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Cyclodextrins
Cyclodextrins
Cyclodextrins are a class of cyclic oligosaccharides composed of glucopyranose units, commonly used in pharmaceutical and chemical applications.
These macrocyclic compounds have a hydrophilic exterior and a lipophilic interior cavity, allowing them to form inclusion complexes with a variety of guest molecules.
Cyclodextrins offer enhanced solubility, stability, and bioavailability for pharmaceuticals, as well as serving as molecular hosts for catalysis, separation, and delivery applications.
Reserach into the diverse applications of cyclodextrins continues to advance, with a focus on optimizing protocols and ensuring reproducibility of results. [typo: 'reserach' instead of 'research']
These macrocyclic compounds have a hydrophilic exterior and a lipophilic interior cavity, allowing them to form inclusion complexes with a variety of guest molecules.
Cyclodextrins offer enhanced solubility, stability, and bioavailability for pharmaceuticals, as well as serving as molecular hosts for catalysis, separation, and delivery applications.
Reserach into the diverse applications of cyclodextrins continues to advance, with a focus on optimizing protocols and ensuring reproducibility of results. [typo: 'reserach' instead of 'research']
Most cited protocols related to «Cyclodextrins»
Antidepressive Agents
beta-Arrestin 2
Brain
Corticosterone
Cortisone
Cyclodextrins
Fluoxetine
Fluoxetine Hydrochloride
Hypromellose
Imipramine Hydrochloride
Light
Mice, House
Reboxetine
Tube Feeding
Animals
Cells
Common Cold
Cyclodextrins
Doxycycline
Food
Hypromellose
Leukemia
Mice, House
RNA Interference
Short Hairpin RNA
Sucrose
Sulfoxide, Dimethyl
Transplantation
Zebrafish embryos of the AB wild-type strain (originally obtained from the Zebrafish International Resource Center, Eugene, Oregon, USA) were raised at 28°C. Zebrafish husbandry, embryo collection, and embryo and larva maintenance were performed as described [20] , [21] . Toxicity assays were standardly performed in 24-well microtiter plates (wrapped with Parafilm to limit solvent evaporation) using 10 embryos per well in 1 ml of 0.3× Danieau's medium (17 mM NaCl, 2 mM KCl, 0.12 mM MgSO4, 1.8 mM Ca(NO3)2 and 1.5 mM HEPES, pH 7.6). Each experiment was repeated 3 times for a total of 30 embryos or larvae analyzed per solvent per developmental staged tested. Data were only recorded for experiments in which the percentage of normal embryos or larvae in the control group was at least 90%. Embryos and larvae were exposed to solvents and carriers at 2–4 cells, 4 hpf, and at 1, 2, 3, 4, and 7 dpf and evaluated for signs of toxicity 24 hours later. In determining the maximum tolerated concentration (MTC) for each solvent and carrier, all post-exposure embryos and larvae were allowed to develop in larva medium to 9 dpf, so as to detect any deleterious effects appearing after this 24-hour window. Solvents and carriers were obtained from the following suppliers: acetone (Chemlab, Zedelgem, Belgium), acetonitrile (Acros Organics, Geel, Belgium), albumin (BSA, Sigma-Aldrich, Bornem, Belgium), butanone (Riedel-de Haën, Seelze, Germany), cyclodextrin (2- hydroxypropyl-beta-cyclodextrin, Sigma-Aldrich), dimethyl formamide (Acros), DMSO (Agros), ethanol (Fisher Scientific, Doornik, Belgium), glycerol (Acros), isopropanol (Chemlab), methanol (Chemlab), polyethylene glycol-400 (Fluka, Bornem, Belgium), propylene glycol (Certa, Eigenbrakel, Belgium), solketal (Merck, Overijse, Belgium). Statistical analyses were done using chi-square in Microsoft Excel.
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2-Hydroxypropyl-beta-cyclodextrin
Acetone
acetonitrile
Albumins
Biological Assay
Cells
Certa
Cyclodextrins
Dimethylformamide
Embryo
Ethanol
Glycerin
HEPES
Isopropyl Alcohol
Larva
Methanol
methylethyl ketone
polyethylene glycol 400
Propylene Glycol
Sodium Chloride
Solvents
Strains
Sulfate, Magnesium
Sulfoxide, Dimethyl
Zebrafish
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acetonitrile
Carbonates
Cyclodextrins
diphenyl
Ethanol
ferric chloride
formic acid
Griseofulvin
Methanol
Poly A
Polyvinyl Chloride
Propranolol Hydrochloride
Solvents
Nuf mice were maintained on the inbred 102/H background, which is a substrain bred at the Mary Lyon Centre. Mice were kept in accordance with United Kingdom Home Office welfare guidance and project license restrictions. Mice were fed ad libitum on a commercial diet (which contained 1.2% calcium, 0.8% phosphate, and 3000-IU/kg vitamin D; Rat and Mouse Diet No. 3; Special Diet Services). A single bolus of NPS 2143 or vehicle (15% aqueous solution of 2-hydroxypropyl-β-cyclodextrin) was administered by ip injection to wild-type, Nuf/+, and Nuf/Nuf mice aged between 16 and 20 weeks (n = 8–14 for all groups). An aqueous solution of 2-hydroxypropyl-β-cyclodextrin was used as the drug vehicle for NPS 2143, because this has previously been demonstrated to be effective at dissolving this calcilytic compound and to be safe and well tolerated in rodent studies (15 (link), 16 (link), 28 (link)). Based on the findings of previous rodent studies involving NPS 2143 (16 (link), 28 (link)), a dose of 30 mg/kg was administered to wild-type and Nuf mice. Plasma samples were obtained at either 0, 1, 4, or 24 hours by tail vein or terminal bleed. Urine samples were obtained from untreated mice or mice that had been bled at 1 hour after administration of NPS 2143 or drug vehicle alone and then immediately housed in metabolic cages (Tecniplast) for a 24-hour period and fed ad libitum on water and powdered chow (29 (link)). Urine samples were analyzed for calcium and creatinine and plasma samples analyzed for total calcium, albumin, sodium, potassium, phosphate, urea, creatinine, and alkaline phosphatase activities using a Beckman Coulter AU680 analyzer, as previously described (29 (link)). Plasma calcium was adjusted for albumin using the formula: ((albumin-mean albumin) × 0.02) + calcium, as reported (29 (link)). The calcium to creatinine clearance ratio (CCCR) was calculated using the formula UCa/PCa × PCr/UCr, where UCa is the urinary concentration of calcium in mmol/L, PCa is the plasma concentration of adjusted calcium in mmol/L, UCr is the urinary concentration of creatinine in mmol/L, and PCr is the plasma concentration of creatinine in mmol/L (29 (link)). Plasma PTH concentrations were determined using an ELISA for mouse intact PTH (Immutopics), as described (30 (link)).
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Albumins
Alkaline Phosphatase
Calcium, Dietary
Creatinine
Cyclodextrins
Diet
Dietary Services
Enzyme-Linked Immunosorbent Assay
Hypromellose
Injections, Intraperitoneal
Mice, House
NPS 2143
Pharmaceutical Vehicles
Phosphates
Plasma
Potassium
Rodent
Sodium
Tail
Urea
Urine
Veins
Vitamin D
Most recents protocols related to «Cyclodextrins»
Example 20
Coupling of the ligand to the nanoparticle may be achieved uniquely by following an inclusion compound protocol with β-cyclodextrin (β-CD) on the particle spontaneously interacting with adamantane on the peptide or small molecule ligand to form an inclusion complex. Briefly, cyclodextrin-PEG-DSPE derivative will be synthesized via mono-6-deoxy-6-amino-β-cyclodextrin. One of the seven primary hydroxyl groups of β-cyclodextrin will be tosylated using p-toluenesulfonyl chloride. Substitution of the tosyl group by azide and subsequent reduction with triphenylphosphine will yield mono-6-deoxy-6-amino-β-cyclodextrin. Carboxyl-activated PEG-DSPE will be conjugated to mono-6-deoxy-6-amino-β-cyclodextrin to produce cyclodextrin-PEG-DSPE. Adamantane-amine will be directly conjugated through a short spacer in the solid phase peptide synthesis to the carboxyl end of the peptide to produce adamantane-peptide/ligand. The simple room temperature mixing of adamantane-amine and β-cyclodextrin bearing nanoparticle will produce peptide coupled targeted nanoparticle.
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4-toluenesulfonyl chloride
Adamantane
Amines
Azides
Cyclodextrins
Hydroxyl Radical
Ligands
oxytocin, 1-desamino-(O-Et-Tyr)(2)-
Peptides
polyethylene glycol-distearoylphosphatidylethanolamine
triphenylphosphine
Example 4
A compound of formula (I) can be used in a manner known per se as the active ingredient for the production of an infusion solution of the following composition:
-
- Sodium chloride q.s. or glucose q.s. for adjustment of the osmolality to 290 mOsm/kg
- Water for injection (WFI) ad 100 ml
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11-dehydrocorticosterone
Cyclodextrins
Glucose
Heterocyclic Compounds
Sodium Chloride
Example 8
A portion of the analyzed hemp sap was incorporated into a nutritional composition according to the composition detailed in the following formulation table.
Example 11
In the same manner as used in Example 8, dried barley was reconstituted, and its aqueous extract was juiced and filtered. The elemental analysis is reported in the following table.
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Ammonia
betadex
boric acid
Boron
Boron-8
Boron-9
Boron-10
Boron-12
Boron-13
Calcium, Dietary
calcium nitrate
Calcium Sulfate
Copper
Cyclodextrins
Ethanol
Gluconate, Calcium
Hemp
hempseed oil
Hordeum vulgare
Iron
Lavandula
lavender oil
Magnesium
Manganese
Methoxypectin
Molybdenum
Nitrogen-15
Phosphorus
Plants
Scents
Silicon Dioxide
sodium gluconate
Sulfate, Magnesium
Sulfur
The following reagents were used: chloroform, potassium nitrate, potassium chloride, sodium azide, 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid (HEPES), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), cannabidiol, methanol, ethanol, polyethylene glycol 20000, olivetol, γ-cyclodextrin (98%), and MilliQ water. More details about these reagents can be found in the Electronic Supporting Material (ESM).
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Cannabidiol
Chloroform
Cyclodextrins
ethane sulfonate
Ethanol
Glycerylphosphorylcholine
HEPES
Methanol
olivetol
Piperazine
Polyethylene Glycols
Potassium Chloride
potassium nitrate
Sodium Azide
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Animals
Chemokine
Cocaine
Cyclodextrins
Cytokine
Growth Factor
HIV Envelope Protein gp120
Microinjections
NOAC protocol
Saline Solution
Self Administration
Ventricle, Lateral
Top products related to «Cyclodextrins»
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Methyl-β-cyclodextrin is a cyclic oligosaccharide compound commonly used as a laboratory reagent. It is a derivative of the natural compound β-cyclodextrin, with methyl groups attached to the hydroxyl groups. Methyl-β-cyclodextrin has the ability to form inclusion complexes with various organic molecules, which can be utilized in various applications involving solubilization, stabilization, and delivery of compounds in research and development settings.
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β-cyclodextrin is a cyclic oligosaccharide composed of seven glucose units. It is a versatile lab equipment product used as a complexation agent, solubilizer, and stabilizer in various applications.
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2-hydroxypropyl-β-cyclodextrin is a modified form of the naturally occurring cyclodextrin molecule. It is a cyclic oligosaccharide composed of seven glucose units. The hydroxypropyl group is used to increase the solubility and stability of the cyclodextrin.
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Methyl-β-cyclodextrin (MβCD) is a cyclic oligosaccharide composed of seven glucose units. It is used as a solubilizing and complexing agent in various pharmaceutical and laboratory applications.
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DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
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Fetal Bovine Serum (FBS) is a cell culture supplement derived from the blood of bovine fetuses. FBS provides a source of proteins, growth factors, and other components that support the growth and maintenance of various cell types in in vitro cell culture applications.
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Hydroxypropyl-β-cyclodextrin is a modified form of the naturally occurring cyclodextrin compound. It is a white, water-soluble powder commonly used as an excipient in pharmaceutical and biotechnology applications. Hydroxypropyl-β-cyclodextrin is capable of forming inclusion complexes with a variety of guest molecules, which can help improve their solubility, stability, and bioavailability.
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Cholesterol is a lab equipment product that measures the concentration of cholesterol in a given sample. It provides quantitative analysis of total cholesterol, HDL cholesterol, and LDL cholesterol levels.
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Acetonitrile is a colorless, volatile, flammable liquid. It is a commonly used solvent in various analytical and chemical applications, including liquid chromatography, gas chromatography, and other laboratory procedures. Acetonitrile is known for its high polarity and ability to dissolve a wide range of organic compounds.
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Chlorpromazine is a pharmaceutical compound used as a laboratory reagent. It is a white crystalline solid that is soluble in water and organic solvents. Chlorpromazine is commonly used in research and laboratory settings as a reference standard or for various analytical purposes.
More about "Cyclodextrins"
Cyclodextrins are a versatile class of cyclic oligosaccharides composed of glucopyranose units.
These macrocyclic compounds have a hydrophilic exterior and a lipophilic interior cavity, allowing them to form inclusion complexes with a variety of guest molecules.
Cyclodextrins are commonly used in pharmaceutical and chemical applications due to their ability to enhance solubility, stability, and bioavailability of various compounds.
In addition to their pharmaceutical uses, cyclodextrins also serve as molecular hosts for catalysis, separation, and delivery applications.
Researchers continue to explore the diverse applications of cyclodextrins, focusing on optimizing protocols and ensuring the reproducibility of results.
Some related cyclodextrin derivatives include Methyl-β-cyclodextrin (MβCD), 2-Hydroxypropyl-β-cyclodextrin, and Hydroxypropyl-β-cyclodextrin.
These modified cyclodextrins offer unique properties and functionalities, expanding the versatility of these macrocyclic compounds.
Cyclodextrins can also interact with other compounds, such as DMSO, FBS, Cholesterol, Acetonitrile, and Chlorpromazine, which can further influence their behavior and applications.
Researchers continue to investigate these interactions and their implications in various fields.
By incorporating the insights gained from the MeSH term description and Metadescription, researchers can optimize their cyclodextrin research protocols, enhance reproducibility, and explore the diverse applications of these versatile macrocyclic compounds.
These macrocyclic compounds have a hydrophilic exterior and a lipophilic interior cavity, allowing them to form inclusion complexes with a variety of guest molecules.
Cyclodextrins are commonly used in pharmaceutical and chemical applications due to their ability to enhance solubility, stability, and bioavailability of various compounds.
In addition to their pharmaceutical uses, cyclodextrins also serve as molecular hosts for catalysis, separation, and delivery applications.
Researchers continue to explore the diverse applications of cyclodextrins, focusing on optimizing protocols and ensuring the reproducibility of results.
Some related cyclodextrin derivatives include Methyl-β-cyclodextrin (MβCD), 2-Hydroxypropyl-β-cyclodextrin, and Hydroxypropyl-β-cyclodextrin.
These modified cyclodextrins offer unique properties and functionalities, expanding the versatility of these macrocyclic compounds.
Cyclodextrins can also interact with other compounds, such as DMSO, FBS, Cholesterol, Acetonitrile, and Chlorpromazine, which can further influence their behavior and applications.
Researchers continue to investigate these interactions and their implications in various fields.
By incorporating the insights gained from the MeSH term description and Metadescription, researchers can optimize their cyclodextrin research protocols, enhance reproducibility, and explore the diverse applications of these versatile macrocyclic compounds.