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Amides

Amides are a class of organic compounds containing the carbonyl group (C=O) linked to a nitrogen atom.
They are widely used in a variety of applications, including pharmaceuticals, agrochemicals, and industrial chemicals.
Amides display a diverse range of physical and chemical properties, making them versatile building blocks for various chemical reactions and syntheses.
Researchers often encounter challenges in optimizing amide synthesis protocols, requiring efficient tools to identify and compare the most suitable methods from the literature, preprints, and patents.
PubCompare.ai's AI-driven platform can enhance the reproducibility of amides research by enabling easy access to relevant protocols and providing intelligent comparisons to select the most optimal procedures and products.
This streamlines the amides optimization process and supports researchers in their quest for innovative amides-based solutions.

Most cited protocols related to «Amides»

1
Automated Protein Structure Correction with H++
Cited 230 times
Input PDB files can contain numerous errors and format inconsistencies, such as missing heavy atoms, suboptimal residue conformations and non-standard atom names. H++ attempts to make automatic, albeit conservative corrections for many of these problems when possible. Otherwise the errors are identified for possible manual correction. For example, the N and O atoms in the amide groups of ASN and GLN, and the N and C atoms in the imidazole ring of HIS cannot be easily distinguished from electron density maps. Thus, the assignment of these atoms in the PDB file may be (optionally) ‘flipped’ using the reduce algorithm that is based on an analysis of van der Waals contacts and H-bonding (26 (link)). An example of errors that are identified for manual correction are missing residues in the middle of protein chains. Input PDB files may also contain HETATM entries for solvent and ligand molecules; H++ removes these entries. Solvent molecules are removed by default because they are treated implicitly by the continuum solvent methodology used. Non-protein ligands are removed by default, but an option is now available to manually include many ligands and specific buried water molecules for processing, as described on the H++ site. Inclusion of buried waters has been shown to improve the accuracy of computed pK of nearby groups (27 (link)). For peptide, protein, DNA and RNA ligands, current AMBER force field parameters are used to add H atoms and assign atomic partial charges. For other organic ligands, H++ uses OpenBabel (28 ) to add H atoms, and atomic partial charges are assigned using the antechamber module from AmberTools (29 (link)) and the generalized AMBER force field (GAFF) parameter set. PDB structures may also contain residues with partial occupancy representing multiple possible conformations. Without manual intervention from the user, H++ selects the ‘A’ conformation and ignores all others.
An input PQR file, on the other hand, is assumed to have already been validated (e.g. in order to compute the atomic charges and radii included in the PQR file). Therefore, most error and consistency checks are bypassed for input PQR files. In addition, H++ requires AMBER compatible atom and residue names in the input PQR file.
Anandakrishnan R., Aguilar B, & Onufriev A.V. (2012). H++ 3.0: automating pK prediction and the preparation of biomolecular structures for atomistic molecular modeling and simulations. Nucleic Acids Research, 40(Web Server issue), W537-W541.
Publication 2012
Amber Amides Electrons Imidazoles Ligands Microtubule-Associated Proteins Peptides Proteins Radius Solvents
2
Modeling Non-Rotameric Side Chain Angles
Cited 145 times

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Publication 2011
Acclimatization Amides Vertebral Column
3
Computational Validation of Experimental NMR Data
Cited 45 times
For all four protein systems, experimentally measured 3J coupling constants for Hα–Cα–Cβ–Hβ1,2 dihedrals are available23 (link)–27 (link) (and Bax, personal communication). The experimental values were compared to those calculated using a Karplus relationship28 from the torsion angles observed in the MD simulations. For BPTI, HEWL, and Ubq, stereo-specific assignments allow us to distinguish between couplings for Hβ1 and Hβ2. In GB3, where stereospecific assignments are not available, we used the independently measured Cβ–Hβ1,2 residual dipolar couplings (RDCs) to determine the most likely assignment, as has been suggested previously.26 In addition to calculating Hα–Cα–Cβ–Hβ1,2 couplings for all four proteins, we also calculated N–Cα–Cβ–Cγ and C′–Cα–Cβ–Cγ couplings in GB3 and Ubq29 ,30 (link) and C′–Cα–Cβ–Hβ1,2 couplings in HEWL.24 For the N–Cα–Cβ–Cγ and C′–Cα–Cβ–Cγ couplings in Ile, Val, and Thr, we used Karplus parameters from Chou et al.30 (link); for all other couplings, we used amino acid–specific parameters from Pérez et al.31 (link)
Side-chain RDCs for GB3 and HEWL were calculated as ensemble averages, as described earlier.32 (link) For HEWL, the alignment tensor was first determined using a set of backbone HN RDCs, and the resulting alignment tensor was then used to calculate RDCs for Asn side-chain amides.33 (link) As the experiment reports only the sum of the two RDCs for the Nδ–Hδ1,2 bonds, we calculated the same sum from the simulations. In GB3, the same procedure was used to determine the alignment tensor from a set of backbone couplings, resulting in a calculation of Cβ–Hβ1,2 couplings.26 In total, 390 scalar couplings and 50 RDCs were calculated from the MD simulations and compared to experimental values. The complete dataset, together with the values calculated using ff99SB and ff99SB-ILDN, is available in the Supporting Information for this article.
Lindorff-Larsen K., Piana S., Palmo K., Maragakis P., Klepeis J.L., Dror R.O, & Shaw D.E. (2010). Improved side-chain torsion potentials for the Amber ff99SB protein force field. Proteins, 78(8), 1950-1958.
Full text: Click here
Publication 2010
Amides Amino Acids Aprotinin Proteins Vertebral Column
4
Cytochrome c2 Dynamic Analysis
Cited 45 times
The R1 and R2 relaxation rates for the 44 helical residues of cytochrome c2 from Rhodobacter capsulatus were obtained from the supplementary material of Blackledge et al. (1998 (link)). For consistency and to enable a direct comparison with the original publication a PDB file was created from the amide NH coordinates from the same supplementary material. For optimisation model-free model m1 (1.1) was selected for all residues. Rather than using a grid search for finding the optimal parameter values to use as an initial position for minimisation, this position was chosen to be where the S2 values of all residues are 0.8. The diffusion tensor parameters were set approximately to the values in the supplementary material of Blackledge et al. (1998 (link)). For the constants used in minimisation the values from Cordier et al. (1998 (link)) were used. The NH bond length was set to 1.01 Å, the CSA value set to  −170 ppm, and the field strength of the relaxation data was assumed to be exactly 600 MHz.
d’Auvergne E.J, & Gooley P.R. (2007). Optimisation of NMR dynamic models I. Minimisation algorithms and their performance within the model-free and Brownian rotational diffusion spaces. Journal of Biomolecular Nmr, 40(2), 107-119.
Publication 2007
Amides Cytochromes c2 Diffusion Helix (Snails) Rhodobacter capsulatus
5
HILIC-MS Metabolome Profiling Protocol
Cited 43 times
The LC–MS method involved hydrophilic interaction chromatography (HILIC) coupled with negative mode electrospray ionization to the Q Exactive PLUS hybrid quadrupole-orbitrap mass spectrometer (Thermo Scientific). The LC separation was performed on a XBridge BEH Amide column (150 mm × 2.1 mm, 2.5 μm particle size, Waters, Milford, MA) using a gradient of solvent A (95%:5% H2O:Acetonitrile with 20 mM Ammonium Bicarbonate), and solvent B (100% Acetonitrile). The gradient was 0 min, 85% B; 2 min, 85% B; 3 min, 80% B; 5 min, 80% B; 6 min, 75% B; 7 min, 75% B; 8 min, 70% B; 9 min, 70% B; 10 min, 50% B; 12 min, 50% B; 13 min, 25% B; 16 min, 25% B; 18 min, 0% B; 23 min, 0% B; 24 min, 85% B; 30 min, 85% B. The flow rate was 150 μl min−1. Injection volume was 5 μL and column temperature 25 °C. The MS scans were in negative ion mode with a resolution of 140,000 at m/z 200 unless specified otherwise. The automatic gain control (AGC) target was 5e5 unless specified otherwise. The maximum injection time was 30 ms. Scan range was 75–1000 unless specified otherwise.
Su X., Lu W, & Rabinowitz J.D. (2017). Metabolite Spectral Accuracy on Orbitraps. Analytical chemistry, 89(11), 5940-5948.
Publication 2017
acetonitrile Amides ammonium bicarbonate Chromatography Hybrids Hydrophilic Interactions M-200 Radionuclide Imaging Solvents

Most recents protocols related to «Amides»

1
Polyamide-Imide Films for Flexible Displays
Not available on PMC !

Example 8

An adhesive layer (product name: OCA #8146 from 3M company) was interposed between the prepared film and a PET substrate to obtain a multilayer film. It was folded to have a radius of curvature of 3 mm, which was left at a low temperature of −20° C. for 72 hours, and then unfolded. The extent of wrinkles was visually observed. In such event, if no wrinkles were visually observed, it was evaluated as o. If wrinkles were visually observed slightly, it was evaluated as Δ. If wrinkles were visually observed readily, it was evaluated as x.

TABLE 1
Ex. 1aEx. 2aEx. 3aEx. 4aC. Ex. 1aC. Ex. 2aC. Ex. 3a
CompositionDiamineTFMBTFMBTFMBTFMBTFMBTFMBTFMB
100100100100100100100
Dianhydride6FDA 36FDA 36FDA 106FDA 156FDA 246FDA 06FDA 0
DicarbonylTPC 75TPC 75TPC 75TPC 75TPC 29TPC 75TPC 75
compoundIPC 22IPC 22IPC 15IPC 10BPDC 47IPC 25IPC 25
Imide:amide3:973:9710:9015:8524:760:1000:100
Type of metal saltLiClLi2CO3Li2CO3Li2CO3—LiBrLiBr
Content of metal salt (based on10.50.50.5011
100 parts by weight of polymer
solids content)
Tensile strength (TS1a)kgf/mm232.131.630.427.726.329.221.3
Tensile strength at highkgf/mm226.425.924.62318.721.617.1
temperatures (TS2a)
TSR%82.2481.9680.9283.0371.1073.9780.28
Elongation at break%23.722.721.4218.817.317.618.3
(EL1a)
Elongation at break at%20.718.218.915.114.714.414.3
high temperatures
(EL2a)
ELR%87.3480.1888.2480.3284.9781.8278.14
Modulus (MO1a)GPa7.437.256.86.55.867.47.6
Modulus at highGPa5.85.85.45.14.25.35
temperatures (MO2a)
MOR%78.0680.0079.4178.4671.6771.6265.79
Film thicknessμm50505050505050
Light transmittance%88.888.989.589.688.988.587.9
Haze%0.50.50.40.40.50.82.4
YI—2.82.52.52.52.93.66.12
Flexural resistance (1 R, 20K)passpasspasspassfailfailpass
ProcessDrying step125/15 125/15 115/15 115/15 150/20 150/20 115/15 
(temp./min.)
First thermal125/1 125/1 115/1 115/1 150/1 150/1 115/1 
treatment step
(temp./min.)
Second thermal225/10 225/10 225/10 225/10 225/10 225/10 225/10 
treatment step
(temp./min.)

As can be seen from Table 1 above, the polyamide-imide films of Examples 1a to 4a had an MOR value of 75% or more. Thus, they maintained the modulus at least at a certain level even under the harsh conditions of high temperatures.

Since the display device is an electronic device, it generates heat during its use and it is to be used in a hot place as well, it is essential to secure mechanical properties at least at a certain level at high temperatures. Specifically, when a film is applied to a cover window for a display device, if the MOR value is 75% or more, no problem arises when a display device is fabricated.

In addition, the polyamide-imide films of Examples 1a to 4a were all excellent in the TSR value, ELR value, MO1a value, TS1a value, EL1a value, MO2a value, TS2a value, and EL2a value, in addition to the MOR value. That is, the polymer films of Examples 1a to 4a had high mechanical properties such as tensile strength, elongation at break, and modulus at room temperature and maintained the excellent mechanical properties even after the treatment under the severe conditions of high temperatures for a certain period of time.

Further, the polyamide-imide films of Examples 1a to 4a were all excellent in the evaluation of flexural resistance.

In contrast, since the films of Comparative Examples 1a to 3a had a low MOR value of 72% or less, when the film is applied to cover window for display device, it would have defects in appearance stability. In addition, the films of Comparative Examples 1a and 2a failed in the evaluation of flexural resistance. Thus, they are unsuitable for application to foldable display device or flexible display device.

TABLE 2
Ex. 1bEx. 2bEx. 3bEx. 4bEx. 5bEx. 6bEx. 7bEx. 8bC. Ex. 1bC. Ex. 2b
CompositionDiamineTFMBTFMBTFMBTFMBTFMBTFMBTFMBTFMBTFMBTFMB
100100100100100100100100100100
Dianhydride6FDA6FDA6FDA6FDA6FDA6FDA6FDA6FDA—6FDA
33791215242550
BPDA
10
DicarbonylTPC 70TPC 70TPC 65TPC 69TPC 66TPC 75TPC 29TPC 65TPC 75TPC 25
compoundIPC 27IPC 27IPC 28IPC 22IPC 22IPC 10BPDC 47IPC 25IPC 25
Imide:amide3:973:977:939:9112:8815:8524:7635:650:10050:50
Type/content metal saltLiCl/1LiCl/0.5——————LiBr/1—
Tensile strengthkgf/mm228.4532.1329.630.730.127.529.6128.3124.6122.62
(TS1b)
Tensile strengthkgf/mm227.7828.2430.128.62826.127.4122.9523.222.71
at low
temperatures
(TS2b)
dTS%2.3612.111.696.846.985.097.4318.935.730.40
Elongation at%19.8923.6719.223.12319.427.827.81178.9
break (EL1b)
Elongation at%23.0617.6821.51919.517.121.220.616.211.71
break at low
temperatures
(EL2b)
dEL%115.9425.3111.9817.7515.2211.8623.7425.934.7131.57
Modulus (MO1b)GPa7.427.436.025.925.546.156.446.657.454.83
Modulus at lowGPa7.577.646.216.035.716.326.556.767.464.87
temperatures
(MO2b)
dMO%2.022.833.161.863.072.761.7111.650.130.83
LMO1GPa1.4761.7591.1561.3681.2741.1931.7901.8491.2670.430
LMO2GPa1.7461.3511.3351.1461.1131.0811.3891.3931.2090.570
Thicknessμm50505050505050505050
Transmittance%89898989.189.3898988.588.490.8
Haze%0.470.480.660.520.670.560.460.542.410.41
YI—2.622.653.42.963.122.442.872.74.59141
Folding evaluation○Δ○○○○○Δxx
at low temperatures
(3 R, −20° C., 72 hours)
ProcessDrying125/15 125/15 125/15 125/15 115/15 115/15 115/15 115/15 150/20 115/15 
(temp/min.)First thermal125/1 125/1 125/1 125/1 115/1 115/1 115/1 115/1 150/1 150/1 
treatment
Second thermal225/10 225/10 225/10 225/10 225/10 225/10 225/10 225/10 225/10 225/10 
treatment

As can be seen from Table 2 above, the polyamide-imide films of Examples 1b to 8b had a dMO value of 1% to 8%. Thus, they maintained the modulus at least at a certain level even under the harsh conditions of low temperatures.

In the case where the polyamide-imide film is applied to a cover window for a display device and to a display device, it may be used in an extremely cold environment. Thus, it is essential to secure mechanical properties at least at a certain level even in such an extremely cold environment. Specifically, when the polyamide-imide film is applied to a cover window for a display device and to a display device, if the dMO value is within 1% to 8%, no problem arises.

In addition, the polyamide-imide films of Examples 1b to 8b were all excellent in the dTS value, dEL value, MO1b value, TS1b value, EL1b value, MO2b value, TS2b value, and EL2b value, in addition to the dMO value. That is, the polymer films of Examples 1b to 8b had high mechanical properties such as tensile strength, elongation at break, and modulus at room temperature and maintained the excellent mechanical properties even after the treatment under the severe conditions of low temperatures for a certain period of time.

Further, the polyamide-imide films of Examples 1b to 8b were all excellent in the folding characteristics at low temperatures.

In contrast, since the films of Comparative Examples 1b and 2b had a low dMO value of 1% or less, when it is applied to a cover window for a display device, it would not be balanced with other layers, resulting in cracks, which is defective in terms of the appearance stability. In addition, the films of Comparative Examples 1b and 2b failed in the evaluation of flexural resistance at low temperatures. Thus, they are unsuitable for application to a foldable display device or a flexible display device.

US11873372B2. Polyamide-imide film, preparation method thereof, and cover window comprising same (2024-01-16). SK microworks Co., Ltd. [KR]. Inventors: Han Jun Kim [KR], Sunhwan Kim [KR], Dae Seong Oh [KR], Jin Woo Lee [KR], Sang Hun Choi [KR], Jung Hee Ki [KR], Dong Jin Lim [KR].
Full text: Click here
Patent 2024
1-(decanoylthio)-2-decanoyl-3-phosphatidylcholine 2,2'-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride Amides Cold Temperature Diamines Fever GPA 7 Imides Light LMO1 protein, human Medical Devices Metals Nylons Polymers Radius Sodium Chloride Vision
2
Optimizing FAAH Inhibitor Potency
Not available on PMC !

Example 37

To improve inhibition potency relative to FAAH, various portions of the t-TUCB molecule were modified to identify potential FAAH pharmacophores. The 4-trifluoromethoxy group on t-TUCB was modified to the unsubstituted ring (A-3), 4-fluorophenyl (A-2) or 4-chlorophenyl (A-26). Potency on both sEH and FAAH increased as the size and hydrophobicity of the para position substituent increased, with 4-trifluoromethoxy being the most potent on both enzymes. Substituting the aromatic ring for a cyclohexane (A-3) or adamantane (A-4) resulted in a complete loss in activity against FAAH. Results are summarized in Table 1 below.

TABLE 1
Modification of the 4-trifluoromethoxy group of t-TUCB
[Figure (not displayed)]
Stereo-IC50 (nM)
R2—N(R3)—L1—chemistryhsEHhFAAH
t-TUCB[Figure (not displayed)]
[Figure (not displayed)]
trans0.8140
A1-[Figure (not displayed)]
[Figure (not displayed)]
trans309,200
A-2[Figure (not displayed)]
[Figure (not displayed)]
trans184,600
A-26[Figure (not displayed)]
[Figure (not displayed)]
trans7380
A-3[Figure (not displayed)]
[Figure (not displayed)]
trans6>1,000
A-4[Figure (not displayed)]
[Figure (not displayed)]
trans3>10,000
A-10[Figure (not displayed)]
[Figure (not displayed)]
81,800

Next, the center portion of the molecule was modified to further investigate the specificity of t-TUCB on FAAH. Switching the cyclohexane linker to a cis conformation (A-5) resulted in a 20-fold loss of potency while removing the ring and replacing it with a butane chain (A-6) resulted in a completely inactive compound. While this suggests the compound must fit a relatively specific conformation in the active site to be active, we found the aromatic linker had essentially the same potency on FAAH (A-7). Although many potent urea-based FAAH inhibitors have a piperidine as the carbamoylating nitrogen, the modification to piperidine here reduced potency 13-fold. Results are summarized in Table 2 below.

TABLE 2
Modification of the central portion of t-TUCB
[Figure (not displayed)]
Stereo-IC50 (nM)
R2—N(R3)—L1—chemistryhsEHhFAAH
t-TUCB[Figure (not displayed)]
[Figure (not displayed)]
trans0.8140
A-5[Figure (not displayed)]
[Figure (not displayed)]
cis22,800
A-6[Figure (not displayed)]
[Figure (not displayed)]
15>10,000
A-7[Figure (not displayed)]
[Figure (not displayed)]
7170

Since none of the modifications at this point improved potency towards FAAH, we focused on the benzoic acid portion of the molecule as shown in Table 3. To determine the importance of the terminal acid, the corresponding aldehyde (A-20) and alcohol (A-24) in addition to the amide (A-19) and nitrile (A-11) were tested. While the amide had slightly improved potency, the more reduced forms of the acid (A-20 and A-24) and amide (A-11) had substantially less activity on FAAH. Converting the benzoic acid to a phenol (A-21) increased potency while the anisole (A-22) was completely inactive. Since the amide and acid appeared to be active, the amide bioisostere oxadiazole (A-25) was tested and had 38-fold less potency than the initial compound.

TABLE 3
Modification of the benzoic acid portion of t-TUCB
[Figure (not displayed)]
IC50 (nM)
R1hsEHhFAAH
t-TUCB[Figure (not displayed)]
0.8140
A-11[Figure (not displayed)]
5>10,000
A-19[Figure (not displayed)]
270
A-20[Figure (not displayed)]
41,100
A-24[Figure (not displayed)]
35,800
A-21[Figure (not displayed)]
2120
A-22[Figure (not displayed)]
3>10,000
A-25[Figure (not displayed)]
45,300

Since the substrates for FAAH tend to be relatively hydrophobic lipids, we speculated that conversion of the acid and primary amide to the corresponding esters or substituted amides would result in improved potency. The methyl ester (A-12) had 4-fold improved potency relative to the acid. Improving the bulk of the ester with an isopropyl group (A-13) results in a 11-fold loss in potency relative to the methyl ester. However, the similar potency of the benzyl ester (A-14) to the methyl ester demonstrates the bulk but not the size affects potency. Reversing the orientation of the ester (A-23) reduces the potency 3.4-fold. Relative to the primary amide, the methyl (A-18), ethanol (A-15) and glycyl (A-16) amides were all slightly less potent; however, the benzyl amide (A-27) was substantially less potent (16-fold). Generating the methyl ester of the glycyl amide (A-17) increased the potency 4-fold compared to the corresponding acid.

TABLE 4
Potency of ester and amide conjugates of t-TUCB
[Figure (not displayed)]
IC50 (nM)
R1hsEHhFAAH
t-TUCB[Figure (not displayed)]
0.8140
A-12[Figure (not displayed)]
735
A-13[Figure (not displayed)]
5400
A-14[Figure (not displayed)]
324
A-23[Figure (not displayed)]
4120
A-18[Figure (not displayed)]
2170
A-15[Figure (not displayed)]
2100
A-16[Figure (not displayed)]
2130
A-17[Figure (not displayed)]
330
A-27[Figure (not displayed)]
51,100

US11873288B2. Inhibitors for soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) (2024-01-16). The Regents of the University of California [US]. Inventors: Bruce Hammock [US], Sean Kodani [US].
Full text: Click here
Patent 2024
Acids Adamantane Aldehydes Amides anisole Benzoic Acid Butanes Cyclohexane Dietary Fiber Enzymes Esters Ethanol inhibitors Lipids Nitriles Nitrogen Oxadiazoles Phenol piperidine Psychological Inhibition SOCS2 protein, human Urea
3
Synthesis and Characterization of Polymer 14
Not available on PMC !

Example 14

[Figure (not displayed)]

Polymer 13 (0.250 g, 1.396 mmol) was placed in a RB flask under a nitrogen atmosphere. Compound 14-a (90 mg, 0.679 mmol) was dissolved in dry DMF (5 mL) under nitrogen atmosphere and added to polymer 13 with stirring. The reaction mixture was stirred for 90 min at RT under a nitrogen atmosphere before being filtered and washed with DMF (5×5 mL) and methanol (5×5 mL). The product was concentrated in vacuo to yield polymer 14 as off-white powdery solid. Weight=0.1852 g (52% yield). A Kaiser test was used to confirm presence of terminal amines (a reading at 570 nm equating to 1.86 nmol amine). FTIR: 3251 (N—H/O—H), 2915/2874 (C—H), 1649 (C═O, amide of coupled product), 1583 (C═O of CMC), 1405/1316/1262/1020. Elemental analysis: Expected of product if DoS of raw material were 0.7: Mass 519 g mol−1: C 48%, H 5.8%, N 5.6%. Actual: C 42.8%, H 6.95%, N 4.25%. Therefore of all monomers, approximately 53% contain the linker group.

Solubility of Polymer 14 was determined in a similar manner as for compound 1-c. Data is shown below: x indicates insoluble material.

AfterAfter
SolventInitialheatingsonicationOvernight
pH 9 bufferxNot testedNot testedSlight swelling/gelling
over time; particles
well dispersed

US11865192B2. Modified wound dressings (2024-01-09). CONVATEC TECHNOLOGIES INC. [US]. Inventors: Lucy Ballamy [GB].
Full text: Click here
Patent 2024
Amides Amines Atmosphere Buffers Gels Methanol Nitrogen Polymers Powder Solvents Spectroscopy, Fourier Transform Infrared
4
Molecular Modeling of ALK Inhibitor Compound 6
Not available on PMC !

Example 13

Molecular modeling study based upon the co-crystal structure of ALK with Alectinib (PDB: 3AOX) (Sakamoto, H. et al., Cancer Cell 2011, 19, 679) was performed to assess the structure-activity relationship of inhibition of ALK and/or ALK mutants by the compounds of the present application. The modeling showed that Compound 6 makes the same backbone hinge contact as Alectinib, however, Compound 6 forms two additional hydrogen bond interactions between the guanidine moiety of R1120 and the carbonyl group of the dimethyl acetamide group (FIG. 1A). Furthermore, in the G1202R mutant, Compound 6 forms an additional hydrogen bond interaction between the guanidine moiety of R1202 and the nitrogen of the pyrazole ring (FIG. 1B). The modeling study predicted that the methylene spacer between the pyrazole ring and the dimethylacetamide moiety is preferable for the carbonyl amide of Compound 6 to interact with the guanidine moiety of R1120.

US11858897B2. Substituted 6,11-dihydro-5H-benzo[b]carbazoles as inhibitors of ALK and SRPK (2024-01-02). DANA-FARBER CANCER INSTITUTE, INC. [US]. Inventors: John Hatcher [US], Nathanael S. Gray [US], Hwangeun Choi [KR], Pasi Janne [US], Tinghu Zhang [US].
Full text: Click here
Patent 2024
alectinib Amides carbene Cells dimethylacetamide Guanidine Hydrogen-6 Hydrogen Bonds Malignant Neoplasms Nitrogen Psychological Inhibition pyrazole Vertebral Column
5
Synthesis of Functionalized Polymer 22
Not available on PMC !

Example 22

[Figure (not displayed)]

Polymer 21 (100 mg, 0.165 mmol) was ground into a fine powder and mixed with DMF (10 mL) for 20 minutes. Fmoc-Val-OH (0.167 g, 0.494 mmol), HBTU (0.187 g, 0.494 mmol), EDC (95 mg, 0.494 mmol) and DIPEA (0.064 mL, 0.494 mmol) were added to a filtration column tube and sealed. A lab rotor was used to facilitate mixing overnight. The solid was filtered and washed with DCM (5×20 mL) and methanol (5×20 mL). The resulting product was dried to provide Polymer 22-a as an off-white powder. Weight=0.0603 g. A positive Kaiser test result indicated presence of unreacted amine.

Polymer 22-a (60 mg) was placed in a solution of piperidine: DMF (20:80 v/v), (20 mL) and stirred for 1 hour, after which the solid was filtered and washed with ethanol (3×50 mL) and DCM (3×50 mL). This process was then repeated, and the product was dried to provide Polymer 22 as an off-white powder. Weight=0.0553 g (48% yield). A positive Kaiser test result indicated presence of free amine. FTIR: Peaks at 3300 (N—H/O—H), 2850 (C—H), 1748 (amide), 1648 (C═O, amide of coupled product), 1585 (C═O of CMC), 1453/1403/1024/1095/1058, 961, 841.

US11865192B2. Modified wound dressings (2024-01-09). CONVATEC TECHNOLOGIES INC. [US]. Inventors: Lucy Ballamy [GB].
Full text: Click here
Patent 2024
Amides Amines DIPEA Ethanol Filtration Methanol piperidine Polymers Powder Spectroscopy, Fourier Transform Infrared

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1
Acquity uplc beh amide column by Waters Corporation
Sourced in United States, United Kingdom, Ireland
The ACQUITY UPLC BEH Amide column is a high-performance liquid chromatography (HPLC) column designed for the separation and analysis of polar and hydrophilic compounds. The column features a proprietary hybrid organic/inorganic particle technology that provides excellent peak shape and resolution for a wide range of analytes.
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Xbridge amide column by Waters Corporation
Sourced in United States
The Xbridge amide column is a chromatography column designed for the separation and analysis of a wide range of polar and hydrophilic analytes. The column features a stationary phase with a proprietary amide-based chemistry that provides excellent selectivity and retention for these types of compounds.
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Xbridge beh amide column by Waters Corporation
Sourced in United States, Japan
The XBridge BEH Amide column is a high-performance liquid chromatography (HPLC) column designed for the separation and analysis of polar and hydrophilic compounds. It features a bridged ethylene hybrid (BEH) particle technology and an amide-modified stationary phase, which provides enhanced retention and selectivity for a wide range of analytes.
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Xcalibur by Thermo Fisher Scientific
Sourced in United States, Germany, France, Canada, Italy, United Kingdom, Slovenia
Xcalibur is a powerful data acquisition and analysis software for Thermo Fisher Scientific mass spectrometry systems. It enables users to control instrument operation, acquire data, and perform data analysis.
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Beh amide column by Waters Corporation
Sourced in United States, United Kingdom
The BEH Amide column is a hydrophilic interaction liquid chromatography (HILIC) column designed for the separation and analysis of polar and hydrophilic compounds. It features a bead-based ethylene-bridged hybrid (BEH) stationary phase with amide functional groups. The BEH Amide column provides effective retention and separation of a wide range of polar analytes, including carbohydrates, amino acids, and nucleosides.
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Uplc beh amide column by Waters Corporation
Sourced in United States
The UPLC BEH Amide column is a high-performance liquid chromatography (HPLC) column designed for the separation and analysis of polar compounds. It features a bridged ethylene hybrid (BEH) technology and an amide-based stationary phase, which provides enhanced selectivity and resolution for the separation of polar analytes. The column is compatible with ultra-high performance liquid chromatography (UPLC) systems and can be used for a variety of applications in analytical chemistry and life sciences.
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Tskgel amide 80 column by Tosoh
Sourced in Japan, United States
The TSKgel Amide-80 column is a high-performance liquid chromatography (HPLC) column designed for the separation and analysis of peptides, proteins, and other biomolecules. The column features a hydrophilic amide-based stationary phase that provides superior performance in the separation of these compounds.
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Q exactive hf x mass spectrometer by Thermo Fisher Scientific
Sourced in United States, Germany, Denmark, China
The Q Exactive HF-X mass spectrometer is a high-performance, hybrid quadrupole-Orbitrap mass spectrometer designed for advanced proteomics and small molecule analysis. It features high-resolution, accurate mass detection capabilities and a rapid scan speed.
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Acquity uplc beh amide by Waters Corporation
Sourced in United States
The ACQUITY UPLC BEH Amide is a high-performance liquid chromatography (HPLC) column designed for the separation and analysis of polar and hydrophilic analytes. It features a hybrid silica-based stationary phase with amide functionality, which enables efficient separation of a wide range of polar compounds. The column is suitable for use with ultra-high-performance liquid chromatography (UPLC) systems, providing rapid, high-resolution separations.
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Uplc beh amide column by Thermo Fisher Scientific
Sourced in United States, China
The UPLC BEH Amide column is a high-performance liquid chromatography (HPLC) column designed for the separation and analysis of polar analytes. It features a hybrid bonded phase that combines the advantages of ethylene-bridged hybrid (BEH) and amide chemistries, providing excellent peak shape and resolution for a wide range of polar compounds.

More about "Amides"

Amides are a crucial class of organic compounds that feature the carbonyl group (C=O) bonded to a nitrogen atom.
These versatile molecules find widespread applications in the pharmaceutical, agrochemical, and industrial sectors.
Amides exhibit a diverse range of physical and chemical properties, making them valuable building blocks for various chemical reactions and syntheses.
Researchers often face challenges in optimizing amide synthesis protocols, requiring efficient tools to identify and compare the most suitable methods from literature, preprints, and patents.
PubCompare.ai's AI-driven platform can enhance the reproducibility of amides research by enabling easy access to relevant protocols and providing intelligent comparisons to select the most optimal procedures and products.
This streamlines the amides optimization process and supports researchers in their quest for innovative amides-based solutions.
The ACQUITY UPLC BEH Amide column, Xbridge amide column, XBridge BEH Amide column, and TSKgel Amide-80 column are examples of specialized chromatographic tools used for the analysis and purification of amides.
The Xcalibur software and Q Exactive HF-X mass spectrometer are also commonly employed in amides research, providing advanced analytical capabilities.
By leveraging the insights and capabilities offered by these technologies, researchers can enhance their understanding of amides and accelerate the development of novel amides-based applications.
The streamlined access to optimized protocols and intelligent comparisons provided by PubCompare.ai's platform can further contribute to the efficiency and reproducibility of amides research, ultimately leading to groundbreaking discoveries and innovative solutions.