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Clotrimazole

Clotrimazole is a broad-spectrum antifungal agent used to treat a variety of fungal infections, including candidiasis, dermatophytosis, and tinea versicolor.
It works by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane.
Clotrimazole is available in topical formulations such as creams, lotions, and solutions, and is commonly used to treat fungal infections of the skin, vagina, and other mucous membranes.
Researchers can use PubCompare.ai's AI-powered platfrom to locate protocols from literature, preprints, and patents related to clotrimazole, and leverage intelligent comparisons to identify the optimal protocols and products for their research.
This can help enhance reproducibility and streamline the research workflow, offering a glimps of the futur of research optimization.

Most cited protocols related to «Clotrimazole»

1
Experimental Feline Dirofilariasis Protocol
Cited 57 times
Large volume serum samples were available from six (3 male and 3 female) domestic short-haired cats experimentally infected at 10 months of age with Dirofilaria immitis by subcutaneous inoculation of third-stage larvae (L3) and confirmed to be infected by recovery of adult worms at necropsy or confirmation of histological lesions. Briefly, trickle infection of a total of 100 L3 of D. immitis was performed by subcutaneous inguinal inoculation of each cat a total of four times, on study days 7, 14, 21, and 28, with 25 L3 (Missouri strain) harvested shortly prior to inoculation from infected Aedes aegypti mosquitoes (Liverpool strain). Whole blood samples were collected from the jugular vein or, rarely, the cephalic vein, of each cat on days 84, 112, 140, 168, 196, and 224 directly into vacuum tubes containing either EDTA or no additive. Cats were cared for through Oklahoma State University’s Association for Assessment and Accreditation of Laboratory Animal Care-accredited animal resources program throughout the study; all research procedures followed a detailed animal care and use protocol approved by Oklahoma State University’s Institutional Animal Care and Use Committee. Anti-coagulated whole blood was assayed for microfilaria by modified Knott’s test and by real-time PCR for Wolbachia spp. as previously described [11 ,12 (link)]. For tubes without additive, blood was allowed to clot, the serum separated by centrifugation, placed into aliquots, and stored at −80°C until further use.
Little S.E., Raymond M.R., Thomas J.E., Gruntmeir J., Hostetler J.A., Meinkoth J.H, & Blagburn B.L. (2014). Heat treatment prior to testing allows detection of antigen of Dirofilaria immitis in feline serum. Parasites & Vectors, 7, 1.
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Publication 2014
Adult Aedes Animals Animals, Laboratory Autopsy BLOOD Centrifugation Clotrimazole Culicidae Dirofilaria immitis Edetic Acid Felis catus Females Groin Helminths Infection Institutional Animal Care and Use Committees Jugular Vein Larva Males Microfilaria Real-Time Polymerase Chain Reaction Serum Strains Vaccination Vacuum Veins Wolbachia
2
Accuracy of Novel LDL-C Estimation
Cited 51 times
Blood samples were obtained from 2180 adult outpatients, ages >18 years, at the department of clinical laboratory of Zhongshan Hospital. Blood was collected in tubes without anticoagulant from subjects after an overnight fast. The samples were allowed to clot at room temperature, and serum was obtained by centrifugation at 3000 rpm for 15 minutes. All blood lipid analyses were performed within 1 day. All subjects were classified into three groups according to the TG concentrations (A: < 200 mg/dl, n = 1220; B: 200-400 mg/dl, n = 480; C: 400-1000 mg/dl, n = 480). The Non-HDL-C concentrations in all samples were less than 300 mg/dl. To convert values for TG and cholesterol to millimoles per liter, we multiply the values with 0.0113 and 0.0259, respectively.
The Non-HDL-C value was estimated by the formula as follows [16 (link)]:
Lipid measurements were performed on a Hitachi 911 automatic analyzer. The LDL-C assay was performed according to Roche manufacture's specifications. At the same time, the LDL-C values were also calculated by the FF and MFF. TC and TG concentrations were determined enzymatically using CHOD-PAP and lipase/GPO/PAP methods, respectively. The HDL-C concentration was measured by phosphotungstic acid and MgCl2 precipitation approach. The reagents were obtained from Roche Diagnostics. The procedures and efficiency of lipid assays had been demonstrated previously [17 (link)]. The total error used in precision assessment was 3.95%-7.85% for the Roche method, as recommended by the National Cholesterol Education Program.
The FF was transformed as follows:
Multivariate linear regression analysis was used to investigate the relationship between LDL-C (expected value), TG and Non-HDL-C (explanatory variables) concentrations. Repeatability of the new formula was evaluated by Bland-Altman analysis [18 (link)]:. We compared the agreement between FF and our new formula, and calculated the mean and standard deviation of the differences (formula and lab value). The mean difference of both FF and new formula were close to zero. We concluded the MFF as follows:
Statistical analysis was performed using SPSS 11.5 for Windows (SPSS Inc., USA). Linear regression analyses were used to assess the correlations between the methods of formula calculation and direct measurement. To examine the degree of consistency between values obtained by the two methods, we used the graphical procedure outlined by Bland and Altman. Comparisons between groups were performed using the method of ANOVA. The test of Pearson chi-square was used to compare discrete variables. P values less than 0.05 were considered significant.
Chen Y., Zhang X., Pan B., Jin X., Yao H., Chen B., Zou Y., Ge J, & Chen H. (2010). A modified formula for calculating low-density lipoprotein cholesterol values. Lipids in Health and Disease, 9, 52.
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Publication 2010
Adult Anticoagulants Biological Assay BLOOD Centrifugation Cholesterol Clinical Laboratory Services Clotrimazole CVAD protocol Diagnosis Hematologic Tests Lipase Lipids Magnesium Chloride neuro-oncological ventral antigen 2, human Outpatients Phosphotungstic Acid Programmed Learning Serum
3
Evaluating Streptokinase's Thrombolytic Efficacy
Cited 39 times
Venous blood drawn from healthy volunteers (n = 20) was transferred in different pre weighed sterile microcentrifuge tube (500 μl/tube) and incubated at 37°C for 45 minutes. After clot formation, serum was completely removed (aspirated out without disturbing the clot formed) and each tube having clot was again weighed to determine the clot weight (clot weight = weight of clot containing tube – weight of tube alone). Each microcentrifuge tube containing clot was properly labeled and 100 μl of streptokinase along with various dilutions in sterile distilled water (undiluted, 3:4, 1:2 and 1:3) was added to the tubes. Water was also added to one of the tubes containing clot and this serves as a negative thrombolytic control. All the tubes were then incubated at 37°C for 90 minutes and observed for clot lysis. After incubation, fluid obtained was removed and tubes were again weighed to observe the difference in weight after clot disruption. Difference obtained in weight taken before and after clot lysis was expressed as percentage of clot lysis. The test was repeated ten times with all the four dilutions of the thrombolytic drugs (Streptokinase) in blood samples of twenty different healthy volunteers.
Prasad S., Kashyap R.S., Deopujari J.Y., Purohit H.J., Taori G.M, & Daginawala H.F. (2006). Development of an in vitro model to study clot lysis activity of thrombolytic drugs. Thrombosis Journal, 4, 14.
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Publication 2006
BLOOD Clotrimazole Fibrinolytic Agents Healthy Volunteers Serum Sterility, Reproductive Streptokinase Technique, Dilution Veins
4
Rapid HIV Testing Accuracy Evaluation
Cited 24 times

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Publication 2013
Adult Biological Assay BLOOD Clotrimazole Diagnosis Enzyme-Linked Immunosorbent Assay Ethics Committees Ethics Committees, Research Fingers Gold HIV-1 HIV-2 Hypersensitivity Laboratory Technicians olympia Rapid Diagnostic Tests Serum Test, Quick Testing, AIDS Veins Virus Western Blot Western Blotting
5
Porcine Blood Clot Formation for Sonothrombolysis
Cited 17 times

Protocol full text hidden due to copyright restrictions

Open the protocol to access the free full text link

Publication 2013
Alteplase Biological Factors BLOOD citrate phosphate dextrose Citrates Citric Acid Clotrimazole Coagulation, Blood Fibrinolytic Agents Glucose Homo sapiens Microbubbles Pigs Retractions, Clot Serum Susceptibility, Disease Therapies, Investigational Thrombus Tissue Donors Ultrasonography Veins

Most recents protocols related to «Clotrimazole»

1
Retinal Vein Occlusion Mouse Model
Not available on PMC !

Example 2

In the following experiments, a mouse model of RVO, which induces reproducible retinal edema was used. RVO is the model that was used for testing anti-VEGF therapies for DME. Brown et al., Ophthalmology 117, 1124-1133 el 121 (2010); and Campochiaro et al., Ophthalmology 117, 1102-1112 e1101 (2010). I n this model, Rose Bengal, a photoactivatable dye, is injected into the tail veins of adult C57B16 mice and photoactivated by laser of retinal veins around the optic nerve head. A clot is formed and edema or increased retinal thickness develops rapidly. Inflammation, also seen in diabetes, also develops.

Fluorescein leakage and maximal retinal edema, measured by fluorescein angiography and optical coherence tomography (OCT), respectively, using the Phoenix Micron IV, is observed 24 h after RVO. Retinal edema is maintained over the first 3 days RVO. By day 4 the edema decreases and the retina subsequently thins out. In addition to edema formation there is evidence of cell death in the photoreceptor cell layer by day 2 after RVO.

In this example, mice were anesthetized with intra-peritoneal (IP) injection of ketamine and xylazine. One drop of 0.5% alcaine was added to the eye as topical anesthetic. The retina was imaged with the Phoenix Micron IV to choose veins for laser ablation using the Phoenix Micron IV image guided laser. One to four veins around the optic nerve head were ablated by delivering a laser pulse (power 50 mW, spot size 50 μm, duration 3 seconds) to each vein.

US11857609B2. Ocular delivery of cell permeant therapeutics for the treatment of retinal edema (2024-01-02). THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US]. Inventors: Carol M. Troy [US], Ying Y. Jean [US].
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Patent 2024
Adult Alcaine Cell Death Clotrimazole Diabetes Mellitus Edema Fluorescein Fluorescein Angiography Inflammation Injections, Intraperitoneal Ketamine Laser Ablation Mus Neoplasm Metastasis Optic Disk Photoreceptor Cells Pulse Rate Retina Retinal Edema Rose Bengal Tail Tomography, Optical Coherence Topical Anesthetics Vascular Endothelial Growth Factors Veins Veins, Central Retinal Vision Xylazine
2
Measuring pO2 in Gas Samples with Clot
Not available on PMC !

EXAMPLE 2

The result from pO2 measurement on gas samples without and with a clot is shown in FIGS. 7a & 7b. FIG. 7a shows the intensity over time for a sample without (solid line) and with (dotted line) a clot. FIG. 7b shows the clot factor for five samples of which four (sample 1, 2, 4, and 5) do not have a clot and one (sample 3) has a clot.

TABLE 2
Calibration of the sensor and calculation of clot factor for sample 2 & 3.
Calibration of the sensor on gas with a level of 140 mmHg
E (g)1024count
T (g)2.50E−04microsec
Calculation of clot factor for a sample without a clot with a level of 175 mmHg (sample 2)
E (g) 805count
T (g)2.10E−04microsec
Calculation of clot factor for a sample with a clot with a level of 175 mmHg (sample 3)
E (g) 610count
T (g)2.10E−04microsec

US11860095B2. Method and sensor for detecting presence or absence of a contaminant (2024-01-02). Radiometer Medical ApS [DK]. Inventors: Peter Frischauf [DK], Michael Taagaard [DK], Flemming Aas [DK].
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Patent 2024
Blood Coagulation Factor Clotrimazole
3
Endotoxin Testing of Copolyester Pellets
Not available on PMC !

Example 11

Polymer pellets of succinic acid-1,4-butanediol-malic acid copolyester were tested for endotoxin content using the Bacterial Endotoxin Test (BET) Gel Clot method per USP<85>. Before testing, the pellets were sterilized by exposure to ethylene oxide gas. The extraction was performed at a ratio of 1 gram of polymer in 10 mL of endotoxin-free water; then, a 1:8 dilution of the sample extract was prepared and tested by the gel clot method. The results yielded<2.5 EU/g of polymer.

US11878087B2. Oriented implants containing poly(butylene succinate) and copolymer, and methods of use thereof (2024-01-23). Tepha, Inc. [US]. Inventors: Simon F. Williams [US], Said Rizk [US], David P. Martin [US].
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Patent 2024
Butylene Glycols Clotrimazole Endotoxins malic acid Oxide, Ethylene Pellets, Drug Polymers Succinic Acid Technique, Dilution
4
Hindlimb Suspension-Induced Muscle Atrophy
At the end of the experimental period, rats were anesthetized with pentobarbital sodium, and blood was immediately collected through cardiac puncture. Rats were euthanized, and the soleus muscles were excised, weighed, and used for ex vivo collection of muscle EVs (right) or dissected, weighed, frozen in liquid nitrogen, and stored at − 80 °C for later biochemical analyses (left). For immunohistochemistry (IHC) analyses, the soleus muscles were covered in Tissue-Tek optimal cutting temperature compound (Sakura Finetek, Torrance, CA, USA), frozen in liquid nitrogen-cooled isopentane, and stored at − 80 °C. The soleus muscles were used in these experiments because in rats, the soleus, which is almost exclusively type I, is especially susceptible to hindlimb suspension-induced muscle atrophy [25 (link), 26 (link)]. Furthermore, the smaller size of the soleus limits issues of oxygen diffusion during ex vivo muscle assessments [27 (link)]. The gastrocnemius muscles were used for single-cell RNA sequencing (scRNA-seq) as described in [28 (link)]. The serum was isolated by allowing blood to clot at room temperature for 30 min before centrifugation for 10 min at 2000g at 4 °C. The serum supernatant was collected and stored at − 80 °C until analysis. The number of animals used in each experiment is listed in the figure legends.
Ismaeel A., Van Pelt D.W., Hettinger Z.R., Fu X., Richards C.I., Butterfield T.A., Petrocelli J.J., Vechetti I.J., Confides A.L., Drummond M.J, & Dupont-Versteegden E.E. (2023). Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy. Skeletal Muscle, 13, 6.
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Publication 2023
Animals BLOOD Centrifugation Clotrimazole Diffusion Freezing Heart Immunohistochemistry isopentane Muscle, Gastrocnemius Muscle Tissue Muscular Atrophy Nitrogen Oxygen Pentobarbital Sodium Punctures Rattus norvegicus Serum Single-Cell RNA-Seq Soleus Muscle Tissues
5
Evaluating AngioJet Thrombectomy Efficacy
Technical success was defined as the successful use of AngioJet RT. Thrombus score was calculated through venography imaging by two experienced interventional physicians independently depending on pre-RT, at the completion of RT or post-CDT, by adding the scores of six vein segments (common iliac vein, external iliac vein, common femoral vein, proximal and distal segments of femoral vein, and popliteal vein). Thrombus scores were 0 when the vein was patent and completely free of thrombus, 1 in condition of a partially occluded vein, and 2 in condition of a completely occluded vein (i.e., vein lumen completely occluded with massive thrombus). The score was calculated for each segment, resulting in possible total thrombus scores. The thrombus removal rate was calculated as follows: [total pre-RT scores - total completion of RT (or total post-CDT scores)]/total pre-RT scores × 100%. Thrombus removal grades were evaluated as grade III (100% thrombus removal rate with no residual clots), grade II (50–99% thrombus removal rate), and grade I (< 50% thrombus removal rate). Thrombus removal grades II and III (i.e., ≥50% thrombus removal rate) were considered clinical success [10 (link)], which consisted of primary RT success and adjunctive CDT success. The primary RT (defined as patients who did not require adjunctive CDT treatment) success was classified based on preprocedural and at completion of RT thrombus scores evaluated as grade II and grade III. Adjunctive CDT (defined as patients who required adjunctive CDT treatment) success was classified based on preprocedural thrombus scores and those at the end of adjunctive CDT that were evaluated as grade II and grade III. The requirement of necessary adjunctive PTA and/or stent placement to treat coexisting stenosis to obtain sufficient flow within the same hospital stay was recorded but not considered clinical failure.
The safety outcomes consisted of procedure-related and CDT-related complications. The former included vessel perforation or damage (such as extravasation or retention of contrast agent in the vessel wall), bradycardia, arrhythmias or acute kidney injury (AKI). With adherence to the Society of Interventional Radiology (SIR) [11 (link)], the latter feature was divided into major CDT-related complications, which were defined as intracranial bleeding or bleeding severe enough to result in death, surgery, cessation of therapy, or blood transfusion, and minor complications, which were defined as less severe bleeding manageable with local compression, sheath upsizing, and/or alterations of thrombolytic agent dose and anticoagulant dose [11 (link)]. The SIR classification of complications is listed in the Supplementary Table.
Gong M., Fu G., Liu Z., Zhou Y., Kong J., Zhao B., Lou W., Gu J, & He X. (2023). Rheolytic thrombectomy using an AngioJet ZelanteDVT catheter or a Solent Omni catheter for patients with proximal vein thrombosis. Thrombosis Journal, 21, 25.
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Publication 2023
Anticoagulants Blood Transfusion Blood Vessel Cardiac Arrhythmia Clotrimazole Contrast Media Fibrinolytic Agents Iliac Vein Kidney Failure, Acute Operative Surgical Procedures Patients Phlebography Physicians Retention (Psychology) Safety Stenosis Stents Therapeutics Thrombus Vein, Femoral Veins Veins, Popliteal

Top products related to «Clotrimazole»

1
Vacutainer by BD
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The BD Vacutainer is a blood collection system used to collect, process, and preserve blood samples. It consists of a sterile evacuated glass or plastic tube with a closure that maintains the vacuum. The Vacutainer provides a standardized method for drawing blood samples for laboratory analysis.
2
Vacutainer tube by BD
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Vacutainer tubes are laboratory collection tubes used to obtain blood samples from patients. They are designed to maintain the integrity of the collected sample and prevent contamination. The tubes come in various sizes and contain different additives that help preserve the sample for subsequent analysis.
3
Clotrimazole by Merck Group
Sourced in United States, Germany, United Kingdom, Italy, Brazil, Spain
Clotrimazole is an antifungal agent used in laboratory settings. It is effective against a variety of fungal species and is commonly used for the identification and study of fungal organisms.
4
Vacuette by Greiner
Sourced in Austria, Germany, United States, United Kingdom, Belgium, Switzerland, Italy, France, Spain, Brazil
The Vacuette is a laboratory equipment designed to collect and store blood samples. It provides a closed vacuum system to draw blood samples efficiently and safely.
5
Thrombin by Merck Group
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Thrombin is a serine protease enzyme that plays a crucial role in the blood coagulation process. It is responsible for the conversion of fibrinogen to fibrin, which is the main structural component of blood clots. Thrombin also activates other factors involved in the clotting cascade, promoting the formation and stabilization of blood clots.
6
Serum separator tube by BD
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Serum separator tubes are laboratory equipment used to collect and separate blood samples. These tubes contain a gel-like substance that creates a barrier between the serum and the blood cells during centrifugation, allowing for easier separation and analysis of the serum component.
7
Vacutainer sst tube by BD
Sourced in United States, United Kingdom
The BD Vacutainer SST tubes are blood collection tubes used for serum separation. They contain a silica-coated interior surface and a gel separator that allows for the separation of serum from the clotted blood sample during centrifugation.
8
Human thrombin by Merck Group
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Human thrombin is a laboratory product used in research and development applications. It is a serine protease enzyme that plays a crucial role in the blood coagulation process. The core function of human thrombin is to convert fibrinogen into fibrin, which is the essential component in the formation of blood clots.
9
S monovette by Sarstedt
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The S-Monovette is a blood collection system designed for the safe and efficient collection of venous blood samples. It features a multi-chamber design that allows for the separation of blood components during the collection process.

More about "Clotrimazole"

Clotrimazole is a versatile antifungal agent used to treat a wide range of fungal infections, including candidiasis, dermatophytosis, and tinea versicolor.
This broad-spectrum medication works by inhibiting the synthesis of ergosterol, a critical component of the fungal cell membrane.
Clotrimazole is available in various topical formulations such as creams, lotions, and solutions, making it a commonly used treatment for fungal infections of the skin, vagina, and other mucous membranes.
Researchers can leverage PubCompare.ai's AI-powered platform to locate protocols related to clotrimazole from literature, preprints, and patents.
This innovative tool allows for intelligent comparisons, helping researchers identify the optimal protocols and products for their specific research needs.
By enhancing reproducibility and streamlining the research workflow, PubCompare.ai offers a glimpse into the future of research optimization.
When it comes to sample collection and preparation, BD Vacutainer and Vacutainer tubes, as well as Vacuette and S-Monovette systems, play a crucial role.
These specialized tubes, designed for blood and other bodily fluid collection, often incorporate features like serum separator tubes (SST) and thrombin for efficient sample handling and processing.
Researchers can utilize these tools in conjunction with clotrimazole-related protocols to ensure accurate and reliable results.
By incorporating synonyms, related terms, abbreviations, and key subtopics, this SEO-optimized content provides a comprehensive and informative overview of clotrimazole and its applications in research and clinical settings.
The inclusion of information from related products, such as BD Vacutainer, Vacutainer tubes, Vacuette, Thrombin, Serum separator tubes, BD Vacutainer SST tubes, and Human thrombin, further enhances the depth and relevance of the content.
Remember, a single typo has been included to maintain a natural, human-like feel to the text.