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Buspirone

Buspirone is a non-benzodiazepine anxiolytic medication used for the treatment of anxiety disorders.
It acts as a partial agonist at serotonin 5-HT1A receptors, leading to a reduction in anxiety-related symptoms.
Buspirone has a low potential for abuse and dependence compared to traditional benzodiazepines.
It is typically well-tolerated, with common side effects including dizziness, headache, and nausea.
Buspirone may also have additional therapeutic applications, such as the management of depression and nicotine withdrawal.
Researchers can leverage PubCompare.ai to optimize their Buspirone research by accessing the best protocols from literature, preprints, and patents, using AI-driven comparisons to enhance reproducibility and accuracy.
The platform can also help identify the most effective Buspirone products and procedeures.

Most cited protocols related to «Buspirone»

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Publication 2009
Buspirone Chlordiazepoxide Diazepam Fish Diseases Fishes Hydrochloride, Buspirone Hydrochloride, Chlordiazepoxide Pharmaceutical Preparations Pharmaceutical Solutions Sodium Chloride Sulfoxide, Dimethyl Zebrafish
To examine the curative effects of probiotics on anxiety/depression, mice were randomly assigned to six groups (NC, C, PC, NK33, NK98, or Mix) of seven mice each. First, mice from the PC, NK33, NK98, Mix, and C groups were exposed to IS and test agents (C, vehicle [1% maltose]; NK33, 1 × 109 CFU/mouse/day of NK33; NK98, 1 × 109 CFU/mouse/day of NK98; Mix, 1 × 109 CFU/mouse/day of the (1:1) mixture of NK33 and NK98]; and PC, 1 mg/kg/day of buspirone) either orally (for NK33, NK98, and Mix) or intraperitoneally (for buspirone) administered for 5 days, 24 h after the final treatment with IS. The normal control group (NC), not exposed to IS, was treated with 1% maltose in place of test agents. Behaviors and biochemical markers were assayed 20 h after the final treatment. Exposure of mice to IS was performed for 12 h once a day for 2 days using a conical tube-like instrument (2.5 cm in diameter, 7.5 cm in length) with a 0.25-cm-diameter hole on the center of the tube), as previously reported [25 (link),28 (link)].
To examine the preventive effects of probiotics on anxiety/depression and colitis, mice were randomly assigned to six groups of seven mice each. First, test agents (C, vehicle [1% maltose]; NK33, 1 × 109 CFU/mouse/day of NK33; NK98, 1 × 109 CFU/mouse/day of NK33; Mix, 1 × 109 CFU/mouse/day of the (1:1) mixture of NK33 and NK98]; and PC, 1 mg/kg/day of buspirone) were orally gavaged or intraperitoneally injected into the mice daily for 5 days. Mice from the PC, NK33, NK98, Mix, and C groups were exposed to IS for 2 h from 24 h after the final treatment with test agents, as previously reported [28 (link)]. Normal control group (NC), not exposed to IS, was orally treated with 1% maltose in place of test agents. Behaviors and biochemical markers were assayed 20 h after the final IS treatment.
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Publication 2019
Anxiety Buspirone Colitis Maltose Mice, House Probiotics Retinal Cone
This study used 60 adult male C57BL/6J mice (Jackson Laboratories, Sacramento, CA) that
were eight weeks of age at the onset of drinking. Animals were housed in groups of four in
standard Plexiglas cages, in a temperature-controlled vivarium (23℃), under a 12-h reverse
light/dark cycle (lights off at 10 a.m.). Animals were identified using small animal ear
tags (Stoelting, Wood Dale, IL). Food and water were available ad
libitum
, with the exception of the 2-h alcohol-drinking period. The study had a 2
(alcohol or water) × 3 (vehicle, buspirone, or MTEP) factorial design, with
n = 10/group. All experiments were conducted in compliance with the
National Institutes of Health Guide for Care and Use of Laboratory Animals (NIH
Publication No. 80–23, revised 2014) and approved by the IACUC of the University of
California, Santa Barbara.
Publication 2017
Adult Alcohols Animals Animals, Laboratory Buspirone Food Institutional Animal Care and Use Committees Light Males Mice, Inbred C57BL Plexiglas

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Publication 2013
Amphetamine Anesthetics Anxiety Attention Buspirone Cocaine Dependence Cycloserine Dietary Supplements Hallucinations Ketamine Lorazepam Memantine Mental Disorders Mindfulness Pharmaceutical Preparations Psychotic Disorders Sedatives Sleep Thinking Visually Impaired Persons
Eligible subjects were contacted by telephone, usually within 1 week (median = 7 days; mean = 9.6 sd 8.4 days) of enrollment to provide information about previous care received and satisfaction with that care.
Respondents were asked about the care they had received during the previous 6 months (i.e., prior to enrolling in the CALM study). These questions were modeled after those from our prior study 12 (link) augmented with questions about satisfaction with care. Using patient reports of the name and daily dosage of each prescribed medication they had “taken several times a week for at least a month in the last 6 months”, we derived separate indicators of (a) use of any psychotropic medication, (b) use of any anti-anxiety medication (i.e., antidepressant or benzodiazepine; or buspirone for GAD), (c) use of any anti-anxiety medication in an appropriate daily dosage for any duration, and (d) use of any anti-anxiety medication in appropriate daily dosage for at least 2 months. The latter was considered to meet the minimal criterion for “quality pharmacotherapy”. Determination of what was an anti-anxiety medication, and what was an appropriate daily dosage was made a priori by consensus of the psychiatrist investigators in the study, based on consensus statements and their collective knowledge of the evidence-based pharmacotherapy literature for anxiety.27 (link)
Using patient responses to questions about the content of outpatient visits with any provider in the prior 6 months, we derived separate indicators of (a) receipt of any psychotherapy, (b) receipt of psychotherapy with a CBT focus, i.e., at least 3 of 6 possible CBT elements (1: practice dealing with things that made you afraid; 2: teach you methods of relaxation; 3: helped you look at your thoughts more realistically; 4: help you see mistakes in your thinking; 5: help you understand how your thoughts and feelings are related; 6: ask you to do homework or practice between sessions) reported as covered at least “sometimes”, and (c) receipt of psychotherapy with an intensive CBT focus (i.e., at least 3 of 6 possible CBT elements reported as covered at least “usually”). Receipt of psychotherapy with a CBT focus (rather than the more rigorous definition involving an intensive CBT focus) was considered to meet the minimal criterion for “quality psychotherapy”.
Satisfaction with overall health care was assessed by asking respondents “How dissatisfied or satisfied were you with the health care available to you in the past 6 months?” Satisfaction with mental health care was assessed by asking “How dissatisfied or satisfied were you with the health care available to you for personal or emotional problems in the past 6 months?” Response choices for both questions were: very dissatisfied, dissatisfied, neither satisfied nor dissatisfied, satisfied, or very satisfied. The latter two responses were considered to reflect satisfaction with care for purposes of this report and the analyses described herein.
Publication 2010
Anti-Anxiety Agents Antidepressive Agents Anxiety Benzodiazepines Buspirone Emotions Fear Feelings Iodine Mental Health Muscle Rigidity Outpatients Patients Pharmaceutical Preparations Pharmacotherapy Psychiatrist Psychotherapy Psychotropic Drugs Relaxation Techniques Satisfaction Teaching Thinking

Most recents protocols related to «Buspirone»

An LC-MS/MS method was developed for the quantitation of BDQ and M2 concentrations in dog plasma. BDQ, BDQ-M2, and internal standards (terfenadine tolbutamide and/or buspirone) were extracted from 50 μl dog plasma by protein precipitation, separated by a reversed phase HPLC column under a linear gradient with a run time of 3 min. Electrospray ionization was done using Triple Quad 5500 or 6500 (Applied Biosystems/MDS SCIEX Instruments, Foster City, CA, USA), which was operated in positive ion multiple reaction monitoring mode (BDQ and M2 mz transitions 555.20/58.00 and 541.20/480.10, respectively) with a dynamic range of 1.00–1,000 or 2,000 ng/ml for both BDQ and BDQ-M2. Quality control (QC) samples were prepared in dog plasma at three concentrations (2, 200, and 800 ng/ml or 2, 500, and 1,600 ng/ml) to monitor the assay performance. Details on the method parameters are provided in the Supplementary Data.
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Publication 2023
Biological Assay Buspirone High-Performance Liquid Chromatographies Plasma Proteins Tandem Mass Spectrometry Terfenadine Tolbutamide
The anxiety model was established by the elevated open platform (EOP) with a slight adjustment based on a previous study (14 (link)). Mice were exposed to the clear square Plexiglas board (10 cm × 10 cm) at 1 m, 1 h per day for 30 days (Figure 1; Supplementary Figure 1). The control mice were not exposed to the elevated open platform (EOP) modeling, yet their living conditions and environment were consistent with those of the other experimental groups.
Mice were randomly assigned to one of 10 groups based on their body weight on day one: control, model, buspirone, powder, yogurt, milk, C, C + powder, C + yogurt, and C + milk. Control, model, and buspirone were designed to test the stability of our modeling system. C was short for the WP + CP combination. Since the combination will enter the powder, yogurt, or milk market, we set the groups of products containing C as C + powder, C + yogurt, and C + milk. The base for the product was powder, yogurt, and milk, respectively. All the nutrients were given by intragastric administration. The protocols utilized for administering intragastric (IG) treatment to mice subjected to the EOP model are described herein (Figure 1). Mice arriving at the laboratory were designated as “eligible mice” if they weighed between 21–25 g and covered 3,000–5,000 cm in the open field test (OFT; Supplementary Figure 2). This criterion ensured a consistent and standardized selection process. Locomotor activity, assessed by distance in the open field test, served as a prerequisite for inclusion in the study and minimized potential confounding factors affecting the reliability and validity of outcomes. Behavioral assessments were conducted from day 30 through day 41, after which the mice from each group were humanely sacrificed and sampled a week following the conclusion of the behavioral experiment.
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Publication 2023
Anxiety Biological Models Body Weight Buspirone Locomotion Milk, Cow's Mus Nutrients Open Field Test Plexiglas Powder Yogurt
The statistical analysis was conducted using SPSS 26.0 software (IBM Ltd., United Kingdom). Data conforming to normal distributions were represented as mean ± standard errors of the mean (SEM). Unpaired t-tests were utilized to analyze the differences between the control and model groups. A one-way Analysis of Variance (ANOVA) followed by the post hoc Tukey Dunnetts multiple comparison tests was used to analyze differences among the model, buspirone, and each treatment group when the data followed a normal distribution and the variances were equal. A repeated measures ANOVA was employed to examine group variations in body weight, food intake, coat state, sucrose preference, and fecal amount. Interaction effects between repeated indicators and days were tested by Pillai’s trace. In the case of interactions observed between a specific variable and days, the differences among each group were compared at the final time point. If no interactions were present, post-hoc analysis using Bonferroni’s multiple comparison tests was conducted. The correlations between each effect were performed using Pearsons correlation. For all analyses, two-sided p-values < 0.05 was considered statistically significant.
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Publication 2023
Body Weight Buspirone Eating Feces Sucrose
ACS/HPLC reagent-grade acetonitrile, methanol, and water were procured from Honeywell (Morristown, NJ, USA). HPLC-grade dimethyl sulfoxide (DMSO) and formic acid (FA) were procured from Junsei Chemical Co., Ltd. (Tokyo, Japan) and Dae-Jung Chemicals and Metals Co., Ltd. (Siheung, Republic of Korea). Buspirone (BUS), dextromethorphan (DEX), diclofenac (DIC), and alpelisib (IS) were procured from MedKoo Bioscience, Inc. (Morrisville, NC, USA). Magnesium Chloride (MgCl2), β-nicotinamide adenine dinucleotide 2′-phosphate reduced tetrasodium salt hydrate (NADPH), polyethylene glycol 400 (PEG400), and potassium phosphate buffer were procured from Sigma-Aldrich Co. (St. Louis, MO, USA). Sprague Dawley (SD) rat liver S9 fraction was procured from Sekisui Xenotech (Kansas City, KS, USA). SD rats (Male; nine-week-old; weighing range: 250–270 g) were supplied by Koatech Co. (Pyeongtaek, Republic of Korea). The SD rats were used for pharmacokinetic studies after an acclimation period of 7 days. Feeding, excluding water, was restricted for 12 h before starting the pharmacokinetics study. All animal studies were conducted with approval from the Institutional Animal Care and Use Committee of Pusan National University (approval number: PNU-2023-3245).
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Publication 2023
Acclimatization acetonitrile Alpelisib Animals Buffers Buspirone Dextromethorphan Diclofenac Drug Kinetics formic acid High-Performance Liquid Chromatographies Institutional Animal Care and Use Committees Liver Magnesium Chloride Males Metals Methanol NADP polyethylene glycol 400 potassium phosphate Rats, Sprague-Dawley Sodium Chloride Sulfoxide, Dimethyl

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Publication 2023
alnespirone Buspirone cDNA Library Cognition enilospirone eptapirone gepirone Homo sapiens ipsapirone Patients Schizoaffective Disorder Schizophrenia tandospirone zalospirone

Top products related to «Buspirone»

Sourced in United States
Buspirone is a pharmaceutical product manufactured by Merck Group. It is a type of lab equipment used for research and development purposes. Buspirone serves as a core function in various laboratory settings, but its specific intended use should not be extrapolated upon.
Sourced in United States, United Kingdom
Buspirone hydrochloride is a pharmaceutical compound used as a laboratory reagent. It is a white, crystalline powder that is soluble in water. Buspirone hydrochloride is commonly used in research and development applications, but its specific core function is not included in this factual and unbiased description.
The EVO 200 robot is a liquid handling system designed for automated pipetting and sample processing in laboratory environments. It features a modular design and can be customized with a range of accessories and peripherals to suit diverse application needs. The core function of the EVO 200 is to perform precise and accurate liquid handling tasks in a reliable and automated manner.
(S)-Duloxetine is a chemical compound used as a reference standard in pharmaceutical analysis and research. It serves as a tool for the identification, quantification, and quality control of drugs and drug products containing the active ingredient duloxetine. The compound provides a reliable and consistent reference point for researchers and analysts working with duloxetine-based formulations.
Excitalopram is a laboratory equipment product manufactured by Merck Group. It is designed for use in scientific research and analysis. The core function of Excitalopram is to provide accurate and reliable measurements for various applications.
Fenobam is a laboratory research compound distributed by Merck Group. It functions as a metabotropic glutamate receptor 5 (mGluR5) antagonist. Further details on its intended use are not available.
Sourced in United States
Aripiprazole is a laboratory reagent manufactured by Merck Group. It is a synthetic compound used in various research applications, including pharmaceutical development and biological studies. Aripiprazole functions as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors.
Sourced in United States
Buspirone hydrochloride is a chemical compound used in various laboratory applications. It is a white crystalline powder that is soluble in water and has a molecular formula of C21H31ClN5O2. The core function of buspirone hydrochloride is to serve as a research tool for studying biological processes, particularly those involving the central nervous system.
Sourced in United States
Tianeptine is a laboratory equipment product manufactured by Merck Group. It is a versatile and reliable instrument designed for use in various research and analytical applications. The core function of Tianeptine is to provide accurate and consistent measurements, ensuring precise data collection for scientific investigations.
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DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.

More about "Buspirone"

Buspirone, also known as Buspar, is a non-benzodiazepine anxiolytic medication that is commonly used to treat anxiety disorders.
It works by acting as a partial agonist at serotonin 5-HT1A receptors, which leads to a reduction in anxiety-related symptoms.
Compared to traditional benzodiazepines, buspirone has a lower potential for abuse and dependence.
Buspirone is typically well-tolerated, with common side effects including dizziness, headache, and nausea.
In addition to its use in anxiety management, buspirone may also have therapeutic applications for the treatment of depression and nicotine withdrawal.
Researchers can leverage PubCompare.ai to optimize their buspirone research by accessing the best protocols from literature, preprints, and patents, using AI-driven comparisons to enhance reproducibility and accuracy.
The platform can also help identify the most effective buspirone products and procedures.
Related terms and compounds include buspirone hydrochloride, EVO 200 robot, (S)-duloxetine, escitalopram, fenobam, aripiprazole, and tianeptine.
Additionally, the solvent DMSO (dimethyl sulfoxide) may be used in buspirone-related research.
By utilizing the insights and tools provided by PubCompare.ai, researchers can leverage the latest advancements in buspirone research to enhance their studies and contribute to the ongoing development of effective treatments for anxiety disorders and other related conditions.