CDC calculated prescribing rates per 100 persons for the United States, each census region, and each state. CDC described the distribution of state rates using mean, standard deviation (SD), coefficient of variation (CV) (SD divided by the mean), the interquartile ratio (IQ) (75th percentile rate divided by the 25th percentile rate), and the ratio of the highest/lowest rates. Rates were transformed into multiples of the SD above or below the mean state rate of each drug.
Alprazolam
It is used in the treatment of anxiety disorders and panic attacks.
Alprazolam works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmmiter that promotes relaxation and reduces neuronal excitability.
This MeSH term description provides a concise overview of Alprazolam's pharmacological profile and clinical applications.
Reserchers can use PubCompare.ai's AI-driven platform to optimize their Alprazolam studies by identifiying the best protocols from literature, preprints, and patents, enhancing reproducibility and accuracy to deliver reliable results.
Most cited protocols related to «Alprazolam»
CDC calculated prescribing rates per 100 persons for the United States, each census region, and each state. CDC described the distribution of state rates using mean, standard deviation (SD), coefficient of variation (CV) (SD divided by the mean), the interquartile ratio (IQ) (75th percentile rate divided by the 25th percentile rate), and the ratio of the highest/lowest rates. Rates were transformed into multiples of the SD above or below the mean state rate of each drug.
Protocol full text hidden due to copyright restrictions
Open the protocol to access the free full text link
Most recents protocols related to «Alprazolam»
Example 3
Eudragit® E PO (EPO) is a cationic copolymer based on dimethylaminoethyl methacrylate, butyl methacrylate, and methyl methacrylate. Technical literature indicates that this polymer is soluble in acid, up to pH 5; above pH 5 it swells rather than dissolves. Dry granulations containing 5% alprazolam in EPO polymer were prepared and size fractions collected at −16 mesh and +20 mesh (16/20) and at −20 mesh and +30 mesh (20/30). Dissolution on the granulation size fractions were performed at both low pH (pH 1.5) where EPO is soluble and at high pH (pH 6) were EPO is less soluble. The results are shown in
Example 6
The following example provides details of a study used to determine whether alprazolam-induced changes in subjective experience during psilocybin therapy are due to changes in 5-HT2A occupancy. If not, downstream molecular and cellular effects that may be important in psilocybin's therapeutic effects may be preserved after co-treatment with a benzodiazepine.
In this study, [11C]CIMBI-36 (a selective 5-HT2A receptor agonist positron emission tomography (PET) radioligand) will be used to investigate whether 5-HT2A binding is affected by placebo vs. alprazolam.
At time t=0, subjects will be administered 25 mg psilocybin (PSI) in combination with either a placebo, or alprazolam. At t=2 hours, subjects will be given a tracer dose of [11C]CIMBI-36. At t=2-3 hours, a PET scan will be performed, to determine whether 5-HT2A binding is affected by either dose of alprazolam.
This study may optionally be performed using diazepam instead of alprazolam.
Example 2
A challenge faced in designing a self-regulating dosage form is to institute regulation (i.e., slower or incomplete release) at elevated pH without compromising the desired rapid release rate associated with immediate release tablets when a single dose is taken. Calcium carbonate was evaluated both in direct blend matrix tablets and dry granulation tablets containing alprazolam, where the granule contained calcium carbonate to control drug release and calcium carbonate outside the granule to effect pH change. Both approaches resulted in slower alprazolam release in single tablets at higher pH (approx. pH 6) compared to low pH (pH1), however, in this case the release separation was not as high as desired (
In the MEOPA group, administration was started at the same time as the local anesthesia. In the VR group, a 5-minute demonstration session was proposed on the day of randomization to assess tolerance before the biopsy, and the program was started 5 minutes before anesthesia with a maximum duration of 40 minutes. In cases of intolerable pain during the procedure, salvage treatment with a second local injection of lidocaine and/or paracetamol (1 g) or alprazolam (0.25 mg) was proposed.
Protocol full text hidden due to copyright restrictions
Open the protocol to access the free full text link
Top products related to «Alprazolam»
More about "Alprazolam"
As a benzodiazepine derivative, Alprazolam works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that promotes relaxation and reduces neuronal excitability in the brain.
Alprazolam's pharmacological profile includes anxiolytic (anxiety-reducing), sedative, hypnotic (sleep-inducing), anticonvulsant, and muscle relaxant properties.
This makes it an effective treatment for managing the physical and psychological symptoms associated with anxiety and panic attacks.
In addition to its clinical applications, Alprazolam is also used in research settings.
Researchers may utilize Alprazolam, along with related compounds such as Acetonitrile, Methanol, Formic acid, Alprazolam-d5, Dextromethorphan, and Ammonium formate, to conduct studies on the drug's pharmacokinetics, pharmacodynamics, and therapeutic efficacy.
LC-MS grade formic acid is often used in analytical techniques to improve the sensitivity and accuracy of Alprazolam quantification.
By leveraging PubCompare.ai's AI-driven platform, researchers can optimize their Alprazolam studies by identifying the best protocols from literature, preprints, and patents.
This enhances the reproducibility and accuracy of their research, ensuring reliable results and advancing our understanding of this important medication.