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Hydralazine

Hydralazine is a potent vasodilator medication used primarily in the treatment of hypertension.
It acts by directly relaxing vascular smooth muscle, leading to a reduction in peripheral vascular resistance and lowered blood pressure.
Hydralazine may also be employed in the management of heart failure and certain types of malignant hypertension.
Researchers can leverage PubCompare.ai's AI-driven platform to easily locate and compare hydralazine research protocols from literature, preprints, and patents, enhancing reproducibility and accuracy.
The advanced comparison tools can help identify the best hydralazine protocols and products for specific research needs.

Most cited protocols related to «Hydralazine»

1
Cardiac Function in RVH Pig Model
Cited 8 times
Domestic pigs were randomized to control, RVH, and RVH treated with Valsartan (320 mg/day; RVH+Valsartan) or triple-therapy (Reserpine+hydralazine+hydrochlorothiazide, RVH+TT) for 4 wks post 6-wks of RVH (n=7 each). Cardiac function and myocardial oxygenation were then studied in-vivo using multi-detector computer tomography (CT) and blood oxygen level dependent (BOLD)-magnetic resonance imaging (MRI), respectively, and microvascular architecture ex-vivo with micro-CT. Myocardial protein expression and staining were measured ex-vivo. (Detailed descriptions of all experimental methods are included in the Online-only Data Supplementhttp://hyper.ahajournals.org).
Zhang X., Li Z.L., Crane J.A., Jordan K.L., Pawar A.S., Textor S.C., Lerman A, & Lerman L.O. (2014). VALSARTAN REGULATES MYOCARDIAL AUTOPHAGY AND MITOCHONDRIAL TURNOVER IN EXPERIMENTAL HYPERTENSION. Hypertension, 64(1), 87-93.
Publication 2014
Blood Oxygen Levels Cell Respiration Heart Hydralazine Hydrochlorothiazide Myocardium Proteins Reserpine Sus scrofa domestica Therapeutics Tomography Valsartan
2
Warfarin Therapy for Heart Failure
Cited 8 times
Eligible patients were 18 years of age or older and had normal sinus rhythm, no contraindication to warfarin therapy, and an LVEF of 35% or less as assessed by quantitative echocardiography (or a wall-motion index of ≤1.2) or as assessed by radionuclide or contrast ventriculography within 3 months before randomization. Patients who had a clear indication for warfarin or aspirin were not eligible. Patients in any New York Heart Association (NYHA) functional class were eligible, but patients in NYHA class I could account for no more than 20% of the total number of patients undergoing randomization. Additional eligibility criteria were a modified Rankin score of 4 or less (on a scale of 0 to 6, with higher scores indicating more severe disability), and planned treatment with a beta-blocker, an angiotensin-converting–enzyme (ACE) inhibitor (or, if the side-effect profile with ACE inhibitors was unacceptable, with an angiotensin-receptor blocker), or hydralazine and nitrates. Patients were ineligible if they had a condition that conferred a high risk of cardiac embolism, such as atrial fibrillation, a mechanical cardiac valve, endocarditis, or an intracardiac mobile or pedunculated thrombus.
Homma S., Thompson J.L., Pullicino P.M., Levin B., Freudenberger R.S., Teerlink J.R., Ammon S.E., Graham S., Sacco R.L., Mann D.L., Mohr J.P., Massie B.M., Labovitz A.J., Anker S.D., Lok D.J., Ponikowski P., Estol C.J., Lip G.Y., Di Tullio M.R., Sanford A.R., Mejia V., Gabriel A.P., del Valle M.L, & Buchsbaum R. (2012). Warfarin and Aspirin in Patients with Heart Failure and Sinus Rhythm. The New England journal of medicine, 366(20), 1859-1869.
Publication 2012
Adrenergic beta-Antagonists Angiotensin-Converting Enzyme Inhibitors Angiotensin Receptor Antagonists Aspirin Atrial Fibrillation Cerebral Ventriculography Disabled Persons Echocardiography Eligibility Determination Embolism Endocarditis Heart Heart Valves Hydralazine Nitrates Patients Radioisotopes Sinuses, Nasal Thrombus Warfarin
3
Mice Ureter Obstruction Study
Cited 5 times

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Publication 2015
Azacitidine Buffers Buprenorphine Hydralazine Inhalation Isoflurane Kidney Ligation Ligature Management, Pain Mice, House Subcutaneous Injections Surgery, Day Tissues Ureter
4
Unilateral Ureteral Obstruction in Mice
Cited 5 times
Eight to twelve week old CD57BL/6 mice were anesthetized with isoflurane inhalation, analgesia was performed by subcutaneous Buprenorphine injection. The ureter was separated from the surrounding tissues and two ligatures were placed about 5 mm apart in the upper two-thirds of the ureter of the left kidney to obtain reliable obstruction. On the same day after surgery and recovery, mice were treated with either vehicle buffer PBS, 5′-Azacytidine (10 mg/kg/day, Sigma, St. Louis, USA), low-dose, or high-dose Hydralazine (5 mg/kg/day or 50 mg/kg/day, respectively, Sigma, St. Louis, USA) given intraperitoneally every other day. Mice were sacrificed at indicated time points after ureter ligation (Tampe et al., 2014 (link)).
Tampe B., Tampe D., Zeisberg E.M., Müller G.A., Bechtel-Walz W., Koziolek M., Kalluri R, & Zeisberg M. (2014). Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease. EBioMedicine, 2(1), 19-36.
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Publication 2014
Azacitidine Buffers Buprenorphine Hydralazine Inhalation Isoflurane Kidney Ligation Ligature Management, Pain Mice, House Subcutaneous Injections Surgery, Day Tissues Ureter
5
Hypertension Models and Treatments
Cited 4 times
Rats used included spontaneously hypertensive (SHR), Wistar Kyoto (WKY), and Wistar rats either sham-operated or subjected to a partial occlusion of the left renal artery (renovascular hypertensive, RVH)19 (link). Subgroups of SHRs were treated with losartan (20mg/kg/day, starting at 5 to 6-week-old, lasting for 7 weeks) or hydralazin (10mg/kg/day, starting at 8 to 9-week-old animals, lasting for 4 weeks) in drinking water20 (link),21 (link). Systolic blood pressure (BP) was measured using tail cuff method (coda 6; Kent Scientific Corporation, CT). All procedures were approved by the Georgia Regents University Institutional Animal Care and Use Committee Guidelines.
Biancardi V.C., Son S.J., Ahmadi S., Filosa J.A, & Stern J.E. (2013). CIRCULATING ANGIOTENSIN II GAINS ACCESS TO THE HYPOTHALAMUS AND BRAINSTEM DURING HYPERTENSION VIA BREAKDOWN OF THE BLOOD BRAIN BARRIER. Hypertension, 63(3), 572-579.
Publication 2013
Animals Cavitary Optic Disc Anomalies Hydralazine Institutional Animal Care and Use Committees Losartan Rats, Inbred WKY Rats, Wistar Rattus norvegicus Renal Artery Obstruction SHORT ROOT protein, Arabidopsis Systolic Pressure Tail

Most recents protocols related to «Hydralazine»

1
Adrenal Vein Sampling and MTO
All patients underwent both AVS and MTO. The order that each participant underwent each investigation was determined by a minimization program within the study data center (Robertson Centre for Biostatistics, University of Glasgow), designed to maintain a balance with respect to study site, sex and age (<55 or ≥55 years). Both AVS and MTO were performed with the patient taking non-interfering medications such as doxazosin, verapamil and hydralazine, according to Endocrine Society consensus guidelines11 (link).
Wu X., Senanayake R., Goodchild E., Bashari W.A., Salsbury J., Cabrera C.P., Argentesi G., O’Toole S.M., Matson M., Koo B., Parvanta L., Hilliard N., Kosmoliaptsis V., Marker A., Berney D.M., Tan W., Foo R., Mein C.A., Wozniak E., Savage E., Sahdev A., Bird N., Laycock K., Boros I., Hader S., Warnes V., Gillett D., Dawnay A., Adeyeye E., Prete A., Taylor A.E., Arlt W., Bhuva A.N., Aigbirhio F., Manisty C., McIntosh A., McConnachie A., Cruickshank J.K., Cheow H., Gurnell M., Drake W.M, & Brown M.J. (2023). [11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial. Nature Medicine, 29(1), 190-202.
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Publication 2023
Doxazosin Hydralazine Patients Pharmaceutical Preparations System, Endocrine Verapamil
2
Culturing Immortalized Human Lens Epithelial Cells
Human LECs cell line ((SRA01/04) immortalized with SV40 [73 (link)], a kind gift from late Dr. Venkat N. Reddy, Oakland University, Rochester, MI, USA) [73 (link)] were maintained routinely in our laboratory. Briefly, cells were cultured in a 100 mm tissue culture plate in Dulbecco’s Modified Eagle Medium (DMEM, Invitrogen, Waltham, MA, USA) supplemented with 15% heat-inactivated fetal bovine serum (FBS, Atlanta Biologicals, Atlanta, GA, USA), 100 µg/mL streptomycin, and 100 µg/mL penicillin in an incubator maintained at 37 °C with 5% CO2, as described previously [5 (link),74 (link)]. In the paper text, we will designate the immortalized LECs as SRA-hLECs. For the experimentation, SRA-hLECs were plated the day before treatment, and cells attaining 60–70% confluency were treated with nontoxic concentrations of hydralazine (Hyd).
Chhunchha B., Kubo E., Krueger R.R, & Singh D.P. (2023). Hydralazine Revives Cellular and Ocular Lens Health-Span by Ameliorating the Aging and Oxidative-Dependent Loss of the Nrf2-Activated Cellular Stress Response. Antioxidants, 12(1), 140.
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Publication 2023
Biological Factors Cell Lines Cells Eagle Homo sapiens Hydralazine Penicillins Simian virus 40 Streptomycin Tissues
3
Investigating Cisplatin-Induced Oxidative Stress
Cisplatin (cDDP), vitamin E (VitE) and hydralazine (Hlz) were obtained from Sigma (St. Louis, MO, USA) and 4μ8cα was purchased from Millipore (Burlington, MA, USA). MK2206, an AKT inhibitor, was purchased from Selleck (Shanghai, China). Intracellular reactive oxygen species (ROS) were detected via 2′,7′‐dichlorofluorescin diacetate (DCFDA) staining (Thermo Scientific, Waltham, MA, USA). Moreover, 4,4‐difluoro‐1,3,5,7,8‐pentamethyl‐4‐bora‐3a,4a‐diaza‐s‐indacene (BODIPY 493/503) was obtained from Thermo Scientific, and 4‐hydroxy‐trans‐2‐nonenal (4‐HNE)‐protein adducts in the indicated cells were detected through competitive enzyme‐linked immunosorbent assays (ELISAs) (Abcam, Cambridge, UK). Primary antibodies (Abs) against amphiregulin (AREG) (AB‐262‐NA) and basic fibroblast growth factor (bFGF) (AF‐233‐NA) were obtained from R&D Systems (Minneapolis, MN, USA).
Jia X., Wang G., Wu L., Pan H., Ling L., Zhang J., Wen Q., Cui J., He Z., Qi B., Zhang S., Luo L, & Zheng G. (2023). XBP1‐elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR‐22/lncRNA/KAT6B‐dependent NF‐κB signalling. Clinical and Translational Medicine, 13(1), e1166.
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Publication 2023
4,4-difluoro-1,3,5,7,8-pentamethyl-4-bora-3a,4a-diaza-s-indacene 4-hydroxy-2-nonenal Amphiregulin Antibodies Cells Cisplatin dichlorofluorescin Enzyme-Linked Immunosorbent Assay Fibroblast Growth Factor 2 Hydralazine MK 2206 Proteins Protoplasm Reactive Oxygen Species Vitamin E
4
Synthesis and Characterization of Epigenetic Modulators
Thirty-two compounds synthetized to target epigenetic pathways were studied (Figure 1). BIX-01294, apicidin, chaetocin, SGI-1027 and hydralazine were obtained from Sigma-Aldrich (St. Louis, MO, USA). TM2-115 was first synthetized at Imperial College London (M. Fuchter’s laboratory), United Kingdom and then obtained from Aobious (Gloucester, MA, USA). Trichostatin A, JIB-04, MG149 and C646 were obtained from Adooq Biosciences (Irvine, CA, USA). CB3717 was kindly provided by the Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute (Frederick, MD, USA). SAHA, JAHA, PCI 34051, TC-H 106, MC 1568, tubastatin A, (+)-JQ-1, (+)-JD-1, SHH-878-1, AKE-040 [34 (link)] were from John Spencer’s laboratory and MZ1 was obtained from Biotechne, Tocris (Avonmouth, UK); https://www.tocris.com/products/mz-1_6154, accessed on 1 June 2021). Flv69 [35 (link)], Flv880 [36 (link)], MLo1302, MLo1401, MLo1406, MLo1502, MLo1507, MLo1508, MLo1509 [37 (link)] and NFlav2018 synthesized following our previously described procedures. Different batches of apicidin, BIX-01294 and TM2-115 were used during this work.
Artemisinin (ART) and atovaquone (ATQ) were purchased from TCI. Dihydroartemisinin (DHA) was provided by the WorldWide Antimalarial Resistance Network reference standards programme (WWARN, Bangkok, Thailand).
All compounds were prepared as stock solutions in 100% DMSO (Sigma-Aldrich).
Reyser T., Paloque L., Nguyen M., Augereau J.M., Fuchter M.J., Lopez M., Arimondo P.B., Hassell-Hart S., Spencer J., Di Stefano L, & Benoit-Vical F. (2023). Epidrugs as Promising Tools to Eliminate Plasmodium falciparum Artemisinin-Resistant and Quiescent Parasites. Pharmaceutics, 15(10), 2440.
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Publication 2023
Antimalarials apicidin artemisinine artenimol Atovaquone BIX 01294 CB 3717 chaetocin Diagnosis Hydralazine JIB-04 Malignant Neoplasms MG149 PCI 34051 SGI-1027 Sulfoxide, Dimethyl trichostatin A Vorinostat
5
Confounding Factors in Immune-Mediated Diseases
Age, sex, body mass index (BMI), smoking status, ethnicity, previous exposure to relevant viral infections (Epstein-Barr virus (EBV), human cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), human T lymphotropic virus type 1 (HTLV-1), hepatitis C virus (HCV), influenza A virus, and parvovirus B19), and previous prescriptions of selected medications (procainamide, hydralazine, quinidine, and isoniazid) were included as potential confounders. Previous studies found these variables to be associated with at least one of the outcome IMIDs and were thus adjusted for in the analysis [21 (link)–33 (link)].
Age was divided into the following bands: 18 to 29, 30 to 39, 40 to 49, 50 to 59, 60 to 69, and ≥ 70 years. Ethnicity was identified through SNOMED CT codes and was classified into the following groups: white, South Asian, black, mixed ethnicity and other. BMI was divided in accordance with the WHO classification: underweight (body mass index (BMI) < 18.5 kg/m2), normal weight (18.5–24.9 kg/m2), overweight (25–29.9 kg/m2) and obese (≥ 30 kg/m2) [34 ]. Smoking status was categorised as current smoker, ex-smoker and never smoked. A separate ‘data missing’ category was used where data were missing for ethnicity, smoking status, and BMI.
Syed U., Subramanian A., Wraith D.C., Lord J.M., McGee K., Ghokale K., Nirantharakumar K, & Haroon S. (2023). Incidence of immune-mediated inflammatory diseases following COVID-19: a matched cohort study in UK primary care. BMC Medicine, 21, 363.
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Publication 2023
Epstein-Barr Virus Ethnicity Ex-Smokers Hepatitis C virus Human Herpesvirus 5 Human Herpesvirus 6 Human T-lymphotropic virus 1 Hydralazine Immunomodulatory IMiD Drugs Index, Body Mass Influenza A virus Isoniazid Obesity Parvovirus B19, Human Procainamide Quinidine South Asian People Virus Diseases

Top products related to «Hydralazine»

1
Hydralazine by Merck Group
Sourced in United States, France
Hydralazine is a pharmaceutical product used as a laboratory reagent. It functions as a vasodilator, specifically relaxing and dilating blood vessels. This results in a decrease in peripheral resistance and a subsequent reduction in blood pressure.
2
5 azacytidine by Merck Group
Sourced in United States, Germany, Sao Tome and Principe, Switzerland
5-azacytidine is a synthetic nucleoside analog used as a research tool in molecular biology and genetics laboratories. It functions as a cytosine analog and can be incorporated into DNA and RNA, potentially altering gene expression patterns.
3
Dulbecco modified eagle medium (dmem) by Thermo Fisher Scientific
Sourced in United States, China, United Kingdom, Germany, France, Australia, Canada, Japan, Italy, Switzerland, Belgium, Austria, Spain, Israel, New Zealand, Ireland, Denmark, India, Poland, Sweden, Argentina, Netherlands, Brazil, Macao, Singapore, Sao Tome and Principe, Cameroon, Hong Kong, Portugal, Morocco, Hungary, Finland, Puerto Rico, Holy See (Vatican City State), Gabon, Bulgaria, Norway, Jamaica
DMEM (Dulbecco's Modified Eagle's Medium) is a cell culture medium formulated to support the growth and maintenance of a variety of cell types, including mammalian cells. It provides essential nutrients, amino acids, vitamins, and other components necessary for cell proliferation and survival in an in vitro environment.
4
Fetal bovine serum (fbs) by Corning
Sourced in United States, China, Japan, Germany, Switzerland, New Zealand, Australia, Canada, United Kingdom, Colombia, France, Italy, Macao, Israel, Netherlands
FBS is a serum derived from the blood of fetal bovine (cattle) used as a supplement in cell culture media. It provides a complex mixture of proteins, growth factors, attachment factors, and other components that support the growth and maintenance of various cell types in vitro.
5
Fluostar omega by BMG Labtech
Sourced in Germany, United Kingdom, United States, Australia, France, Switzerland, Canada
The FLUOstar Omega is a multimode microplate reader designed for a variety of fluorescence, luminescence, and absorbance-based applications. It offers high-performance detection capabilities and supports a wide range of microplate formats.
6
Hydralazine hydrochloride by Merck Group
Sourced in United States
Hydralazine hydrochloride is a chemical compound used as a pharmaceutical ingredient. It is a vasodilator that relaxes and widens blood vessels, which can be used to lower blood pressure. The core function of hydralazine hydrochloride is to act as a therapeutic agent for the treatment of hypertension.
7
Carnosine by Merck Group
Sourced in United States, Germany
Carnosine is a dipeptide compound composed of the amino acids beta-alanine and histidine. It is naturally found in various tissues, including skeletal muscle, brain, and the cardiovascular system. Carnosine functions as an antioxidant and has been studied for its potential roles in cellular health and athletic performance.
8
C57bl 6j mice by Jackson ImmunoResearch
Sourced in United States, Montenegro, Japan, Canada, United Kingdom, Germany, Macao, Switzerland, China
C57BL/6J mice are a widely used inbred mouse strain. They are a commonly used model organism in biomedical research.
9
Olmesartan by Daiichi Sankyo
Sourced in Japan
Olmesartan is a pharmaceutical product used as a laboratory reagent. It is an angiotensin II receptor antagonist and functions to inhibit the renin-angiotensin-aldosterone system, which plays a role in regulating blood pressure.
10
Crit xt bis tris gels by Bio-Rad
Sourced in United States
The Crit XT Bis-Tris gels are pre-cast polyacrylamide gels designed for protein separation and analysis. They feature a Bis-Tris buffer system and are suitable for a range of molecular weight proteins. The gels provide consistent performance and reliable results for electrophoretic applications.

More about "Hydralazine"

Hydralazine is a powerful vasodilator medication primarily used to treat hypertension (high blood pressure).
It works by directly relaxing the smooth muscle of blood vessels, leading to a reduction in peripheral vascular resistance and lower blood pressure.
Additionally, hydralazine may be employed in the management of heart failure and certain types of malignant hypertension.
Researchers can leverage PubCompare.ai's AI-driven platform to easily locate and compare hydralazine research protocols from literature, preprints, and patents, enhancing reproducibility and accuracy.
The advanced comparison tools can help identify the best hydralazine protocols and products for specific research needs.
Hydralazine hydrochloride is a common form of the drug used in research and clinical settings.
Related terms and compounds include 5-azacytidine, a DNA methyltransferase inhibitor, and Carnosine, a naturally occurring dipeptide with potential therapeutic applications.
C57BL/6J mice are a commonly used mouse strain in hydralazine research.
Olmesartan, an angiotensin II receptor blocker, may be used in combination with hydralazine for the treatment of hypertension.
DMEM (Dulbecco's Modified Eagle Medium) and FBS (Fetal Bovine Serum) are commonly used cell culture media and supplements in hydralazine studies.
The FLUOstar Omega is a versatile microplate reader that can be used to analyze various assays related to hydralazine research, such as cell viability, cytotoxicity, and signaling pathways.
By leveraging the insights and tools provided by PubCompare.ai, researchers can optimize their hydralazine studies, enhance reproducibility, and identify the most effective protocols and products for their specific research needs.