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Equol

Equol is a nonsteroidal estrogen compound produced by the metabolism of the isoflavone daidzein in the gastrointestinal tract of some individuals.
It has been studied for its potential health benefits, including its role in women's health, cardiovascular function, and bone health.
PubCompare.ai's AI-driven platform can help researchers optimize their equol research by comparing protocols from literature, preprints, and patents to identify the most reproducible and accurate approaches.
Leveraging intelligent comparisons, researchers can find the best equol protocols and products to improve their research outcomes.

Most cited protocols related to «Equol»

1
Menopausal Women's Gut Microbiome Response
This study was approved by the Research Ethics Committee of the Principado de Asturias, Spain. The selection of donors and later sampling was performed following standardized protocols recommended by the above committee. Sixteen menopausal women (age range 48–61; average 53.4) were recruited at the Obstetrics and Gynaecology Service of the Hospital de Cabueñes (Gijón, Spain). No participants suffered from any disease or intestinal disorder. Additionally, they had received no treatment with antibiotics or any other medication for at least 6 months prior to the start of the study. All participants consumed one tablet containing 80 mg of an isoflavone concentrate (Fisiogen; Zambon, Bresso, Italy) per day for 6 months. Urine and fecal samples were collected at four time points: before the start of the treatment (t = 0), and at one (t = 1), three (t = 3), and six (t = 6) months. Morning urine samples and freshly voided stools were collected by the volunteers themselves, the latter in sterile plastic containers, in which they were maintained under anaerobic conditions via the use of Anaerocult A (Merck, Darmstadt, Germany). All samples were a transported to the laboratory by courier. Stool samples were subjected to microbial analyses within 2 h of arrival; dilutions for culture-independent techniques were kept frozen at –80°C until use, as were urine samples for later equol and creatinine analysis.
Guadamuro L., Delgado S., Redruello B., Flórez A.B., Suárez A., Martínez-Camblor P, & Mayo B. (2015). Equol status and changes in fecal microbiota in menopausal women receiving long-term treatment for menopause symptoms with a soy-isoflavone concentrate. Frontiers in Microbiology, 6, 777.
Publication 2015
Antibiotics, Antitubercular Creatinine Culture Techniques Donor Selection Equol Ethics Committees, Research Feces Freezing Intestinal Diseases Isoflavones Menopause Pharmaceutical Preparations Sterility, Reproductive Tablet Technique, Dilution Urine Voluntary Workers Woman
2
Mitochondrial ROS Measurement in HUVECs
Mitochondrial ROS production was measured using the fluorogenic dye MitoSOX Red, a mitochondrially targeted derivative of hydroethidine.30 (link) HUVECs on glass cover slips were loaded with MitoSOX Red (5 μmol/L) for 30 minutes. Cells were subsequently treated in duplicate for 20 minutes with equol (100 nmol/L) or vehicle (0.01% DMSO), and fluorescence was detected in 4% paraformaldehyde-fixed cells by confocal microscopy (560/625 nm). Fluorescence images were obtained from a total of 200 cells per cover slip in each of 4 cultures from 4 different donors. In other experiments, cells were pretreated with the cytoskeletal disrupting agent cytochalasin D (2.5 μmol/L) or EGFR tyrosine kinase inhibitor AG-1478 (5 μmol/L) and then stimulated acutely with equol (100 nmol/L) and monitored with MitoSOX Red fluorescence.
Rowlands D.J., Chapple S., Siow R.C, & Mann G.E. (2011). Equol-Stimulated Mitochondrial Reactive Oxygen Species Activate Endothelial Nitric Oxide Synthase and Redox Signaling in Endothelial Cells: Roles for F-Actin and GPR30. Hypertension, 57(4), 833-840.
Publication 2011
AG-1478 Cells Cytochalasin D Cytoskeleton Donors EGFR protein, human Equol Fluorescence hydroethidine Microscopy, Confocal Mitochondrial Inheritance paraform Sulfoxide, Dimethyl
3
Neuro-2A Cell Differentiation Assay
Neuro-2A cells, which are mouse neuroblastoma-derived clonal cells, were maintained in Dulbecco’s modified Eagle’s medium (DMEM) supplemented with 10% FBS and antibiotics (100 U/mL penicillin, and 100 µg/mL streptomycin) with 5% CO2 at 37 °C. The serum was stripped of hormones by constantly mixing with 5% (w/v) AGXI-8 resin (Bio-Rad, Hercules, CA, USA) and powdered charcoal prior to ultrafiltration [48 (link)]. Neuro-2A cells were seeded at a density of 1 × 105 cells/1 mL per well the day before the experiment in DMEM + 10% FBS on 6- or 24- well plates coated with poly-l-lysine. Differentiation was induced by serum deprivation as described previously [49 (link),50 (link)]. In short, the DMEM +10% FBS culture medium was changed to a DMEM +1% FBS culture medium to induce differentiation. On the next day, the culture medium was changed to prewarmed DMEM containing 1% FBS with or without the indicated concentration of S-equol, 10 nM of G15 and/or 10 nM of ICI to trigger differentiation, and it was then cultured for one to three days. The cultures were then harvested for RT-qPCR and immunocytochemistry. The cells were rinsed three times with PBS, fixed with 4% PFA, and then blocked with 2% FBS. The cells were then incubated with mouse monoclonal anti-β-tubulin III (neuronal) antibody and rabbit anti-doblecortin (C-terminal) antibody (1:200; Sigma) followed by donkey anti-mouse IgG (H + L) secondary antibody, Alexa Fluor® 594 and donkey anti-rabbit IgG (H + L) secondary antibody, Alexa Fluor® 488 conjugate (1:200; Thermo Fisher Scientific, Inc.). Cell nuclei were also stained with DAPI. The cells were then inspected under a laser confocal scanning microscope (Zeiss LSM 880, Carl Zeiss Microscopy GmbH). Neurite length measurements were performed using ImageJ Fiji (NIH).
Ariyani W., Miyazaki W, & Koibuchi N. (2019). A Novel Mechanism of S-equol Action in Neurons and Astrocytes: The Possible Involvement of GPR30/GPER1. International Journal of Molecular Sciences, 20(20), 5178.
Publication 2019
Alexa594 alexa fluor 488 anti-IgG Antibiotics Cell Nucleus Cells Charcoal Clone Cells DAPI Eagle Equol Equus asinus Hormones Immunocytochemistry Immunoglobulins Lysine Microscopy Microscopy, Confocal Microscopy, Confocal, Laser Scanning Mus Neurites Neuroblastoma Neurons Penicillins Poly A Precipitating Factors Rabbits Resins, Plant Serum Streptomycin Tubulin Ultrafiltration
4
Phytoestrogen-Enriched Rodent Diets
Three rodent diets were custom manufactured by Harlan Laboratories (Madison, WI). The composition of each diet is described in our previous report [11 (link)]. In brief, the base/control diet was prepared from Teklad Global 16% Protein Rodent Diet (Harlan Laboratories), which was ground and repelleted. This diet has a fixed formula and is nutritionally balanced, containing 16% protein and 3.6% fat that support the growth and maintenance of rodents and not containing alfalfa or soybean meal, thus minimizing the levels of natural phytoestrogens. The phyto-β-SERM diet was prepared by adding equal parts of genistein, daidzein, and equol (LC Laboratories, Woburn, MA) to the base diet. The soy extract diet was prepared by adding a commercial soy extract product, Healthy Women Soy Extract Supplement (Amazon, Seattle, WA), to the base diet. The phyto-β-SERM and soy extract diets were designed to deliver to a mouse a daily intake of 0.25 mg of added total phytoestrogens, or 10 mg/kg (body weight [BW]) mouse per day, assuming a 25-g mouse eating 2.5-g diet per day. This mouse dose is biologically equivalent to a daily intake of 50mg in humans. The conversion of human dose to mouse equivalent dose was based on the conversion factor of equivalent surface area dose from human to mouse [13 (link)]: 50 mg/60 kg (BW, human) × 12 (human to mouse conversion factor) = 10 mg/kg (BW, mouse). This human dose is the estimated average amount of phytoestrogens that Asians regularly ingest from the dietary consumption of soy foods [6 (link)] and is the recommended daily serving dose for many commercial soy extract supplements sold to the women in the United States, including the one tested in this study [14 (link)].
Zhao L., Mao Z., Chen S., Schneider L.S, & Brinton R.D. (2013). Early Intervention with an Estrogen Receptor β-Selective Phytoestrogenic Formulation Prolongs Survival, Improves Spatial Recognition Memory, and Slows Progression of Amyloid Pathology in a Female Mouse Model of Alzheimer’s Disease. Journal of Alzheimer's disease : JAD, 37(2), 403-419.
Publication 2013
Alfalfa Asian Americans Body Weight daidzein Diet Dietary Proteins Dietary Supplements Equol Genistein Homo sapiens Mice, House Phytoestrogens Proteins Rodent Selective Estrogen Receptor Modulators SELL protein, human Soybean Flour Soy Foods Woman
5
Measurement of Urinary Estrogens and Isoflavonoids
In both studies, repeated overnight urine samples were collected during the luteal phase, aliquoted into 2 mL containers, and stored at -80°C. Ascorbic and boric acid were added to the urine collection containers to control bacterial growth. For the BEAN1 study, the baseline and the final samples were analyzed for 188 women after 8-11 years of storage. If no sample was available at month 24, the month 12 sample was used instead. For the 79 BEAN2 participants, 3 samples (baseline and at the end of low-soy [month 6] and high-soy [month 13] diets) were analyzed after 1-4 years of storage. For one woman, only months 0 and 13 samples were available for this analysis.
In both studies, the most predominant steroidal estrogens in premenopausal women,14 (link) namely E1, E2, 2-OHE1, 2-OHE2, 2-MeOE1, 4-OHE1, E3, 16keto-E2, 16α-OHE1 were measured by LCMS (model Exactive, Thermo Fisher Scientific, Waltham, MA) using 5 labeled internal standards as described in detail previously.15 (link) Ascorbic acid was added during hydrolysis and during derivatization to prevent artificial oxidation of sensitive analytes.15 (link) Analysis of an external urine pool from premenopausal women repeated on 9 different days revealed coefficients of variation of 4-21% depending on the analyte concentrations. Urinary creatinine concentrations were measured using a Roche-Cobas MiraPlus clinical chemistry autoanalyzer (Roche Diagnostics, Switzerland). All estrogen and isoflavonoid measurements were expressed per mg creatinine to adjust for urine volume.
Urinary isoflavonoids as a biomarker for soy intake were measured previously by high-pressure liquid chromatography in BEAN116 (link) and by LCMS in BEAN2.17 (link) The isoflavonoid equol was assessed by LCMS in both studies, but in BEAN1, it was measured at the same time as the estrogen metabolites in 2 urine samples only, whereas in BEAN2 equol was measured together with genistein and dadzein in 8 urine samples per woman. Since equol producers are thought to experience more protective effects of isoflavones than non-producers,20 (link) equol producer status was determined based on 2 criteria: urinary daidzein excretion ≥2 nmol/mg creatinine and a urinary equol to daidzein ratio ≥0.018.21 ;22 In BEAN1, 23 women met the criteria at least once and were considered equol producers: 7 were of Asian ethnicity and 16 were non-Asian. In BEAN2, 41 women were equol producers, of which 10 were of Asian ethnicity.
Maskarinec G., Morimoto Y., Heak S., Isaki M., Steinbrecher A., Custer L, & Franke A.A. (2012). Urinary Estrogen Metabolites in 2 Soy Trials with Premenopausal Women. European journal of clinical nutrition, 66(9), 1044-1049.
Publication 2012
2-hydroxyestrone 4-hydroxyestrone Ascorbic Acid Asian Persons Bacteria Biological Markers boric acid Creatinine daidzein Diagnosis Diet Equol Estrogens Ethnicity Genistein High-Performance Liquid Chromatographies Hydrolysis Isoflavones Laser Capture Microdissection Luteal Phase Steroids Urinalysis Urine Urine Specimen Collection Woman

Most recents protocols related to «Equol»

1
Urinary Phytoestrogen Metabolite Profiles
The levels of isoflavone metabolites, daidzein (ng/mL), equol (ng/mL), genistein (ng/mL), and O-desmethylangolensin (ODMA, ng/mL) as well as lignan metabolites, enterodiol (ng/mL) and enterolactone (ng/mL) in the urine were measured by high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry. The association between urinary phytoestrogen levels and isoflavone intake in the years 2007–2010 was analyzed using the Pearson correlation method.
Zhou F., Gu K, & Zhou Y. (2023). Flavonoid intake is associated with lower all-cause and disease-specific mortality: The National Health and Nutrition Examination Survey 2007–2010 and 2017–2018. Frontiers in Nutrition, 10, 1046998.
Publication 2023
2,3-bis(3'-hydroxybenzyl)butyrolactone Atmospheric Pressure daidzein enterodiol Equol Genistein High-Performance Liquid Chromatographies Isoflavones Lignans O-desmethylangolensin Phytoestrogens Tandem Mass Spectrometry Urine
2
Quantifying Phytoestrogen Metabolites in Biological Samples
ENL, GEN, DAI, and equol (EQ)—a DAI metabolite produced by the gut flora of EQ-producers-were assayed in the urine and plasma samples using specific ELISAs, as described previously [22 (link),23 (link)]. Haptens functionalized on different carbon atoms were previously synthesized [23 (link),24 (link),25 (link)]. Specific polyclonal antibodies were obtained for each PHYTO bound to bovine serum albumin and the best antibodies were retained for assay development. Standard curve preparations and sample dilutions were performed in silicone-coated glass vials. The ELISAs followed a competitive procedure with an immobilized competitor, which was the homologous hapten bound to swine thyroglobulin, except for ENL [23 (link)]. The sensitivities varied between 0.08 ng/well and 0.4 ng/well, depending on the substance assayed, and intra-assay variation was always below 7% and inter-assay variation was below 17%. For the plasma samples, final dilutions varied between 1:5 and 1:20. For urine samples, the final dilutions varied between 1:5 and 1:4000 due to various levels of natural dilution of the urine samples. To take this phenomenon into account, the measured concentrations were corrected based on a creatinine excretion measurement performed on the same urine samples.
Bensaada S., Raymond I., Pellegrin I., Viallard J.F, & Bennetau-Pelissero C. (2023). Validation of ELISAs for Isoflavones and Enterolactone for Phytoestrogen Intake Assessment in the French Population. Nutrients, 15(4), 967.
Publication 2023
Antibodies Biological Assay Carbon Creatinine Enzyme-Linked Immunosorbent Assay Equol Gastrointestinal Microbiome Haptens Hypersensitivity Pigs Plasma Serum Albumin, Bovine Silicones Standard Preparations Technique, Dilution Thyroglobulin Urine
3
Urinary Isoflavone Metabolites and Cancer Mortality
The levels of isoflavone metabolites, including daidzein (ng/mL), equol (ng/mL), genistein (ng/mL), and O-desmethylangolensin (O-DMA, ng/mL) in the urine, were obtained from the NHANES, which were measured by high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry. Only the data in the year 2007–2010 were publicly accessible in the survey years of our study. The association between urinary isoflavone metabolite levels and cancer-related mortality was analyzed using Cox proportional hazards analysis. Meanwhile, the special weights “wtsb2yr” or “wtsa2yr” for special urine examination were employed in the Cox analysis.
Zhou Y., Gu K, & Zhou F. (2023). Dietary Flavonoid Intake and Cancer Mortality: A Population-Based Cohort Study. Nutrients, 15(4), 976.
Publication 2023
Atmospheric Pressure daidzein Equol Genistein High-Performance Liquid Chromatographies Isoflavones Malignant Neoplasms O-desmethylangolensin Tandem Mass Spectrometry Urinalysis Urine
4
Urinary Zinc Levels in Equol Producers
Values under the detection limits were recorded as half of the detection limit. The urinary concentrations were normalized to urinary creatinine amounts (g-Cr). To enable a statistical analysis comparison, the urinary concentrations were transformed into common logarithmic values because the distributions were not normal. EQPs were defined according to the criteria proposed by Ideno et al. [18 (link)]: log(equol/daidzein) ≥ −1.42 indicates EQP status, and log(equol/daidzein) < −1.42 indicates non-EQP status.
Urinary zinc concentrations between EQP and non-EQP were compared by Student’s t-test. To adjust the potential confounders (age, BMI, etc.), we conducted multivariable regression analyses. Records with missing values were excluded from the main analyses while the missing values (smoking: 19, menstrual status: 13) were processed by single imputation methods (mode imputations) as additional analyses. JMP Pro (ver. 15; SAS Institute, Cary, NC) was used to perform these calculations. The alpha level for all tests was 0.05.
Fujitani T., Lyu Z., Sassa M.H, & Harada K.H. (2023). Association between urinary zinc excretion and isoflavone-metabolizing enterotypes among Japanese females: a cross-sectional study. Environmental Health and Preventive Medicine, 28, 63.
Publication 2023
Creatinine daidzein Equol Menstruation Student Urine Zinc
5
Fetal Metabolite Effects on Placental Phenotypes
To test the effects of the candidate microbiome-dependent fetal metabolites, the Metab cocktail or vehicle control was administered intraperitoneally once daily from E0.5 to E14.5 to minimize stress to pregnant dams. Metabolite dosages were calculated on the basis of fetal serum metabolomic data and physiologically relevant metabolite concentrations reported in literature, to reflect the daily levels needed to match those observed in SPF fetal serum (table S2). Metabolite concentrations were calculated on the basis of physiological levels in mouse or human blood (table S2), total blood volume of pregnant mouse dams [approximately 58.5 ml/kg (48 (link))], and relative reductions observed in fetal sera of ABX fetuses compared to SPF fetuses (table S2). The metabolite stock solution consisted of: 29.64 μM imidazole propionate, 714.096 μM N,N,N-trimethyl-5-aminovalerate, 13.452 μM 4-hydroxyphenylacetate, 316.008 μM phenol sulfate, 428.868 μM indolepropionate, 360.24 μM indoxyl glucuronide, 323.76 μM N-methylproline, 595.080 μM phenylacetylglycine, 957.6 μM trimethylamine N-oxide, 118.56 μM taurodeoxycholate, 160.8768 μM biotin, 893.76 μM hippurate, 42.864 μM 2-(4-hydroxyphenyl)propionate, 222.072 μM cinnamoylglycine, 273.6 nM equol glucuronide, 433.2 μM 2-aminophenol sulfate, 1.55952 mM 3-indoxyl sulfate, and 268.128 μM p-cresol sulfate in 0.1 M PBS. The stock solution was then diluted 1:100 in sterile 0.1 M PBS, and 200 μl of the working solution was injected intraperitoneally into E0.5 ABX dams once a day daily for 14 days. For SCFA treatment, sodium propionate (25 mM), sodium butyrate (40 mM), and sodium acetate (67.5 mM) were supplemented to drinking water of pregnant ABX dams from E0 to E14.5. These concentrations were determined on the basis of existing studies demonstrating that these concentrations were able to sufficiently penetrate host tissues distal from the gut and restore circulating physiological concentrations (12 (link)). SCFA-supplemented drinking water and sodium-matched control drinking water were sterile filtered and made fresh every 4 days. To assess placental phenotypes, dams treated with metabolites were euthanized on E14.5, and placentas were harvested and processed as described in sections above.
Pronovost G.N., Yu K.B., Coley-O’Rourke E.J., Telang S.S., Chen A.S., Vuong H.E., Williams D.W., Chandra A., Rendon T.K., Paramo J., Kim R.H, & Hsiao E.Y. (2023). The maternal microbiome promotes placental development in mice. Science Advances, 9(40), eadk1887.
Publication 2023
Biotin BLOOD Blood Volume Care, Prenatal cinnamoylglycine Equol Fetus Glucuronides hippurate Homo sapiens imidazole propionate Indican indoxyl glucuronide metacresol Mice, House Microbiome Phenol Phenotype phenylacetylglycine physiology Placenta Propionates Serum Sodium Sodium Acetate Sodium Butyrate sodium propionate Strains Sulfates, Inorganic Taurine Deoxycholate Tissues trimethyloxamine

Top products related to «Equol»

1
Daidzein by Merck Group
Sourced in United States, Germany, Poland, Italy, United Kingdom
Daidzein is a naturally occurring isoflavone compound. It functions as an antioxidant and has been studied for its potential biological activities.
2
Genistein by Merck Group
Sourced in United States, Germany, China, France, United Kingdom, Sao Tome and Principe, Italy, Australia, Poland
Genistein is a lab equipment product from Merck Group. It is a naturally occurring isoflavone compound found in various plants. Genistein can be used as a research tool in various scientific applications.
3
Equol by Merck Group
Sourced in United States
Equol is a lab equipment product manufactured by Merck Group. It is a chemical compound that is used as a standard reference material in analytical and biomedical research applications. Equol is a metabolite of the isoflavone daidzein, which is found in certain plant-based foods.
4
Gallic acid by Merck Group
Sourced in United States, Germany, Italy, Spain, France, India, China, Poland, Australia, United Kingdom, Sao Tome and Principe, Brazil, Chile, Ireland, Canada, Singapore, Switzerland, Malaysia, Portugal, Mexico, Hungary, New Zealand, Belgium, Czechia, Macao, Hong Kong, Sweden, Argentina, Cameroon, Japan, Slovakia, Serbia
Gallic acid is a naturally occurring organic compound that can be used as a laboratory reagent. It is a white to light tan crystalline solid with the chemical formula C6H2(OH)3COOH. Gallic acid is commonly used in various analytical and research applications.
5
S equol by Cayman Chemical
Sourced in United States
S-equol is a synthetic chemical compound produced by Cayman Chemical. It is a phytoestrogen, a plant-derived compound that can mimic the effects of the hormone estrogen. S-equol is used in research applications to study the biological and physiological effects of phytoestrogens.
6
Resveratrol by Merck Group
Sourced in United States, Germany, Italy, Sao Tome and Principe, France, China, Canada, Spain, United Kingdom, Poland, Japan, India, Macao, Argentina
Resveratrol is a naturally occurring polyphenolic compound found in various plants, including grapes and berries. It is commonly used as a dietary supplement and in laboratory research settings. Resveratrol has been studied for its potential antioxidant and anti-inflammatory properties, but its specific functions and applications should be evaluated based on scientific evidence.
7
Equol by LC Laboratories
Sourced in United States
Equol is a metabolite of the isoflavone daidzein, which is found in soy and other plants. It is an organic compound with the chemical formula C₁₅H₁₄O₃.
8
P coumaric acid by Merck Group
Sourced in United States, Germany, Italy, Spain, France, China, Poland, United Kingdom, Sao Tome and Principe, Switzerland, Canada, Ireland, India, Australia, Japan, Macao, Portugal
P-coumaric acid is a naturally occurring phenolic compound that can be utilized as a reference standard or an analytical reagent in various laboratory settings. It is a white to off-white crystalline solid that is soluble in organic solvents. P-coumaric acid is commonly used as a standard in analytical techniques, such as high-performance liquid chromatography (HPLC) and spectrophotometric measurements, to quantify and characterize similar compounds in sample matrices.
9
Glycitein by Merck Group
Sourced in United States
Glycitein is a naturally occurring isoflavone compound found in soybeans and other legumes. It serves as a laboratory standard for the identification and quantification of this compound in various samples.
10
Dimethyl sulfoxide (dmso) by Merck Group
Sourced in United States, Germany, United Kingdom, China, Italy, Sao Tome and Principe, France, Macao, India, Canada, Switzerland, Japan, Australia, Spain, Poland, Belgium, Brazil, Czechia, Portugal, Austria, Denmark, Israel, Sweden, Ireland, Hungary, Mexico, Netherlands, Singapore, Indonesia, Slovakia, Cameroon, Norway, Thailand, Chile, Finland, Malaysia, Latvia, New Zealand, Hong Kong, Pakistan, Uruguay, Bangladesh
DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.

More about "Equol"

Equol is a non-steroidal, phytoestrogen compound that is produced by the metabolism of the isoflavone daidzein in the gastrointestinal tract of some individuals.
It is structurally similar to the naturally-occurring estrogen 17β-estradiol and has been studied for its potential health benefits related to women's health, cardiovascular function, and bone health.
Equol is synthesized from daidzein, a soy-derived isoflavone, by specific gut bacteria.
The ability to produce equol varies among individuals and is influenced by factors like diet, gut microbiome composition, and genetic predisposition.
Some people are 'equol producers' while others are 'equol non-producers'.
Equol has been shown to exhibit estrogenic and anti-estrogenic properties, depending on the physiological context.
It can bind to and activate estrogen receptors, modulating estrogenic signaling pathways.
Equol also has antioxidant, anti-inflammatory, and anti-cancer properties that may contribute to its potential health benefits.
Research on equol has investigated its role in menopause symptom management, bone health preservation, cardiovascular disease risk reduction, and cancer prevention.
Potential applications of equol include dietary supplements, functional foods, and pharmaceutical formulations.
Optimizing equol research is crucial to fully understanding its mechanisms of action and therapeutic potential.
PubCompare.ai's AI-driven platform can help researchers identify the most reproducible and accurate protocols for equol production, detection, and analysis by comparing methods across literature, preprints, and patents.
Leveraging this intelligent comparison, scientists can find the best equol-related products and experimental approaches to improve their research outcomes.