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Buprenex

Buprenex is a potent partial opioid agonist used for the treatment of moderate to severe pain.
It has a high affinity for mu-opioid receptors and exhibits a ceiling effect on respiratory depression, making it a safer alternative to full opioid agonists.
Buprenex is available as an injectable formulation and is commonly used in both acute and chronic pain management.
Its unique pharmacological profile offers a favorable safety profile, with reduced risk of overdose and dependence compared to traditional opioids.
Researchers and clinicians rely on PubCompare.ai to quickly identify the best Buprenex protocols from the latest literature, preprints, and patents, empowering them to make informed decisions and advance pain management therapies.

Most cited protocols related to «Buprenex»

1
Humanized Intestinal Organoid Transplantation in NSG Mice
NSG mice were kept on antibiotic chow (275 p.p.m. Sulfamethoxazole and 1,365 p.p.m. Trimethoprim; Test Diet). Food and water was provided ad libitum before and after surgeries. A single HIO, matured in vitro for 35 d, was removed from Matrigel, washed with cold phosphate-buffered saline (DPBS; Gibco), and embedded into purified type I collagen (rat tail collagen; BD Biosciences) 12 h before surgery to allow for formation of a solidified gel plug. These plugs were then placed into standard growth media overnight in intestinal growth medium (Advanced DMEM/F-12, B27, 15 mM HEPES, 2 mM L-glutamine, penicillin-streptomycin) supplemented with 100 ng ml−1 EGF (R&D). HIOs were then transplanted under the kidney capsule. Briefly, the mice were anesthetized with 2% inhaled isoflurane (Butler Schein), and the left side of the mouse was then prepped in sterile fashion with isopropyl alcohol and povidine-iodine. A small left-posterior subcostal incision was made to expose the kidney. A subcapsular pocket was created and the collagen-embedded HIO was then placed into the pocket. The kidney was then returned to the peritoneal cavity and the mice were given an IP flush of Zosyn (100 mg/kg; Pfizer Inc.). The skin was closed in a double layer and the mice were given a subcutaneous injection with Buprenex (0.05 mg/kg; Midwest Veterinary Supply). At 6 weeks following engraftment, the mice were then humanely euthanized or subjected to further experimentation.
Watson C.L., Mahe M.M., Múnera J., Howell J.C., Sundaram N., Poling H.M., Schweitzer J.I., Vallance J.E., Mayhew C.N., Sun Y., Grabowski G., Finkbeiner S.R., Spence J.R., Shroyer N.F., Wells J.M, & Helmrath M.A. (2014). An in vivo model of human small intestine using pluripotent stem cells. Nature medicine, 20(11), 1310-1314.
Publication 2014
Antibiotics Buprenex Capsule Collagen Collagen Type I Common Cold Culture Media Diet Flushing Food Glutamine HEPES Intestines Iodine Isoflurane Isopropyl Alcohol Kidney matrigel Mice, House Operative Surgical Procedures Penicillins Peritoneal Cavity Phosphates Saline Solution Skin Sterility, Reproductive Streptomycin Subcutaneous Injections Sulfamethoxazole Tail Trimethoprim Zosyn
2
Targeted GCaMP3 Expression in Hippocampal Astrocytes
Postnatal day 49–63 (P49–P63) male and female C57BL/6 mice were used in all experiments in accordance with institutional guidelines. All surgical procedures were conducted under general anesthesia using continuous isoflurane (induction at 5%, maintenance at 1–2.5% vol/vol). Depth of anesthesia was monitored continuously and adjusted when necessary. After induction of anesthesia, the mice were fitted into a stereotaxic frame, with their heads secured by blunt ear bars and their noses placed into an anesthesia and ventilation system (David Kopf Instruments). Mice were administered 0.05 ml buprenorphine (0.1 mg/ml; Buprenex) subcutaneously before surgery. The surgical incision site was then cleaned three times with 10% povidone iodine and 70% ethanol. Skin incisions were made, followed by craniotomies of 2–3 mm in diameter above the left parietal cortex using a small steel burr (Fine Science Tools) powered by a high speed drill (K.1070; Foredom). Saline (0.9%) was applied onto the skull to reduce heating caused by drilling. Unilateral viral injections were performed by using stereotaxic apparatus (David Kopf Instruments) to guide the placement of beveled glass pipettes (World Precision Instruments) into the left hippocampus (2 mm posterior to bregma, 1.5 mm lateral to midline, and 1.6 mm from the pial surface). Either 2 µl AAV2/5 gfaABC1D Lck-GCaMP3 (1.2 × 1013 gc/ml), 1.5 µl AAV2/5 gfaABC1D GCaMP3 (1.5 × 1013 gc/ml), 1.5 µl AAV2/5 gfaABC1D Lck-GFP (2.41 × 1013 gc/ml), or 1.0 µl AAV2/5 gfaABC1D tdTomato (2.5 × 1013 gc/ml) was injected using a syringe pump (Pump11 PicoPlus Elite; Harvard Apparatus). Glass pipettes were left in place for at least 10 min. Surgical wounds were closed with single external 5–0 nylon sutures. After surgery, animals were allowed to recover overnight in cages placed partially on a low voltage heating pad. Buprenorphine was administered two times per day for up to 2 d after surgery. In addition, trimethoprim sulfamethoxazole (40 and 200 mg, respectively, per 500 ml water) was dispensed in the drinking water for 1 wk. Mice were killed 12–20 d after surgery for imaging (typically 13–15 d). We chose this period because generally it takes ∼2 wk to achieve GECI expression in cells by AAV infection and because it has been suggested that long-term expression (>3 wk after AAV injection) can cause toxicity in neurons (Akerboom et al., 2012 (link)).
Shigetomi E., Bushong E.A., Haustein M.D., Tong X., Jackson-Weaver O., Kracun S., Xu J., Sofroniew M.V., Ellisman M.H, & Khakh B.S. (2013). Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses. The Journal of General Physiology, 141(5), 633-647.
Publication 2013
Anesthesia Animals Buprenex Buprenorphine Cells Craniotomy Cranium Drill Ethanol General Anesthesia Head Infection Isoflurane Males Mice, Inbred C57BL Microinjections Mus Neurons Nose Nylons Operative Surgical Procedures Parietal Lobe Povidone Iodine Reading Frames Saline Solution Seahorses Skin Steel Surgical Wound Sutures Syringes tdTomato Trimethoprim-Sulfamethoxazole Combination Woman
3
TMJ Disc Removal Surgery in Mice

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Publication 2009
Analgesics Animals Bladder Detrusor Muscle Buprenex Cartilage Food Ketamine Mice, House Mice, Inbred C57BL Operative Surgical Procedures Peritoneum Powder
4
Laparoscopic Gastric Sleeve Surgery in Rats

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Publication 2010
Abdomen Abdominal Cavity Buprenex Diet Duodenum Esophagus Food Forceps Gastric Stump Intensive Care Laparotomy Ligaments Liver Operative Surgical Procedures Osmolite Pressure Pylorus Rattus norvegicus Saline Solution Spleen Staple, Surgical Stomach Subcutaneous Injections Wall, Abdominal
5
Standardized Rodent Spinal Cord Injury Model
After making an incision on the skin, longitudinal incisions with approximately 2–3 mm depth were made on the left and right side of the spinous processes of the vertebrae T6-T12 using scalpel #10. The paravertebral muscles were then gently pulled away from the spine, without any further incision or damage to the muscles. With retractors holding the muscle aside, laminectomy was performed using a Zeiss operating microscope, by cutting and removing the lamina at T8 to expose the dorsal surface of the spinal cord. Stabilization clamps were placed at the posterior spinous processes of the vertebrae T6 and T12 to support the vertebral column during impact.
The exposed spinal cord was then contused at the thoracic vertebra T8 using the NYU-MASCIS (New York University - Multicenter Animal Spinal Cord Injury Study) weight-drop impactor11 (link). This device consists of a 10g rod with a flat circular impact surface of diameter 2mm, which is slightly less than that of the rodent spinal cord (body weight >200g) to clear the edges of the vertebral canal as the impactor hits the cord. This also ensures that the entire impact surface is in complete contact with the cord during the contusion, so that all the energy from the weight drop is transferred to the spinal cord parenchyma. This impactor rod was directed towards the midline of the exposed spinal cord and was released from a height of 6.25 mm (n=3), 12.5 mm (n=3), 25 mm (n=3) or 50 mm (n=3), producing more severe neurologic injuries with increasing height. The control group (n=3) underwent laminectomy only. The impactor device was connected to a software Impactor v. 7.0 on a computer, which displayed the impact trajectory curves using the impactor and vertebral position sensors and the cord contact sensor11 (link). It also computed the actual height, time and velocity of the impact. Only rats with <0.05% variation in these values were considered for this study.
After injury, the muscles were sutured in layers and the skin closed with metal wound clips. Gentamycin (5 mg/kg, intramuscular; Abbott Laboratories, North Chicago, IL) was administered immediately post-surgery and then daily for 7 days. The analgesic, Buprenex (0.3 mg/kg, subcutaneous; Reckitt Benckiser, Richmond, VI), was delivered post-surgery and daily for 2 days. After surgery, their bladders were expressed regularly with no complications or other infections to report. No sign of autotomy or autophagy were observed. The rats were maintained for 7 weeks after injury.
Agrawal G., Kerr C., Thakor N.V, & All A.H. (2010). Characterization of Graded MASCIS Contusion Spinal Cord Injury using Somatosensory Evoked Potentials. Spine, 35(11), 1122-1127.
Publication 2009
Analgesics Animals Autophagy Buprenex Clip Cone-Rod Dystrophy 2 Contusions Gentamicin Infection Injuries Laminectomy Medical Devices Metals Microscopy Muscle Tissue Operative Surgical Procedures Rattus norvegicus Rodent Skin Spinal Canal Spinal Cord Spinal Cord Injuries Spinous Processes Trauma, Nervous System Urinary Bladder Vertebra Vertebrae, Thoracic Vertebral Column Wounds

Most recents protocols related to «Buprenex»

1
Evaluating Analgesic Efficacy in Squid
We identified candidate analgesics from published reports of efficacy in fish and other vertebrates [32 (link),33 (link),34 (link),35 (link)]. We selected drugs from several different drug classes and based dosing on published studies in fish if available, and then in rodents. We chose an initial drug dose toward the upper end of doses reported to be effective in other species, and in cases where we observed possible effects on squid behavior, we also tested 10× the initial dose chosen. Doses are reported as ranges in cohorts of squid where size was variable, or as a single value where cohorts for that drug were similar sizes.
Drugs chosen were as follows: Buprenorphine (“Buprenex”, an opioid), Ketorolac (an NSAID), Ketamine (a dissociative anaesthetic with analgesic properties), Dexmedetomidine (“Dexdomitor”), an alpha2 adrenoreceptor agonist) and acetominophen (a COX-2 inhibitor). Drugs were obtained either through a retail pharmacy (Rite-Aid, San Francisco, CA) (acetominophen, ketorolac) or from Covetrus Veterinary Supply (Phoenix, AZ, USA) (Buprenex, Dexdomitor, Ketamine). All drugs except for acetominophen were delivered via intramuscular injection into the base of the arm crown on the dorsal body surface. Acetominophen was dosed orally by injecting the drug solution into a live shrimp, which was then fed immediately to the squid. All drugs were diluted in filtered, sterile artificial seawater. Control injections were vehicle (ASW) only.
Deutsch S., Parsons R., Shia J., Detmering S., Seng C., Ng A., Uribe J., Manahan M., Friedman A., Winters-Bostwick G, & Crook R.J. (2023). Evaluation of Candidates for Systemic Analgesia and General Anesthesia in the Emerging Model Cephalopod, Euprymna berryi. Biology, 12(2), 201.
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Publication 2023
Acetaminophen Adrenergic Agonists Analgesics Anesthetics, Dissociative Anti-Inflammatory Agents, Non-Steroidal Buprenex Buprenorphine Cyclooxygenase 2 Inhibitors Dexmedetomidine Fishes Human Body Intramuscular Injection Ketamine Ketorolac Opioids Pharmaceutical Preparations Pharmaceutical Solutions Rodent Squid Sterility, Reproductive Vertebrates
2
Anesthesia and Surgical Procedures
All mice were anesthetized using 4% Isoflurane for induction and maintained at 2%. Hair was shaved, and skin was prepped with betadine. For all surgeries, fascia and skin were sutured using 6–0 and 5–0 plain gut resorbable sutures, respectively. All animals were given Buprenex (0.01 mg/kg) for immediate postoperative pain management, and Baytril (0.01 mL) for infection prophylaxis by subcutaneous injections at time of surgery which continued for 48 h.
Liu Y., Ilinski A., Gerstenfeld L.C, & Bragdon B. (2023). Prx1 cell subpopulations identified in various tissues with diverse quiescence and activation ability following fracture and BMP2 stimulation. Frontiers in Physiology, 14, 1106474.
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Publication 2023
Animals Baytril Betadine Buprenex Fascia Hair Infection Isoflurane Mice, House Operative Surgical Procedures Pain, Postoperative Skin Subcutaneous Injections Sutures
3
Anesthetic and Analgesic Protocol for Mice
Mice were anesthetized with isoflurane in oxygen (5% induction, 2% maintenance) and placed in a stereotaxic frame (Kopf Model 1900). A homeothermic blanket system was used to maintain body temperature at 36.6° (FHC). Lidocaine hydrochloride was administered subcutaneously to numb the scalp. At the conclusion of the procedure and 24hr post-recovery, Buprenex (0.05 mg/kg) and meloxicam (0.1 mg/kg) were administered, and the animal was transferred to a warmed recovery chamber.
Asokan M.M., Watanabe Y., Kimchi E.Y, & Polley D.B. (2023). Potentiated cholinergic and corticofugal inputs support reorganized sensory processing in the basolateral amygdala during auditory threat acquisition and retrieval. bioRxiv.
Publication Preprint 2023
Animals Body Temperature Buprenex Isoflurane Lidocaine Hydrochloride Meloxicam Mice, House Oxygen Reading Frames Scalp
4
Surgical Implantation of Titanium Headpost
Mice were anesthetized with a mixture of ketamine/xylazine (ketamine: 50 mg/kg, xylazine: 5 mg/kg; intraperitoneal) and isoflurane (1.2–2% in 100% O2). Meloxicam was administered pre-operatively (1 mg/mL, 5 mg/kg; subcutaneous). Using aseptic technique, a custom-made titanium headpost was secured over V1 using clear dental cement (C&B Metabond, Parkell). Buprenex (0.05 mg/kg) and cefazolin (50 mg/kg) were administered post-operatively. Animals were allowed to recover for at least 1 week prior to experiments.
Li J.Y, & Glickfeld L.L. (2023). Input-specific synaptic depression shapes temporal integration in mouse visual cortex. bioRxiv.
Publication Preprint 2023
Animals Asepsis Buprenex C & B Metabond Cefazolin Dental Cements Isoflurane Ketamine Meloxicam Mice, House Titanium Xylazine
5
Volumetric Muscle Loss Repair in Rats
Adult Sprague Dawley rats (n = 20) weighing ~ 350 g, were subjected to an established VML injury model67 (link). VML defects were created in the middle third of the Tibialis anterior (TA) muscle in the left leg by excising about 20% of the TA weight using an 8 mm biopsy punch. VML defect plugs were minced using a scalpel blade into 1 mm3 fragments and used to repair the VML injuries. Fascia and skin were closed using interrupted stiches with 5–0 Vicryl sutures (J463G, Ethicon). The contralateral limb was not injured and served as an uninjured control. Buprenorphine (0.1 mL at 0.3 mg/mL) (LIST 7571, Buprenex) was administered to all rats subcutaneously for postoperative analgesia and access to Rimadyl (MD150-2, Bio-Serv) was provided at up to 1 mg per day for seven days post-injury + repair (DPI). Food and water were provided ad libitum. All animal procedures were approved by the Institutional Animal Care and Use Committee of the University of Arkansas. All experiments were performed in accordance with all guidelines and ARRIVE guidelines. Animals were randomly assigned to one of two treatment groups (n = 10/treatment group): either rat recombinant IL-10 (400-19, PeproTech) in sterile phosphate buffered solution (PBS) (2000 ng/ml) or PBS injection (IM at site of repair) beginning 7 days after the initial surgery and continuing until day 14 (100 µL every other day = 4 injections total) (Fig. 1a,b). Animals (n = 5/treatment/time point) from each treatment group were allowed either 14 or 56 days of recovery.
Huynh T., Reed C., Blackwell Z., Phelps P., Herrera L.C., Almodovar J., Zaharoff D.A, & Wolchok J. (2023). Local IL-10 delivery modulates the immune response and enhances repair of volumetric muscle loss muscle injury. Scientific Reports, 13, 1983.
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Publication 2023
Adult Animals Biopsy Buprenex Buprenorphine Fascia Food IL10 protein, human Injuries Institutional Animal Care and Use Committees Lamina 1 Management, Pain Phosphates Rats, Sprague-Dawley Skin Sterility, Reproductive Sutures Tibial Muscle, Anterior Vicryl Wound Healing

Top products related to «Buprenex»

1
Buprenex by Reckitt Benckiser
Sourced in United Kingdom, United States
Buprenex is a pharmaceutical product used as a laboratory reagent. It contains the active ingredient buprenorphine, which is a controlled substance. Buprenex is primarily used in research and scientific applications, and its core function is to serve as a tool for investigating and studying various biological and pharmacological processes.
2
Cefazolin by Reckitt Benckiser
Sourced in United Kingdom
Cefazolin is a prescription antibiotic medication that belongs to the cephalosporin class of antibiotics. It is used to treat a variety of bacterial infections. Cefazolin works by interfering with the bacterial cell wall formation, which leads to the death of the bacteria.
3
Fast green by Merck Group
Sourced in United States, Germany, Japan, Spain, China, United Kingdom, France, Italy, Canada
Fast Green is a laboratory staining dye used in various scientific applications. It is a synthetic, water-soluble dye that provides a green coloration. The core function of Fast Green is to stain and visualize specific components or structures within biological samples during microscopy and other analytical procedures.
4
C57bl 6 mice by Jackson ImmunoResearch
Sourced in United States, Montenegro, Canada, China, France, United Kingdom, Japan, Germany
C57BL/6 mice are a widely used inbred mouse strain commonly used in biomedical research. They are known for their black coat color and are a popular model organism due to their well-characterized genetic and physiological traits.
5
Buprenex by Henry Schein
Sourced in United States
Buprenex is a pharmaceutical product used as a veterinary analgesic. It contains the active ingredient buprenorphine hydrochloride, which is an opioid agonist-antagonist. Buprenex is designed to provide pain relief in animals.
6
C57bl 6j mice by Jackson ImmunoResearch
Sourced in United States, Montenegro, Japan, Canada, United Kingdom, Germany, Macao, Switzerland, China
C57BL/6J mice are a widely used inbred mouse strain. They are a commonly used model organism in biomedical research.
7
Bv 10 micropipette beveller by Sutter Instruments
The BV-10 micropipette Beveller is a lab equipment product designed to bevel the tips of micropipettes. It is a specialized tool used in various scientific and laboratory applications.
8
Ketaved by Vedco
Sourced in United States, Israel, Sao Tome and Principe
KetaVed is a laboratory equipment product offered by Vedco. It is designed for use in various scientific and research applications. The core function of KetaVed is to provide a controlled environment for conducting experiments and analyses.
9
Matrigel by Corning
Sourced in United States, China, Germany, United Kingdom, Canada, Japan, France, Netherlands, Montenegro, Switzerland, Austria, Australia, Colombia, Spain, Morocco, India, Azerbaijan
Matrigel is a complex mixture of extracellular matrix proteins derived from Engelbreth-Holm-Swarm (EHS) mouse sarcoma cells. It is widely used as a basement membrane matrix to support the growth, differentiation, and morphogenesis of various cell types in cell culture applications.
10
Lactated ringer s solution by Baxter
Sourced in United States, Canada
Lactated Ringer's solution is a sterile, isotonic electrolyte solution commonly used in medical settings. It contains a balanced combination of sodium, potassium, calcium, and lactate ions. The primary function of Lactated Ringer's solution is to provide fluid and electrolyte replacement therapy.

More about "Buprenex"

Buprenex, a potent partial opioid agonist, is a widely used medication for the treatment of moderate to severe pain.
It has a high affinity for mu-opioid receptors, which are responsible for the analgesic (pain-relieving) effects of opioid drugs.
Buprenex exhibits a ceiling effect on respiratory depression, making it a safer alternative to full opioid agonists like morphine or oxycodone.
Buprenex is available as an injectable formulation and is commonly used in both acute and chronic pain management, including for postoperative pain, cancer pain, and chronic noncancer pain.
Its unique pharmacological profile offers a favorable safety profile, with reduced risk of overdose and dependence compared to traditional opioids.
Researchers and clinicians often utilize PubCompare.ai, an advanced AI-driven research platform, to quickly identify the best Buprenex protocols from the latest literature, preprints, and patents.
This empowers them to make informed decisions and advance pain management therapies.
In addition to Buprenex, other related terms and substances that may be of interest include Cefazolin (an antibiotic), Fast Green (a dye), C57BL/6 mice and C57BL/6J mice (commonly used laboratory mouse strains), BV-10 micropipette Beveller (a laboratory instrument), KetaVed (a veterinary anesthetic), Matrigel (an extracellular matrix product), and Lactated Ringer's solution (a common medical infusion fluid).