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Dihydrotestosterone

Dihydrotestosterone (DHT) is a potent androgen hormone that plays a crucial role in male sexual development and function.
It is derived from the conversion of testosterone by the 5α-reductase enzyme.
DHT binds to androgen receptors and mediates a range of physiological processes, including the growth and maintenance of male secondary sexual characteristics, prostate health, and hair follicle regulation.
Understanding the complexities of DHT research is essential for advancing our knowledge of androgen-related disorders and developing targeted therapies.
PubCompare.ai's AI-driven platform can help you optimize your DHT research by efortlessly locating the best protocols, products, and methodologies from literature, pre-prints, and patents.
Experieence the power of PubCompare.ai today to enhance reproducibility and accuracy, ensuring your research is informed by the most reliable and up-to-date information.

Most cited protocols related to «Dihydrotestosterone»

1
Murine and Human Prostate Organoid Culture
Cited 25 times

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Publication 2014
A-83-01 Cells Collagenase Culture Media Culture Media, Conditioned Dihydrotestosterone Dinoprostone FGF10 protein, human Fibroblast Growth Factor 2 Growth Factor Homo sapiens matrigel Mus Niacinamide noggin protein Patients Prostate Prostatectomy SB 202190 Tissues Transforming Growth Factor beta
2
Prostate Tumor Slice Culture Protocol
Cited 12 times
Information about donors and tissues is presented in Supplementary Table 1. Figure 1 illustrates the acquisition, generation, and culture of prostate TSCs. Radical prostatectomy specimens were obtained immediately post-surgery and 8-mm diameter cores of putative benign and PCa regions were taken from the peripheral zones according to needle biopsy maps and gross analysis (Figure 1A, B). The cores were aseptically precision-cut to 300-µm thickness in the Krumdieck Tissue Slicer (Alabama Research and Development, Mundford, AL, USA),8 , 29 from which they emerged in a sequential manner (Figure 1C, D). Alternating slices were formalin-fixed for paraffin-embedding or frozen and sectioned for histological verification by hematoxylin and eosin (H&E) staining (Supplementary Figure 1). Adjacent slices were transferred with sterile forceps on to titanium mesh inserts in 6-well plates with 2.5 mL of culture medium and one to five tissue slices per well (Figure 1E). The plates were incubated at 37°C with 95% air/5% CO2 on a rotating platform set at a 30° angle (Alabama Research and Development, Figure 1F). Intermittent submersion in the medium caused by the angled rotation facilitates nutrient and gas diffusion throughout the 300-µm slices (Figure 1G), which is critical for maintaining cell viability over time. M199, Keratinocyte Serum-Free Medium (KSFM), and antibiotic/antimycotic were from Gibco Life Technologies (Grand Island, NY, USA) and were prepared as in Blauer et al.19 (link) Complete PFMR-4A was prepared as previously reported.30 Dihydrotestosterone (DHT, Steraloids Inc., Newport, RI, USA) and R1881 (Perkin Elmer, Waltham, MA, USA) stocks were prepared in ethanol (Sigma-Aldrich, St. Louis, MO, USA). Piperlongumine (Indofine Chemical Company Inc., Hillsborough, NJ, USA) was prepared in dimethyl sulfoxide (DMSO, Fisher Scientific Inc., Hampton, NH, USA).
Maund S.L., Nolley R, & Peehl D.M. (2013). Optimization and comprehensive characterization of a faithful tissue culture model of the benign and malignant human prostate. Laboratory investigation; a journal of technical methods and pathology, 94(2), 208-221.
Publication 2013
Antibiotics Cell Survival Diffusion Dihydrotestosterone Donors Eosin Ethanol Forceps Formalin Freezing Hematoxylin Keratinocyte Microtubule-Associated Proteins Nutrients Operative Surgical Procedures Piperlongumine Prostate Prostatectomy Puncture Biopsy R-1881 Serum Sterility, Reproductive Submersion Sulfoxide, Dimethyl Tissues Titanium
3
Prostate Cancer Cell Line Cultivation
Cited 6 times
The human prostate cell lines LAPC4 (lymph node metastasis) were a gift from Dr. A. Cato (University of Karlsruhe, Germany). DuCaP (brain metastasis) were a gift from from Dr. J Schalken (Radboud University, Nijmegen, The Netherlands). The subline LNCaP Abl was previously established by our group after long term cultivation of LNCaP (lymph node metastasis) in steroid free medium as described earlier [15 (link)]. The identity of the used cell lines was confirmed by short tandem repeat analysis. LAPC4 and DuCaP cells were cultured in RPMI 1640 containing 10% fetal bovine serum (FBS; PAA Laboratories) and 2 mM glutamax (Thermo Fisher Scientific). LAPC4 were in addition supplemented with 1 nM dihydrotestosterone (DHT). LNCaP Abl cells were grown in RPMI 1640 containing 10% charcoal stripped FBS (HyClone, GE Healthcare) and 2 mM glutamax. Androgen stimulation experiments were performed using 1 nM of the synthetic androgen R1881 (Organon) dissolved in EtOH. Enzalutamide and abiraterone (both MedChemExpress) were dissolved in EtOH at a concentration of 1mM. Bicalutamide (AstraZeneca) was dissolved in DMSO at a concentration of 5mM.
Hoefer J., Akbor M., Handle F., Ofer P., Puhr M., Parson W., Culig Z., Klocker H, & Heidegger I. (2016). Critical role of androgen receptor level in prostate cancer cell resistance to new generation antiandrogen enzalutamide. Oncotarget, 7(37), 59781-59794.
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Publication 2016
2-chloro-4-amino-1,3,5-triazine-6(5H)-one abiraterone Androgens Androgens, Synthetic bicalutamide Brain Metastases Cell Lines Cells Charcoal Dihydrotestosterone enzalutamide Ethanol Homo sapiens Lymph Node Metastasis Prostate R-1881 Short Tandem Repeat Steroids Sulfoxide, Dimethyl
4
Testosterone Therapy Monitoring Protocol
Cited 6 times
At the end of the trials, the serum concentrations of total testosterone, free testosterone, dihydrotestosterone, estradiol, and sex hormone–binding globulin were measured in serum samples frozen at −80°C (see the Supplementary Appendix, available at NEJM.org). Steroid assays were performed at the Brigham Research Assay Core Laboratory (Boston) by liquid chromatography with tandem mass spectroscopy, and free testosterone was measured by equilibrium dialysis. All samples from each participant were measured in the same assay run.
Serum prostate-specific antigen (PSA) was measured and a digital rectal examination was performed at months 3 and 12, and PSA was measured at month 18. Detection of a prostate nodule or a confirmed increase in the PSA level by at least 1.0 ng per milliliter above baseline led to referral to the site urologist for consideration of prostate biopsy. The IPSS was determined at months 3 and 12. At every visit, adverse events were recorded and a cardiovascular-event questionnaire (see the protocol) was administered. Cardiovascular events were adjudicated by two cardiologists and two neurologists (see the Supplementary Appendix).
Snyder P.J., Bhasin S., Cunningham G.R., Matsumoto A.M., Stephens-Shields A.J., Cauley J.A., Gill T.M., Barrett-Connor E., Swerdloff R.S., Wang C., Ensrud K.E., Lewis C.E., Farrar J.T., Cella D., Rosen R.C., Pahor M., Crandall J.P., Molitch M.E., Cifelli D., Dougar D., Fluharty L., Resnick S.M., Storer T.W., Anton S., Basaria S., Diem S.J., Hou X., Mohler ER I.I.I., Parsons J.K., Wenger N.K., Zeldow B., Landis J.R, & Ellenberg S.S. (2016). Effects of Testosterone Treatment in Older Men. The New England journal of medicine, 374(7), 611-624.
Publication 2016
Biological Assay Biopsy Cardiologists Cardiovascular System Dialysis Digital Rectal Examination Dihydrotestosterone Estradiol Freezing Liquid Chromatography Neurologists Prostate Prostate-Specific Antigen Serum Sex Hormone-Binding Globulin Steroids Tandem Mass Spectrometry Testosterone Urologists
5
DNase-seq Mapping of Chromatin Accessibility
Cited 6 times
DNaseI hypersensitivity mapping was performed as previously described with brief modifications 9 (link)-11 (link). LNCaP cells were starved for 3 days in phenol-red-free medium supplemented with 10% charcoal stripped FBS and then treated with ethanol or active androgen 5α-dihydrotestosterone (DHT) at a final concentration of 10 nM for 4 hours. MCF-7 cells were starved the same way and then treated with ethanol or 17β-estrodial (E2) at a final concentration of 10 nM for 45 min. The cells were trypsinized and pelleted prior to washing and resuspension in buffer A (15 mM Tris-Cl (pH 8.0), 15 mM NaCl, 60 mM KCl, 1 mM EDTA (pH 8.0), 0.5 mM EGTA (pH 8.0), 0.5 mM spermidine and 0.15 mM spermine). Nuclei were extracted by adding Buffer A containing NP-40. The nuclei were washed with buffer A and resuspended in prewarmed lysis buffer at a concentration of 5 M/mL and then digested with different amounts of DNase I for 5 min at 37 °C. The reactions were terminated by the addition of an equal volume of stop buffer and incubated at 55 °C. After 15 min, Proteinase K (final concentration of 20 μg/mL) was added to each digestion reaction and incubated for 2 hours at 55 °C. DNA was extracted by careful phenol-chloroform purification using phase lock gel. qPCR on the 3 CTCF sites and 3 housekeeping gene promoters were performed to determine the ideal digestion level. DNA fragments of 50-100, 100-200, 200-300 bp long or 50-300 bp (for pair-end sequencing) were selected using low melting agarose gel. The sequencing libraries were prepared following the Rubicon Genomics ThruPLEX-FD library preparation protocol. DNase-seq libraries were sequenced at the Center for Cancer Computational Biology (CCCB) at the Dana-Farber Cancer Institute.
He H.H., Meyer C.A., Hu S.S., Chen M.W., Zang C., Liu Y., Rao P.K., Fei T., Xu H., Long H., Liu X.S, & Brown M. (2013). Analysis of optimized DNase-seq reveals intrinsic bias in transcription factor footprint identification. Nature methods, 11(1), 73-78.
Publication 2013
Androgens Buffers Cell Nucleus Cells Charcoal Chloroform CTCF protein, human Deoxyribonuclease I Deoxyribonucleases Digestion Dihydrotestosterone Edetic Acid Egtazic Acid Endopeptidase K Ethanol Genomic Library Hypersensitivity Malignant Neoplasms MCF-7 Cells Nonidet P-40 Phenol Promoter, Genetic Sepharose Sodium Chloride Spermidine Spermine Tromethamine

Most recents protocols related to «Dihydrotestosterone»

1
Synthesis and Characterization of [2,3,4C-13C]Testosterone
The [2,3,4C-13C]testosterone was purchased from Isosciences. Commercially available steroid standards [androstadienedione (ADD), androstenedione (AD), cholesterol, dihydrotestosterone (DHT), estradiol, 17α-ethinylestradiol, progesterone, and testosterone] were purchased from Sigma-Aldrich (St. Louis, MO, USA). The androgenic ring-cleaved metabolites 3,17-DHSA and 2,3-SAOA were produced as described elsewhere29 (link). Other chemicals used were of analytical grade and were purchased from Mallinckrodt Baker (Phillipsburg, USA), Merck Millipore (Burlington, USA), and Sigma-Aldrich unless specified otherwise.
Hsiao T.H., Chou C.H., Chen Y.L., Wang P.H., Brandon-Mong G.J., Lee T.H., Wu T.Y., Li P.T., Li C.W., Lai Y.L., Tseng Y.L., Shih C.J., Chen P.H., Chen M.J, & Chiang Y.R. (2023). Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut. Gut Microbes, 15(1), 2183685.
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Publication 2023
Androgens Androstenedione Cholesterol Dihydrotestosterone Estradiol Ethinyl Estradiol Progesterone Steroids Testosterone
2
Prenatal Androgenization in Mice
Control (VEH) and prenatally-androgenized (PNA) male and female mice were generated using the well-characterized prenatally androgenized (PNA) mouse model protocol (29 (link)–33 (link), 57 (link)). Adult male and female C57BL/6J mice were paired overnight on the day of proestrus. Gestational day 1 was recorded as the following day after overnight mating and the male was removed from the cage. Females were then monitored for signs of pregnancy such as increased body weight and increased belly circumference. From gestational day 16-19, pregnant dams received a daily subcutaneous (s.c.) injection in the nape of the neck of either 100 µL dihydrotestosterone (DHT, 250 µg/100µL) in sesame oil as the PNA treatment or 100 µL of sesame oil only as the vehicle control. This window of prenatal androgen exposure has been shown to lead to PCOS-like features in mice and largely avoid the critical period for the differentiation of external genitalia (29 (link)–33 (link), 57 (link)).The male (M) and female (F) offspring of dams injected with DHT (PNAM or PNAF) and vehicle control (VEH) mice were studied from adulthood (postnatal day (PND) 60 onward) in the following experimental protocols. Oestrous cyclicity of VEH and PNA female mice was assessed to establish the expected loss of oestrous cyclicity in PNA mice by collecting daily vaginal smears over a 20-day period (PND 60–80) (Figure S1) as previously described (29 (link)–31 (link), 33 (link), 58 (link)).
Donaldson N.M., Prescott M., Ruddenklau A., Campbell R.E, & Desroziers E. (2023). Maternal androgen excess significantly impairs sexual behavior in male and female mouse offspring: Perspective for a biological origin of sexual dysfunction in PCOS. Frontiers in Endocrinology, 14, 1116482.
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Publication 2023
Adult Androgens Dihydrotestosterone Females Males Mice, House Mice, Inbred C57BL Neck Polycystic Ovary Syndrome Pregnancy Proestrus S100 Proteins Sesame Oil Vaginal Smears Vulva
3
Binding Free Energy Analysis of Steroid Hormones
Hexaconazole, dihydrotestosterone, and aminoglutethimide binding free energy analyses for SHBG were calculated. The binding free energy was calculated as per the protocol by MM-PBSA. The van der Waals energy and electrostatic energy of hexaconazole were calculated in comparison with dihydrotestosterone and aminoglutethimide. The following methods were used to calculate the binding free energy:
ΔG represents the binding free energy of the ligand (hexaconazole, dihydrotestosterone, and aminoglutethimide) with SHBG, G protein represents the SHBG binding energy, and G represents the ligand [10 (link)].
, & Alquraini A. (2023). Potency of Hexaconazole to Disrupt Endocrine Function with Sex Hormone-Binding Globulin. International Journal of Molecular Sciences, 24(4), 3882.
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Publication 2023
Aminoglutethimide Dihydrotestosterone Electrostatics GTP-Binding Proteins hexaconazole Ligands poly(tetramethylene succinate-co-tetramethylene adipate)
4
Molecular Docking and Dynamics of Hexaconazole with SHBG
Cited 1 time
The X-ray crystal structure of SHBG (1D2S) was acquired from Protein Data Bank (PDB). The native ligands are dihydrotestosterone PUBChem Id 10635 and aminoglutethimide PUBChem Id 2145, which were used to understand the interaction pattern of hexaconazole 66461.
For molecular docking analyses, hexaconazole was docked with SHBG using the program AutoDock version 4.2 (San Diego, CA, USA) [18 (link)]. For the precise molecular interaction analyses, all crystallographic water was removed from SHBG (1D2S) protein and energy was minimized by Swiss PDBViewer, and the active site was obtained from PDBSUM. In addition, ligand energy was minimized by chimera (dihydrotestosterone PUBChem Id 10635, aminoglutethimide PUBChem Id 2145, and hexaconazole 66461). Before docking was run with AutoDock version 4.2, the structure of the target was optimized by Kollman with combined charges and solvation parameters. After this, hydrogen was added to SHBG in ideal geometry, and torsions were fixed. In addition, the protein’s van der Waals well depth was assigned, and the files were saved in PDBQT format. For the generation of grid parameters, AutoDock tools were used, and grid parameter files (GPFs) and docking parameter files (DPFs) were generated. For ligand and protein interaction analyses, the Lamarckian genetic algorithm [18 (link)] was applied. A total of 50 different poses were used to obtain the binding score [19 (link)]. The best complex was taken for molecular dynamics (MD) studies on the basis of a high binding score. For the visualization of the complex, Discovery Studio 16, molecular visualization software (Biovia, 2019) was used. In addition, molecular interaction analysis of hexaconazole-similar azole fungicide compounds with 1D2S was performed to understand the chemical feature of hexaconazole.
, & Alquraini A. (2023). Potency of Hexaconazole to Disrupt Endocrine Function with Sex Hormone-Binding Globulin. International Journal of Molecular Sciences, 24(4), 3882.
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Publication 2023
Aminoglutethimide Azoles Chimera Crystallography Dihydrotestosterone hexaconazole Hydrogen Industrial Fungicides Ligands Molecular Dynamics Proteins Protein S Radiography Reproduction
5
Molecular Dynamics of SHBG-Ligand Complexes
The structural and dynamics changes in the complex of SHBG and the respective ligand with the dihydrotestosterone, aminoglutethimide, and hexaconazole were assessed. The duration of the MD simulation was 30 ns in triplicate using GROMACS 2021 software, (Groningen, The Netherlands) and the Charmm 27 force field was applied to all atoms [20 (link)]. SHBG and the respective complex were solvated by simple point charge (SPC) water molecules. In addition, counter ions (Cl or Na) to neutralize the protein [21 (link)] were applied. Furthermore, van der Waals contacts between the atoms were eliminated by energy minimization. The complex was equilibrated in two phases. The next step was a constant number of particles, volume, and temperature (NVT) ensemble with endothermic and exothermic processes, which was exchanged with the thermostat, followed by a constant number of particles, pressure, and temperature (NPT) ensemble at 300 K with constant pressure. The linear constraint solver (LINCS) algorithm was then used to constrain the covalent bonding approach. Finally, 30 ns of MD was run to examine the stability of each system. MD was performed 3 times to verify the MD findings [10 (link),11 (link),12 (link),13 (link)]. The details related to the set-up of MD simulations are given in Table 4.
, & Alquraini A. (2023). Potency of Hexaconazole to Disrupt Endocrine Function with Sex Hormone-Binding Globulin. International Journal of Molecular Sciences, 24(4), 3882.
Full text: Click here
Publication 2023
Aminoglutethimide Dihydrotestosterone hexaconazole Ions Ligands Pressure Proteins

Top products related to «Dihydrotestosterone»

1
Dihydrotestosterone by Merck Group
Sourced in United States, United Kingdom, Germany, China
Dihydrotestosterone is a synthetic organic compound that is an androgen and anabolic steroid. It is primarily used in research and laboratory settings for scientific analysis and experimentation purposes.
2
Dihydrotestosterone dht by Merck Group
Sourced in United States, Macao, Sweden
Dihydrotestosterone (DHT) is a naturally occurring androgen hormone. It is the primary active metabolite of testosterone and plays a crucial role in the development and maintenance of male secondary sexual characteristics. As a lab equipment product, DHT can be used for research purposes to study its biological functions and interactions within the body.
3
Lncap by American Type Culture Collection
Sourced in United States, United Kingdom, Italy, Germany, France, China, Canada, Denmark, Switzerland, Spain, Australia
The LNCaP cell line is a human prostate adenocarcinoma cell line. It is a well-characterized in vitro model system for the study of prostate cancer.
4
Fetal bovine serum (fbs) by Thermo Fisher Scientific
Sourced in United States, China, United Kingdom, Germany, Australia, Japan, Canada, Italy, France, Switzerland, New Zealand, Brazil, Belgium, India, Spain, Israel, Austria, Poland, Ireland, Sweden, Macao, Netherlands, Denmark, Cameroon, Singapore, Portugal, Argentina, Holy See (Vatican City State), Morocco, Uruguay, Mexico, Thailand, Sao Tome and Principe, Hungary, Panama, Hong Kong, Norway, United Arab Emirates, Czechia, Russian Federation, Chile, Moldova, Republic of, Gabon, Palestine, State of, Saudi Arabia, Senegal
Fetal Bovine Serum (FBS) is a cell culture supplement derived from the blood of bovine fetuses. FBS provides a source of proteins, growth factors, and other components that support the growth and maintenance of various cell types in in vitro cell culture applications.
5
5α dihydrotestosterone dht by Merck Group
Sourced in United States
5α-dihydrotestosterone (DHT) is a naturally occurring androgen hormone. It is a metabolite of testosterone and functions as a potent agonist of the androgen receptor. DHT plays a crucial role in the development and maintenance of male sexual characteristics.
6
Dimethyl sulfoxide (dmso) by Merck Group
Sourced in United States, Germany, United Kingdom, China, Italy, Sao Tome and Principe, France, Macao, India, Canada, Switzerland, Japan, Australia, Spain, Poland, Belgium, Brazil, Czechia, Portugal, Austria, Denmark, Israel, Sweden, Ireland, Hungary, Mexico, Netherlands, Singapore, Indonesia, Slovakia, Cameroon, Norway, Thailand, Chile, Finland, Malaysia, Latvia, New Zealand, Hong Kong, Pakistan, Uruguay, Bangladesh
DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
7
Rpmi 1640 by Thermo Fisher Scientific
Sourced in United States, China, United Kingdom, Germany, France, Canada, Japan, Australia, Italy, Switzerland, Belgium, New Zealand, Austria, Netherlands, Israel, Sweden, Denmark, India, Ireland, Spain, Brazil, Norway, Argentina, Macao, Poland, Holy See (Vatican City State), Mexico, Hong Kong, Portugal, Cameroon
RPMI 1640 is a common cell culture medium used for the in vitro cultivation of a variety of cells, including human and animal cells. It provides a balanced salt solution and a source of essential nutrients and growth factors to support cell growth and proliferation.
8
Penicillin streptomycin by Thermo Fisher Scientific
Sourced in United States, Germany, United Kingdom, China, Canada, France, Japan, Australia, Switzerland, Israel, Italy, Belgium, Austria, Spain, Gabon, Ireland, New Zealand, Sweden, Netherlands, Denmark, Brazil, Macao, India, Singapore, Poland, Argentina, Cameroon, Uruguay, Morocco, Panama, Colombia, Holy See (Vatican City State), Hungary, Norway, Portugal, Mexico, Thailand, Palestine, State of, Finland, Moldova, Republic of, Jamaica, Czechia
Penicillin/streptomycin is a commonly used antibiotic solution for cell culture applications. It contains a combination of penicillin and streptomycin, which are broad-spectrum antibiotics that inhibit the growth of both Gram-positive and Gram-negative bacteria.
9
Enzalutamide by Selleck Chemicals
Sourced in United States, China, Germany
Enzalutamide is a chemical compound used as a laboratory reagent. It is a synthetic small molecule that functions as an androgen receptor antagonist. The core function of Enzalutamide is to inhibit the activity of the androgen receptor, which plays a crucial role in the growth and development of certain types of cells.
10
Testosterone by Merck Group
Sourced in United States, Germany, United Kingdom, Sao Tome and Principe, Czechia, China, Australia, Italy, Switzerland, Macao, France, Israel, Japan
Testosterone is a laboratory equipment product that measures the concentration of the hormone testosterone in biological samples. It is used in research and clinical settings to assess testosterone levels for various purposes, such as evaluating hormonal imbalances or monitoring treatment effects.

More about "Dihydrotestosterone"

Dihydrotestosterone (DHT) is a potent androgen hormone that plays a crucial role in male sexual development and function.
It is derived from the conversion of testosterone by the 5α-reductase enzyme.
DHT binds to androgen receptors and mediates a range of physiological processes, including the growth and maintenance of male secondary sexual characteristics, prostate health, and hair follicle regulation.
Understanding the complexities of DHT research is essential for advancing our knowledge of androgen-related disorders and developing targeted therapies.
Key subtopics in DHT research include the use of cell lines like LNCaP, which are often used to study the effects of DHT on prostate cancer cells.
Researchers may also examine the impact of serum components like FBS (fetal bovine serum) and the use of solvents like DMSO to dissolve DHT.
Additionally, the use of RPMI 1640 medium and Penicillin/streptomycin antibiotics are common in DHT-related studies.
Researchers may also investigate the effects of anti-androgen drugs like Enzalutamide, which can block the action of DHT, or compare the effects of DHT to those of its precursor, Testosterone.
PubCompare.ai's AI-driven platform can help you optimize your DHT research by effortlssly locating the best protocols, products, and methodologies from literature, pre-prints, and patents.
Experience the power of PubCompare.ai today to enhance reproducibility and accuracy, ensuring your research is informed by the most reliable and up-to-date information.