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Buprenorphine

Buprenorphine is a semisynthetic opioid analgesic derived from the opium alkaloid thebaine.
It is used as an analgesic and as a treatment for opioid dependence.
Buprenorphine exhibits partial agonist activity at the mu-opioid receptor and antagonist activity at the kappa-opioid receptor.
This unique pharmacological profile contributes to its therapeutic effects and safety profile.
Buprenorphine is availabel in various formulations for the management of pain and opioid use disorder.
Researchers can utilize PubCompare.ai to optimize their Buprenorphine studies, accessing AI-driven protocols from literature, preprints, and patents, and leveraging intelligent comparisons to identify the most effective products and procedures.
This innovative tool can enhance reproducibility and accuracy in Buprenorphine research.

Most cited protocols related to «Buprenorphine»

1
Improved Myocardial Infarction Modeling
Cited 154 times
Experiments were carried out according to National Institutes of Health Guidelines on the Use of Laboratory Animals and all procedures were approved by the Thomas Jefferson University Committee on Animal Care. A total of 497 (384 mice for MI and 113 for I/R) male 8-10 week old C57/B6 mice were used for this study. For the MI model, mice were subjected to permanent coronary artery ligation using either the new (N) method or the classical (C) method. Mice were randomly assigned to four groups: new method of MI (MI-N) or sham (S-N); classical method of MI (MI-C) or sham (S-C). There were 119 mice used for survival study. Some of the mice survived at the end of 28 days were also used for echocardiographic, hemodynamic and infarct size studies as indicated in each study. The rest of 232 mice survived from all kinds of 265 procedures (33 mice died) were used for 24h infarct size measurement (32 mice), Masson's trichrome stain (18 mice), arrhythmia analysis (28 mice), myeloperoxidase (MPO, 81) and TNFα (73) assays. In I/R model, mice were subjected to 30 min of myocardial ischemia followed by 24 hrs of reperfusion. Mice were divided into four groups also: new method of I/R (I/R-N, n=41) or sham (SI/R-N, n=16), classical method of I/R or sham I/R (I/R-C, n=40, SI/R-C, n=16, respectively). All animals were monitored after the surgery and received one dose (0.3mg/kg) of buprenophine within 6 hours post surgery and another dose was administered the following morning. No further analgesia was given thereafter.
Gao E., Lei Y.H., Shang X., Huang Z.M., Zuo L., Boucher M., Fan Q., Chuprun J.K., Ma X.L, & Koch W.J. (2010). A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse. Circulation research, 107(12), 1445-1453.
Publication 2010
Animals Animals, Laboratory Artery, Coronary Biological Assay Buprenorphine Cardiac Arrhythmia Echocardiography Hemodynamics Infarction Ligation Males Management, Pain Mice, House Myocardial Ischemia Operative Surgical Procedures Peroxidase Reperfusion trichrome stain Tumor Necrosis Factor-alpha
2
Optogenetic Manipulation of Neural Circuits
Cited 44 times
All procedures were in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and approved by the Massachusetts Institute of Technology Committee on Animal Care. C57BL/6J E16-timed pregnant mice were used for electroporation. Surgery was done under ketamine-xylazine anesthesia and buprenorphine analgesia. For cortical experiments, DNA solution containing plasmids of interest were injected into lateral ventricle of each embryo using a pulled capillary tube. Five square pulses (50ms width, 1Hz, 35V) were applied using tweezer electrode for electroporation (Harvard Apparatus, ECM 830). Direct opsin-expressing experimental mice were electroporated with pCAG-opsin-GFP plasmid. Post-synaptic experimental mice were electroporated with pCAG-FLEX-rc[Chronos-GFP] and/or pCAG-FLEX-Chrimson-mOrange2, and pCAG-Cre plasmids. pCAG-Chrimson-tdTomato was additionally used in half of the single post-synaptic experiments.
For the retinal ganglion cell-superior colliculus experiment, intravitreal virus injection was performed on P0 C57BL/6 mice with Nanoject II (Drummond) under cold anesthesia. 100 nL of rAAV2/8-Synapsin-Chronos-GFP (titer 1.4×1013 particles/mL) was injected into the eye. AAV particles were produced by the University of North Carolina Chapel Hill Vector Core.
Klapoetke N.C., Murata Y., Kim S.S., Pulver S.R., Birdsey-Benson A., Cho Y.K., Morimoto T.K., Chuong A.S., Carpenter E.J., Tian Z., Wang J., Xie Y., Yan Z., Zhang Y., Chow B.Y., Surek B., Melkonian M., Jayaraman V., Constantine-Paton M., Wong G.K, & Boyden E.S. (2014). Independent Optical Excitation of Distinct Neural Populations. Nature methods, 11(3), 338-346.
Publication 2014
Anesthesia Animals Animals, Laboratory Buprenorphine Capillaries Cloning Vectors Common Cold Cortex, Cerebral Electroporation Therapy Embryo Ketamine Management, Pain Mice, Inbred C57BL Mus Operative Surgical Procedures Plasmids Pulses Retinal Ganglion Cells Rod Opsins Synapsins tdTomato Tectum, Optic Ventricle, Lateral Virus Xylazine
3
Optogenetic Manipulation of Neural Circuits
Cited 38 times
All procedures were in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and approved by the Massachusetts Institute of Technology Committee on Animal Care. C57BL/6J E16-timed pregnant mice were used for electroporation. Surgery was done under ketamine-xylazine anesthesia and buprenorphine analgesia. For cortical experiments, DNA solution containing plasmids of interest were injected into lateral ventricle of each embryo using a pulled capillary tube. Five square pulses (50ms width, 1Hz, 35V) were applied using tweezer electrode for electroporation (Harvard Apparatus, ECM 830). Direct opsin-expressing experimental mice were electroporated with pCAG-opsin-GFP plasmid. Post-synaptic experimental mice were electroporated with pCAG-FLEX-rc[Chronos-GFP] and/or pCAG-FLEX-Chrimson-mOrange2, and pCAG-Cre plasmids. pCAG-Chrimson-tdTomato was additionally used in half of the single post-synaptic experiments.
For the retinal ganglion cell-superior colliculus experiment, intravitreal virus injection was performed on P0 C57BL/6 mice with Nanoject II (Drummond) under cold anesthesia. 100 nL of rAAV2/8-Synapsin-Chronos-GFP (titer 1.4×1013 particles/mL) was injected into the eye. AAV particles were produced by the University of North Carolina Chapel Hill Vector Core.
Klapoetke N.C., Murata Y., Kim S.S., Pulver S.R., Birdsey-Benson A., Cho Y.K., Morimoto T.K., Chuong A.S., Carpenter E.J., Tian Z., Wang J., Xie Y., Yan Z., Zhang Y., Chow B.Y., Surek B., Melkonian M., Jayaraman V., Constantine-Paton M., Wong G.K, & Boyden E.S. (2014). Independent Optical Excitation of Distinct Neural Populations. Nature methods, 11(3), 338-346.
Publication 2014
Anesthesia Animals Animals, Laboratory Buprenorphine Capillaries Cloning Vectors Common Cold Cortex, Cerebral Electroporation Therapy Embryo Ketamine Management, Pain Mice, Inbred C57BL Mus Operative Surgical Procedures Plasmids Pulses Retinal Ganglion Cells Rod Opsins Synapsins tdTomato Tectum, Optic Ventricle, Lateral Virus Xylazine
4
Sepsis Induction in Mice
Cited 26 times
For sepsis induction, each mouse was given an intraperitoneal (i.p.) injection of 0.5 mL of the fecal slurry solution using a syringe and 27G needle. Depending on the fecal concentrations (45, 90, and 180 mg/mL) used, each mouse therefore received 2, 4, or 8 mg of FIP solution per 1 g body weight respectively. Sham mice were injected with sterile normal saline (NS). Pain (either from the injection or from the fecal slurry)was assessed using facial expression as described by Langford et al.[16 (link)], as well as body posture and vocalization. Analgesia was provided by a subcutaneous injection of buprenorphine (0.1 mg/kg).
Shrum B., Anantha R.V., Xu S.X., Donnelly M., Haeryfar S.M., McCormick J.K, & Mele T. (2014). A robust scoring system to evaluate sepsis severity in an animal model. BMC Research Notes, 7, 233.
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Publication 2014
Body Weight Buprenorphine Feces Management, Pain Mus Needles Normal Saline Pain PER1 protein, human Sepsis Sterility, Reproductive Subcutaneous Injections Suby's G solution Syringes
5
Implant-Associated Staphylococcus aureus Infection in Mice
Cited 24 times
Mice were anesthetized via inhalation isoflurane (2%). The surgical procedure was modified from previous work [49] (link), [50] (link). A skin incision was made over the right knee (Figure 1A). The distal right femur was accessed through a medial parapatellar arthrotomy with lateral displacement of the quadriceps-patellar complex (Figure 1B). After locating the femoral intercondylar notch (Figure 1B), the femoral intramedullary canal was manually reamed with a 25 gauge needle (Figure 1C). An orthopaedic-grade stainless steel Kirschner (K)-wire (diameter 0.6 mm) (Synthes) was surgically placed in a retrograde fashion and cut with 1 mm protruding into the joint space (Figure 1D). An inoculum of S. aureus in 2 µl of normal saline was pipetted into the joint space containing the cut end of the implant (Figure 1E). The quadriceps-patellar complex was reduced to the midline (Figure 1F) and the surgical site was closed with Dexon 5-0 sutures (Figure 1G). A representative radiograph demonstrates the position of the implant with good intramedually fixation of the stem and prominence of the cut surface in the joint (Figure 1H). Buprenorphine (0.1 mg/kg) was administered subcutaneously every 12 hours as an analgesic for the duration of the experiment.
Bernthal N.M., Stavrakis A.I., Billi F., Cho J.S., Kremen T.J., Simon S.I., Cheung A.L., Finerman G.A., Lieberman J.R., Adams J.S, & Miller L.S. (2010). A Mouse Model of Post-Arthroplasty Staphylococcus aureus Joint Infection to Evaluate In Vivo the Efficacy of Antimicrobial Implant Coatings. PLoS ONE, 5(9), e12580.
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Publication 2010
Analgesics Buprenorphine dexon (fungicide) Femur Inhalation Isoflurane Joints Kirschner Wires Knee Joint Mus Needles Normal Saline Operative Surgical Procedures Patella Pulp Canals Quadriceps Femoris Skin Stainless Steel Stem, Plant Sutures X-Rays, Diagnostic

Most recents protocols related to «Buprenorphine»

1
Opioid Exposure in Chronic Pain
Exposure to opioids was captured using prescription information available in the pharmacy claims (e.g., medication name, fill date, days supplied). Opioid exposure was examined at monthly intervals from each person’s study entry date to their drop in health plan enrollment or end of study period, whichever came first. Individuals were included in the analysis per month if they had enrollment for that entire month. Opioid exposure was determined by an outpatient pharmacy fill for a product containing hydrocodone, oxycodone, tramadol, codeine, morphine, fentanyl, and “other”, which included hydromorphone, buprenorphine, propoxyphene, oxymorphone, methadone, dihydrocodeine, levorphanol tartrate, meperidine hydrochloride, opium, pentazocine, and tapentadol.
The timing of opioid exposure was based on the date of prescription and number of days supplied, which allowed for the determination of monthly exposure as binary (yes/no) and number of days supplied. To standardize the number of days supplied per month, the proportion of each month exposed was calculated as the days supplied divided by the number of days in that month. This study did not standardize doses across opioid types (e.g., oral morphine equivalents) given the variability in suggested conversion factors [24 (link)]. Further, it is unknown if the proportion of opioid prescriptions by type differs for adults with and without CP, and how variation in conversion factors could impact interpretations. Therefore, this study focused on measures of opioid exposure as exposed/not exposed, the number of days supplied, and the proportion of opioid prescriptions by type.
Whitney D.G., Peterson M.D, & Hurvitz E.A. (2023). Population- and individual-level trajectories of opioid prescription patterns among adults with cerebral palsy: a retrospective cohort study. International Journal of Clinical Pharmacy, 45(3), 669-680.
Publication 2023
Adult Buprenorphine Codeine dihydrocodeine Fentanyl Health Planning Hydrocodone Hydromorphone Meperidine Hydrochloride Methadone Morphine Opioids Opium Outpatients Oxycodone Oxymorphone Pentazocine Pharmaceutical Preparations Prescriptions Propoxyphene Tapentadol Tartrate, Levorphanol Tramadol
2
Intracerebroventricular and Intraperitoneal Delivery of Antisense Oligonucleotides in Mice
Mice were housed in a pathogen-free barrier facility with a 12-h light/12-h dark cycle and provided food and water ad libitum. GrnR493X knock-in mice [17 (link)] and Upf3b knockout mice [26 (link)] were on the C57BL/6J background and were genotyped by real-time PCR (Transnetyx). For intracerebroventricular (ICV) ASO delivery, 200–500 μg ASO was administered by bolus injection into the right lateral ventricle of mice anesthetized with isoflurane, as previously described [27 (link)]. After 2–3 weeks, mice were sacrificed and brain tissues were collected for RNA and protein analyses, as described below. For immunofluorescence, mice were transcardially perfused with PBS followed by 4% paraformaldehyde. For intraperitoneal (IP) ASO delivery, 50 mg/kg of ASO was administered every other day for a total of 4 injections. One day after the final injection, mice were sacrificed and tissues were collected for qPCR analysis.
Animal procedures were approved by the Institutional Animal Care and Use Committee of Saint Louis University (protocol #2764) and followed NIH guidelines. For ICV administration, mice were anesthetized with isoflurane and also provided bupivacaine and buprenorphine. For perfusion, mice were anesthetized with a ketamine/xylazine cocktail followed by transcardial perfusion. For tissue collection, mice were anesthetized with ketamine/xylazine cocktail followed by rapid decapitation.
Smith D.M., Niehoff M.L., Ling K., Jafar-Nejad P., Rigo F., Farr S.A., Wilkinson M.F, & Nguyen A.D. (2023). Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn R493X mouse model of frontotemporal dementia. PLOS ONE, 18(3), e0282822.
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Publication 2023
Animals Brain Bupivacaine Buprenorphine Decapitation Food Immunofluorescence Institutional Animal Care and Use Committees Isoflurane Ketamine Mice, House Mice, Knockout Obstetric Delivery paraform Pathogenicity Perfusion Proteins Real-Time Polymerase Chain Reaction Tissues Ventricle, Lateral Xylazine
3
Surgical Implantation of Intracranial Guide Cannulae and Jugular Vein Catheters

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Publication 2023
Animals Buprenorphine Cannula Catheters Cefazolin Cocaine Cranium Dental Health Services Heparin Isoflurane Jugular Vein Meloxicam Operative Surgical Procedures Polyurethanes Saline Solution Scapula Self Administration Sterility, Reproductive Ventricle, Lateral
4
Disability Impacts on Opioid Use Treatment
Data analysis was performed from January to September 2022. Analyses were conducted by person-year. After conducting descriptive analyses and χ2 tests, we fit generalized estimating equations with robust SEs assuming an exchangeable correlation structure using SAS statistical software version 9.4 (SAS Institute) to account for correlated outcomes of individuals in the data for multiple years. Two-tailed P < .05 was considered to denote statistical significance. Models adjusted for the confounding variables of age, gender, race and ethnicity (identified via database; race and ethnicity were included to isolate their associations with disability to the extent possible), urban residence, SUD other than OUD in the year, mental disorder in the year, eligibility year, and living in an institution for at least 2 months of the year, to be consistent with the literature. Model 1 included any disability as a dichotomous independent variable. Model 2 included each type of disability, also dichotomous with each compared with persons without that disability, as some enrollees have more than 1 type. Full models are in eTables 4, 5, 6, and 7 in Supplement 1. We also modeled type of medication by disability status and type among those receiving buprenorphine or methadone.
Thomas C.P., Stewart M.T., Ledingham E., Adams R.S., Panas L, & Reif S. (2023). Quality of Opioid Use Disorder Treatment for Persons With and Without Disabling Conditions. JAMA Network Open, 6(3), e232052.
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Publication 2023
Buprenorphine Dietary Supplements Disabled Persons Eligibility Determination Ethnicity Gender Mental Disorders Methadone Pharmaceutical Preparations
5
Anesthesia and Intracranial Optogenetic Manipulations in Mice
For all surgeries, mice were anesthetized with 1–2% isoflurane, and placed in a stereotaxic apparatus (Kopf Instruments) on a heating pad (Harvard Apparatus). Fur was removed from the scalp, the incision site was cleaned with betadine and a midline incision was made. Sterile surgical techniques were used, and mice were injected with sustained-release buprenorphine for post-operative recovery. Mice were allowed to recover for at least two weeks after surgery before behavioural experiments.
For intracranial optogenetic experiments, virus was injected using a 33-gauge beveled needle and a 10-µl Nano-fil syringe (World Precision Instruments), controlled by an injection pump (Harvard Apparatus). Five hundred nanolitres of AAVdj-hSyn::iC++-eYFP or AAVdj-hSyn::eYFP (5×1011 vg ml−1) was injected at 150 nl per min and the syringe was left in place for at least 10 min before removal. The following coordinates were used (relative to Bregma): posterior insula (−0.58 (anterior–posterior (AP)), ±4.2 (medial–lateral (ML)), −3.85 (dorsal–ventral (DV)); mPFC (1.8 (AP), ±0.35 (ML), −2.9 (DV)). Optical fibres (0.39 NA, 200 µm; Thorlabs) were implanted 200 µm above virus injection coordinates. Fibres were secured to the cranium using Metabond (Parkell). Mice were allowed to recover for at least two weeks before behavioural testing.
Hsueh B., Chen R., Jo Y., Tang D., Raffiee M., Kim Y.S., Inoue M., Randles S., Ramakrishnan C., Patel S., Kim D.K., Liu T.X., Kim S.H., Tan L., Mortazavi L., Cordero A., Shi J., Zhao M., Ho T.T., Crow A., Yoo A.C., Raja C., Evans K., Bernstein D., Zeineh M., Goubran M, & Deisseroth K. (2023). Cardiogenic control of affective behavioural state. Nature, 615(7951), 292-299.
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Publication 2023
Betadine Buprenorphine Cranium Fibrosis Insula of Reil Isoflurane Mice, House Needles Operative Surgical Procedures Optogenetics Scalp Sterility, Reproductive Syringes Virus

Top products related to «Buprenorphine»

1
Buprenorphine by Reckitt Benckiser
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Buprenorphine is a synthetic opioid compound that is used as a laboratory reagent and analytical standard. It is a Schedule III controlled substance in many countries. Buprenorphine is utilized in various research and analytical applications, but its detailed intended use cannot be provided in an unbiased and factual manner without further interpretation.
2
C57bl 6j mice by Jackson ImmunoResearch
Sourced in United States, Montenegro, Japan, Canada, United Kingdom, Germany, Macao, Switzerland, China
C57BL/6J mice are a widely used inbred mouse strain. They are a commonly used model organism in biomedical research.
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Temgesic by Merck & Co
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Temgesic is a laboratory instrument designed for the measurement and analysis of various parameters in a controlled environment. It is a versatile tool used in research and development, as well as in quality control processes. The core function of Temgesic is to provide accurate and reliable data collection and analysis.
4
Stereotaxic frame by Kopf Instruments
Sourced in United States, Germany, Italy
The Stereotaxic frame is a laboratory instrument used to immobilize and position the head of a subject, typically an animal, during surgical or experimental procedures. It provides a secure and reproducible method for aligning the subject's head in a three-dimensional coordinate system to enable precise targeting of specific brain regions.
5
Isoflurane by Baxter
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Isoflurane is a volatile anesthetic agent used in the medical field. It is a clear, colorless, and nonflammable liquid that is vaporized and administered through inhalation. Isoflurane is primarily used to induce and maintain general anesthesia during surgical procedures.
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C57bl 6 mice by Jackson ImmunoResearch
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C57BL/6 mice are a widely used inbred mouse strain commonly used in biomedical research. They are known for their black coat color and are a popular model organism due to their well-characterized genetic and physiological traits.
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Metacam by Boehringer Ingelheim
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Metacam is a veterinary pharmaceutical product manufactured by Boehringer Ingelheim. It contains the active ingredient meloxicam, which is a nonsteroidal anti-inflammatory drug (NSAID).
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Temgesic by Reckitt Benckiser
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Temgesic is a prescription medication used in medical settings. It is a synthetic opioid analgesic primarily used for the treatment of moderate to severe pain.
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Vetbond by 3M
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Vetbond is a tissue adhesive product manufactured by 3M for use in veterinary applications. It is designed to quickly and effectively bond tissues together, facilitating wound closure and healing. The core function of Vetbond is to provide a reliable and secure means of joining various types of tissue, such as skin, muscle, and membranes, without the need for sutures or other invasive methods.
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Midazolam by Roche
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Midazolam is a benzodiazepine compound used as a sedative and hypnotic in medical and clinical settings. It is commonly used for the induction and maintenance of anesthesia, as well as for the management of certain types of seizures. Midazolam primarily functions as a short-acting central nervous system depressant, exhibiting anxiolytic, amnestic, hypnotic, anticonvulsant, and muscle relaxant properties.

More about "Buprenorphine"

Buprenorphine is a partial opioid agonist and kappa-opioid receptor antagonist, commonly used as an analgesic and for the treatment of opioid dependence.
This unique pharmacological profile contributes to its therapeutic effects and safety profile.
Buprenorphine is available in various formulations, including sublingual, transdermal, and injectable forms, for the management of pain and opioid use disorder.
Researchers can utilize PubCompare.ai to optimize their Buprenorphine studies, accessing AI-driven protocols from literature, preprints, and patents, and leveraging intelligent comparisons to identify the most effective products and procedures.
This innovative tool can enhance reproducibility and accuracy in Buprenorphine research.
Related terms and topics include Temgesic (a brand name for buprenorphine), C57BL/6J and C57BL/6 mice (commonly used in preclinical Buprenorphine studies), Stereotaxic frames (used for precise delivery of Buprenorphine in animal studies), Isoflurane (an anesthetic used in conjunction with Buprenorphine), Metacam (an anti-inflammatory medication), Vetbond (a surgical adhesive), and Midazolam (a sedative used in Buprenorphine research).
By incorporating these related terms and concepts, researchers can optimize their Buprenorphine studies and enhance the overall quality and impact of their work.