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Anisole

Anisole, also known as methoxybenzene, is a colorless, volatile organic compound with a distinct sweet, anise-like aroma.
It is commonly used as a flavoring agent, solvent, and intermediate in the synthesis of various pharmaceutical and industrial chemicals.
Anisole can be found in a variety of natural sources, including certain essential oils and plant extracts.
Researchers studying anisole can leverage the PubCompare.ai platform to easily locate the most reliable research protocols from published literature, preprints, and patents.
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By streamlining the research process, PubCompare.ai can help optimzie anisole research and advance scientific discoveries in this field.

Most cited protocols related to «Anisole»

hBN single crystals are grown under high pressure and high temperature, as detailed in ref. 80 (link). The graphite is first cleaved using adhesive tape. The Si + SiO2 substrate is then exposed to an oxygen plasma (100 W, 360 s). The surface of the tape is brought into contact with the SiO2 substrate, which is then placed on a hot plate at 100 °C for 2 min, before the tape is removed. Heating the substrate allows us to achieve large (>100 μm) SLG flakes, whereas flakes produced without heating are typically <50 μm in size, in agreement with findings of ref. 50 (link). For the exfoliation of hBN, no plasma treatment of the SiO2 surface is used, as we find this has no effect on the flakes’ lateral size. Polymer-contaminated samples are produced by first exfoliating SLG and subsequently depositing PMMA (8% in Anisole, 495 K molecular weight) via spin coating at 4000 rpm for 60 s. PMMA is then removed by acetone and isopropyl alcohol.
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Publication 2018
Acetone anisole Fever Graphite Isopropyl Alcohol Oxygen Plasma Polymers Polymethyl Methacrylate Pressure Tooth Exfoliation
All peptide sequences were synthesized using standard Fmoc-chemistry on an Advanced Chemtech Apex 396 peptide synthesizer as described previously.17 , 19 , 53 (link), 54 Briefly, the peptides were alkylated at the N-termini with palmitic acid in a mixture of o-benzotriazole-N, N, N′,,N′-tetramethyluroniumhexafluorophosphate (HBTU), diisopropylethylamine (DiEA), and dimethylformamide (DMF). Alkylation was performed twice for two 12 hour intervals at room temperature. Cleavage and deprotection followed for 3 hours, using a mixture of trifluoroacetic acid (TFA), deionized (DI) water, triisopropylsilane, and anisole (40:1:1:1). The collected samples were rotoevaporated to remove excess TFA, precipitated in ether, and dried under vacuum using lyophilization. Successful PA syntheses were confirmed by matrix-assisted laser desorption ionization time of flight (MALDI-TOF) mass spectrometry.
Publication 2009
Alkylation Anabolism anisole benzotriazole Cytokinesis Dimethylformamide Ethers Freeze Drying Palmitic Acid Peptides Specimen Collection Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Trifluoroacetic Acid Vacuum
Details regarding
TIMS operation and differences from traditional IMS can be found elsewhere.25 (link) TIMS mobility separation utilizes an electric
field to hold ions stationary against a moving gas, so that the drift
force is compensated by the electric field. This concept follows the
idea of a parallel flow ion mobility analyzer,27 with the main difference being that ions are also confined
radially using a quadrupolar field to guarantee higher ion transmission
and sensitivity. The separation in a TIMS device can be described
by the center of the mass frame using the same principles as in a
conventional IMS drift tube.28 ,29 Because mobility separation
is related to the number of ion-neutral collisions (or drift time
in traditional drift tube cells), the mobility separation in a TIMS
device depends on the bath gas drift velocity, ion confinement, and
ion elution parameters. The mobility, K, of an ion
in a TIMS cell is described by: where vg, E, Velution, and Vbase are the velocity
of the gas, applied electric field,
elution voltage, and base voltage, respectively. The constant A, which accounts for the velocity of gas, can be determined
using calibration standards of known mobilities. In TIMS operation,
multiple geometric isomers/conformers are trapped simultaneously at
different E values resulting from a voltage gradient
applied across the IMS cell. After thermalization, geometrical isomers/conformers
are eluted by decreasing the electric field in stepwise decrements
(referred to as the “ramp”). Each isomer/conformer eluting
from the TIMS cell can be described by a characteristic voltage gradient
(i.e., Velution – Vbase). Eluted ions
are then mass analyzed and detected by a maXis impact Q-ToF mass spectrometer
(Bruker, Billerica, MA). The elution voltage, Velution, can be calculated from the elution time: and where V0 is the
initial potential at the entrance to the TIMS analyzer, r is the rate at which the potential is ramped, Telute is the time at which the ion elutes, Tramp is the total ramp time, Ttotal is the total time for a single TIMS experiment, Ttrap is the time before the mobility analysis (i.e., to
inject ions into the TIMS trap), and TOF is the time between elution
of the ion and detection of the ion at the TOF detector.
The
TIMS funnel was controlled using in-house software, written in National
Instruments LabVIEW, and synchronized with the maXis Impact Q-ToF
acquisition program (more details in ref (25 (link))). Separation was performed using nitrogen as
a bath gas at ≈300 K, and the gas flow velocity was controlled
by the pressure difference between the front (P1) and back (P2) of the TIMS analyzer. P1 and P2 values
were set to 2.6 and 1.0 mbar for all experiments. The same RF (880
kHz and 200–350 Vpp) was applied to all electrodes including
the entrance funnel, the mobility separating section, and the exit
funnel. An atmospheric pressure photoionization source (APPI, Apolo
II Bruker Daltonics, Inc., MA) using a Kr lamp with main emission
bands at 10.0 and 10.6 eV was used for all the analyses.
A Tuning
Mix mass spectrometry standard (Tunemix, G2421A, Agilent
Technologies, Santa Clara, CA) was used as a mobility calibration
standard. Details on the Tunemix structures (e.g., m/z = 322 K= 1.376
cmV–1 s–1, m/z = 622 K0 = 1.013 cm2 V–1 s–1, and m/z = 922 K= 0.835 cmV–1 s–1) can be found in ref (30 ). Carotenoid samples (lutein
and zeaxanthin) were reconstituted in a 70:30 acetonitrile/methanol
solution to a final concentration of 1–10 nM. Toluene (8.8
eV IP), acetone (9.7 eV IP), or anisole (8.2 eV IP) were used as APPI
additives at a concentration of 10% (v/v) to enhance ionization31 (link) and to study the effect of solvent conditions
on ionization patterns and relative proportions of geometrical isomers/conformers
formed during the photoionization process. For simplicity, lutein
samples were only analyzed with added anisole APPI. Mobility values
(K) were correlated with CCS (Ω) using the
equation: where z is the charge of
the ion, kB is the Boltzmann constant,
N* is the number density, and mI and mb refer to the masses of the ion and bath gas,
respectively.28 Instrumental parameters
were optimized to achieve the highest IMS
resolution for the carotenoid molecular ions. A peak width (i.e.,
fwhm of the mobility peak) that corresponds to a single isomer was
measured using the sphere-like tune mix mobility standard series.
In addition, to ensure that the IMS peak width was not influenced
by the number of ions in the TIMS cell (i.e., columbic effects compromising
ion trapping), a dilution series (1:10–1:103) of
the tune mix was used to determine the mobility peak width as a function
of the concentration in all APPI solvent conditions. No significant
variation in the IMS peak width was observed beyond a 1:100 fold dilution.
The 622 m/z (K0 = 1.013 cm2 V–1 s–1, CCS = 202 Å2) component yielded a 1.74 Å2 peak width and was used as a reference for the peaks observed
for the carotenoid isomers. Under these experimental conditions, a
mobility resolution of over 110 was obtained in the TIMS analyzer
(more details in the Supporting Information).
Publication 2014
All PAs were synthesized using standard Fmoc-chemistry on an Advanced Chemtech Apex 396 peptide synthesizer at a 0.30 mmol scale, similar to previously described syntheses.16 (link), 21 , 34 (link), 35 Alkylation was obtained by reacting N-termini of the peptides with 2 equivalents of palmitic acid, 2 equivalents of o-benzotriazole-N,N,N′,N′-tetramethyluroniumhexafluorophosphate (HBTU), and 4 equivalents of diisopropylethylamine (DiEA) in dimethylformamide (DMF) for 12 hours at room temperature. After repeating the alkylation reaction once, cleavage and deprotection of the PAs were performed using a mixture of trifluoroacetic acid (TFA), deionized (DI) water, triisopropylsilane, and anisole in the ratio of 40:1:1:1 for 3 hours at room temperature. The resulting solution for each was filtered, and the resin was rinsed with 20 mL of TFA. The collected samples were rotoevaporated and then precipitated in cold ether. The precipitates were collected and dried under vacuum. PAs were analyzed for impurities by matrix-assisted laser desorption ionization time of flight (MALDI-TOF) mass spectrometry.
Publication 2009
Alkylation Anabolism anisole benzotriazole Cold Temperature Cytokinesis Dimethylformamide Ethers Palmitic Acid Peptides Resins, Plant Specimen Collection Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Trifluoroacetic Acid Vacuum
Paradigms used olfactory cues to evaluate the what, where, and when components of episodic-type memories in FVB-129 mice.
What: A serial odor task was used to assess encoding of cue identify (what) information (see Fig. 1a). Odorants were diluted in mineral oil and 100 µl of the scented mixture was pipetted onto filter paper (final concentration of 0.1 Pascals) which was placed in a glass jar (5.25 cm diameter × 5 cm height) with a plastic lid containing a ~1.5 cm diameter hole to allow the mouse to explore the odorant. During the habituation session, the mouse was allowed to explore for 5 min a plexiglass arena (30 × 25 cm floor, 21.5 cm walls) containing two cups (without odor). The mouse was then moved to an identical empty chamber for 5 min while the cups in the test arena were replaced with cups containing odor A (in duplicate) for the next session. After 3 min exploration, the mouse was again moved to the holding chamber for 5 min and the cups with odor A in the test chamber were replaced with cups containing odor B. This sequence was repeated with odor C. In the final test session 5 min later the mouse was exposed to two different odors: a previously sampled odor A and a novel odor D. The time spent sampling D versus A was used as a measure of retention.
Where: This paradigm used a large plexiglass arena (60 cm × 60 cm floor, 30 cm walls) containing four odor cups (see Fig. 1b). Mice were habituated to the chamber for 5 min with cups not containing odors and then transferred to an alternate identical empty holding chamber for 5 min. During the following training session the mouse was returned to the initial arena and allowed to explore cups scented with four different odors for 5 min. After placement in the holding chamber (5 min) the mouse was returned to the original arena in which the location of two of the four scented cups had been switched. In this final 5-min test session, the times spent exploring odors in the new and familiar locations were compared.
Four odor What: This paradigm was run identically to the Where task (above) except during the test session, rather than changing odor locations, one of the four odors was replaced with a novel odor. Time spent exploring the novel odor versus the average of the three familiar odors was assessed.
When: This paradigm was largely identical to the What task, except that an additional odor pair D:D was added to the last step in the training sequence (see Fig. 1c). After exposure to odor pair D:D, the final test session presented two different odors selected from the prior sequence. Untreated mice explored the odor sampled least recently (e.g., odor B more than C). To assess how sequential learning was affected by interval time, additional experiments were run with the interval between odor pair exposures reduced to 30 s and the mice were not removed from the chamber.
Two-odor discrimination: The mice were first exposed to odor pair A:A, moved to a holding chamber for 21 min (the same period covered by presentation of odors B and C in the What task) and then returned to the odor chamber and tested for discrimination of a novel odor D from familiar odor A (see Fig. 1f).
All testing was counterbalanced by location of odors and treatment where applicable. Training and testing sessions were video recorded and later analyzed by an individual blind to group and treatment. A mouse was scored as exploring an odor when its nose was within 2 cm of, and directed toward, the odor hole. Odorants used in the above tests were as follows: (+)-Limonene (≥97% purity, Sigma-Aldrich); cyclohexyl ethyl acetate (≥97%, International Flavors & Fragrances Inc.); (+)-Citronellal (~96%, Alfa Aesar); octyl aldehyde (~99%, Acros Organics); Anisole (~99%, Acros Organics); 1-pentanol (~99%, Acros Organics).
Automated software (Ethovision XT, Noldus) was used to analyze locomotor activity (distance traveled) during the spatial tests.
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Publication 2019

Most recents protocols related to «Anisole»

SnO2 colloid precursor (tin(IV) oxide 15% H2O colloidal dispersion), PbI2 (≥99.999, ultradry) and PbBr2 (Puratronic, ≥99.998) were obtained from Alfa Aesar. CsI (≥99.999, anhydrous) and acetonitrile (ACN) were obtained from Acros Organics. Anisole (≥99.7 anhydrous) was purchased from Sigma Aldrich. N,N-dymethylformamide (DMF) (Merk life science s.r.l., Milano, Italy), dimethyl sulfoxide (DMSO), formamidinium iodide (FAI), methylammonium bromide (MaBr, ≥99%, anhydrous), Spiro-OMeTAD, chlorobenzene (CB), 4-tert-butylpyridine (TBPy), bis(trifluoromethane)sulfonimide lithium salt (Li-TFSI), and FK 209 Co(III) TFSI salt were purchased from Merck. All the chemicals were used without further purification. We used 2 × 2 cm2 glass/ITO substrates received from Kintec (10 Ω sq−1).
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Publication 2024
As described by Hansen and Hodgson (1971 (link)) and Moustafa et al. (2023a ), P-nitro anisole (PN) was used for measuring cytochrome P-450 activity. A mixture of 100 µL of 2 mM p-nitro anisole and 90 µL of homogenate sample was incubated at 27 °C for 2 min then 10 µL of 9.6 mM NADPH was added. The optical density was determined at 405 nm using a microplate reader (Clindiag-MR-96, ISO09001:2008, Belgium).
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Publication 2024
The ITO-coated substrates were cleaned by sequential sonication in acetone and ethanol for 15 min in each solvent and then dried using nitrogen flux. After 20 min of UV ozone treatment for ITO, two layers of SnO2, as electron transport materials (ETLs), were deposited using a spin coater at 6000 rpm for 30 s, under a fume extractor system, where temperature and relative humidity were monitored but not controlled, depending on the outdoor atmospheric conditions. Tin dioxide layers were annealed at 130 °C for 1 h on a hotplate and controlled using a thermocouple. The devices were treated again 30 min under UV ozone treatment and then inserted into a nitrogen-filled glovebox (O2 ≤ 1 ppm and RH ≤ 1 ppm) for perovskite and hole transport material (HTM) spinning deposition and the subsequent thermal evaporation of gold electrical contacts. The perovskite spin-coating process was set as a two-step program with 1000 and 6000 rpm for 10 and 20 s. A few seconds before spin coating was completed, 200 µL of CB or anisole, as an antisolvent, was added dropwise to the substrates. PAL was crystallized by annealing at 100 °C for 1 h. HTM solution was spun onto PAL at 4000 rpm for 30 s. Finally, the devices were completed in a thermal evaporator inside the glovebox and an 80 nm Au back-contact layer was evaporated on the HTM, using a mask to define the positive electrode. Different batches were prepared by varying the amount of CsI (5% and 10%) in the precursor solution and comparing the CB and ANI antisolvents. In the following section, we refer to the devices as Cs5 and Cs10, adding CB or ANI to distinguish the antisolvents. The schematic of the device is shown in Figure 1.
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Publication 2024
Aluminum nitrate nonahydrate (Al(NO3)3•9H2O), urea, 3,4,9,10-perylene tetracarboxylic dianhydride (PTCDA, 98%), anisole, methanol, and thioanisole were all purchased from Energy Chemical and used without further purification.
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Publication 2024
The PMMA-SiO2 microstructures were synthesized by mixing SiO2 aerogel microparticles (4–10 μm in size, Sigma-Aldrich) and 20 wt% PMMA solution in anisole (950 A2, Kayaku) at a mass ratio of 1:5 using a central mixer (ARE-310, Thinky) at 2000 rpm for 3 min. Then, the mixture was baked at 100 °C for 1 min to remove anisole. Then, c-PI (TPI-100, PNS tech) was then mixed with the prepared PMMA-SiO2 microstructures at the desired mass ratio (0–24 wt% (i.e., 0–16 vol%) PMMA-SiO2 microstructures in c-PI). The prepared mixture was spin-coated onto an aluminum substrate at 700 rpm for 5 min. The samples were cured at 100 °C for 30 min, and 150 °C for 30 min in successive manner. Finally, the cured film was peeled off from the substrate, and the film thickness was approximately 50 μm.
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Publication 2024

Top products related to «Anisole»

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Anisole is a colorless, volatile liquid organic compound with a characteristic sweet, herbal odor. It is commonly used as a solvent and as a raw material in the production of various chemicals and pharmaceuticals.
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Methanol is a clear, colorless, and flammable liquid that is widely used in various industrial and laboratory applications. It serves as a solvent, fuel, and chemical intermediate. Methanol has a simple chemical formula of CH3OH and a boiling point of 64.7°C. It is a versatile compound that is widely used in the production of other chemicals, as well as in the fuel industry.
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Anisole is an organic compound with the chemical formula CH3OC6H5. It is a colorless liquid with a characteristic aromatic odor. Anisole serves as a precursor for the synthesis of various chemical compounds and is used in a variety of industrial and laboratory applications.
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Butylated hydroxyl anisole is a chemical compound used as a food preservative and antioxidant. It is a white or off-white crystalline solid with a mild aromatic odor.
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N,N-dimethylformamide is a clear, colorless liquid organic compound with the chemical formula (CH3)2NC(O)H. It is a common laboratory solvent used in various chemical reactions and processes.
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Piperidine is a colorless, flammable liquid organic compound with the chemical formula C₅H₁₁N. It is a heterocyclic amine that is widely used as a building block in the synthesis of various pharmaceutical and industrial chemicals.
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DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
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Trifluoroacetic acid is a colorless, corrosive liquid commonly used as a reagent in organic synthesis and analytical chemistry. It has the chemical formula CF3COOH.
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Thioanisole is a colorless, volatile organic compound used as a chemical intermediate in the pharmaceutical and agricultural industries. It is a colorless, flammable liquid with a characteristic sulfurous odor. Thioanisole serves as a precursor in the synthesis of various pharmaceuticals and agrochemicals, but a detailed description of its specific applications is not within the scope of this response.
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Acetonitrile is a colorless, volatile, flammable liquid. It is a commonly used solvent in various analytical and chemical applications, including liquid chromatography, gas chromatography, and other laboratory procedures. Acetonitrile is known for its high polarity and ability to dissolve a wide range of organic compounds.

More about "Anisole"

Anisole, also known as methoxybenzene, is a versatile aromatic compound with a wide range of applications.
This colorless, volatile organic substance has a distinct sweet, anise-like aroma, making it a popular flavoring agent in food and cosmetic products.
Beyond its use as a flavoring, anisole serves as a valuable solvent and an important intermediate in the synthesis of various pharmaceutical and industrial chemicals.
Anisole can be found naturally in a variety of essential oils and plant extracts, indicating its presence in the natural world.
Researchers studying this fascinating compound can leverage the PubCompare.ai platform to effortlessly locate the most reliable research protocols from published literature, preprints, and patents.
The AI-driven tools offered by PubCompare.ai enable users to identify the best approaches and products, enhancing the reproducibility and accuracy of their anisole-related studies.
By streamlining the research process, PubCompare.ai can help optimize anisole research and drive scientific discoveries in this field.
Researchers can explore related compounds like methanol, butylated hydroxyl anisole, N,N-dimethylformamide, piperidine, DMSO, trifluoroacetic acid, thioanisole, and acetonitrile to deepen their understanding of anisole and its applications.
Harnessing the power of PubCompare.ai, scientists can effortlessly navigate the vast landscape of anisole research, unlocking new insights and advancing the frontiers of knowledge in this dynamic field of study.