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Galangin

Galangin is a flavonoid compound found in various plant species, particularly in the rhizomes of the Alpinia officinarum plant.
It has been the subject of extensive research due to its potent antioxidant, anti-inflammatory, and neuroprotective properties.
Galangin has demonstrated the ability to modulate signaling pathways involved in cell proliferation, apoptosis, and inflammation, making it a promising candidate for the development of new therapies.
Researchers can leverage PubCompare.ai's advanced AI-driven platform to easily locate protocols from literature, pre-prints, and patents, and identify the best protocols and products for their Galangin-related research needs.
Experence the power of PubCompare.ai's innovative solutions today.

Most cited protocols related to «Galangin»

1
LC-HRMS Analysis of Phytochemicals
Cited 6 times
All prepared sample extracts were analysed by LC-HRMS as described earlier [13 (link)]. In brief, a UHPLC system (Accela, Thermo Fisher Scientific, San Jose, CA, USA) equipped with a reversed-phase XBridge C18, 150 × 2.1 mm i.d., 3.5 µm particle size (Waters, Milford, MA, USA) analytical column as well as water containing 0. % FA (v/v) (eluent A) and MeOH containing 0.1% FA (v/v) (eluent B) were used for linear gradient elution starting with 90% A and continuous increase of B up to 100% in 30 min after an initial hold time of 2 min. The UHPLC system was coupled to an LTQ Orbitrap XL (Thermo Fisher Scientific) equipped with an ESI source. All measurements were performed in the positive ionisation mode with a scan range of m/z 100–1000 and a resolving power setting of 60,000 full width at half maximum (FWHM) at m/z 400.
For quality control (QC), a standard solution consisting of 15 authentic reference standards (N-methylanthranilate, ferulic acid, 2.5-dihydroxybenoic acid, syringic acid, methyl-indole-3-carboxylate, indole-3-acetonitrile, kaempferol, 4-triacetate lactone, l-tryptophan, alpha linolenic acid, galangin, 3′,4′,5′-O-trimethyltricetin, orientin, schaftoside and reserpine) each in a concentration of 1 mg/L, dissolved in MeOH + H2O 1 + 1 (v/v) + 0.1% formic acid was prepared and measured every eighth injection throughout each LC-HRMS sequence. Retention time stability, peak area precision as well as mass accuracy were determined for all QC samples to verify proper measurement performance throughout the whole sequence with the help of QCScreen [35 (link)] (data not shown).
Doppler M., Kluger B., Bueschl C., Schneider C., Krska R., Delcambre S., Hiller K., Lemmens M, & Schuhmacher R. (2016). Stable Isotope-Assisted Evaluation of Different Extraction Solvents for Untargeted Metabolomics of Plants. International Journal of Molecular Sciences, 17(7), 1017.
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Publication 2016
Acids alpha-Linolenic Acid ferulic acid formic acid galangin indole indole-3-acetonitrile kaempferol Lactones methyl anthranilate orientin Radionuclide Imaging Reserpine Retention (Psychology) schaftoside syringic acid Tryptophan Z-100
2
Identification and Quantification of Galangin Reaction Products
Cited 3 times
The reaction of galangin with 3,5,7-trihydroxychromone proceeded under the conditions described in our previous study [44 (link)]. In brief, a methanol solution of galangin was mixed with a methanol DPPH• solution at a molar ratio of 1:2, and the resulting mixture was incubated for 10 h at room temperature. The product was then filtered through a 0.22-μm filter for UPLC-ESI-Q-TOF-MS/MS analysis.
The UPLC-ESI-Q-TOF-MS/MS analysis was based on the method described in our previous study [45 (link)]. The UPLC-ESI-Q-TOF-MS/MS analysis system was equipped with a C18 column (2.0 mm i.d. × 100 mm, 2.2 μm, Shimadzu Co., Kyoto, Japan). The mobile phase was used for the elution of the system and consisted of a mixture of acetonitrile (phase A) and 0.1% formic acid water (phase B). The column was eluted at a flow rate of 0.2 mL/min with the following gradient elution program: 0–2 min, maintained at 30% B; 2–10 min, 30–0% B; and 10–12 min, 0–30% B. The sample injection volume was set at 1 μL for the separation of the different components. Q-TOF-MS/MS analysis was performed on a Triple TOF 5600plus mass spectrometer (AB SCIEX, Framingham, MA, USA) equipped with an ESI source, which was run in the negative ionization mode. The scan range was set at 100–2000 Da. The system was run with the following parameters: ion spray voltage, −4500 V; ion source heater, 550 °C; curtain gas (CUR, N2), 30 psi; nebulizing gas (GS1, air), 50 psi; and Tis gas (GS2, air), 50 psi. The declustering potential (DP) was set at −100 V, whereas the collision energy (CE) was set at −40 V with a collision energy spread (CES) of 20 V. The RAF final products were quantified by extracting the corresponding formula from the total ion chromatogram and integrating the corresponding peak. The above experiments were repeated using 3,5,7-trihydroxychromone.
Ouyang X., Li X., Lu W., Zhao X, & Chen D. (2018). A Null B-Ring Improves the Antioxidant Levels of Flavonol: A Comparative Study between Galangin and 3,5,7-Trihydroxychromone. Molecules, 23(12), 3083.
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Publication 2018
acetonitrile formic acid galangin Methanol Molar Radionuclide Imaging Tandem Mass Spectrometry
3
Cytotoxicity Evaluation of Galangin Nanoformulation
Cited 3 times
The tested cell lines (200 μL, 1 × 105 cells mL−e) were suspended and cultured in 96-well flat-bottom plates (Falcon, Lincoln Park, NJ, USA). Following 48 h maintenance in the exponential growth phase, the cells were treated for 24 h with free galangin and GAL/β-CD. MTT in PBS (100 µL) was then used to label the well-maintained cells for 10–15 min at 37 °C. Tap water was used to wash excess dye, whereas treatment with 50 µL DMSO for 10 min was applied to dissolve air bubbles. The absorbance of cell cultures was measured by using a microplate reader (ELx 800, Bio-Tek Instruments Inc., Winooski, VT, USA) at 492 nm [29 (link)]. The calculation of the rate of inhibition of cell growth was performed by applying the following equation: Inhibition rate %=Abc - AbsAbc
where Abc and Abs refer to the OD values for the control and tested samples, respectively.
Abbas Z.S., Sulaiman G.M., Jabir M.S., Mohammed S.A., Khan R.A., Mohammed H.A, & Al-Subaiyel A. (2022). Galangin/β-Cyclodextrin Inclusion Complex as a Drug-Delivery System for Improved Solubility and Biocompatibility in Breast Cancer Treatment. Molecules, 27(14), 4521.
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Publication 2022
Cell Culture Techniques Cell Lines galangin Psychological Inhibition Sulfoxide, Dimethyl
4
HPLC Identification of Phenolic Compounds
Cited 3 times
The EEP was injected in HPLC equipment (Agilent 1100 Series, CA) and separated with an Agilent ZORBAX Eclipse XDB-C18 column; 4.6 × 150 mm, 5 μm chromatographic column. The mobile phases were (A) 0.1% formic acid in water and (B) methanol. Separations were performed at room temperature by linear gradient elution from 0 min at 50% A/50% B to 35 min at 75% A/25% B with a flow rate of 1.0 ml/min. The eluent was continuously monitored at a wavelength of 267 nm for 35 min. The identification of the phenolic compounds was carried out by comparing the retention time of the sample with gallic acid, quercetin, pinocembrin, chrysin, and galangin standards. All analyses were performed in triplicate.
Iadnut A., Mamoon K., Thammasit P., Pawichai S., Tima S., Preechasuth K., Kaewkod T., Tragoolpua Y, & Tragoolpua K. (2019). In Vitro Antifungal and Antivirulence Activities of Biologically Synthesized Ethanolic Extract of Propolis-Loaded PLGA Nanoparticles against Candida albicans. Evidence-based Complementary and Alternative Medicine : eCAM, 2019, 3715481.
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Publication 2019
Chromatography chrysin formic acid galangin Gallic Acid High-Performance Liquid Chromatographies Methanol pinocembrin Quercetin Retention (Psychology)
5
Characterization of PaSSB Protein Binding Assay
Cited 3 times
The EMSA [82 ] was conducted in accordance with a previously described protocol [83 (link),84 (link)]. The EMSA was performed using a LightShift Chemiluminescent EMSA Kit (Thermo Scientific, Waltham, MA, USA) with a minor modification for PaSSB. In brief, PaSSB (0–5 μM) was incubated for 60 m at 37 °C with a DNA substrate (30 fmol/μL) in a total volume of 6 μL in 40 mM Tris-HCl (pH 7.5) and 50 mM NaCl. Following incubation, 4 μL of a dye mixture (0.01% bromophenol blue and 40% glycerol) was added. Native polyacrylamide gel (8%) was pre-electrophoresed at 110 V for 10 min. Thereafter, the resulting samples were loaded and resolved on pre-run gel and electrophoresed at 100 V for 1 h in a TBE running buffer (89 mM Tris borate and 1 mM EDTA). The protein-DNA complexes were electroblotted to a positively charged nylon membrane (GE, USA) at 100 V for 30 min in a fresh and cold TBE buffer. The transferred DNA was cross-linked with a nylon membrane using a UV light cross-linker instrument equipped with 312 nm bulbs for a 10 min exposure. Biotin-labeled DNA was detected using a streptavidin-horseradish peroxidase conjugate and a chemiluminescent substrate contained in a SuperSignal™ West Atto Ultimate Sensitivity Substrate (Pierce Biotechnology, Rockford, IL, USA). The ssDNA binding ability of the protein was estimated through linear interpolation from the concentration of the protein that bound 50% of the input DNA. To assess whether the flavonol inhibited the binding activity of SSB, PaSSB (1.25 μM) with a DNA substrate was individually incubated with myricetin (0, 1.5, 3.1, 6.3, 12.5, 25, 50, 75, and 100 μM), quercetin (12–100 μM), kaempferol (12–100 μM), or galangin (12–100 μM) for 60 m at 37 °C. The resultant protein solution was then analyzed using the EMSA.
Lin E.S., Luo R.H, & Huang C.Y. (2022). A Complexed Crystal Structure of a Single-Stranded DNA-Binding Protein with Quercetin and the Structural Basis of Flavonol Inhibition Specificity. International Journal of Molecular Sciences, 23(2), 588.
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Publication 2022
Biotin Borates Bromphenol Blue Cold Temperature DNA, A-Form Edetic Acid Electrophoretic Mobility Shift Assay Flavonols galangin Glycerin Horseradish Peroxidase HSP40 Heat-Shock Proteins Hypersensitivity kaempferol myricetin Nylons Plant Bulb polyacrylamide gels Proteins Quercetin Single-Stranded DNA Binding Proteins Sodium Chloride Streptavidin Tissue, Membrane Tris-borate-EDTA buffer Tromethamine Ultraviolet Rays

Most recents protocols related to «Galangin»

1
Identifying Anti-Hepatocarcinoma Targets of Galangin
The predicted targets of galangin from the SwissTargetPrediction website were intersected with the targets of galangin screened from the BATMAN-TCM database. After being corrected by the UniProt Knowledgebase, the drug targets of galangin were determined. The keyword “Hepatocarcinoma” was used to search the databases, including PharmGKB, DisGeNET, OMIM, and GeneCards, with the search limited to the species “Homo sapiens”. Subsequently, the disease targets of HCC were gathered by applying screening conditions of a GeneCards score of ≥ 15 and a DisGeNET value of ≥ 0.10. Duplicate entries were then removed. The drug target of galangin and the disease target of HCC were intersected using Venny2.1 to obtain the anti-HCC target of galangin.
Li X., Zhou M., Chen W., Sun J., Zhao Y., Wang G., Wang B., Pan Y., Zhang J, & Xu J. (2024). Integrating network pharmacology, bioinformatics, and experimental validation to unveil the molecular targets and mechanisms of galangin for treating hepatocellular carcinoma. BMC Complementary Medicine and Therapies, 24, 208.
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Publication 2024
2
Molecular Docking of Galangin with Key Targets
Autodock Vina 1.2.2, a computational software for protein-ligand docking, was used for this study. The molecular structure of galangin was obtained from the PubChem compound database (https://pubchem.ncbi.nlm.nih.gov/). The 3D coordinates of TRPV1 (PDB number: 3J5R, resolution: 4.20 Å), COX-2 (PDB number: 4PH9, resolution: 1.81 Å), NF-κB p65 (PDB number: 1RAM, resolution: 2.7 Å), and TNF-α (PDB number: 2AZ5, resolution: 2.10 Å) were downloaded from the Protein Data Bank (PDB) (http://www.rcsb.org/). The molecular docking studies were visualized using Autodock Vina 1.2.2 (http://autodock.scripps.edu/).
Lin K., Fu D., Wang Z., Zhang X, & Zhu C. (2024). Analgesic and anti-inflammatory effects of galangin: a potential pathway to inhibit transient receptor potential vanilloid 1 receptor activation. The Korean Journal of Pain, 37(2), 151-163.
Publication 2024
3
Galangin and Celecoxib in Nociceptive Behavior
In this experiment, galangin and celecoxib were dissolved in a 0.5% solution of carboxymethylcellulose sodium. After 2 days of acclimation, the animals were randomly divided into different experimental groups. For the nociceptive behavior tests in the mouse model, the 60 mice were divided into four groups with 15 mice in each group: (1) the control group (mice received 0.5% carboxymethylcellulose sodium), (2) the celecoxib group (mice received celecoxib at a dose of 20 mg/kg), (3) the galangin low-dose group (mice received galangin at a dose of 25 mg/kg), and (4) the galangin high-dose group (mice received galangin at a dose of 50 mg/kg). All rats were treated with the corresponding drugs (different concentrations of galangin and celecoxib) or 0.5% carboxymethylcellulose sodium for seven consecutive days; For the study on pain induced by capsaicin and the protective mechanism of galangin in rats, the 48 rats were divided into six groups with 8 rats in each group: (1) the control group (rats received 0.5% carboxymethylcellulose sodium), (2) the model group (rats received 0.5% carboxymethylcellulose sodium), (3) the capsazepine group (rats received the TRPV1 antagonist capsazepine at a dose of 2 mg/kg, 200, intravenous injection), (4) the celecoxib group (rats received celecoxib at a dose of 20 mg/kg), (5) the galangin low-dose group (rats received galangin at a dose of 25 mg/kg), and (6) the galangin high-dose group (rats received galangin at a dose of 50 mg/kg). The corresponding drugs were administered via continuous gavage or intraperitoneal injection for 7 days. Rats in all groups, except the control group, were then injected with 0.5% capsaicin (TRPV1 agonist).
Lin K., Fu D., Wang Z., Zhang X, & Zhu C. (2024). Analgesic and anti-inflammatory effects of galangin: a potential pathway to inhibit transient receptor potential vanilloid 1 receptor activation. The Korean Journal of Pain, 37(2), 151-163.
Publication 2024
4
Galangin Mitigates Allergic Rhinitis
Not available on PMC !
Mice were sensitized on alternate days by administration of OVA (500 μL, 5%, IP) till day 14. 29 (link) Sensitized mice were randomly divided (n = 18 mice/group) into various groups AR control (received distilled water [DW; 10 mg/kg, PO]), montelukast (10 mg/kg, PO), 30, (link)31 and galangin (5, 10, and 20 mg/kg, PO) 32 (link) and received respective treatments till day 21. The normal group of mice received aluminum hydroxide IP without OVA and was treated with DW (10 mg/kg), whereas the per se group received galangin (20 mg/kg) only till day 21. On day 21, nasal symptoms were evaluated using a method reported elsewhere. 29 (link) The solutions of galangin were freshly prepared daily by dissolving in DW (1 mg/ml) and administered orally for biological evaluations.
Chen J, & Zhou Y. (2024). Ameliorative potential of galangin in murine model of ovalbumin-induced allergic rhinitis: a role of PI3K-PKB pathway. American journal of veterinary research, 85(6).
Publication 2024
5
Capsaicin-Induced Inflammatory Pain in Rats
As described in Section 6 of Chapter 4 in the “MATERIALS AND METHODS”, inflammation-induced pain in rats was induced by administering capsaicin. After appropriate pharmacological treatment, serum samples were obtained from the abdominal aorta under deep isoflurane anesthesia. Additionally, segments L4-5 of the dorsal root ganglion, as well as tissues from the injected hindfoot and plantar areas of the rats, were immediately excised and stored at –80°C for subsequent biochemical analysis.
Lin K., Fu D., Wang Z., Zhang X, & Zhu C. (2024). Analgesic and anti-inflammatory effects of galangin: a potential pathway to inhibit transient receptor potential vanilloid 1 receptor activation. The Korean Journal of Pain, 37(2), 151-163.
Publication 2024

Top products related to «Galangin»

1
Galangin by Merck Group
Sourced in United States, Germany, Switzerland, Italy, Sao Tome and Principe
Galangin is a laboratory equipment product manufactured by Merck Group. It is a chemical compound commonly used in research and scientific applications. The core function of Galangin is to serve as a reference standard or analytical tool in various laboratory procedures.
2
Quercetin by Merck Group
Sourced in United States, Germany, Italy, India, Spain, United Kingdom, France, Poland, China, Sao Tome and Principe, Australia, Brazil, Macao, Switzerland, Canada, Chile, Japan, Singapore, Ireland, Mexico, Portugal, Sweden, Malaysia, Hungary
Quercetin is a natural compound found in various plants, including fruits and vegetables. It is a type of flavonoid with antioxidant properties. Quercetin is often used as a reference standard in analytical procedures and research applications.
3
Apigenin by Merck Group
Sourced in United States, Germany, Italy, Poland, France, India, Spain, Sao Tome and Principe, China, Switzerland, Macao, Ireland, Portugal, Austria
Apigenin is a naturally occurring plant flavonoid compound. It is a light yellow crystalline solid that is widely used as a laboratory reagent in biochemical research.
4
Caffeic acid by Merck Group
Sourced in United States, Germany, Italy, France, Poland, Spain, China, United Kingdom, Australia, Sao Tome and Principe, Switzerland, India, Ireland, Canada, Macao, Brazil, Austria, Mexico, Czechia, Portugal
Caffeic acid is a phenolic compound commonly found in various plants. It serves as a laboratory standard for the identification and quantification of similar phenolic compounds using analytical techniques such as high-performance liquid chromatography (HPLC) and spectrophotometry.
5
P coumaric acid by Merck Group
Sourced in United States, Germany, Italy, Spain, France, China, Poland, United Kingdom, Sao Tome and Principe, Switzerland, Canada, Ireland, India, Australia, Japan, Macao, Portugal
P-coumaric acid is a naturally occurring phenolic compound that can be utilized as a reference standard or an analytical reagent in various laboratory settings. It is a white to off-white crystalline solid that is soluble in organic solvents. P-coumaric acid is commonly used as a standard in analytical techniques, such as high-performance liquid chromatography (HPLC) and spectrophotometric measurements, to quantify and characterize similar compounds in sample matrices.
6
Chrysin by Merck Group
Sourced in United States, Germany, India, United Kingdom, Sao Tome and Principe, Switzerland
Chrysin is a laboratory equipment product manufactured by Merck Group. It is a naturally-occurring flavonoid compound that serves as a core functional component in various research and analytical applications.
7
Pinocembrin by Merck Group
Sourced in United States, Germany, Sao Tome and Principe, Switzerland
Pinocembrin is a flavonoid compound that is found in various plant species. It is a crystalline solid with a molecular formula of C₁₅H₁₂O₄. Pinocembrin has antioxidant and anti-inflammatory properties, and is often used in biochemical and biological research applications.
8
Naringenin by Merck Group
Sourced in United States, Germany, Italy, China, United Kingdom, France, Australia, Hungary, Poland, Sao Tome and Principe
Naringenin is a flavanone compound found in various citrus fruits. It is a crystalline solid commonly used as a reference standard and reagent in research and analytical applications involving the identification and quantification of flavonoids.
9
Kaempferol by Merck Group
Sourced in United States, Germany, Poland, Italy, China, Spain, Sao Tome and Principe, United Kingdom, France, India, Malaysia, Czechia, Switzerland, Macao, Australia
Kaempferol is a chemical compound used as a lab equipment product. It is a type of flavonoid, a class of plant-based compounds. Kaempferol is primarily used in research and scientific applications.
10
Ferulic acid by Merck Group
Sourced in United States, Germany, Italy, United Kingdom, Spain, China, France, Poland, Australia, Ireland, Malaysia, Canada, India, Switzerland, Sao Tome and Principe, Japan, Brazil, Denmark
Ferulic acid is a phenolic compound that can be found in various plant sources, including rice, wheat, oats, and vegetables. It is commonly used as a lab equipment product for research and analysis purposes. Ferulic acid has antioxidant properties and can be used in a variety of applications, such as the study of plant-based compounds and their potential health benefits.

More about "Galangin"

Galangin is a remarkable flavonoid compound that has been the subject of extensive scientific research.
This potent phytochemical is found in various plant species, particularly in the rhizomes of the Alpinia officinarum plant, also known as the lesser galangal.
Galangin has been widely studied for its impressive antioxidant, anti-inflammatory, and neuroprotective properties, making it a promising candidate for the development of new therapeutic interventions.
Researchers can leverage the advanced AI-driven platform of PubCompare.ai to easily locate and identify the best protocols and products for their Galangin-related research needs.
The platform allows researchers to access a wealth of information from literature, pre-prints, and patents, empowering them to make informed decisions and optimize their investigations.
In addition to Galangin, other phytochemicals such as Quercetin, Apigenin, Caffeic acid, P-coumaric acid, Chrysin, Pinocembrin, Naringenin, Kaempferol, and Ferulic acid have also garnered significant attention for their potential health benefits.
These compounds, collectively known as flavonoids, share similar structural and functional characteristics, and have been studied for their diverse pharmacological activities.
Researchers can utilize PubCompare.ai's innovative solutions to explore the synergistic effects and interactions between these related compounds, potentially unlocking new avenues for the development of effective and targeted therapies.
The platform's AI-powered comparisons and analytic capabilities can provide invaluable insights, empowering researchers to make more informed decisions and drive their Galangin-related research forward with confidence.
Experence the power of PubCompare.ai's innovative solutions today and discover the full potential of Galangin and other related phytochemicals in your research endeavors.