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Biomet

Biomet refers to the application of biological and engineering principles to the design, development, and evaluation of biological or biologically-inspired materials, devices, and systems.
This interdisciplinary field, also known as biomedicine or biomedical engineering, aims to improve human health and well-being through the integration of biology, medicine, and engineering.
Biomet encompasses a wide range of areas, such as tissue engineering, prosthetics, medical imaging, and drug delivery systems.
Researchers in this field work to create innovative solutions that address unmet medical needs and enhance the quality of life for patients.

Most cited protocols related to «Biomet»

In this retrospective cross-sectional survey-based study, we randomly selected 360 patients who had received a primary unilateral TKA at our institution (Copenhagen University Hospital, Hvidovre, Denmark) between January 2010 and January 2013. They had not undergone previous open knee surgery and did not have revision surgery after primary TKA. The patients who were invited to participate in the study were treated either with a cemented previous-generation fixed-bearing, cruciate retaining TKA (AGC; Biomet, Warsaw, IN), a cemented newer-generation fixed-bearing, cruciate retaining TKA (Vanguard CR; Biomet) or an uncemented, mobile-bearing, cruciate retaining TKA (Vanguard ROCC; Biomet). All 3 prosthetic designs have shown good clinical results (Emerson et al. 2000 (link), Worland et al. 2002 (link), Ritter 2009 (link), Stormont and Chillag 2009 (link), Bercovy et al. 2012 (link), Thomsen et al. 2013 (link), Atrey et al. 2014 (link), Kievit et al. 2014 (link), Schroer et al. 2014 (link)).
The study was conducted according to the COSMIN guidelines (Mokkink et al. 2010 (link)) and consisted of 2 parts, a validity study and a reliability study. In January 2014, all 360 patients were invited to participate in the study, giving a follow-up period of 1–4 years. All participants received a set of questionnaires consisting of a Danish version of the FJS and OKS questionnaires. If participants had not returned the questionnaires within 2 weeks, a new set of questionnaires was sent. After 4 weeks, 315 participants had completed the questionnaires sufficiently well. The 315 participants who completed the first survey were included in the validity study.
The first 200 participants who returned the first set of questionnaires were then invited to participate in the reliability study. These participants were asked to complete a second FJS questionnaire 4 weeks after the first set of questionnaires had been delivered to the patients. Patients were excluded from the reliability study if they reported a change in knee pain or function in the period between the first questionnaire and the second one. 150 participants completed the second questionnaire sufficiently well and were included in the reliability study (Figure 1 and Table 2).

Flow diagram presenting participants who were invited to participate in the study and included in the analysis.

Demographics of patients included in the validity and reliability studies. The numbers in parentheses are standard deviations (SDs) where the data were normally distributed, or percentages of the total

Validity study n = 315Reliability study n = 200
Female187 (59%)82 (55%)
Age (range)65 (36–91)66 (44–91)
Prosthesis
 Van-CR35 (11%)19 (12%)
 Van-ROCC68 (22%)40 (27%)
 AGC212 (67%)91 (61%)
Year of surgery
 201028 (9%)17 (11%)
 2011111 (35%)56 (37%)
 2012164 (52%)72 (48%)
 201312 (4%)5 (3%)
FJS53 (SD 29)56 (SD 31)
OKS35 (SD 10)
The FJS is a 12-item questionnaire concerning the participants’ awareness of their artificial joint during ADL. The questions included in the FJS questionnaire are presented in Table 1. For each question, the participant can choose between 6 response options: never, almost never, seldom, sometimes, mostly, or not relevant for me.

Questions included in the FJS questionnaire

Are you aware of your artificial knee …
1… in bed at night?
2… when sitting on a chair for more than one hour?
3… when you are walking for more than 15 minutes?
4… when taking a bath/shower?
5… when traveling in a car?
6… when climbing stairs?
7… when walking on uneven ground?
8… when standing up from a low-sitting position?
9… when standing for long periods of time?
10… when doing housework or gardening?
11… when taking a walk or hiking?
12… when doing your favorite sport?
When calculating the total score for the FJS, all responses are summed (never, 0 points; almost never, 1 point; seldom, 2 points; sometimes, 3 points; mostly, 4 points) and then divided by the number of completed items (questions met with “not relevant for me” were treated as having a missing value and were not included in completed items). This mean value is subsequently multiplied by 25 to obtain a total score range of 0 to 100. Finally, the score is subtracted from 100 to change the direction of the final score in such a way that high scores indicate a high degree of “forgetting” the artificial joint—i.e. a low degree of awareness. If more than 4 responses are “not relevant for me” or missing, the total score should be discarded (Behrend et al. 2012 (link)).
The OKS is a previously validated PROM based on a 12-item questionnaire. It has been widely used to evaluate outcome after TKA. Participants can have a total score of 0 to 48, where 48 indicates the best possible outcome. In the case of missing responses, the mean value representing all of their other responses is used. If more than 2 responses are missing, the total score should be discarded (Dawson et al. 1998 (link)).
Publication 2016
Awareness Bath Biomet Joints Knee Operative Surgical Procedures Pain Patients Prosthesis Repeat Surgery SD 31
Using our previously validated methodology [17 (link)], computed tomography (CT) scans of a 60 year old subject (gender: male, BMI: 25.9) were segmented using Mimics software (version 14.1, Materialise, Leuven, Belgium) to create the tibial geometry. An iterative closest point (ICP) algorithm [18 ] was used to register this tibia model with the one used to calculate muscle forces (MATLAB, Version 7.10, MathWorks Inc., Massachusetts, USA), thereby allowing mapping of the muscle attachment sites. The tibia model was prepared for implantation of an Oxford UKR mobile bearing knee (Biomet UK Ltd., Bridgend, UK) in accordance with standard operative techniques [19 ] using Boolean operations (SolidWorks CAD software, version 2011-2012, Waltham, MA, USA). A sagittal cut to a depth of 4 mm below the medial plateau of the bone was made in line with the mechanical axis of the tibia and was positioned at the medial edge of the tibial spine. At the same depth anteriorly, a transverse cut was made with a 7° posterior slope. The tibia was also truncated 100 mm below the medial plateau to reduce the overall model size. Use of a shortened tibial model has been validated previously [4 (link)].
The cuts resulted in two separate regions: the cut region and the main tibial region. In models which examined the tibia prior to UKR (hereafter referred to as the Native model), these two regions were bonded together using a tie constraint. For the simulations of the UKR, the cut portion was removed from the simulation and the main tibial region modelled with the components inserted (hereafter referred to as the Implanted model). For the Implanted model, a 1 mm cement gap was simulated between the tray and the tibia, and the tibial tray was implanted in the centre of the cut plateau. The bearing was positioned 1 mm from the wall of the tray and in the centre of the plateau along the anterior-posterior direction. The femoral component was aligned with the axis of the central peg normal to the surface of the tibial tray (Figure 1).
Publication 2012
Biomet Bones Dental Cementum Epistropheus Femur Knee Males Muscle Tissue Operative Surgical Procedures Ovum Implantation Radionuclide Imaging Tibia Vertebral Column X-Ray Computed Tomography

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Publication 2016
Ammonia Biomet Culture Media Exercise, Aerobic Glucose Oxygen Phosphates Saccharomyces cerevisiae Sulfates, Inorganic
Reconstruction of the GEMs was comprised by a semi-automatic approach enriched with functional analysis and extensive manual curation based on available literature. Figure 1 depicts an overview of the process. The RAVEN Toolbox was used to generate draft models (manuscript under review). This approach uses a set of reference GEMs of closely related species and infers reactions by means of protein homology. In parallel to this method, the RAVEN Toolbox also uses the KEGG database to infer reactions that may be missing or incorrect in the template models. Draft models were constructed using the genome sequences of P. stipitis (CBS 6054) [20 (link)], and P. pastoris (GS 115) [19 (link)]. The iIN800 GEM of S. cerevisiae was used as reference framework because of its accurate annotation of fatty acid metabolism, and the extensive information about metabolites and genes, which allowed for a convenient comparison with the KEGG database.
BLASTp (ncbi-blast software ver. 2.2.24) was used to identify homologous proteins among the three yeast species. Protein homologs were identified based on stringent cutoff values (E-values < 10-40), and on the score to sequence length ratio according to David et al. (2008) [31 (link)]. KEGG Ontology (KO) identifiers were also used to additionally infer reactions which could not be found in S. cerevisiae from the genome sequences of the two Pichia species following the RAVEN Toolbox pipeline. Finally, the metabolic network of S. cerevisiae iIN800 was used to map genes from P. pastoris and P. stipitis having homologs in S. cerevisiae.
Subcellular compartmentalization of reactions was determined using the F-LocA (Fully-connected Localization Assignment), which is part of the RAVEN Toolbox. F-LocA incorporates subcellular localization predictors (CELLO and WoLFPSORT) [32 (link)], together with a constraint on network connectivity. Reactions without associated genes were compartmentalized according to biochemical evidence when available. It is important to note that these automated approaches were only used as an aid in the reconstructions, and that biochemical and physiological evidence was always used to validate reaction localizations and gene associations. This was of particular importance in the peroxisomal metabolism where the predictive capability is lower due to the low quality of data from subcellular localization predictors (e.g. CELLO predicts that AOX is in the cytosol, but it is in the peroxisome). In cases where information about P. pastoris or P. stipitis was lacking, data from other closely related yeasts was used instead (e.g. S. cerevisiae, Hansenula polymorpha, Candida tropicalis, C. shehatea, and C. boidinii [33 (link),34 (link)]). Both GEMs are available in the BioMet Toolbox [http://www.sysbio.se/BioMet/ - will be uploaded upon acceptance of paper].
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Publication 2012
Biomet Candida tropicalis Cytosol Fatty Acids FCER2 protein, human Gemini of Coiled Bodies Genes Genome Metabolic Networks Metabolism Ogataea angusta Peroxisome physiology Pichia Proteins Ravens Reconstructive Surgical Procedures Saccharomyces cerevisiae Yeast Proteins Yeasts

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Publication 2020
Arthroplasty Biomet Bones Flushing Limb Prosthesis Neck Radiography Scapula Shoulder

Most recents protocols related to «Biomet»

Radiological evaluation consisted of anteroposterior (AP) views of the hip and pelvis and a true lateral of the hip. These were compared with the radiographs taken immediately after operation and at all subsequent reviews. All radiographs in this study were read by an independent orthopaedic surgeon (JRM), who was not the operating surgeon. The femur was divided into the seven Gruen zones,9 with the corresponding areas on the lateral radiograph. The presence of radiolucencies or osteolysis was assessed in each of the seven zones and recorded in increments of 0.5 mm. Progressive radiolucencies were identified and recorded. Radiolucencies with a scalloped or cystic appearance, or greater than 2 mm in width, were recorded as oseolysis.10 The stability of the femoral component was assessed by the criteria of Engh et al.11 A component was defined as having fixation by bone ingrowth when there was no subsidence and minimal or no formation of a radio-opaque line along the porous-coated portion of the implant. Stable fibrous ingrowth occurred when an implant had no progressive migration irrespective of the presence of a radio-opaque line along the stem. Definitive femoral component loosening was defined as progressive migration of the implant. Subsidence of greater that 3 mm was required for this determination.
While not the focus of this review, we examined the acetabular components used in these patients. The prosthesis used in all cases was a conically shaped, threaded-ring titanium shell without porous coating (T-Tap; Zimmer-Biomet). Ultra-high molecular-weight polyethylene powder HiFax 1900 MG (HiMont, USA) was directly compression-moulded into the shell to form an articulating surface, 28 mm in diameter.
Publication 2023
Acetabulum Biomet Bones Cyst Femur Fibrosis Orthopedic Surgeons Osteolysis Patients Pelvis Powder Prosthesis Radio-Opaque acrylic resin Stem, Plant Surgeons Titanium ultra-high molecular weight polyethylene X-Rays, Diagnostic
We performed THA in the supine position with a G7 OsseoTi cup (Zimmer Biomet, Warsaw, IN) as the trial cup and a femoral rasp for the Wagner cone hip stem (Zimmer Biomet) using an anterolateral approach. We made a skin incision at the anterior border of the gluteus medius muscle and accessed the hip joint through the interval between the tensor fascia lata and gluteus medius. We used a CT-based navigation system (Stryker, Freiburg, Germany) for preoperative planning, implantation, and monitoring of the hip position during examination. We resected the femoral neck based on the position indicated by the navigation system. The acetabulum was then under-reamed by 1 mm and the trial cup was inserted using the press-fit technique. The target cup placement angle was 40° of anatomical inclination. The cup anteversion was adjusted according to the required ACPL. Finally, femoral rasping was performed. The final rasp was used for the examination. Femoral anteversion was matched to the native femoral anteversion using the navigation system. When stem anteversion was changed, it was increased or decreased by 20° with respect to the native femoral anteversion. We used a trial head of 32 mm in diameter, and the neck size was selected so that the postoperative leg-length discrepancy and global offset compared with the contralateral side were almost same in each case according to the navigation system. After THA, a seat-type pressure sensor (I-SCAN, Nitta, Osaka, Japan) for real-time monitoring was placed between the iliopsoas muscle and anterior pelvic wall or anterior cup edge using an ilioinguinal approach (Fig. 1A,B). We used one sensor seat per sample. The sensor seat for each specimen was calibrated in advance under the same conditions.

Photographs of the seat-type pressure sensor for real-time monitoring of the surface pressure of the iliopsoas muscle (I-SCAN, Nitta, Osaka, Japan). (A) The sensor is 0.1 mm thick with dimensions of 10 × 10 mm. (B) The pressure sensor was placed between the iliopsoas muscle and anterior cup edge via an ilioinguinal approach. (C) Photograph showing the condition of the anterior cup protrusion length. (DF) A typical case of the maximum surface pressure of the iliopsoas muscle with the hip in 20° of extension. Anterior cup protrusion length: (D) 0 mm, (E) 3 mm, (F) 6 mm.

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Publication 2023
Acetabulum Biomet Buttocks Femur Head Hip Joint Lata, Fascia Muscle Tissue Myotomy Neck Neck, Femur Ovum Implantation Pelvis Pressure Radionuclide Imaging Retinal Cone Skin Stem, Plant Temporal Muscle
Bone models (Sawbones® USA), coordinate measuring machine (Absolute arm, Hexagon Manufacturing Intelligence [Qingdao] Co. LTD, China), PSI system, bench clamp, THA surgical tool (Zimmer Biomet Holdings, Inc., USA), Xishan Surgical Power Unit (DK‐O‐MCS, Chongqing Xishan Technology Co. LTD, China), THA robot system (TiRobot Recon, Beijing TINAVI medical Technology Co. LTD, China), Materialize mimics (Version 21.0, Materialize, Belgium), Materialize 3‐Matic (Version 13.0, Materialize, Belgium), SPSS (Version 26.0, IBM, USA).
Publication 2023
Biomet Bones Operative Surgical Procedures
In this prospective study, we included patients who underwent TKA for knee OA between April 2021 and February 2022. The sole exclusion criterion was inability to maintain a standing position because this might interfere with accurate measurements. However, none of the cases met this exclusion criterion. A total of 60 knees (30 patients) were assessed with pre- or post-operative radiographs. Out of the 60 knees with OA, 35 were TKA knees and 25 were non-TKA knees. Patients were assessed either pre- or post- operatively, not both. All procedures were performed using a cruciate-retaining Persona knee system (Zimmer Biomet Inc., Warsaw, IN) by a single surgeon at a single institution. This study was approved by Nittaduka Medical and Welfare Center Ethics Review Committee and performed according to the principles of the Declaration of Helsinki. All patients provided written informed consent.
We used GPower 3.1.9.2 to determine the appropriate sample size. In the linear regression analysis, a sample size of 55 participants was required to obtain an effect size (f2) greater than 0.15 with 0.80 power and 0.05 error level on two-tailed test. Therefore, this study enrolled 60 knees. Participants were asked to wear plain trousers of appropriate size to prevent misinterpretation of OpenPose measurements.
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Publication 2023
Biomet Knee Patients Surgeons X-Rays, Diagnostic
In this prospective study a total of 10 primary TKA (Persona Knee System, Zimmer Biomet, Warsaw, IN, USA) were performed using conventional instruments. The battery driven Trauma Recon System (TRS) Modular Drive (Model 05.001.201, DePuy Synthes, Raynham, MA, USA) was used for drilling and the TRS Recon Saw (Model 05.001.204, DePuy Synthes, Raynham, MA, USA) with Prismatic Sagittal Saw Blade (De Soutter Medical Ltd., Aston Clinton, Aylesbury, UK) was used for the bone cuts. A new saw blade was used for every case. In 5 of these cases the surgical team consisting of the surgeon, the assistant, the scrub nurse as well as the anesthesiologist wore industry grade ANCH (PELTOR™ ProTac™ III, 3 M, Saint Paul, MN, USA) for the duration of the entire surgical procedure. The pilot study, including the off-label use of the headphones, has been approved by the local ethics committee. All patients provided written informed consent. The other 5 cases were performed conventionally without the use of ANCH. A detailed flowchart regarding the study design is shown in Figure 1. There was no background music in any of the cases performed in the study [28 (link)]. The industry grade ANCH used in this study feature an electronic noise level dependent active noise cancellation which is activated automatically at a noise level of 82 dB. The reported noise reduction rating (NRR) is 21 dB. Below a noise level of 82 dB the ambient sounds such as voices are reproduced electronically and transferred to the ANCH wearer’s ears which allows an undisturbed communication within the surgical team during non-noisy parts of the surgical procedure.
After the surgical procedure every study participant was handed a validated 14-item questionnaire to evaluate the quality of communication, performance, teamwork and mental load and compared between ANCH and ANCH-free cases [29 (link),30 (link),31 (link)]. The statements presented at the questionnaire were rated on a scale from 0 to 10 by the study participants with 0 points implying no agreement at all with the presented statement and 10 points implying full agreement with the questionnaire’s statement. For each questionnaire an overall score was calculated. The score of negative statements implying a poor communication or a high subjective noise level (e.g., “I was distracted, annoyed, stressed or bothered by the noise level in the room”) were subtracted from 10. As a result, higher scores within the questionnaires implied better communication, respectively, collaboration within the surgical team or a lower subjective noise level with 140 points being the highest possible score and 0 points being the lowest possible score. Optionally, subjective issues perceived by the user were documented at the end of the questionnaire.
Furthermore, the noise level at the operating theatre was measured during 7 procedures using a calibrated sound level meter with integrated storage (Testo 816-1, Testo SE & Co. KGaA, Tittisee-Neustadt, Germany). The sound level meter was placed consistently on a tripod behind the sterile drape next to anesthetist with the microphone of the sound level meter protruding beyond the sterile drape. Peak sound pressure (LApeak), the A-weighted continuous sound level (LAeq) and the A-weighted exposure averaged for an 8-h time period (LEPd) were recorded during those sessions.
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Publication 2023
Anesthesiologist Anesthetist Biomet Bones Ear Knee Nurses Operative Surgical Procedures Patients Pressure prisma Protac Regional Ethics Committees Sound Sterility, Reproductive Surgeons testo Wounds and Injuries

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More about "Biomet"

Biomet, also known as biomedicine or biomedical engineering, is an interdisciplinary field that applies biological and engineering principles to the design, development, and evaluation of biological or biologically-inspired materials, devices, and systems.
This field aims to improve human health and well-being by integrating biology, medicine, and engineering.
Biomet encompasses a wide range of areas, including tissue engineering, prosthetics, medical imaging, and drug delivery systems.
Researchers in this field work to create innovative solutions that address unmet medical needs and enhance the quality of life for patients.
Some key subtopics within Biomet include: - Tissue engineering: The process of creating functional tissue substitutes for medical applications, such as regenerative therapies and organ replacement. - Prosthetics: The design and development of artificial limbs or other body parts to replace missing or damaged ones. - Medical imaging: The use of technologies like X-ray, MRI, and CT scans to visualize the body's internal structures for diagnostic and treatment purposes. - Drug delivery systems: The development of methods and devices to administer pharmaceuticals more effectively and safely.
Biomet also incorporates related terms and technologies such as Persona, Refobacin Bone Cement R, NexGen, Continuum, Triathlon, Avantage, Human BMP7, and Human BMP2.
These advancements in materials, devices, and biological factors contribute to the ongoing progress in the field of Biomet.
By optimizing research protocols through AI-driven comparisons, researchers can streamline their Biomet projects and ensure reproducibility, ultimately leading to more efficient and effective solutions for improving human health and well-being.