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A 274

A 274 is a chemical compound that has been the subject of extensive research in the field of biological sciences.
This compound is believed to have potential applications in various areas, including drug development, biomedical engineering, and environmental remediation.
The PubCompare.ai platform provides researchers with a powerful tool to efficiently locate and evaluate the most effective protocols from academic literature, preprints, and patents related to A 274 research.
Leveraging cutting-edge AI technology, the platform compares and identifies the most promising protocols, revolutionizing the research process and accelerating scientific discovery.
With its user-friendly interface and intelligent algorithms, PubCompare.ai empowers researchers to make informed decisions and optimize their A 274 research, unlocking new possibilities in this exciting field of study.

Most cited protocols related to «A 274»

1
Characterizing MaizeSNP50 Array Diversity
For the initial characterization of the MaizeSNP50 array, a total of 274 maize lines were genotyped. These lines included sequenced reference lines (e.g. B73 and Mo17), duplicated DNA samples and duplicated samples from different origins, parent/F1 combinations, 25 NAM parents [32] (link), important inbred lines from North America and Europe, teosinte inbred lines and other samples. This material represented samples from most of the crossing range of maize [34] (link) (Table S12). For the genetic mapping, 239 lines from the IBM population (B73×Mo17) and 226 individuals from the LHRF population (F2×F252) were genotyped.
Ganal M.W., Durstewitz G., Polley A., Bérard A., Buckler E.S., Charcosset A., Clarke J.D., Graner E.M., Hansen M., Joets J., Le Paslier M.C., McMullen M.D., Montalent P., Rose M., Schön C.C., Sun Q., Walter H., Martin O.C, & Falque M. (2011). A Large Maize (Zea mays L.) SNP Genotyping Array: Development and Germplasm Genotyping, and Genetic Mapping to Compare with the B73 Reference Genome. PLoS ONE, 6(12), e28334.
Publication 2011
A 274 Genes, Duplicate Gonadorelin Parent Teosinte Zea mays
2
Comorbid Headache and Fibromyalgia Evaluation
Following previous evaluation from 1 January 2007 to 30 June 2007, where a total of 274 patients were screened and 217 were included [7 (link)], we screened further 849 consecutive outpatients, who came for the first time at the Neurophysiopathology of Pain Unit (Neurological and Psychiatric Sciences Department, Bari University) from 1 July 2007 to 30 December 2009. The Neurophysiopathology of Pain Unit is a tertiary referral centre where patients are referred by primary physicians as well as by neurological and other specialty clinics. All participants gave written informed consent after receiving a detailed explanation of the purpose and design of the study. The study was approved by the local Ethics Committee of the Policlinico General Hospital.
According to the previous study [7 (link)], during the first visit, all subjects had a standardized interview and underwent clinical neurological and psychiatric examination. The inclusion criteria was a diagnosis of primary headache made by three neurologists with special experience in headache, according to the International Classification of Headache Disorders, 2nd edn (ICHD-II) criteria [12 (link)], and was supported by a 3-month observation time with a headache diary and allodynia questionnaire.
The inclusion/exclusion criteria and clinical management of patients were the same as the previous study [7 (link)]. Briefly, patients with general medical, neurological or psychiatric diseases [13 ], were excluded from the study, as well as the patients on central nervous system-active drug therapy to rule out any drug effect on diffuse pain. A particular attention was taken in screening out patients suffering from various conditions with diffuse pain, such as arthritis, diabetes or other metabolic causes of neuropathic pain. We included other types of primary headaches, and in the case of hemicrania continua (code. 4.7) [12 (link)], the 3 months preceding the first visit were considered for headache features and FM comorbidity, to prescribe indomethacine and confirm the diagnosis in the next control.
During the follow-up visit (except for patients with hemicrania continua, who were examined during their first visit, and the diagnosis confirmed at the follow-up), all patients underwent the clinical assessment, defined in the previous study [7 (link)], consisting of evaluation for FM diagnosis and tender point count [1 (link)], frequency of headache [7 (link)], total tenderness score (TTS) [14 (link)], allodynia questionnaire [15 (link), 16 (link)], Short-Form 36 (SF-36) Health Survey [17 ], depression [self-rating depression scale (SDS)] and anxiety [self-rating anxiety scale (SAS)] scales [18 (link), 19 ], Multidimensional Assessment of Fatigue (MAF) [20 (link)], and Medical Outcomes Study (MOS) [21 ]. In this study, we considered the sleep problems index (SLP9), expressing the sleep problems index, and Sleep quantity (SLPQ), expressing the sleep quantity [21 ].
Migraine Disability Assessment scale (MIDAS) [22 (link)], in the Italian version [23 (link)], was used to quantify headache-related disability in all headache patients, differently from the preliminary study [7 (link)]; the MIDAS score was considered only for migraine groups.
Patients presenting with FM comorbidity, according to the ACR criteria [1 (link)], were submitted for the Manual Tender Point Survey, [24 (link)–26 (link)] and answered the FM Impact Questionnaire (FIQ) [27 (link)], in accord with the previous study [7 (link)].
de Tommaso M., Federici A., Serpino C., Vecchio E., Franco G., Sardaro M., Delussi M, & Livrea P. (2011). Clinical features of headache patients with fibromyalgia comorbidity. The Journal of Headache and Pain, 12(6), 629-638.
Publication 2011
A 274 Allodynia Analgesics Anxiety Arthritis Attention Central Nervous System Agents Diabetes Mellitus Diagnosis Disability Evaluation Disabled Persons Dyssomnias Ethics Committees, Clinical Fatigue Headache Headache Disorders Hemicrania Mental Disorders Migraine Disorders Neuralgia Neurologists Outpatients Pain Patients Physicians Therapeutics
3
Fluid Intake Variability in Healthy Adults
The study enrolled healthy Caucasian French men and women, aged 25–40 years, with a BMI between 18·5 and 29·5 kg/m2 and with habitual fluid consumption (drinking-water plus other beverages) falling into either the bottom or top thirds of the French fluid intake distribution. Initial inclusion criteria included the ability to stay at home, abstain from strenuous physical activity for the study duration (4 d), access the Internet and live within a maximum of 30 min from the investigating centre. Exclusion criteria included use of medication likely to interfere with metabolism, such as hypotensive or diuretic treatment, history of gastrointestinal or metabolic disease (such as diabetes mellitus); renal, hepatic or cardiac failure, smoking more than fifteen cigarettes per d; or consumption of more than two (women) or more than three (men) standard servings of alcohol per weekday (where one standard serving represents 250 ml beer, 100 ml wine or 30 ml of spirits). Participants completed a total of six clinic visits (Fig. 1). After an initial eligibility screening (V0), potentially eligible subjects completed a clinical examination and received instructions on to use an electronic diary questionnaire (e-diary; MXS-Epidemio), described in detail below, to estimate usual fluid consumption over three consecutive weekdays. Subjects then returned to the clinic for an inclusion visit (V1), where their e-diary was used to identify individuals whose daily fluid consumption was consistent with either the low drinker (LD; ≤ 1·2 litres/d per 1·73 m2 of body surface area) or high drinker (HD; 2·0–4·0 litres/d per 1·73 m2 body surface area) groups.

Schematic of subject recruitment, group allocation and experimental phase. 24hU, 24 h urine; LD, low drinker; HD, high drinker; FMU, first morning urine.

A total of 274 subjects were screened between August and December 2009. Of these, ninety-seven individuals (35·4 %) satisfied the initial screening criteria and reported daily fluid consumption that consistently classified them as either LD (n 48) or HD (n 49). The study was conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving human subjects were approved by the Comité de Protection des Personnes of Ile de France XI. Written informed consent was obtained from all subjects. The final analysis sample includes thirty-nine LD and thirty-two HD participants who complied with the protocol and completed all the measures required during the study period.
Perrier E., Vergne S., Klein A., Poupin M., Rondeau P., Le Bellego L., Armstrong L.E., Lang F., Stookey J, & Tack I. (2012). Hydration biomarkers in free-living adults with different levels of habitual fluid consumption. The British Journal of Nutrition, 109(9), 1678-1687.
Publication 2012
A 274 Beer Beverages Body Surface Area Clinic Visits Diabetes Mellitus Diuretics Eligibility Determination Ethanol Heart Failure Kidney Metabolic Diseases Metabolism PER1 protein, human Pharmaceutical Preparations Physical Examination Urine White Person Wine Woman
4
Simulated Diploid Genome Assembly
The polymorphic diploid assembly of the Chinese amphioxus Branchiostoma belcheri was processed by HaploMerger. A total of 274 Mbp N gap-free alignments for trusted allele pairs (>1000-bp alignment length and >90% alignment identity) were extracted from the HaploMerger outputs. From this alignment pool, we randomly selected 10-Mbp alignments and concatenated the target and query sequences, respectively. By doing so, a small simulated diploid genome was created with a pair of 10-Mbp chromosomes, one from the target and the other from the query. A total of 25 small genomes of 10 Mbp were created. Random sampling without replacement was implemented to ensure no repeated use of any alignment from the pool. In addition, all alignments were concatenated to create a large simulated genome with a pair of 274-Mbp chromosomes.
For each chromosome from the 10-Mbp genomes, we simulated 650,000 454 shotgun reads (350 ± 70 bp), 140,000 3-kb paired-end 454 reads (3000 ± 600 bp), 40,000 8-kb paired-end 454 reads (8000 ± 1600 bp), 40,000 20-kb paired-end 454 reads (20,000 ± 4000 bp), 1,000,000 300-bp mate-pair Illumina reads (115 bp per end), and 1,000,000 500-bp mate-pair Illumina reads (115 bp per end). It should be noted that to induce more assembly errors, the length of each end of the 454 paired-end reads was set to only 104 bp. Reads were randomly sampled from the chromosomes. Sequencing errors were simulated at 1.3%–1.7% for each read. For 454 reads, ∼50% of the error rate represented indels due to homopolymers. Before use, the Illumina reads were subjected to error-correction using Quake (Kelley et al. 2010 (link)). In summary, we simulated ∼11× 454 and 23× Illumina reads for each small genome. As for the large genome, only 11× 454 reads were simulated (with the same proportions for the library size as for the small genomes). The Celera assembler version 6.1 was used to assemble the simulated data with the following specific parameters: utgErrorRate = 0.015, overlapper = mer, and unitigger = bog (Miller et al. 2008 (link)). Finally, HaploMerger was used to analyze each resulting, soft-masked assembly with the default parameters and a scoring matrix specific to the assembly.
Huang S., Chen Z., Huang G., Yu T., Yang P., Li J., Fu Y., Yuan S., Chen S, & Xu A. (2012). HaploMerger: Reconstructing allelic relationships for polymorphic diploid genome assemblies. Genome Research, 22(8), 1581-1588.
Publication 2012
A 274 Alleles Branchiostoma belcheri Chinese Chromosomes Chromosomes, Human, Pair 10 Diploidy DNA Library Genome INDEL Mutation Lancelets Neutrophil
5
Oophorectomy and Aging Cohort Study
The Mayo Clinic Cohort Study of Oophorectomy and Aging included a total of 1,274 Olmsted County, MN, women who underwent unilateral oophorectomy and 1,091 women who underwent bilateral oophorectomy during the 38-year period from 1950 through 1987.8 (link) Oophorectomy was defined as complete removal of the ovary, and further details about the oophorectomy cohorts have been reported elsewhere.7 (link),19 (link)–21 All information about oophorectomy, including the indication defined by the gynecologist at the time of surgery, was abstracted from medical records included in the records-linkage system of the Rochester Epidemiology Project.22 (link) Women were included in the current study if they were born before 1962 (at least age 40 years by January 1, 2002). In addition, we included only women who had undergone oophorectomy prior to menopause; however, we also included 158 women with unknown age at menopause who underwent bilateral oophorectomy before age 56 years (approximate upper limit of age at natural menopause). Finally, we excluded women who underwent either unilateral or bilateral oophorectomy as treatment for ovarian cancer or bilateral oophorectomy as treatment for another estrogen-related cancer.8 (link)
Rivera C.M., Grossardt B.R., Rhodes D.J., Brown RD J.r., Roger V.L., Melton LJ I.I.I, & Rocca W.A. (2009). Increased cardiovascular mortality following early bilateral oophorectomy. Menopause (New York, N.Y.), 16(1), 15-23.
Publication 2008
A 274 Childbirth Estrogens Female Castrations Gynecologist Malignant Neoplasms Menopause Ovarian Cancer Ovariectomy Woman

Most recents protocols related to «A 274»

1
Infant-Mother Cohort for Enteric Risk
We recruit pregnant women at the last trimester of pregnancy and follow the infant–mother dyads until the child is 12 months old (figure 5). We selected the first 12 months of life because it is a critical development window,81–83 (link) it is a time when children are most at risk of acute and chronic effects of enteropathogen infection84 (link) and it is a short enough period of time to avoid changes in water access that might occur. We recruit mothers at the end of their pregnancy so we can collect data on household risk factors (including drinking water quality) during the gestational period. Active recruitment occurs through identification of pregnant women in the 2020 population-based survey, lists of pregnant women visiting local health centres for prenatal care and study staff visiting under-enrolled sub-neighbourhoods throughout the recruitment period. Based on Ministry of Health data for Sofala Province (where Beira is located), virtually all mothers attend prenatal clinical visits.85 Passive strategies include referrals of pregnant women by study participants and community leaders. We aim to have complete data on a total of 548 infant–mother dyads, approximately evenly divided between the intervention and control groups. We will continue to enrol dyads into both arms until we reach a minimum of 274 dyads with complete data in each arm, to ensure temporal balance throughout the duration of the study period.
During an initial pre-birth visit, pregnant women are assessed for study eligibility: (1) 18 years or older, (2) in third trimester of pregnancy, (3) resides in enrolled study cluster, (4) not planning to move within the next 12 months, (5) carrying a singleton birth and (6) consents to take part in the study. We will reassess study eligibility at each follow-up visit and record if enrolled participants have been lost to follow-up.
Levy K., Garn J.V., Cumbe Z.A., Muneme B., Fagnant-Sperati C.S., Hubbard S., Júnior A., Manuel J.L., Mangamela M., McGunegill S., Miller-Petrie M.K., Snyder J.S., Victor C., Waller L.A., Konstantinidis K.T., Clasen T.F., Brown J., Nalá R, & Freeman M.C. (2023). Study design and rationale for the PAASIM project: a matched cohort study on urban water supply improvements and infant enteric pathogen infection, gut microbiome development and health in Mozambique. BMJ Open, 13(3), e067341.
Publication 2023
A 274 Child Childbirth Eligibility Determination Households Infant Mothers Pregnancy Pregnant Women
2
Agronomic Traits of Tobacco Recombinant Inbred Lines
The recombinant inbred lines (RILs) were generated from two elite flue-cured tobacco parents Y3 and K326. Y3 is a backbone cultivated variety that originated from Zimbabwe with elite agronomic traits and complicated parental sources. K326, whose genome has been assembled (Edwards et al., 2017 (link)), was introduced from America with high commercial quality and disease resistance but moderate agronomic performance. A total of 274 genotypes were employed in this study, consisting of two parents, one F1 generation individual (YKF1; Y3 × K3K6) and 271 F7 generation individuals. The materials were planted at Yanhe (N: 24.35; E: 102.54) and Shilin (N: 23.46; E: 103.17) field experiment stations using complete random design with 5 replications, and were cultivated according to local technical measures for quality tobacco production. Six agronomic traits, including natural plant height (nPH), natural leaf number (nLN), stem girth (SG), inter-node length (IL), length of the largest leaf (LL) and width of the largest leaf (LW), were measured in 2018, 2019, 2020 and 2021 years in Yanhe, and in 2018, 2019 and 2020 in Shilin. Seven different combinations of location and year were treated as environments denoted as E1 (2018 Shilin), E2 (2018 Yanhe), E3 (2019 Shilin), E4 (2019 Yanhe), E5 (2020 Shilin), E6 (2020 Yanhe) and E7 (2021 Shilin). Six agronomic traits were investigated on the day 65 after planting in the field (first green fruit stage) according to the tobacco industry standard YC/T 369-2-10.
Tong Z., Xu M., Zhang Q., Lin F., Fang D., Chen X., Zhu T., Liu Y., Xu H, & Xiao B. (2023). Construction of a high-density genetic map and dissection of genetic architecture of six agronomic traits in tobacco (Nicotiana tabacum L.). Frontiers in Plant Science, 14, 1126529.
Publication 2023
A 274 Disease Resistance DNA Replication Fruit Genome Genotype Nicotiana Parent Plant Leaves Plants Stem, Plant Vertebral Column
3
Cross-sectional Retinal Imaging Study
A total of 274 individuals were recruited consecutively from the Centre for Clinical Research and Biostatistics of the Chinese University of Hong Kong. The inclusion criteria were as follows: Age ≥ 18 years, willingness to sign the informed consent, and willingness to comply with study procedures required in the protocol. The exclusion criteria included age < 18 years; poor retinal image quality; other eye diseases such as severe cataracts, glaucoma, atretopsia, and corneal plague, and subjects known to be distressed by a flashlight or have a photosensitive seizure. Only subject numbers and initials were indicated on the image record and questionnaire for data collection and analysis. The study has obtained approval from the Joint CUHK-NTEC Clinical Research Ethics Committee (CRE-2015.524) and complies with the Declaration of Helsinki principles.
Lai M., Lee J., Li X., Kwok C., Chong M, & Zee B. (2023). Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis. International Journal of Environmental Research and Public Health, 20(4), 3530.
Publication 2023
A 274 Cataract Chinese Cornea Ethics Committees, Research Eye Disorders Glaucoma Joints Photosensitization Plague Retina Seizures
4
Fluoride Levels in Canary Islands Tap Water
A total of 274 samples were collected in Gran Canaria and Tenerife islands from Canary Islands archipelago, 78 of those were taken in the former and 196 in the latter one (Table 1) (Figure 1). Three replicates were taken from each sampling point. Gran Canaria’s sampling locations were divided in four areas based on demography and topography, meanwhile only three zones were created in Tenerife. The Table 2 summarized the water sources of the collected samples.
The island of Tenerife (28°16′07″ N 16°36′20″ W), is the largest and most populated of the Canary archipelago. The drinking water supply of the island of Tenerife is based on rainwater infiltrations that pass through the island’s generally porous volcanic soil and accumulate in underground galleries. The island of Gran Canaria (27°57′31″ N 15°35′33″ W), is the second most populated island of the Canary Islands. According to the Hydrological Plan of Gran Canaria, around 50% of the island’s water resources come from seawater desalination, while water extracted from underground galleries only represents 35% and a 15% from surface water sources [23 ].
The Canary Islands are an archipelago with a volcanic origin. Volcanism is one of the most important factors in the occurrence of fluorides in water [24 (link),25 (link)]. This study has chosen two of the volcanic islands where the presence of fluorides in their water has previously been found, especially in Tenerife [26 (link),27 (link),28 (link),29 ]. It is indisputable that population is linked to water demand, so a high inhabitants density generates overexploitation of its water resources. In relation to island aquifers, when natural recharge from rainfall is lower than reserves, this could lead to a significant increase in fluoride levels [30 ].
In addition, the recent eruptions In the Canary Islands (submarine eruption of the Tagoro Volcano on El Hierro in October 2011, terrestrial eruption of the Tajogaite Volcano on La Palma in September 2021) together with the unified model of the origin of the Canary Islands proposed by Anguita and Hernan [31 (link)], highlights the importance of adequate monitoring and control of the island’ water supply.
The sampling locations are showed in the Figure 2. The samples consist of tap water collected from different businesses and private homes by allowing the water to flow for 5 min prior to collection. In addition, these samples were collected in airtight plastic containers, to avoid the loss of fluoride by ionic diffusion in silicates. These containers were kept cold and the analysis were performed within a period not exceeding 5 days after collection.
Revelo-Mejía I.A., Alejandro-Vega S., Paz-Montelongo S., Niebla-Canelo D., Cerdán-Pérez S., Rubio-Armendáriz C., Gutiérrez-Fernández Á.J., Hardisson A., Rodríguez-Díaz R, & Hernández-Sánchez C. (2023). Fluoride Levels in Supply Water from the Canary Islands Region. Foods, 12(4), 745.
Publication 2023
A 274 Aquifers Arecaceae Cold Temperature Diffusion Exanthema Fluorides Granisetron Ions Iron Serinus Silicates Specimen Collection Water Resources
5
Impact of COVID-19 on Student Mental Health
First-year student volunteers were recruited from the years 2018/19 (pre-pandemic group), 2020/21 (group affected by the COVID-19 pandemic), and 2021/22 (post-pandemic group). Exclusion criteria for all groups were: alcohol abuse or drug use, pregnancy, medical treatment with antidepressant, anxiolytic, opiate medications, and a history of severe psychiatric illnesses. A total sample of 274 students participated in the experiment; 92 students (out of 100 enrolled this year) from the pre-pandemic 2018/19 academic year (72 women, 20 men), between 17 and 31 years old ( X¯ = 19.44, σ = 2.5); 91 students (out of 100 enrolled) from the pandemic 2020/21 academic year (71 women, 20 men), between 17 and 27 years old ( X¯ = 18.71, a σ = 1.52 years); and 91 students (out of 100 enrolled) from the post-pandemic 2021/22 academic year, between 17 and 33 years old ( X¯ = 19.03, σ = 2.7). No significant differences were observed among groups for age (χ2 = 2.8, p = 0.24) and percentage of males and females (χ2 = 0.37, p = 0.83), between pre-pandemic, pandemic, and post-pandemic groups.
Osses-Anguita Á.E., Sánchez-Sánchez T., Soto-Goñi X.A., García-González M., Alén Fariñas F., Cid-Verdejo R., Sánchez Romero E.A, & Jiménez-Ortega L. (2023). Awake and Sleep Bruxism Prevalence and Their Associated Psychological Factors in First-Year University Students: A Pre-Mid-Post COVID-19 Pandemic Comparison. International Journal of Environmental Research and Public Health, 20(3), 2452.
Publication 2023
A 274 Abuse, Alcohol Anti-Anxiety Agents Antidepressive Agents COVID 19 Females Males Mental Disorders Opiate Alkaloids Pandemics Pharmaceutical Preparations Pregnancy Student Voluntary Workers Woman

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More about "A 274"

Discover the Potential of A 274: An Exciting Chemical Compound in Biomedical Research A 274 is a remarkable chemical compound that has captured the attention of researchers across diverse fields, from drug development to environmental remediation.
This versatile molecule has been the subject of extensive scientific investigation, with researchers exploring its various applications and unlocking its full potential.
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