “420”). At the time of this campaign, this was the only way Facebook ad could be targeted (ie, there was no way to target keywords to other areas of the Facebook profile). Facebook had to approve all ads based on the company’s guidelines [15 ]. Only one ad type was available to advertisers at the time the campaign was launched. Ads included a short (eg, 2-word) headline, a picture, and a link to the study’s survey website per Facebook’s advertising size and word-count specifications. Facebook rejected an ad that targeted both tobacco and marijuana users through pictures. Therefore that ad made no impressions. We incurred a charge every time a user clicked on one of our ads.
On a daily basis, we could specify a spending limit for each ad and for the entire campaign. We, like other advertisers, could then specify the maximum amount we would be willing to pay for an ad (a “bid”). Then auctions determined the likelihood a given ad would be shown on pages of the target audience. Selection criteria included bid (the amount an advertiser is willing to pay), quality of an ad (including feedback an ad has received from users), and past performance [16 ]. For a given ad, Facebook suggests a “bid range” based on how much other advertisers would be willing to pay to reach the same target audience. This range can change over time based on both the ad space (other ads in the pool of ads) or an ad’s performance. Our bids fluctuated over time in line with the bid range for a given ad. Facebook reports statistics on bids, impressions, clicks, and dollars spent on all ads in a campaign. Impressions are defined as a single time an ad is shown to a user, regardless of whether the user clicks on the ad. Clicks are when a user clicks a link in an ad. We used the Facebook-provided statistics indicating the success of each advertisement we ran and changed or stopped ads that were unsuccessful (ie, they rarely appeared, they received too few clicks, or they were too expensive). As such, we explored various picture and text options and determined the most successful ads based on impressions, clicks, and costs. Facebook, which normally restricts the reporting of its data, gave us permission, conveyed to our university’s legal counsel, to publish these statistics.
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Publication 2012
4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate Cannabis sativa Nicotine Tobacco Products Young Adult

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Publication 2014
4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate Adult Character Ethanol Ethnicity Friend Nicotine Pharmaceutical Preparations Tobacco Products Woman Young Adult

Most recents protocols related to «4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate»

The costs of implementing each treatment were derived the perspective of Chinese healthcare system. All cost data were inflated to 2022, shown as 2022 US dollars (1 USD = 6.36 Chinese Yuan). We considered only direct medical costs, including drug costs, follow-up costs, monitoring costs, death costs, and costs for treatment of adverse reactions (AEs). Drug prices were obtained from the latest local public bid-winning price or public databases (41 –43 ). The prices of camrelizumab used in first-line or tislelizumab used in second-line were assumed to be the same as other indications of them which have entered the NRDL, considering the newly approved indication of sq-NSCLC would likely to be included in the list and the price is the same for all indications of the same drug in the NRDL. Prices for paclitaxel and gemcitabine were from the fifth batch of bids for centralized drug procurement of drugs in China in 2021 (41 –43 ). Because carboplatin, cisplatin, paclitaxel, docetaxel, and nedaplatin have multiple dosage forms in the Chinese market, we chose the commonly used dosage combination under the principle of minimizing cost. Follow-up costs and monitoring costs were derived from the healthcare documents (44 ), which included CT examination, blood test, urinalysis, and blood biochemical examination, as wells as diagnosis fee, injection fee, nursing fee, and bed fee. Costs of BSC and end-of-life were extracted from published literature. We considered only severe AEs (≥grade 3) with rates >5%. AE related treatment costs and durations of AE were extracted from published articles. All AEs were assumed to occur during the first cycle (45 (link)). Details are listed in Table 1.
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Publication 2023
4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate BLOOD camrelizumab Carboplatin Chinese Cisplatin Diagnosis Docetaxel Gemcitabine Hematologic Tests nedaplatin Non-Small Cell Lung Carcinoma Paclitaxel Pharmaceutical Preparations tislelizumab Urinalysis
This study used the CVM to estimate the WTP for building a UFP monitoring and reporting system, to evaluate the economic value of UFP information. The CVM has been widely used for economic valuation of non-market goods, especially environmental goods, and consumer perception analysis (Harrison 1992 (link); Han et al. 2011 (link); Mwebaze et al. 2018 (link)). To estimate the WTP for non-market goods using the CVM, it is important to design a questionnaire that facilitates respondents’ comprehension of issues and obtains their WTP information. Generally, payment card, open-ended, and dichotomous choice (DC) formats are employed to elicit respondents’ WTP data through the CVM. In the DC format, pre-set bids are presented to the respondents with a “Yes” or “No” choice, and econometric analysis—the probit or logit model—is used to estimate the WTP. We designed the questionnaire using the DC format because of its following strengths: easy to answer, low biases, and low likelihood of estimating unreliable WTP (Hanemann 1984 (link); Oerlemans et al. 2016 (link)).
The DC format is divided into the single-bounded dichotomous choice (SBDC) that asks a single bid (Bishop and Heberlein 1979 (link)), and the double-bounded dichotomous choice (DBDC) that asks once more for double or half of the first bid, depending on the respondent’s first answer (Hanemann 1985 (link)). The SBDC is convenient because it asks each respondent only one bid; however, it has the disadvantage of being statistically inefficient. The DBDC, in contrast, has high efficiency, but one disadvantage: the responses of the first and second bids may not be consistent (Cameron and Quiggin 1994 (link); DeShazo 2002 (link)). Respondents are likely to accept or reject the second bid, regardless of their actual WTP, out of guilt for unwillingness to pay for the second bid, which is lower than the first bid, or out of repulsion that the interviewer is trying to make at least some money by offering a lower bid. To overcome SBDC’s inefficiency and DBDC’s bias, Cooper et al. (2002 (link)) suggested the one-and-one-half-bounded dichotomous choice (OOHBDC). OOHBDC divides respondents into two groups and randomly presents an initial lower bid to one group and an initial upper bid to the other group. If respondents answer “No” to the lower bid or “Yes” to the upper bid, the survey ends. However, if they answer “Yes” to the lower bid, then the upper bid is presented as the second bid, and if they answer “No” to the upper bid, then the lower bid is presented as the second bid. This study used the OOHBDC method to reduce SBDC’s inefficiency and DBDC’s bias. In the OOHBDC method, if respondents answer “No” to the lower bid or “No–No” to the upper bid, then their WTP may be zero or between zero and the lower bid. It is important to identify whether the respondent’s WTP is actually zero or between zero and the lower bid, so as to estimate their accurate WTP; we used the spike model to solve this problem (Kriström 1997 (link)). The OOHBDC spike model asks an additional question if respondents answer “No” to the lower bid or “No–No” to the upper bid: “Are you willing to pay at least KRW 1 each year for the next 5 years from the income tax paid by your household to build the UFP monitoring and reporting system?” Fig. 1 shows the structure of the OOHBDC spike format and its possible responses.

The structure of the OOHBDC spike format and possible responses

Publication 2023
4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate dibenzyldithiocarbamate Disgust Guilt Households Interviewers
This study applied the utility difference model suggested by Hanemann (1984 (link)) to estimate the WTP using the OOHBDC spike model. Each respondent has the indirect utility function j,m;S , where j is the status of the UFP monitoring and reporting system: when j is equal to 1, it means the UFP monitoring and reporting system is presented; otherwise j is 0. m is the respondent’s income, and S is the vector of respondent’s socio-economic and cognition characteristics. The indirect utility function can be expressed as the observable deterministic part, vj,m;S , and unobservable stochastic part, εj , as follows: uj,m;S=vj,m;S+εj where εj is an independently and identically distributed (i.i.d.) variable with a zero mean.
When the respondent answers “Yes” to the question “Are you willing to pay A to build the UFPs monitoring and reporting system?,” to maximize his/her utility, the probability of answering “Yes” is expressed as follows: Pr{yes=Pr{Δv(A)η}Fη[Δv(A)] where η is the difference of error terms, ε0-ε1 , and Fη· is the cumulative distribution function (CDF) of η . Meanwhile, if the WTP (denoted as W ) of the respondent is greater than or equal to A , the respondent will answer “Yes,” otherwise “No.” The probability that respondent answers “Yes” can also be expressed as follows: Pr{yes}=Pr{WA}1-GW(A) where GW(A) is CDF of W . When we consider Eqs. (2) and (3) together, we can derive 1-GW(A)Fη[Δv(A)] .
We assume that Ai is an initial bid presented to the respondent i , and AiL and AiU represent lower and upper initial bids, respectively. There are eight possible outcomes in the OOHBDC spike model: IAiU=IiY=1respondentsianswersyes,whereAiU<W<IiNY=1respondentsianswersNo-Yes,whereAiL<W<AiUIiNNY=1respondentsianswersNo-Yes-No,where0<W<AiLIiNNN=1respondentsianswersNo-No-No,whereW=0, and IAiL=IiYY=1(respondentsianswersYes-Yes),whereAiU<W<IiYN=1respondentsianswersYes-No,whereAiL<W<AiUIiNY=1respondentsianswersNo-Yes,where0<W<AiLIiNN=1respondensianswersNo-No,whereW=0, where the indicator function I(·) has a value of 1 if the proposition is true; otherwise, it is 0. Using eight indicator functions, the log-likelihood function for the OOHBDC spike model is expressed as follows: lnL=i=1NIiY+IiYYln1-GWAiU+IiYN+IiNYln[GW(AiU)-GW(AiL)]+IiNNY+IiNYlnGWAiL-GW0+IiNNN+IiNNln[GW(0)]
Assuming that the respondent’s WTP has a logistic CDF, the spike model of GW(A) with parameter a , b is: GWA=[1+exp(a-bA)]-1ifA>0[1+exp(a)]-1ifA=00ifA<0
Here, the spike is defined as [1+expa]-1 , and the mean WTP is calculated as 1bln[1+exp(a)] .
Publication 2023
4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate Cloning Vectors Cognition
Successful digital tool design requires a user-centred process from concept through to design, development, quality testing, implementation, and adoption, and frequently fails when established practices are not used [68 ]. eHealth technologies designed and developed based on assumptions about end-user motivations, goals and needs are often less effective than those that engage end-users throughout the process [68 ]. To optimize the relevance of the Playbook, we will employ a ‘user-centric’ approach in which end-users are central to the design process at each design phase and will allow for iterative modifications on content and functionality that meet user needs best. A ‘user-centric’ approach is paramount for user engagement with the tool and its effectiveness [68 ]. Collaborators, Pivot Design Group, were selected from three vendor bids to lead the design and development work.
The design phase will use discovery phase outputs on personas to sketch, ideate, visualize, and prototype the concept into life. First, we will outline the information architecture and sitemap from user personas, beginning with a series of task flows. Each task flow, or user flow, will be refined to outline the basic user experience and further flesh out the interaction design, from sketches through to wireframes, that outline the priority of information, content hierarchy and key content formats. Wireframes strategically filter the content in a format that considers how users interact with the content on the screen (no visual design, only black and white “blueprints” at this point). Next, we will create a mood board that captures the overall look and feel of the visual user interface and iterate through graphic layouts to come to a design that suits users’ priorities and contexts. All team members and collaborators will be involved and influence this process through discussion meetings guided by Pivot Design Group, which will seek end-user input on tool functionality, task flows, and visual display.
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Publication 2023
4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate Feelings Fingers Mood Motivation Telehealth
We were unable to obtain specific utility values for the patients with PFS and PD status. We used data from previously published studies as the health utility of BTCs patients in PFS and PD states (0.76 for PFS and 0.68 for PD) (31 (link)). To simplify the calculation, Grade 3 or higher adverse events (≥3 AEs) with the highest incidence difference between the durvalumab plus GP and GP groups were selected. Costs were converted based on 2021 US dollar exchange rates (USD 1.0 = CNY 6.34). We only consider the direct costs associated with medication, follow-up treatment, administration, laboratory tests and major ≥3 AEs according to the TOPAZ-1 trial. We obtained the latest prices of the drugs involved in the study through the sales prices of local hospitals or by consulting local drug suppliers. The upper and lower price limits of the drugs were determined by referring to all winning bids on the national pharmaceutical data platform (www.yaozh.com). For advanced BTCs, according to China's National Basic Medical Insurance, Industrial injury insurance and maternity insurance drug catalog (32 ), durvalumab could not be covered to partially reduce patient payments. We present the prices of the relevant drugs as costs both before and after health insurance coverage in Table 1. Except for the cost of ≥3 AEs as a one-time cost input model, the costs were calculated based on the dose used in the clinical trial and on a three-week cycle. As some of the costs referred to previously published literature, we used the consumer price index (CPI) inflation calculator to adjust these costs to 2022 prices (38 ).
The drug dose was based on actual clinical trials. In the GP plus durvalumab group, the patients received 1,500 mg of durvalumab and gemcitabine (1,000 mg/m2) and cisplatin (25 mg/m2) once every 3 weeks. In the control group, the patients received gemcitabine (1,000 mg/m2) and cisplatin (25 mg/m2) once every 3 weeks. According to a report on the status of Chinese residents' nutrition and chronic diseases in 2020, the average weight of the adult Chinese population was 64.8 kg (39 ). However, considering the long progression of BTCs, most patients are likely to be middle-aged and older adults, and in the advanced stage of the disease, patients are likely to suffer from weight loss and other discomforts. Therefore, we assumed that the average weight of patients was 60 kg. The weight set would be used to calculate the drug dose per cycle for durvalumab. A total of 42.5% of patients in the durvalumab plus GP group and 49.4% in the GP group received subsequent treatments.
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Publication 2023
3-(2-aminoethyl)-8-(3-(4-fluorobenzoyl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro(4.5)decan-4-one 4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate Adult Aged BTC protein, human Chinese Cisplatin Disease, Chronic Disease Progression durvalumab Gemcitabine Health Insurance Injuries Patients Pharmaceutical Preparations Topaz resin

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More about "4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate"

4-benzamido-4'-isothiocyanostilbene-2,2'-disulfonate (BIDS) is a chemical compound with potential research applications in various fields.
This compound, also known as BISDS or 4-BIDS, has garnered attention due to its unique properties and potential uses.
BIDS is a stilbene derivative with a benzamido group and an isothiocyanate functional group, as well as two sulfonate groups.
It has been studied for its potential applications in areas such as biochemistry, molecular biology, and pharmaceuticals.
BIDS has been used as a fluorescent label or probe in techniques like Prisma scanner, SPM12, MP150, and ML206 analysis, owing to its ability to interact with specific biomolecules or cellular structures.
Researchers have explored the use of BIDS in MATLAB-based data analysis, often in conjunction with a 64-channel receiver head coil and ActiCAP setup for advanced neuroimaging studies conducted using a 3T MRI scanner.
The compound has also been utilized in cell-based assays, such as those employing the Cytofix/Cytoperm kit, to investigate intracellular processes and mechanisms.
Additionally, BIDS has been studied for its potential therapeutic applications, with researchers using SPSS Statistics 25 to analyze the compound's effects on various biological systems.
The versatility of BIDS makes it an important tool in the fields of biochemistry, drug discovery, and biomedical research, and the optimization of its use can lead to advancements in these areas.