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> Chemicals & Drugs > Organic Chemical > Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate

Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate

Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate is a contrast agent used in magnetic resonance imaging (MRI).
It is a macrocyclic compound that binds to gadolinium ions, allowing for enhanced visualization of tissues and organs.
This agent has been utilized in the diagnosis and monitoring of various medical conditions, including neurological disorders, cardiovascular diseases, and cancer.
Researchers can optimize the use of Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate through PubCompare.ai's AI-driven platform, which helps locate relevant protocols from literature, preprints, and patents, and enables intelligent comparisons to identify the best methods and products.
This cutting-edge tool can enhance research reproducibility and efficiency, supporting advancements in the field of medical imaging and diagnostics.

Most cited protocols related to «Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate»

1
Multifunctional Liposomal Nanoparticles for Biomedical Imaging
Hydrogenated soy phosphatidylcholine (HSPC), cholesterol (CHOL), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-PEG2000-Amine), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(Lissamine rhodamine B sulfonyl) (Rhod-PE) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000] (DSPE-PEG5000-Folate) were obtained from Avanti Polar Lipids (Alabaster, AL). 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid mono (N-hydroxysuccinimide ester) (DOTA-NHS-ester) and gadolinium (1,4,7,10-tetraazacyclododecane)-1,4,7,10-tetraacetate (DOTA-Gd) were obtained from Macrocyclics (Dallas, TX, USA). Europium chloride (EuCl3), praseodymium chloride (PrCl3) and cerium nitrate (Ce(NO3)3) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Ce-DOTA was synthesized in the lab. All other chemical were used as received. All buffer solutions were prepared with ultrapure grade water.
Cheng Z., Zaki A.A., Hui J.Z, & Tsourkas A. (2012). Simultaneous quantification of tumor uptake for targeted and non-targeted liposomes and their encapsulated contents by ICP-MS. Analytical chemistry, 84(17), 7578-7582.
Publication 2012
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000) 1,2-distearoylphosphatidylethanolamine Acids Alabaster Amines Buffers cerium nitrate Chlorides Cholesterol dioleoyl cephalin DOTA-NHS Esters Europium Folate Gadolinium gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate Lipids lissamine rhodamine B N-hydroxysuccinimide Phosphatidylcholines Phosphatidylethanolamines polyethylene glycol 2000 Polyethylene Glycols Praseodymium tetraxetan
2
Doxorubicin-Loaded Nanomedicine Formulation
1,2-Distearoyl-sn-glycero-3-phosphoethanolamine, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-mPEG2000), and cholesterol (CHOL) were purchased from Avanti Polar Lipids Inc. (Alabaster, AL, USA). Doxil® was purchased from ALZA Corporation (Mountain View, CA, USA). Doxorubicin hydrochloride, N,N′-diisopropylethylamine (DiPEA), N,N,N′,N′-tetramethyl-O-(N-succinimidyl) uranium hexafluorophosphate (HSTU), trifluoroacetic acid (TFA), and gadolinium (III) acetate hydrate (Gd(III) (OAc)3) were purchased from Sigma-Aldrich Chemical Co (St. Louis, MO, USA). Fetal bovine serum (FBS), penicillin-streptomycin, paraformaldehyde, and Dulbecco's modified Eagle medium (DMEM) were purchased from Gibco BRL/Life Technologies (New York, NY, USA). Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (protected DOTA) was purchased from Tokyo Chemical Industry Corporation (TCI, Tokyo, Japan). All other materials were of analytical grade and used without further purification.
Jung S.H., Na K., Lee S.A., Cho S.H., Seong H, & Shin B.C. (2012). Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging. Nanoscale Research Letters, 7(1), 462.
Full text: Click here
Publication 2012
1,2-distearoylphosphatidylethanolamine Acetate Alabaster Cholesterol Doxil Eagle Fetal Bovine Serum Gadolinium Hydrochloride, Doxorubicin Lipids monomethoxypolyethylene glycol paraform Penicillins Phosphatidylethanolamines Streptomycin TERT protein, human tetraxetan Trifluoroacetic Acid Uranium
3
Gd-DOTA Nanoparticle Synthesis and Characterization
Gadolinium(III) (1,4,7,10-tetraazacyclododecane)-1,4,7,10-tetraacetate (Gd-DOTA) was purchased from Marcocylics (Dallas, TX). 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycerol)-2000] ammonium salt (DSPE-PEG2000) was purchased from Avanti Polar Lipids, Inc. (Alabaster, AL). Doxorubicin hydrochloride (DOX) was from Sigma (St. Louis, MO). Sodium Acetate-d3, D2O(99.9% atom %D), 3-(Trimethylsilyl) propionic-2,2,3,3,-d4 sodium (TSP) and 3-(Trimethylsilyl)-1-propanesulfonic sodium (DSS) were purchased from Aldrich (St. Louis, MO). The water used in this work was generated from Milli-Q system (Millipore Corporation, Danvers, MA).
Hu W., Mao A., Wong P., Larsen A., Yazaki P.J., Wong J.Y, & Shively J.E. (2017). Characterization of DSPE-PEG2000 and its Complex with Doxorubicin Using NMR Spectroscopy and Molecular Dynamics. Bioconjugate chemistry, 28(6), 1777-1790.
Publication 2017
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000) Alabaster Chloride, Ammonium Gadolinium gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate Glycerin Hydrochloride, Doxorubicin Lipids Phosphatidylethanolamines Polyethylene, High-Density Sodium Sodium Acetate
4
Gadolinium-based Contrast Agent Synthesis
Lactobionic acid, ethylenediamine, gadolinium chloride hexahydrate, trifluoroacetic acid(TFA), N, N-dicyclohexylcarbodiimide (DCC), N-hydroxysuccinimide (NHS), Chelex ®100 (100~ 200 mesh), 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), and xylenol orange disodium salt were purchased from Sigma Aldrich (St. Louis, MO, USA). Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate (tri BOC-DOTA) was purchased from Tokyo Chemical Industry Corporation (Tokyo, Japan). N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and hydrochloric acid (35–37%) were purchased from Junsei Chemical Co. Ltd. (Tokyo, Japan). Ether and acetone were purchased from Samchun Pure chemical Co. Ltd. (South Korea). Dimethyl sulfoxide-d6 (DMSO-d6) and deuterium oxide(D2O) were purchased from Cambridge Isotope Laboratories (Andover, MA, USA). Gadobutrol (Gadovist) was acquired from Bayer (Leverkusen, Germany). Chang cell (human epithelial liver cells) and HCT 116 cell (human colon carcinoma) were acquired from the American Type Culture Collection (ATCC CCL 13, USA).
Jeong Y, & Na K. (2018). Synthesis of a gadolinium based-macrocyclic MRI contrast agent for effective cancer diagnosis. Biomaterials Research, 22, 17.
Full text: Click here
Publication 2018
Acetone Bromides Cancer of Colon Cells Chelex 100 Deuterium Oxide Dicyclohexylcarbodiimide Dimethylformamide diphenyl Epithelial Cells Ethers Ethylenediamines gadobutrol gadolinium chloride Gadovist HCT116 Cells Homo sapiens Hydrochloric acid Isotopes lactobionic acid Liver N-hydroxysuccinimide Sodium Chloride Sulfoxide, Dimethyl TERT protein, human tetraxetan Tetrazolium Salts Trifluoroacetic Acid xylenol orange

Most recents protocols related to «Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate»

1
Gadolinium-based Contrast Agent Synthesis
Lactobionic acid, ethylenediamine, gadolinium chloride hexahydrate, trifluoroacetic acid(TFA), N, N-dicyclohexylcarbodiimide (DCC), N-hydroxysuccinimide (NHS), Chelex ®100 (100~ 200 mesh), 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), and xylenol orange disodium salt were purchased from Sigma Aldrich (St. Louis, MO, USA). Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate (tri BOC-DOTA) was purchased from Tokyo Chemical Industry Corporation (Tokyo, Japan). N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and hydrochloric acid (35–37%) were purchased from Junsei Chemical Co. Ltd. (Tokyo, Japan). Ether and acetone were purchased from Samchun Pure chemical Co. Ltd. (South Korea). Dimethyl sulfoxide-d6 (DMSO-d6) and deuterium oxide(D2O) were purchased from Cambridge Isotope Laboratories (Andover, MA, USA). Gadobutrol (Gadovist) was acquired from Bayer (Leverkusen, Germany). Chang cell (human epithelial liver cells) and HCT 116 cell (human colon carcinoma) were acquired from the American Type Culture Collection (ATCC CCL 13, USA).
Jeong Y, & Na K. (2018). Synthesis of a gadolinium based-macrocyclic MRI contrast agent for effective cancer diagnosis. Biomaterials Research, 22, 17.
Full text: Click here
Publication 2018
Acetone Bromides Cancer of Colon Cells Chelex 100 Deuterium Oxide Dicyclohexylcarbodiimide Dimethylformamide diphenyl Epithelial Cells Ethers Ethylenediamines gadobutrol gadolinium chloride Gadovist HCT116 Cells Homo sapiens Hydrochloric acid Isotopes lactobionic acid Liver N-hydroxysuccinimide Sodium Chloride Sulfoxide, Dimethyl TERT protein, human tetraxetan Tetrazolium Salts Trifluoroacetic Acid xylenol orange
2
Gd-DOTA Nanoparticle Synthesis and Characterization
Gadolinium(III) (1,4,7,10-tetraazacyclododecane)-1,4,7,10-tetraacetate (Gd-DOTA) was purchased from Marcocylics (Dallas, TX). 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycerol)-2000] ammonium salt (DSPE-PEG2000) was purchased from Avanti Polar Lipids, Inc. (Alabaster, AL). Doxorubicin hydrochloride (DOX) was from Sigma (St. Louis, MO). Sodium Acetate-d3, D2O(99.9% atom %D), 3-(Trimethylsilyl) propionic-2,2,3,3,-d4 sodium (TSP) and 3-(Trimethylsilyl)-1-propanesulfonic sodium (DSS) were purchased from Aldrich (St. Louis, MO). The water used in this work was generated from Milli-Q system (Millipore Corporation, Danvers, MA).
Hu W., Mao A., Wong P., Larsen A., Yazaki P.J., Wong J.Y, & Shively J.E. (2017). Characterization of DSPE-PEG2000 and its Complex with Doxorubicin Using NMR Spectroscopy and Molecular Dynamics. Bioconjugate chemistry, 28(6), 1777-1790.
Publication 2017
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000) Alabaster Chloride, Ammonium Gadolinium gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate Glycerin Hydrochloride, Doxorubicin Lipids Phosphatidylethanolamines Polyethylene, High-Density Sodium Sodium Acetate
3
Multifunctional Liposomal Nanoparticles for Biomedical Imaging
Hydrogenated soy phosphatidylcholine (HSPC), cholesterol (CHOL), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-PEG2000-Amine), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(Lissamine rhodamine B sulfonyl) (Rhod-PE) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000] (DSPE-PEG5000-Folate) were obtained from Avanti Polar Lipids (Alabaster, AL). 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid mono (N-hydroxysuccinimide ester) (DOTA-NHS-ester) and gadolinium (1,4,7,10-tetraazacyclododecane)-1,4,7,10-tetraacetate (DOTA-Gd) were obtained from Macrocyclics (Dallas, TX, USA). Europium chloride (EuCl3), praseodymium chloride (PrCl3) and cerium nitrate (Ce(NO3)3) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Ce-DOTA was synthesized in the lab. All other chemical were used as received. All buffer solutions were prepared with ultrapure grade water.
Cheng Z., Zaki A.A., Hui J.Z, & Tsourkas A. (2012). Simultaneous quantification of tumor uptake for targeted and non-targeted liposomes and their encapsulated contents by ICP-MS. Analytical chemistry, 84(17), 7578-7582.
Publication 2012
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000) 1,2-distearoylphosphatidylethanolamine Acids Alabaster Amines Buffers cerium nitrate Chlorides Cholesterol dioleoyl cephalin DOTA-NHS Esters Europium Folate Gadolinium gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate Lipids lissamine rhodamine B N-hydroxysuccinimide Phosphatidylcholines Phosphatidylethanolamines polyethylene glycol 2000 Polyethylene Glycols Praseodymium tetraxetan
4
Doxorubicin-Loaded Nanomedicine Formulation
1,2-Distearoyl-sn-glycero-3-phosphoethanolamine, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-mPEG2000), and cholesterol (CHOL) were purchased from Avanti Polar Lipids Inc. (Alabaster, AL, USA). Doxil® was purchased from ALZA Corporation (Mountain View, CA, USA). Doxorubicin hydrochloride, N,N′-diisopropylethylamine (DiPEA), N,N,N′,N′-tetramethyl-O-(N-succinimidyl) uranium hexafluorophosphate (HSTU), trifluoroacetic acid (TFA), and gadolinium (III) acetate hydrate (Gd(III) (OAc)3) were purchased from Sigma-Aldrich Chemical Co (St. Louis, MO, USA). Fetal bovine serum (FBS), penicillin-streptomycin, paraformaldehyde, and Dulbecco's modified Eagle medium (DMEM) were purchased from Gibco BRL/Life Technologies (New York, NY, USA). Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (protected DOTA) was purchased from Tokyo Chemical Industry Corporation (TCI, Tokyo, Japan). All other materials were of analytical grade and used without further purification.
Jung S.H., Na K., Lee S.A., Cho S.H., Seong H, & Shin B.C. (2012). Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging. Nanoscale Research Letters, 7(1), 462.
Full text: Click here
Publication 2012
1,2-distearoylphosphatidylethanolamine Acetate Alabaster Cholesterol Doxil Eagle Fetal Bovine Serum Gadolinium Hydrochloride, Doxorubicin Lipids monomethoxypolyethylene glycol paraform Penicillins Phosphatidylethanolamines Streptomycin TERT protein, human tetraxetan Trifluoroacetic Acid Uranium

Top products related to «Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate»

1
N dicyclohexylcarbodiimide by Merck Group
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N-dicyclohexylcarbodiimide is a chemical compound commonly used as a coupling agent in organic synthesis. It facilitates the formation of amide bonds between carboxylic acids and amines. The compound functions as a dehydrating agent, removing water from the reaction mixture to drive the equilibrium towards product formation.
2
Ethylenediamine by Merck Group
Sourced in United States, Germany, United Kingdom, Canada, Spain, Italy, Switzerland, China, Czechia, India
Ethylenediamine is a colorless, flammable liquid with a characteristic ammonia-like odor. It is commonly used as a building block for the synthesis of various chemical compounds in laboratory settings.
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Hct116 cell by American Type Culture Collection
Sourced in United States, China
HCT116 cells are a widely used human colorectal carcinoma cell line. They are adherent cells that can be used for various cell biology and cancer research applications.
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Xylenol orange disodium salt by Merck Group
Sourced in Germany, United States
Xylenol orange disodium salt is a chemical compound used as an indicator in various analytical and laboratory applications. It is a yellow-orange powder that changes color in response to changes in pH or the presence of certain metal ions. The core function of xylenol orange disodium salt is to serve as a colorimetric indicator for the detection and quantification of various substances in chemical and biological analyses.
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Gadobutrol gadovist by Bayer
Sourced in Germany, Japan
Gadobutrol (Gadovist) is a paramagnetic contrast agent for magnetic resonance imaging (MRI) developed by Bayer. It contains the active ingredient gadobutrol, a gadolinium-based compound that enhances the visibility of internal body structures during MRI scans.
6
Hydrochloric acid (hcl) by Junsei
Sourced in Japan
Hydrochloric acid is a clear, colorless, and highly corrosive liquid commonly used in laboratory settings. It is an aqueous solution of hydrogen chloride (HCl) that exhibits a sharp, pungent odor. The primary function of hydrochloric acid is as a reagent for various chemical reactions and analyses.
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Deuterium oxide d2o by Cambridge Isotopes
Sourced in United States
Deuterium oxide, also known as heavy water, is a colorless, odorless, and dense liquid. It is a stable isotope of water, with one hydrogen atom replaced by a deuterium atom. Deuterium oxide has a higher molecular weight than regular water, which results in different physical and chemical properties.
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N hydroxysuccinimide by Merck Group
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N-hydroxysuccinimide is a chemical compound commonly used as an activating agent in organic synthesis. It is a stable, crystalline solid that can be used to facilitate the formation of amide bonds between carboxylic acids and primary amines. Its core function is to activate carboxylic acids, enabling their subsequent reaction with other functional groups.
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Lactobionic acid by Merck Group
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Lactobionic acid is a carbohydrate-based compound that can be used as a laboratory reagent. It serves as a component in various buffer solutions and cell culture media. The core function of lactobionic acid is to maintain pH levels and provide a suitable environment for biological applications.
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Trifluoroacetic acid by Merck Group
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Trifluoroacetic acid is a colorless, corrosive liquid commonly used as a reagent in organic synthesis and analytical chemistry. It has the chemical formula CF3COOH.

More about "Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate"

Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate, commonly known as Gd-DOTA or Gadoteridol, is a macrocyclic contrast agent extensively used in magnetic resonance imaging (MRI) procedures.
This compound effectively binds to gadolinium ions, enabling enhanced visualization of various tissues and organs, making it a valuable tool in the diagnosis and monitoring of neurological disorders, cardiovascular diseases, and cancer.
Researchers can optimize the use of Gd-DOTA through PubCompare.ai's AI-driven platform, which helps locate relevant protocols from literature, preprints, and patents, and enables intelligent comparisons to identify the best methods and products.
This cutting-edge tool can enhance research reproducibility and efficiency, supporting advancements in the field of medical imaging and diagnostics.
Gd-DOTA is a macrocyclic compound, meaning it has a cyclic structure with multiple nitrogen atoms, which allows for the stable chelation of gadolinium ions.
This property is crucial, as it reduces the risk of gadolinium deposition and toxicity compared to linear chelates.
The synthesis and characterization of Gd-DOTA often involve the use of related compounds and reagents, such as N,N'-dicyclohexylcarbodiimide (DCC), which is a common coupling agent, and ethylenediamine, which is a precursor in the synthesis of the macrocyclic structure.
Additionally, HCT116 cells, a widely used cancer cell line, may be employed in studies to evaluate the efficacy and safety of Gd-DOTA-based imaging agents.
Other relevant compounds include Xylenol orange disodium salt, a chromogenic reagent used for the quantification of gadolinium, and Gadobutrol (Gadovist), another gadolinium-based contrast agent.
Hydrochloric acid and deuterium oxide (D2O) are commonly used in the characterization and analysis of Gd-DOTA, while N-hydroxysuccinimide and lactobionic acid may be involved in the modification or conjugation of the contrast agent.
By understanding the broader context and related compounds associated with Gd-DOTA, researchers can more effectively navigate the field of medical imaging and diagnostics, leveraging the power of PubCompare.ai's AI-driven platform to enhance their research workflows and drive advancements in this critical area of healthcare.