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Diamines

Diamanes are a class of organic compounds containing two amino groups (NH2) attached to a carbon backbone.
These versatile molecules find applications in various fields, including pharmaceuticals, materials science, and organic synthesis.
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Most cited protocols related to «Diamines»

Thermal-Shift Assay for Ligand Binding

Cited 19 times

Thermal-shift assays were performed using a Corbett Real Time PCR machine with proteins diluted in 150 mM NaCl, 20 mM Tris/HCl (pH 8.0) and 1 mM DTT to 2–5 μM and assayed with the appropriate concentration of ligand in a total reaction volume of 25 μl. SYPRO Orange (Molecular Probes) was used as a probe with fluorescence detected at 530 nm. The temperature was raised in 1^◦C per min steps from 25^◦C to 95^◦C and fluorescence readings were taken at each interval. Nucleotide- or cation-binding experiments were assessed relative to a buffer control. Two generic inhibitors, DAP {N′2′-(4-aminomethyl-phenyl)-5-fluoro-N′4′-phenyl-pyrimidine-2,4-diamine [31 (link)]; supplied by SYNthesis Med Chem} and VI16832 [32 (link)], were assessed relative to a 2% (v/v) DMSO control. With the exception of the titration experiments, nucleotide concentrations of 0.2 mM, divalent cation concentrations of 1 mM, and DAP or VI16832 concentrations of 40 μM were used in each experiment. For each well, sample fluorescence was plotted as a function of increasing temperature. The melting temperature (T_m) corresponding to the midpoint for the protein unfolding transition was calculated by fitting the sigmoidal melt curve to the Boltzmann equation using GraphPad Prism, with R² values of >0.99. Data points after the fluorescence intensity maximum were excluded from fitting. Changes in the unfolding transition temperature compared with the control curve (ΔT_m) were calculated for each ligand (nucleotides cations). A positive ΔT_m value indicates that the ligand stabilizes the protein from denaturation, and therefore binds the protein. A minimum of two independent assays was performed for each protein and representative data are shown for each.

Murphy J.M., Zhang Q., Young S.N., Reese M.L., Bailey F.P., Eyers P.A., Ungureanu D., Hammaren H., Silvennoinen O., Varghese L.N., Chen K., Tripaydonis A., Jura N., Fukuda K., Qin J., Nimchuk Z., Mudgett M.B., Elowe S., Gee C.L., Liu L., Daly R.J., Manning G., Babon J.J, & Lucet I.S. (2014). A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties. The Biochemical journal, 457(2), 323-334.

Publication 2014

Anabolism Biological Assay Body Temperature Changes Buffers Cations Cations, Divalent Diamines Fluorescence Generic Drugs inhibitors Ligands Molecular Probes Nucleotides prisma Protein Denaturation Proteins Pyrimidines Real-Time Polymerase Chain Reaction Sodium Chloride Sulfoxide, Dimethyl Titrimetry Tromethamine

Intestinal Short-Chain Fatty Acid Analysis

Cited 9 times

SCFAs including acetate, propionate, butyrate, isobutyrate, valerate, and isovalerate were analysed as described previously67 (link). To ensure the homogenicity of the intestine content sample, the freeze-dried samples were prepared using a Vacuum freeze-dryer (Hrist ALPHA 2-4/LSC, Germany) at −80 °C. Briefly, freeze-dried samples (0.5–0.6 g) were weighed into 10 ml centrifuge tubes and mixed with 8 ml ddH₂O, homogenised, and centrifuged in sealed tube at 7,000 g and 4 °C for 10 min. A mixture of the supernatant fluid and 25% metaphosphoric acid solution (0.9 and 0.1 ml, respectively) was centrifuged at 20,000 g and 4 °C for 10 min after standing in a 2 ml sealed tube at 4 °C for over 2 h. The supernatant portion was then filtered through a 0.45-μm polysulfone filter and analysed using Agilent 6890 gas chromatography (Agilent Technologies, Inc, Palo Alto, CA, USA) with a flame ionisation detector and a 1.82 m × 0.2 mm I.D. glass column that was packed with 10% SP-1200/1% H₃PO₄ on the 80/100 Chromosorb W AW (HP, Inc., Boise, ID, USA). The concentration of NH₃-N in the supernatant fluid was measured at 550 nm using a UV-2450 spectrophotometer (Shimadzu, Kyoto, Japan)68 . The bioamines including 1,7-heptyl diamine, cadaverine, phenylethylamine, putrescine, trytamine, tyramine, spermidine, and spermine, as well as the indoles and skatoles, were analysed as described previously69 .

Kong X.F., Ji Y.J., Li H.W., Zhu Q., Blachier F., Geng M.M., Chen W, & Yin Y.L. (2016). Colonic luminal microbiota and bacterial metabolite composition in pregnant Huanjiang mini-pigs: effects of food composition at different times of pregnancy. Scientific Reports, 6, 37224.

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Publication 2016

Acetate Butyrates Cadaverine Diamines Flame Ionization Freezing Gas Chromatography Homozygote IGBP1 protein, human Indoles Intestinal Contents metaphosphoric acid Phenethylamines polysulfone Propionate Putrescine Spermidine Spermine Tyramine Vacuum Valerates

Molecular Dynamics of SARS-CoV-2 S Protein Interactions

Cited 7 times

Protocol full text hidden due to copyright restrictions

Open the protocol to access the free full text link

Publication 2020

9-O-acetyl-N-acetylneuraminic acid Carbohydrates Ceramides Diamines Ethanol Gangliosides Glycolipids Glycosides Hydroxylation Ligands Molecular Dynamics N-Acetylneuraminic Acid pentane spike protein, SARS-CoV-2 Tissue, Membrane

Rapid Diamine-Grafting of Mg2(dobpdc) Frameworks

Cited 7 times

Samples of diamine-appended Mg₂(dobpdc) frameworks used for collection of high-throughput isotherm data were prepared following conditions reported previously.^{23 (link)} For each analogue, a solution of 20 v/v% diamine in toluene was stirred over freshly-ground CaH₂, and a quantity corresponding to a 10-fold molar excess of diamine per metal site was added to approximately 100 mg of desolvated Mg₂(dobpdc) under N₂ by syringe or cannula transfer. The slurry was sonicated for 15 min under N₂ and left undisturbed under N₂ for a minimum of 12 h. The solid was then isolated by filtration in air and washed with 30 mL of dry toluene followed by 30 mL of dry hexanes at room temperature. Prior to adsorption measurements, the samples were desolvated by heating in vacuo at 120 °C for 12 h.
For all subsequent experiments, it was found that identical CO₂ adsorption performance could be achieved through direct diamine-grafting of methanol-solvated Mg₂(dobpdc), enabling rapid sample preparation by eliminating time-consuming activation of the parent framework. In this rapid procedure, approximately 30 mg of methanol-solvated Mg₂(dobpdc) was isolated by filtration, washed with 30 mL of toluene, and submerged in 5 mL of a 20 v/v% solution of diamine in toluene. After 12 h, the solid was isolated by filtration and washed with 30 mL of fresh toluene to remove excess diamine.
Powder X-ray diffraction patterns, infrared spectra, and representative diamine loadings obtained from NMR spectra upon digestion of the material are presented in Figures S3–S4 and Table S2.

Siegelman R.L., McDonald T.M., Gonzalez M.I., Martell J.D., Milner P.J., Mason J.A., Berger A.H., Bhown A.S, & Long J.R. (2017). Controlling Cooperative CO2 Adsorption in Diamine-Appended Mg2(dobpdc) Metal–Organic Frameworks. Journal of the American Chemical Society, 139(30), 10526-10538.

Publication 2017

Adsorption Cannula Diamines Digestion Filtration Hexanes Metals Methanol Molar Parent Powder Syringes Toluene X-Ray Diffraction

Oxidative Stress Biomarkers Analysis

Cited 7 times

All blood analyses were performed using a free radical analyzer system (FREE Carpe Diem, Wimerll Company Ltd., Tokyo, Japan) that included a spectrophotometric device reader and a thermostatically regulated mini-centrifuge, and the measurement kits were optimized to the FREE Carpe Diem System, according to the manufacturer's instructions. Based on the recommendation from the manufacturer, all analyses were performed within 48 hours of venous blood collection to avoid falsely high or low results. To analyze the plasma levels of reactive oxygen metabolites, antioxidant capacity, and thiol-antioxidant capacity, diacron reactive oxygen metabolite (dROM), biological antioxidant potential (BAP), and sulfhydryl (SH) tests were performed, respectively.
The dROM test reflects the amount of organic hydroperoxides that is related to the free radicals from which they are formed. When the samples are dissolved in an acidic buffer, the hydroperoxides react with the transition metal (mainly iron) ions liberated from the proteins in the acidic medium and are converted to alkoxy and peroxy radicals. These newly formed radicals oxidize an additive aromatic amine (N,N-diethyl-para-phenylen-diamine) and cause formation of a relatively stable colored cation radical that is spectrophotometrically detectable at 505 nm [33] (link), [36] (link). The results are expressed in arbitrary units (U. Carr), one unit of which corresponds to 0.8 mg/L of hydrogen peroxide [33] (link), [36] (link).
The BAP test provides an estimate of the global antioxidant capacity of blood plasma, measured as its reducing potential against ferric ions. When the sample is added to the colored solution obtained by mixing a ferric chloride solution with a thiocyanate derivative solution, decoloration results. The intensity of the decoloration is spectrophotometrically detectable at 505 nm and is proportional to the ability of plasma to reduce ferric ions [34] (link), [37] (link). The results are expressed in µmol/L of the reduced ferric ions.
The SH test provides an estimate of the total thiol groups in the biologic samples, using a modified Ellman method [38] (link), [39] (link). When the sample is added to the solution, sulfhydryl groups in the sample react with 5,5-dithiobus-2-nitrobenzoic acid, which is followed by development of a stained complex that is spectrophotometrically detectable at 405 nm and is proportional to their concentration according to the Beer-Lambert law [34] (link), [36] (link). The results are expressed as µmol/L of the sulfhydryl groups.

Tanito M., Kaidzu S., Takai Y, & Ohira A. (2012). Status of Systemic Oxidative Stresses in Patients with Primary Open-Angle Glaucoma and Pseudoexfoliation Syndrome. PLoS ONE, 7(11), e49680.

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Publication 2012

Acids alkoxy Amines Antioxidants Beer Biopharmaceuticals BLOOD Buffers Chlorides Diamines ferric chloride ferric thiocyanate Free Radicals Hematologic Tests Ions Iron Medical Devices Nitrobenzoic Acids Oxygen Peroxide, Hydrogen Plasma Proteins Spectrophotometry Sulfhydryl Compounds Thiocyanates Transition Elements Veins

Most recents protocols related to «Diamines»

Synthesis of Pyrido[3,4-b]pyrazine Derivative

Not available on PMC !

Example 11

[Figure (not displayed)]

Step a: To a stirred suspension of 2,4-dichloro-6-methyl-3-nitropyridine (2.5 g, 12 mmol) in 24 mL of THE was added a solution of 7N NH₃in MeOH (14 mL, 98 mmol). After stirring for 3 h, the volatiles were removed in vacuo. The crude residue was purified by silica gel column chromatography to give 2-chloro-6-methyl-3-nitropyridin-4-amine. C₆H₇CN₃O₂[M+H]⁺ 188.0, found 188.0.

Step b: To a stirred mixture of 2-chloro-6-methyl-3-nitropyridin-4-amine (760 mg, 4.1 mmol) and Fe (1.1 g, 20 mmol) in a 5:1 solution of EtOH/H₂O (24 mL) was added 4.4 mL of conc. HCl. The contents were refluxed for 30 min, then cooled to room temperature and quenched with 100 mL of sat. NaHCO₃(aq). The mixture was extracted with EtOAc and the combined organic layers were dried over MgSO₄, filtered, and concentrated in vacuo to yield 2-chloro-6-methylpyridine-3,4-diamine. MS: (ES) m/z calculated for C₆H₉ClN₃[M+H]⁺ 158.0, found 158.0.

Step c: To a stirred solution of 2-chloro-6-methylpyridine-3,4-diamine (0.49 g, 3.1 mmol) in 3 mL of EtOH was added a 40% w/w aqueous solution of glyoxal (2.0 mL, 12 mmol). After refluxing for 16 h, the mixture was diluted with H₂O and extracted with EtOAc. The organic layers were combined, dried over MgSO₄, filtered and concentrated in vacuo. The crude residue was purified by silica gel column chromatography to give 5-chloro-7-methylpyrido[3,4-b]pyrazine. MS: (ES) m/z calculated for C₈H₇ClN₃[M+H]⁺ 180.0, found 180.1.

Step d: To a stirred solution of 5-chloro-7-methylpyrido[3,4-b]pyrazine (200 mg, 1.0 mmol) and 2′-chloro-2-methyl-3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-3-amine (350 mg, 1.0 mmol) in 2 mL of MeCN was added AcOH (0.18 mL, 3.1 mmol). After 30 min, the volatiles were concentrated in vacuo. The crude residue was purified by silica gel column chromatography to give N-(2′-chloro-2-methyl-3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-3-yl)-7-methylpyrido[3,4-b]pyrazin-5-amine. MS: (ES) m/z calculated for C₂₇H₂₉BClN₄O₂[M+H]⁺ 487.2, found 487.2.

Step e: To a stirred solution of N-(2′-chloro-2-methyl-3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-3-yl)-7-methylpyrido[3,4-b]pyrazin-5-amine (390 mg, 0.66 mmol), 6-chloro-2-methoxynicotinaldehyde (240 mg, 1.4 mmol), and K₃PO₄(490 mg, 2.3 mmol) in a 1:1 solution of 1,4-dioxane/H₂O (3.3 mL) under N₂(g) was added Pd(PPh₃)₄(76 mg, 0.066 mmol). The mixture was stirred under N₂(g) at 90° C. for 3 h. The mixture was diluted with H₂O and then extracted with EtOAc. The combined organic layers were dried over MgSO₄, filtered, and concentrated. The crude residue was purified by silica gel column chromatography to give 6-(2-chloro-2′-methyl-3′-((7-methylpyrido[3,4-b]pyrazin-5-yl)amino)-[1,1′-biphenyl]-3-yl)-2-methoxynicotinaldehyde. MS: (ES) m/z calculated for C₂₈H₂₃ClN₅O₂[M+H]⁺ 496.2, found 496.2.

Step f: To a stirred mixture of 6-(2-chloro-2′-methyl-3′-((7-methylpyrido[3,4-b]pyrazin-5-yl)amino)-[1,1′-biphenyl]-3-yl)-2-methoxynicotinaldehyde (120 mg, 0.25 mmol), (S)-5-(aminomethyl)pyrrolidin-2-one hydrochloride (150 mg, 0.99 mmol), and trimethylamine (0.14 mL, 0.99 mmol) in a 4:1 solution of DCM/MeOH (5 mL) was added NaBH(OAc)₃(530 mg, 2.5 mmol). After stirring for 30 min, the mixture was filtered through Celite, and the filtrate was concentrated in vacuo. The product was purified by preparative HPLC to give the product (S)-5-((((6-(2-chloro-2′-methyl-3′-((7-methylpyrido[3,4-b]pyrazin-5-yl)amino)-[1,1′-biphenyl]-3-yl)-2-hydroxypyridin-3-yl)methyl)amino)methyl)pyrrolidin-2-one. ¹H NMR (400 MHz, DMSO-d₆) δ 12.59 (s, 1H), 9.32 (s, 1H), 9.07 (d, J=2.0 Hz, 1H), 8.86 (d, J=2.0 Hz, 1H), 8.23 (d, J=8.7 Hz, 1H), 7.76 (d, J=7.0 Hz, 1H), 7.62 (s, 1H), 7.55 (d, J=7.5 Hz, 1H), 7.50-7.43 (m, 1H), 7.35 (dd, J=7.9, 7.9 Hz, 1H), 7.12 (s, 1H), 6.96 (d, J=7.5 Hz, 1H), 6.55 (s, 2H), 6.43 (d, J=7.1 Hz, 1H), 4.07 (s, 3H), 3.95-3.84 (m, 1H), 2.48 (s, 4H), 2.26-2.15 (m, 3H), 2.11 (s, 3H), 1.86-1.70 (m, 1H). MS: (ES) m/z calculated for C₃₂H₃₁ClN₇O₂[M+H]⁺ 580.2, found 580.1.

US11866429B2. Heteroaryl-biphenyl amines for the treatment of PD-L1 diseases (2024-01-09). CHEMOCENTRYX, INC. [US]. Inventors: Pingchen Fan [US], Christopher W. Lange [US], Rebecca M. Lui [US], Darren J. McMurtrie [US], Ryan J. Scamp [US], Ju Yang [US], Yibin Zeng [US], Penglie Zhang [US].

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Patent 2024

1H NMR 2-picoline 4-nitropyridine Amines Bicarbonate, Sodium Celite Chromatography Diamines Dioxanes diphenyl Ethanol Gel Chromatography Glyoxal High-Performance Liquid Chromatographies Pyrazines Silica Gel Silicon Dioxide Sulfate, Magnesium Sulfoxide, Dimethyl trimethylamine

Polyamide-Imide Films for Flexible Displays

Not available on PMC !

Example 8

An adhesive layer (product name: OCA #8146 from 3M company) was interposed between the prepared film and a PET substrate to obtain a multilayer film. It was folded to have a radius of curvature of 3 mm, which was left at a low temperature of −20° C. for 72 hours, and then unfolded. The extent of wrinkles was visually observed. In such event, if no wrinkles were visually observed, it was evaluated as o. If wrinkles were visually observed slightly, it was evaluated as Δ. If wrinkles were visually observed readily, it was evaluated as x.

TABLE 1

Ex. 1aEx. 2aEx. 3aEx. 4aC. Ex. 1aC. Ex. 2aC. Ex. 3a

CompositionDiamineTFMBTFMBTFMBTFMBTFMBTFMBTFMB

100100100100100100100

Dianhydride6FDA 36FDA 36FDA 106FDA 156FDA 246FDA 06FDA 0

DicarbonylTPC 75TPC 75TPC 75TPC 75TPC 29TPC 75TPC 75

compoundIPC 22IPC 22IPC 15IPC 10BPDC 47IPC 25IPC 25

Imide:amide3:973:9710:9015:8524:760:1000:100

Type of metal saltLiClLi₂CO₃Li₂CO₃Li₂CO₃—LiBrLiBr

Content of metal salt (based on10.50.50.5011

100 parts by weight of polymer

solids content)

Tensile strength (TS_1a)kgf/mm²32.131.630.427.726.329.221.3

Tensile strength at highkgf/mm²26.425.924.62318.721.617.1

temperatures (TS_2a)

TS_R%82.2481.9680.9283.0371.1073.9780.28

Elongation at break%23.722.721.4218.817.317.618.3

(EL_1a)

Elongation at break at%20.718.218.915.114.714.414.3

high temperatures

(EL_2a)

EL_R%87.3480.1888.2480.3284.9781.8278.14

Modulus (MO_1a)GPa7.437.256.86.55.867.47.6

Modulus at highGPa5.85.85.45.14.25.35

temperatures (MO_2a)

MO_R%78.0680.0079.4178.4671.6771.6265.79

Film thicknessμm50505050505050

Light transmittance%88.888.989.589.688.988.587.9

Haze%0.50.50.40.40.50.82.4

YI—2.82.52.52.52.93.66.12

Flexural resistance (1 R, 20K)passpasspasspassfailfailpass

ProcessDrying step125/15 125/15 115/15 115/15 150/20 150/20 115/15

(temp./min.)

First thermal125/1 125/1 115/1 115/1 150/1 150/1 115/1

treatment step

(temp./min.)

Second thermal225/10 225/10 225/10 225/10 225/10 225/10 225/10

treatment step

(temp./min.)

As can be seen from Table 1 above, the polyamide-imide films of Examples 1a to 4a had an MO_Rvalue of 75% or more. Thus, they maintained the modulus at least at a certain level even under the harsh conditions of high temperatures.

Since the display device is an electronic device, it generates heat during its use and it is to be used in a hot place as well, it is essential to secure mechanical properties at least at a certain level at high temperatures. Specifically, when a film is applied to a cover window for a display device, if the MO_Rvalue is 75% or more, no problem arises when a display device is fabricated.

In addition, the polyamide-imide films of Examples 1a to 4a were all excellent in the TS_Rvalue, EL_Rvalue, MO_1avalue, TS_1avalue, EL_1avalue, MO_2avalue, TS_2avalue, and EL_2avalue, in addition to the MO_Rvalue. That is, the polymer films of Examples 1a to 4a had high mechanical properties such as tensile strength, elongation at break, and modulus at room temperature and maintained the excellent mechanical properties even after the treatment under the severe conditions of high temperatures for a certain period of time.

Further, the polyamide-imide films of Examples 1a to 4a were all excellent in the evaluation of flexural resistance.

In contrast, since the films of Comparative Examples 1a to 3a had a low MO_Rvalue of 72% or less, when the film is applied to cover window for display device, it would have defects in appearance stability. In addition, the films of Comparative Examples 1a and 2a failed in the evaluation of flexural resistance. Thus, they are unsuitable for application to foldable display device or flexible display device.

TABLE 2

Ex. 1bEx. 2bEx. 3bEx. 4bEx. 5bEx. 6bEx. 7bEx. 8bC. Ex. 1bC. Ex. 2b

CompositionDiamineTFMBTFMBTFMBTFMBTFMBTFMBTFMBTFMBTFMBTFMB

100100100100100100100100100100

Dianhydride6FDA6FDA6FDA6FDA6FDA6FDA6FDA6FDA—6FDA

33791215242550

BPDA

DicarbonylTPC 70TPC 70TPC 65TPC 69TPC 66TPC 75TPC 29TPC 65TPC 75TPC 25

compoundIPC 27IPC 27IPC 28IPC 22IPC 22IPC 10BPDC 47IPC 25IPC 25

Imide:amide3:973:977:939:9112:8815:8524:7635:650:10050:50

Type/content metal saltLiCl/1LiCl/0.5——————LiBr/1—

Tensile strengthkgf/mm²28.4532.1329.630.730.127.529.6128.3124.6122.62

(TS_1b)

Tensile strengthkgf/mm²27.7828.2430.128.62826.127.4122.9523.222.71

at low

temperatures

(TS_2b)

dTS%2.3612.111.696.846.985.097.4318.935.730.40

Elongation at%19.8923.6719.223.12319.427.827.81178.9

break (EL_1b)

Elongation at%23.0617.6821.51919.517.121.220.616.211.71

break at low

temperatures

(EL_2b)

dEL%115.9425.3111.9817.7515.2211.8623.7425.934.7131.57

Modulus (MO_1b)GPa7.427.436.025.925.546.156.446.657.454.83

Modulus at lowGPa7.577.646.216.035.716.326.556.767.464.87

temperatures

(MO_2b)

dMO%2.022.833.161.863.072.761.7111.650.130.83

LM_O1GPa1.4761.7591.1561.3681.2741.1931.7901.8491.2670.430

LM_O2GPa1.7461.3511.3351.1461.1131.0811.3891.3931.2090.570

Thicknessμm50505050505050505050

Transmittance%89898989.189.3898988.588.490.8

Haze%0.470.480.660.520.670.560.460.542.410.41

YI—2.622.653.42.963.122.442.872.74.59141

Folding evaluation○Δ○○○○○Δxx

at low temperatures

(3 R, −20° C., 72 hours)

ProcessDrying125/15 125/15 125/15 125/15 115/15 115/15 115/15 115/15 150/20 115/15

(temp/min.)First thermal125/1 125/1 125/1 125/1 115/1 115/1 115/1 115/1 150/1 150/1

treatment

Second thermal225/10 225/10 225/10 225/10 225/10 225/10 225/10 225/10 225/10 225/10

treatment

As can be seen from Table 2 above, the polyamide-imide films of Examples 1b to 8b had a dMO value of 1% to 8%. Thus, they maintained the modulus at least at a certain level even under the harsh conditions of low temperatures.

In the case where the polyamide-imide film is applied to a cover window for a display device and to a display device, it may be used in an extremely cold environment. Thus, it is essential to secure mechanical properties at least at a certain level even in such an extremely cold environment. Specifically, when the polyamide-imide film is applied to a cover window for a display device and to a display device, if the dMO value is within 1% to 8%, no problem arises.

In addition, the polyamide-imide films of Examples 1b to 8b were all excellent in the dTS value, dEL value, MO_1bvalue, TS_1bvalue, EL_1bvalue, MO_2bvalue, TS_2bvalue, and EL_2bvalue, in addition to the dMO value. That is, the polymer films of Examples 1b to 8b had high mechanical properties such as tensile strength, elongation at break, and modulus at room temperature and maintained the excellent mechanical properties even after the treatment under the severe conditions of low temperatures for a certain period of time.

Further, the polyamide-imide films of Examples 1b to 8b were all excellent in the folding characteristics at low temperatures.

In contrast, since the films of Comparative Examples 1b and 2b had a low dMO value of 1% or less, when it is applied to a cover window for a display device, it would not be balanced with other layers, resulting in cracks, which is defective in terms of the appearance stability. In addition, the films of Comparative Examples 1b and 2b failed in the evaluation of flexural resistance at low temperatures. Thus, they are unsuitable for application to a foldable display device or a flexible display device.

US11873372B2. Polyamide-imide film, preparation method thereof, and cover window comprising same (2024-01-16). SK microworks Co., Ltd. [KR]. Inventors: Han Jun Kim [KR], Sunhwan Kim [KR], Dae Seong Oh [KR], Jin Woo Lee [KR], Sang Hun Choi [KR], Jung Hee Ki [KR], Dong Jin Lim [KR].

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Patent 2024

1-(decanoylthio)-2-decanoyl-3-phosphatidylcholine 2,2'-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride Amides Cold Temperature Diamines Fever GPA 7 Imides Light LMO1 protein, human Medical Devices Metals Nylons Polymers Radius Sodium Chloride Vision

Synthesis of Methotrexate Conjugates

Not available on PMC !

Example 7

The synthesis of the methotrexate conjugates is described in (FIG. 12). A short ethylene diamine spacer may be introduced between methotrexate and the oxidized lipid. 6-Bromomethyl-pteridine-2,4-diamine trihydrobromide (BPT.HBr, 23) may be purchased from Ube Industries and coupled with intermediate 24 to produce 25. Compound 25 may be deprotected from tert-Boc followed by ester hydrolysis to produce amine terminated methotrexate (26). Reductive amination of 26 with ALDO (PE) or (PC) may be performed as described earlier to produce methotrexate prodrugs (27).

US11872313B2. Prodrug compositions, prodrug nanoparticles, and methods of use thereof (2024-01-16). Washington University [US]. Inventors: Gregory M. Lanza [US], Dipanjan Pan [US].

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Patent 2024

Amination Amines Anabolism Diamines Esters Ethylenediamines Hydrolysis Lipids Methotrexate Prodrugs Pteridines TERT protein, human

Synthesis of Platinum-Based Anti-Cancer Prodrugs

Not available on PMC !

Example 6

For the synthesis of platinum based anti cancer prodrugs, two approaches may be followed. The first approach (FIG. 10) may involve the preparation of an amine terminated cis platin (9) followed by conjugation with oxidized lipids. The coupling intermediate produced from the amidation reaction of compound 8 with mono Boc-ethylenediamine in presence of HATU/DIPEA, may be subjected to deprotection to produce compound 9. Compound 9 may undergo reductive amination with ALDO PC in methanol to generate cis platin prodrug-1 (10).

A second approach (FIG. 11) may involve the synthesis of an analogue bearing hydrophobically modified chelating diamines. Cis-platin intermediate 16 may be obtained in three steps from compound 13. Intermediate 16 may be subjected to complexation with K₂PtCl₄by maintaining the pH of the resulting solution at pH 6-7. Finally, compound 13 may undergo reductive amination with ALDO (PC) or (PE) to produce cis platin prodrug-2 (18).

US11872313B2. Prodrug compositions, prodrug nanoparticles, and methods of use thereof (2024-01-16). Washington University [US]. Inventors: Gregory M. Lanza [US], Dipanjan Pan [US].

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Patent 2024

Amination Amines Anabolism CISH protein, human Cisplatin Diamines DIPEA Ethylenediamines Lipids Malignant Neoplasms Methanol Platinum Prodrugs SOCS2 protein, human

Synthesis of Benzyl (2-Aminoethyl)carbamate

Not available on PMC !

Example 152

[Figure (not displayed)]

To a solution of ethane-1,2-diamine (30.0 g, 0.5 mol, 10.0 eq.) in anhydrous DCM (500 mL) at 0° C. was added CbzCl (8.53 g, 0.050 mol, 1.0 eq.) in anhydrous DCM (250 mL) over 7 h. The reaction was then warmed to r.t. and stirred overnight. The mixture was washed with water and brine, dried over anhydrous Na₂SO₄, and concentrated to give benzyl (2-aminoethyl)carbamate as a white solid (7.0 g, 94% yield). ESI m/z calcd for C₁₀H₁₄N₂O₂[M+H]⁺: 195.1, found: 195.2.

US11873281B2. Conjugates of cell binding molecules with cytotoxic agents (2024-01-16). HANGZHOU DAC BIOTECH CO., LTD. [CN], None [US], None [CN], None [CN]. Inventors: R. Yongxin Zhao [US], Yue Zhang [CN], Yourang Ma [CN].

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Patent 2024

Anabolism brine Carbamates Diamines Ethane

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What are the key applications of Diamines?

Diamines are versatile organic compounds with a wide range of applications. They are commonly used in the pharmaceutical industry for the synthesis of various drug molecules. Diamines also find applications in the production of polymeric materials, such as nylons and polyurethanes, which are essential for the development of advanced materials. Additionally, diamines play a crucial role in organic synthesis, serving as building blocks for various chemical reactions and intermediates.

How can PubCompare.ai help with diamine research?

PubCompare.ai's AI-driven platform can significantly enhance diamine research by optimizing research protocols and improving reproducibility. The platform allows you to effeciently screen protocol literature, leveraging AI to pinpoint critical insights. This enables researchers to identify the most effective protocols related to diamines for their specific research goals. The platform's AI-driven analysis can highlight key differences in protocol effectiveness, helping you choose the best option for reproducibility and accuracy, ultimately taking your diamine research to new heights.

What are the different types or variations of Diamines?

Diamines can exist in various structural forms and configurations. Some common types include aliphatic diamines, such as ethylenediamine and hexamethylenediamine, and aromatic diamines, such as benzidine and toluenediamine. These different diamine structures can exhibit unique chemical and physical properties, making them suitable for diverse applications. The choice of diamine type often depends on the specific requirements of the intended application, such as reactivity, thermal stability, or compatibility with other materials.

What are some common challenges in using Diamines?

One of the key challenges in using diamines is ensuring proper handling and safety precautions, as some diamines can be toxic or corrosive. Additionally, the reactivity of diamines can sometimes lead to undesired side reactions or impurities, requiring careful optimization of reaction conditions and purification steps. Diamines may also exhibit limited solubility in certain solvents, necessitating the use of specialized techniques or solvents to achieve desired outcomes. Proper experimental design and leveraging the insights from PubCompare.ai can help researchers overcome these challenges and optimize diamine-based protocols.

More about "Diamines"

Diamines are a versatile class of organic compounds featuring two amino groups (NH2) attached to a carbon backbone.
These molecules find a wide range of applications in the fields of pharmaceuticals, materials science, and organic synthesis.
Synonyms and related terms include bis-amines, diamine derivatives, and dinitrogen compounds.
Abbreviations such as 'DA' and 'DAB' are commonly used.
Key subtopics encompass the synthesis, reactivity, and uses of diamines.
When studying diamines, researchers may utilize various reagents and solvents, including DMSO (dimethyl sulfoxide), bovine serum albumin (BSA), Meyer's hematoxylin, diamine benzidine hydrochloride, FBS (fetal bovine serum), chloroform, ammonium persulfate, sodium hydroxide, methanol, and acrylamide.
These substances can play crucial roles in assays, purification, and sample preparation.
PubCompare.ai's AI-driven platform can optimize research protocols and enhance reproducibility for diamine studies.
Users can easily locate relevant protocols from literature, preprints, and patents, while the AI-powered comparisons help identify the most effective protocols and products.
Unlocking the power of PubCompare.ai can take diamine research to new heights and unlock exciting new discoveries.
Leveraging this tool can help researchers streamline their work, improve data quality, and accelerate the pace of innovation in this dynamic field.