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Cyclopentolate

Cyclopentolate is a muscarinic antagonist used as a cycloplegic and mydriatic agent.
It is commonly employed in ophthalmological examinations to temporarily paralyze the ciliary muscle and dilate the pupil, facilitating accurate assessment of refractive errors.
PubCompare.ai's AI-driven platform can help researchers identify the most effective protocols for using cyclopentolate, enabling confident reproducibility of their experiments.
The platform seamlessly compares and optimizes product and procedure options, drawing from scientific literature, preprints, and patents to provide a comprehensive resource for enhancing cyclopentolate-related research.

Most cited protocols related to «Cyclopentolate»

CITT-trained and certified optometrists or ophthalmologists using a previously described standardized protocol performed all testing (baseline and masked). An unmasked examiner performed eligibility testing, which included the following: best-corrected visual acuity at distance and near; cover testing at distance and near with objective prism neutralization; near point of convergence; positive and negative fusional vergence at near (fusional convergence and divergence amplitudes); near stereoacuity; monocular accommodative amplitude; and monocular accommodative facility (the ability to quickly achieve clear vision while alternately viewing 20/30 equivalent print through +2 D and −2 D lenses); cycloplegic refraction with 1% cyclopentolate; and an ocular health evaluation. All near testing with at 40cm. A masked examiner administered the CISS.
Major eligibility criteria for the study included best-corrected visual acuity at distance and near of 20/25 or better, no strabismus, heterophoria at near between 2Δ esophoria and 8Δ exophoria, near point of convergence closer than 6.0 cm break, negative fusional vergence at near greater than 7Δ BI-break and 5Δ BI-recovery, positive fusional vergence at near greater than 10Δ BO-break and 7Δ BO-recovery, monocular amplitude of accommodation in diopters greater than 15 minus 25% of the child’s age, and at least 500 seconds of arc of random dot stereopsis on the Randot® Stereotest (Stereo Optical Co, Chicago, IL). A refractive correction was required when the magnitude of uncorrected refractive error or change in refractive error (based on a cycloplegic refraction performed within 2 months) in either eye differed from the current prescription by 0.50 D or more in spherical equivalent of myopia, 1.50D or greater in spherical equivalent of hyperopia, or 0.75 D or greater of astigmatism. Table 1 has the complete listing of eligibility and exclusion criteria.
Publication 2009
Astigmatism Child CISH protein, human Cyclopentolate Cycloplegics Depth Perception Eligibility Determination Esophoria Exophoria Heterophoria Hyperopia Lens, Crystalline Myopia Neoplasm Metastasis Ocular Accommodation Ocular Refraction Ophthalmologists Optometrist prisma Refractive Errors Strabismus Vision Visual Acuity
In the clinic, a detailed parental interview was conducted, including questions regarding family income and preschool or daycare enrollment.11 (link) The examination, described in detail elsewhere,11 (link),12 (link) included VA testing, evaluation of ocular alignment, cycloplegic refractive error measurement, and anterior segment and dilated fundus evaluations. Cycloplegic refraction was performed with the Retinomax Autorefractor (Right Manufacturing, Virginia Beach, VA) at least 30 minutes after instilling the second of 2 drops of 1% cyclopentolate given 5 minutes apart. Cycloplegic retinoscopy was performed if Retinomax readings with confidence ratings of ≥8 were not obtained in both eyes after 3 attempts per eye. If parents refused cycloplegic eyedrops, non-cycloplegic retinoscopy was performed.
Presenting monocular distance VA measurement was attempted using an electronic visual acuity (EVA) tester6 (link) with the ATS protocol.5 (link) The EVA system uses a handheld device programmed with the protocol algorithm to control the presentation of high-contrast black-and-white single HOTV optotypes framed by crowding bars spaced a half-letter width from the letter on a 17-inch monitor. The ATS testing algorithm has been described previously;5 (link),6 (link) an initial screening phase obtaining an approximate VA threshold is followed by a first threshold determination phase, a reinforcement phase, and a second threshold determination phase. The VA score, measured in 0.1 logMAR increments from 20/800 to 20/16, is the smallest logMAR level passed in either of the two threshold phases.
The VA testing protocol specific to MEPEDS has been reported in detail.3 (link) Children were seated 3 meters from the monitor with a lap card containing the single-surround HOTV letters. Children who had difficulty comprehending the task underwent a binocular pretest at near, which if passed was followed by a binocular pretest at 3 meters, and monocular threshold testing for those able to complete the pretests. Children were instructed to identify the letter on the monitor verbally or by pointing to the matching optotype on the hand-held card; those who knew their letters were still encouraged to refer to the card. The right eye was tested first, followed by the left, with the fellow eye occluded with an adhesive patch or, rarely, occluding glasses. Testing was attempted on all children, including those with developmental delay or disability.
Publication 2009
ARID1A protein, human Child Child, Preschool Cyclopentolate Cycloplegics Day Care, Medical Disabled Persons Eye Drops Eyeglasses Medical Devices Ocular Refraction Parent Refractive Errors Reinforcement, Psychological Retinoscopy Vision Visual Acuity
The circadian response of ipRGCs and cone photoreceptors were determined during a
20–24 h laboratory test period, during which the participant remained
awake. On the day of testing, participants arrived at the laboratory at 8 am for
set-up and alignment in the pupillometer, and rinsed their mouth with water in
preparation for the first salivary collection, prior to the commencement of the
first pupil measurements at 9 am (Figure 4). To maximise pupil diameter (>6.5 mm), control retinal
illumination and minimise the effects of accommodation on pupil diameter, the
participant's right pupil was cyclopleged with 1.0% cyclopentolate.
Subjective accommodation was assessed using an optometer (Hartinger, Rodenstock)
and cyclopentolate was re-instilled as required. Exogenous circadian cues of
activity (minimum), sleep (none), posture (seated upright), caffeine (none),
ambient temperature (23–25°C), caloric intake (aliquots <500
kJ.hr−1) and ambient illumination (10 lux) [50] (link) were
controlled for the entire test duration.
Figure 4 is a flowchart
timeline of the hourly measurements procedures. At the start of each hour, after
alignment in the pupillometer, four pupil light reflex measurements were
recorded (2×488 nm; 2×610 nm). Salivary sample collection for dim
light melatonin onset (DLMO) was then completed according to standard protocols
[51] (link).
In between measurements, participants remained in an upright-seated position
with limited physical activity as monitored by the actigraph. The constant
laboratory illumination (10 lux) and repeated hourly delivery of an equivalent
stimulus energy for the pupil light reflex measurements allowed us to determine
if circadian variation in ipRGC and cone photoreceptor activity was independent
of environmental light.
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Publication 2011
Actigraphy Caffeine Cyclopentolate Light Lighting Melatonin Obstetric Delivery Ocular Accommodation Pupil Pupillary Reflex Retinal Cone Sleep Specimen Collection
ERGs were recorded using the Espion E2 system (Diagnosys LLC, Littleton, MA) according to published protocols (Saszik et al., 2002 (link)). 8-12 week old mice were dark-adapted overnight and prepared for recordings in darkness using infrared goggles. Mice were anesthetized by intraperitoneal injection of a ketamine/xylazine mixture (75/10 mg/kg). Pupils were dilated with 1% cyclopentolate-HCl, 2.5% phenylephrine (~2.8 mm in diameter). A drop of the Gonak solution (Akorn, Buffalo Grove, IL) was placed on the cornea. Recordings were performed simultaneously from both eyes with silver loop electrodes supplemented with contact lenses to keep the eyes immersed in Gonak solution. This prevented eyes from drying and cataract development during recording periods of up to 60 min. The reference electrode was a toothless alligator clip wetted with Gonak and attached to the mouse cheek. Mouse body temperature was maintained at 37°C using a Deltaphase Isothermal Pad (Braintree Scientific, Braintree, MA). ERG signals were sampled at 1 kHz and recorded with 0.15 Hz low frequency and 500 Hz high frequency cut-offs.
Publication 2010
Alligators Body Temperature Buffaloes Cataract Cheek Clip Contact Lenses Cornea Cyclopentolate Darkness Dry Eye Eye Injections, Intraperitoneal Ketamine Mus Phenylephrine Pupil Silver Xylazine
This prospective study is covered by Institutional Review Board at Providence Hospital with Clinical Trial Registry (NCT03668067) and de-identified data access from www.ABCD-Vision.org. The study complies with HIPAA and the Declaration of Helsinki. Images and video of children examined by this technique are included. Written parental informed consent with appropriate translation was obtained.
The SBA-RS rack (Eye Care and Cure: 22 cm × 6 cm × 0.5 cm) has one row of convex (plus) lenses from 1 to 10 diopters arranged continuously so extra plus lens can be placed horizontally over the nonretinoscoped eye to achieve fogging. The rack appears like a yellow school bus with a millimeter ruler (Figure 1). One “wheel” has a −5 concave lens and the other a translucent occluder.
The retinoscopy technique presented the previously hidden school bus as a surprise (brought forward from a back pocket) and handed to the child asking if any older siblings ride a bus. Then, sitting behind the windows was demonstrated by the retinoscopist gently transferring the bus toward the child’s eye covering the nonscoped eye with adjacent, higher plus “windows.” The desired response was more “with” retinoscopy reflex 1–3 seconds looking through the skiascopy lens, and sliding the bus back and forth toward higher plus lenses watching for more “with” reflex and mydriasis accompany-relaxed accommodation. Neutralization required confirmation of astigmatism power and axis for the first eye. Then, the “bus” was reversed “to come home from school.” Often accommodation was already relaxed for the second eye as soon as the reversed-direction bus was in place (Supplementary video).
Since SBA-RS has just one row of integer-value plus spherical lenses, retinoscopy made liberal use of 1) adjusting the working distance to determine fractional refractive values for sphere and cylinder power and 2) sliding the bus back and forth to relax more accommodation uncovering more hyperopia. For higher myopic patients, the concave −5 lens in one of the “bus wheels” was utilized. Utilizing this simple device, the single −5 lens and the +1 through +10 convex lenses, sphero-cylinder refraction could be determined with a range from −10D to +8.5D. For the extremely high hyperopic patients, the SBA-RS was checked by holding an additional +12 lens to allow fogging when refracting through the +10 lens.
Patients undergoing initial or follow-up comprehensive ophthalmic examination were screened with SBA-RS before retinoscopy with our “gold-standard” cycloplegia at least 20 mins following instillation of cyclopentolate 1%. For objective comparison, many of the patients also had Retinomax automated refraction before cycloplegic refraction. Data were collected regarding age, indication for examination and neurodevelopmental delay such as autism, syndrome, attention-deficit hyperactivity disorder (ADHD), fetal alcohol syndrome (FAS), etc. The clinician performing the cycloplegic examination mainly used phoropter with refinement and was usually not aware of the Retinomax findings at the time of the refraction.
Refractive values were organized to afford the best comparison. Spherical equivalent was sphere plus 0.5× cylinder power in plus format. Power vectors for astigmatism (J0 Horizontal Jackson-Cross and J45 oblique Jackson-Cross) were calculated by (J0) = [−(Ksteep−Kflat)/2] × cos2α and (J0) = [−(Ksteep−Kflat)/2] × cos2α where K represents cylinder power and alpha (α) the axis in radians.18 (link) We classified cases of hyperopia as those whose cycloplegic spherical equivalent exceeded 0.7 diopters and those with astigmatism as those whose plus cylinder power exceeded 0.7 diopters. Bland-Altman analysis and interclass correlation coefficient (ICC) were determined for these refractive values.
Correlations were assessed by linear regression with Spearman product moment coefficient. Medians between groups were compared with Mann–Whitney test. Proportions were compared with Chi-square test. A probability of 0.05 was considered significant.
Sample size calculation for linear regression with 2 predictors: statistical power level 0.9, probability level 0.01, and the anticipated effect size of 0.05 indicate a minimal sample size of 351.
Publication 2019
Astigmatism Autistic Disorder Child Cloning Vectors Cyclopentolate Cycloplegics Disorder, Attention Deficit-Hyperactivity Epistropheus Ethics Committees, Research Fetal Alcohol Syndrome Gold Hyperopia Lens, Crystalline Medical Devices Mydriasis Myopia Ocular Accommodation Ocular Refraction Parent Patients Reflex Retinoscopy Sibling Syndrome Vision

Most recents protocols related to «Cyclopentolate»

BCVA was tested at 3 m with a linear Konstantin Moutakis VA chart.23 (link) The decimal VA was then converted to the logarithm of the minimum angle of resolution (logMAR). BCVA best eye <0.65 decimal (>0.19 logMAR) was considered subnormal.
Refraction was tested under cycloplegia caused by a mixture of phenylephrine (1.5%) and cyclopentolate (0.85%), using an autorefractor (Topcon A6300/KR-8800; Topcon Corporation, Tokyo, Japan). Significant refractive errors were defined as follows: hyperopia ≥2.5 dioptres (D), spherical equivalents (SE), myopia ≥0.5 D SE, anisometropia ≥1.0 D SE and astigmatism ≥1.0 D.
Publication 2023
Anisometropia Astigmatism Cyclopentolate Cycloplegics Hyperopia MYP5 Ocular Refraction Phenylephrine Refractive Errors
Mice were anesthetized intraperitoneally with a mixture of ketamine (100 mg/kg) and xylazine (10 mg/kg). Pupils were dilated with 1% cyclopentolate-HCL and 2.5% phenylephrine. After dark adaption for 8 hr, ERG was recorded under dim red light using an Espion system (Diagnosys LLC, Lowell, MA, USA) in accordance with recommendations of the International Society for Clinical Electrophysiology of Vision. ERG waves were documented in response to flashes at 0.01, 3.0, and 10.0 cd×s/m2.
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Publication 2023
Cyclopentolate Dark Adaptation Ketamine Light Mice, House Phenylephrine Pupil Vision Xylazine
The primary outcome variables were changes in AL and SER compared to baseline. SER (sphere plus half cylinder) from the pattern of five measurements was measured at least 30 min after instillation of 2 drops of 1% cyclopentolate administered every 5 min. AL was measured by calculating the average of five measurements obtained from the same IOLMaster. The secondary outcome variables included SFChT (Spectralis OCT, Herdingberg, Germany), ACD (from IOLmaster 500) and CCP (from Pentacam). PBM therapy was administered twice a day for 3 min per session with an interval of ≥ 4 h between sessions based on the self-report of participants or their supervision. We also evaluated the subjects’ social context, such as schools, and lifestyle (e.g., outdoor time) via questionnaires.
Due to the small sample size, we aimed to avoid the influence of age on different growth rates of AL. Therefore, the eligibility criteria for age were set from 8 to 12 years old. In addition, we also removed the limitation on baseline AL ≥ 24.40 mm because the myopia suppression effect is unknown for axial lengths greater than 24.40 mm.
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Publication 2023
Cyclopentolate Eligibility Determination Low-Level Light Therapy Myopia Supervision
This study included demographic, biometric, and refractive data from study participants enrolled at the Copenhagen University Hospital. We obtained the age and sex of the participants from the Danish central person registry. Mesopic and photopic pupil sizes were measured during the screening and baseline visits using a computer-based automated binocular pupillometer (DP-2000 Human Laboratory Pupillometer, NeurOptics, Irvine, CA, USA). Measurements were performed in a darkened room with blackout curtains and room lights off. Both eyes were stimulated simultaneously with white light under mesopic (4 lux) and photopic (300 lux) conditions. Continuous binocular pupil size measurements were performed before (3 s) and during (10 s) light stimulus. A total of five minimal pupil size measurements (with a maximum tolerability range of 1.0 mm) were performed during light stimulus for each light condition, completing all mesopic measurements first. Human-assisted readings of pupil diameter were performed using a built-in graphical user interface (GUI) on the pupillometer (DesktopTracker, version 137, NeurOptics, Irvine, CA, USA). If the GUI reported invalid results due to blink artifacts or lost pupil tracking, the minimum pupil size under light stimulus was marked and entered manually in the GUI. Trained investigators performed pupil size measurements and subsequent readings. Each continuous binocular examination was saved as a data file, which was exported and underwent automated data reading using a customized algorithm, see Automated data reading. Axial length (AL) was measured using a swept-source optical coherence tomography (SS-OCT)-based biometer IOLMaster 700 (Carl Zeiss Meditec AG, Jena, Germany). Cycloplegic autorefraction was obtained using the Retinomax K-plus 3 (Right Mfg. Co. Ltd., Tokyo, Japan) 30 min after a complete cycloplegia regimen, consisting of at least two drops of cyclopentolate 1% (Minims Cyclopentolate Hydrochloride 1%, Bausch & Lomb Nordic AB, Stockholm, Sweden), which was administered to both eyes 5 min apart. Cycloplegic spherical equivalent (SE) was calculated as spherical power plus half cylinder power. Cycloplegic autorefraction was the only measurement performed under cycloplegia.
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Publication 2023
Blinking Color Vision Cyclopentolate Cycloplegics Eye Homo sapiens Light Ocular Refraction Pupil Tomography, Optical Coherence Treatment Protocols
We included biometric and refractive examinations from the initial six months of follow-up. We used IOLMaster 700 (Carl Zeiss Meditec AG, Germany), a swept-source optical coherence tomography (SS-OCT)-based biometer, to measure ocular biometrics on undilated eyes. Ocular biometry included measurements of AL, central corneal thickness (CCT), anterior chamber depth (ACD), and lens thickness (LT). Corneal curvatures, K1 (flattest) and K2 (steepest), and their mean (Km) were measured by Scheimpflug imaging (Pentacam HR, Oculus Optikgeräte GmbH, Germany).
Choroidal thickness (ChT) was measured by SS-OCT using the DRI OCT Triton on undilated eyes. We used the central 1.0-mm zone of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid obtained from the built-in software, IMAGEnet 6 (Topcon Europe Medical BV, The Netherlands).
Cycloplegic autorefraction was performed with the Retinomax K-plus 3 (Right Mfg. Co. Ltd., Japan) handheld autorefractor. The average of five readings was calculated with a predefined quality cut-off score of ≥7. Cycloplegic autorefraction was performed 30 min after the last of 2 drops of cyclopentolate 1% (Minims Cyclopentolate Hydrochloride 1%, Bausch & Lomb Nordic AB, Sweden) was administered to both eyes at 5 min apart. SE was calculated as spherical power plus half cylinder power. Cycloplegic autorefraction was the only measurement performed under cycloplegia.
Lens power (LP) was calculated using Bennett’s formula, inserting measured (i.e., AL, ACD, and LT) and calculated (i.e., SE, Km, and VCD) values [12 (link)]. We used the customized c1 and c2 constants introduced by Rozema et al. and 4/3 as the refractive index of aqueous and vitreous humors [13 (link)]. Notably, reported ACD measurements were based on the distance between the corneal endothelium and anterior lens surface, whereas ACD values inserted in Bennett’s formula were measured from the corneal epithelium to the anterior lens surface [13 (link)]. Vitreous chamber depth (VCD) was calculated as the difference between AL and the distance from the corneal epithelium to the posterior lens surface (i.e., CCT, ACD, and LT).
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Publication 2023
Chambers, Anterior Choroid Cornea Corneal Endothelium Cyclopentolate Cycloplegics Diabetic Retinopathy Epithelium, Anterior Corneal Eye Lens, Crystalline Ocular Refraction Physical Examination STEEP1 protein, human Tomography, Optical Coherence Vision Vitreous Body

Top products related to «Cyclopentolate»

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The IOL Master is a non-contact optical biometry device used to measure various parameters of the eye, including axial length, anterior chamber depth, and corneal curvature. It provides precise measurements that are essential for calculating the appropriate intraocular lens power for cataract surgery.
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Cyclopentolate is a topical ophthalmic solution used in the medical field. It is a cycloplegic and mydriatic agent, primarily utilized for diagnostic purposes in eye examinations.
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Cyclogyl is a topical ophthalmic solution used in eye examinations. It contains the active ingredient cyclopentolate hydrochloride, which is a mydriatic and cycloplegic agent. Cyclogyl is used to dilate the pupil and temporarily paralyze the ciliary muscle of the eye, facilitating eye examinations.
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Alcaine is a topical ophthalmic solution. It contains the active ingredient proparacaine hydrochloride, which is a local anesthetic used to numb the eye's surface.
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The KR-8900 is a high-performance automated refractor-keratometer designed for comprehensive vision assessments. The device measures refractive errors and corneal curvature data, providing essential information for prescribing corrective lenses.
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Mydrin-P is a laboratory product used for ophthalmic purposes. It functions as a mydriatic agent, intended to dilate the pupil.
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The IOLMaster 500 is a non-contact optical biometry device designed for ocular measurements. It utilizes optical coherence technology to precisely measure axial length, anterior chamber depth, and corneal curvature. The IOLMaster 500 is a diagnostic tool used in pre-operative evaluations for cataract and refractive surgery.
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The ARK-510A is an automated refractometer designed for eye examinations. It measures the refractive power of the eye and provides data on the corneal curvature. The device is intended for use in ophthalmology and optometry practices.
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The KR8800 is a multi-function clinical refraction system designed for use in ophthalmology and optometry practices. The device is capable of performing automated refraction, keratometry, and corneal topography measurements.
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Tropicamide is a mydriatic and cycloplegic agent used in ophthalmic examinations and procedures. It is a pharmaceutical product designed to temporarily dilate the pupil and temporarily paralyze the ciliary muscle, which controls the eye's focusing ability.

More about "Cyclopentolate"

Cyclopentolate is a muscarinic antagonist, commonly used as a cycloplegic and mydriatic agent in ophthalmological examinations.
It temporarily paralyzes the ciliary muscle and dilates the pupil, enabling accurate assessment of refractive errors.
PubCompare.ai's AI-driven platform can help researchers identify the most effective protocols for using cyclopentolate, ensuring confident reproducibility of their experiments.
The platform seamlessly compares and optimizes product and procedure options, drawing from scientific literature, preprints, and patents to provide a comprehensive resource for enhancing cyclopentolate-related research.
Cyclopentolate is also known by the brand names Cyclogyl, Alcaine, KR-8900, and Mydrin-P.
It is often used in conjunction with other ophthalmic instruments like the IOLMaster 500 and ARK-510A to measure refractive errors and assist in the management of conditions like myopia, hyperopia, and astigmatism.
Researchers can leverage PubCompare.ai's platform to identify the most effective cyclopentolate protocols, enabling them to reproduce their experiments with confidence and advance their understanding of this important ophthalmic agent.
Wheter you're working with cyclopentolate, KR8800, or other related compounds, PubCompare.ai can help optimize your research and ensure the reliability of your findings.