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Hydroxypropylcellulose

Hydroxypropylcellulose is a water-soluble, non-ionic cellulose derivative with a wide range of applications in the pharmaceutical, cosmetic, and food industries.
It is commonly used as a thickening agent, emulsifier, and stabilizer, due to its ability to increase viscosity and improve texture in various formulations.
Hydroxypropylcellulose is also known for its bioadhesive properties, making it useful in drug delivery systems.
Researchers can optimize their Hydroxypropylcellulose studies by utilizing PubCompare.ai, an AI-driven platform that helps locate reliable protocols from literature, pre-prints, and patents, while providing advanced comparisons to identify the most effective methods.
This tool can enhance reproducibilty and accuracy, ensuring the best possible outcomes for Hydroxypropylcelluose research.

Most cited protocols related to «Hydroxypropylcellulose»

1
Xenograft Mouse Model for Breast Cancer
Cited 4 times
All animal studies were performed according to the guidelines and approval of the Animal Care Committee of the University Of Maryland, Baltimore. Female ovariectomized athymic nude mice 4–6 weeks of age were obtained from the National Cancer Institute - Frederick Cancer Research and Development Center (Frederick, MD). The mice were housed in a pathogen-free environment under controlled conditions of light and humidity; received food, and water ad libitum.
The tumor xenografts of MCF-7Ca cells were grown in the mice as previously described (6 (link), 9 (link), 12 (link)-14 (link)). Each mouse received subcutaneous (sc) inoculations in one site per flank with 100μL of cell suspension containing ~ 2.5×107 cells. The mice were injected daily with supplemental Δ4A (100μg/day). Weekly tumor measurements and treatments began when the tumors reached ~ 300 mm3. Mice were assigned to groups for treatment so that there was no statistically significant difference in tumor volume among the groups at the beginning of treatment. Letrozole and Δ4A for injection were prepared using 0.3% HydroxyPropylCellulose (HPC) in 0.9% NaCl solution. Trastuzumab for injection was prepared as 20 mg/ml stock solution in bacteriostatic water for injection which was then diluted in 0.9% NaCl solution to obtain the required concentration. Mice were then injected sc 5 times weekly with the indicated drugs (except trastuzumab was injected intra-peritoneally (ip) twice a week). The doses of trastuzumab (5mg/kg/wk divided in two doses), letrozole (10μg/day) and Δ4A (100μg/day) used are as previously determined and reported (13 (link)).
Sabnis G., Goloubeva O., Gilani R., Macedo L, & Brodie A. (2010). Sensitivity to aromatase inhibitor letrozole is prolonged after a “break” in treatment. Molecular cancer therapeutics, 9(1), 46-56.
Publication 2009
Animal Care Committees Animals Cells Environment, Controlled Food Heterografts Humidity hydroxypropylcellulose Letrozole Light Mice, Nude Mus Neoplasms Normal Saline pathogenesis Pharmaceutical Preparations Thymic aplasia Trastuzumab Vaccination Woman
2
Microglia Depletion and Inhibition
Cited 3 times
To impair microglial function, mice received a daily oral administration by gavage of the CSF1R inhibitor GW2580 [12 (link)] (75 mg/kg body weight in a volume of 0.2 mL) (#S8042, Selleckchem) for 4 days, which is a dosing regimen that does not challenge microglial survival [54 (link)]. Treatment controls received the same volume of the vehicle (0.5% hydroxypropylcellulose, 0.1% Tween-80). Treatment started 2 h prior to induction of ischemia, it was randomly allocated, and was administered in a blinded fashion.
For microglia depletion, mice received the CSF1R inhibitor PLX5622 (Plexxikon) following previously reported protocols [15 (link), 33 (link), 69 (link)]. The inhibitor was mixed into AIN-76A standard chow at 1200 ppm (Brogaarden, Denmark). Mice (8-week-old) received the diet ad libitum for 3 weeks prior to induction of ischemia and the diet was maintained until the mice were killed. Treatment controls received AIN-76A diet for the same period of time. Both diets were given in parallel in groups of five animals per cage.
Otxoa-de-Amezaga A., Miró-Mur F., Pedragosa J., Gallizioli M., Justicia C., Gaja-Capdevila N., Ruíz-Jaen F., Salas-Perdomo A., Bosch A., Calvo M., Márquez-Kisinousky L., Denes A., Gunzer M, & Planas A.M. (2018). Microglial cell loss after ischemic stroke favors brain neutrophil accumulation. Acta Neuropathologica, 137(2), 321-341.
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Publication 2018
Administration, Oral Animals Body Weight Diet Gene, c-fms GW 2580 hydroxypropylcellulose Ischemia Microglia Mus PLX5622 Treatment Protocols Tube Feeding Tween 80
3
Synthesis and Characterization of AT-312
Cited 2 times
AT-312 (1-(1-((cis)-4-isopropylcyclohexyl)piperidin-4-yl)-1H-indol-2-yl)methanol) (Figure 1) was synthesized at Astraea Therapeutics, and was of >99% chemical purity as fully characterized by nuclear magnetic resonance spectroscopy, LC-MS and elemental analysis. SCH221510 (Figure 1) was purchased from Tocris. These test compounds were dissolved in 1-2% DMSO and then diluted to the desired concentration with 0.5% aqueous hydroxypropylcellulose (HPC) and injected subcutaneously (s.c.) in a volume of 0.1 ml/10g of body weight. Controls received 0.1 ml/10g of body weight of the appropriate vehicle (1-2% DMSO in 0.5% of HPC).
Zaveri N.T., Marquez P.V., Meyer M.E., Polgar W.E., Hamid A, & Lutfy K. (2018). A novel and selective nociceptin receptor (NOP) agonist (1-(1-((cis)-4-isopropylcyclohexyl)piperidin-4-yl)-1H-indol-2-yl)methanol (AT-312) decreases acquisition of ethanol-induced conditioned place preference in mice. Alcoholism, clinical and experimental research, 42(2), 461-471.
Publication 2017
Body Weight hydroxypropylcellulose Methanol Sch 221510 Spectroscopy, Nuclear Magnetic Resonance Sulfoxide, Dimethyl Therapeutics
4
Preclinical Evaluation of Drug Combinations for Pancreatic Cancer
Cited 2 times
All animal work was performed with approval by the University of Colorado Anschutz Medical Campus IACUC. Patient-derived tumor samples were collected from consenting PDAC patients at the University of Colorado Cancer Center with approval by the Colorado Multiple Institutional Review Board. These samples were used to generate patient-derived xenograft (PDX) models as described previously (20 (link)). Female athymic nude mice (aged 4-8 weeks) were purchased from Envigo (Indianapolis, IN) and implanted subcutaneously on the hind flanks with tumors sized approximately 3 mm3. Mice were randomized into treatment groups and treatments were initiated when the average tumor volume reached between 100-300 mm3. In the initial PDAC drug screen, mice (n = 3/group) were treated with AZD1775, navitoclax, irinotecan, romidepsin, olaparib, AZD8186, gemcitabine, and the combination of these agents with AZD1775. Percent tumor growth inhibition (TGI) values were calculated using the end of study mean tumor volumes (MTV) of the vehicle and treatment groups with following equation: (1 – (MTVvehicle/MTVtreated) × 100). Drugs with TGI values greater in the combination than both single agents in at least two PDX models were selected for further in vivo validation. The mutational profiles of PDX models were assessed using the ArcherDX FusionPlex Solid Tumor panel, and mutations are indicated in the figure legend’s superscript.
Two PDAC PDX models (n = 10 mice/group) were expanded per drug combination. Treatments included AZD1775 (50 mg/kg, PO, QD, in 0.5% hydroxypropylcellulose), irinotecan (15 mg/kg, IP, QW), capecitabine (60 mg/kg, PO, twice weekly, in corn oil), navitoclax (100 mg/kg, PO, thrice weekly, in 10% ethanol, 30% PEG400, 60% Phosal 50PG), and the combination of AZD1775 with these agents. Mice were monitored daily for signs of toxicity, and tumor volume and weight were measured twice weekly using digital calipers and a scale. Tumor volumes were calculated using the following equation: volume = (length × width2) × 0.52.
Hartman S.J., Bagby S.M., Yacob B.W., Simmons D.M., MacBeth M., Lieu C.H., Davis S.L., Leal A.D., Tentler J.J., Diamond J.R., Eckhardt S.G., Messersmith W.A, & Pitts T.M. (2021). WEE1 Inhibition in Combination With Targeted Agents and Standard Chemotherapy in Preclinical Models of Pancreatic Ductal Adenocarcinoma. Frontiers in Oncology, 11, 642328.
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Publication 2021
Animals Anophthalmia with pulmonary hypoplasia AZD-1775 AZD8186 Capecitabine Corn oil Drug Combinations Ethanol Ethics Committees, Research Fingers Gemcitabine Heterografts hydroxypropylcellulose Institutional Animal Care and Use Committees Irinotecan Malignant Neoplasms Mice, Nude Mus Mutation navitoclax Neoplasms olaparib Patients Pharmaceutical Preparations polyethylene glycol 400 Psychological Inhibition romidepsin Substance Abuse Detection Woman
5
Xenograft Model of Breast Cancer
Cited 2 times
All animal studies were performed according to the guidelines and approval of the Animal Care Committee of the University Of Maryland, Baltimore. Female ovariectomized BALB/c athymic nude mice 4-6 weeks of age were obtained from the National Cancer Institute-Frederick Cancer Research and Development Center (Frederick, MD). The mice were housed in a pathogen-free environment under controlled conditions of light and humidity and received food and water ad libitum.The tumor xenografts of MCF-7Ca cells were grown in the mice as previously described (1 (link), 16 (link), 17 (link)). Each mouse received subcutaneous inoculations in one site per flank with 100μL of cell suspension containing ~ 2.5×107 cells. The mice were injected daily with Δ4A (100μg/day). Weekly tumor measurements and treatments began when the tumors reached ~ 300 mm3. Mice were assigned to groups for treatment so that there was no statistically significant difference in tumor volume among the groups at the beginning of treatment. Letrozole and Δ4A for injection were prepared in 0.3% HydroxyPropylCellulose (HPC). Trastuzumab for injection was prepared as 20 mg/ml stock solution in bacteriostatic water for injection and then diluted in 0.9% NaCl solution to obtain the required concentrations. Mice were then injected subcutaneously (sc) 5 times weekly with the indicated drugs: 100μg/mouse/day of Δ4A plus 10μg/mouse/day of letrozole or 10μg/mouse/day of letrozole plus trastuzumab or 100μg/mouse/day of Δ4A plus trastuzumab for indicated time. The doses of letrozole and Δ4A used are as previously determined and reported (1 (link), 2 (link)). Mice in the trastuzumab group received 5mg/kg/week of the drug intra-peritoneally (ip) divided in two doses. Mice in the Δ4A and trastuzumab group were treated for 7 weeks after which they were sacrificed due to large tumor volumes; by decapitation and the blood was collected for analysis. The other groups (letrozole, trastuzumab plus letrozole, letrozole switched to trastuzumab plus letrozole and letrozole switched to trastuzumab) were sacrificed on week 28.
Sabnis G., Schayowitz A., Goloubeva O., Macedo L, & Brodie A. (2009). Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen. Cancer research, 69(4), 1416-1428.
Publication 2008
Animal Care Committees Animals BLOOD Cells Decapitation Environment, Controlled Food Heterografts Humidity hydroxypropylcellulose Letrozole Mice, Inbred BALB C Mice, Nude Mus Neoplasms Normal Saline pathogenesis Pharmaceutical Preparations Thymic aplasia TNFSF14 protein, human Trastuzumab Vaccination Woman

Most recents protocols related to «Hydroxypropylcellulose»

1
Itraconazole Oral Dosage Form Development
Not available on PMC !
Itraconazole (It was gifted by Nobel İlaç, Turkey), β-cyclodextrin (Roquette, France), D-Mannitol (Roquette, France), Low-substituted Hydroxypropylcellulose (Shin-Etsu, Japan), Ac-Di-Sol (Colorcon, UK), Mg stearate (Ataman Kimya, Türkiye), Aerosil (Degussa, Germany) Mint flavor (Ataman Kimya, Türkiye).
Çomoğlu T. (2024). ENHANCING SOLUBILITY AND DEVELOPING AN ITRACONAZOLE-BETA-CYCLODEXTRIN COMPLEX FOR ANTIFUNGAL THERAPY IN ORALLY DISINTEGRATING TABLETS. Ankara Universitesi Eczacilik Fakultesi Dergisi, 48(3), 9-9.
Publication 2024
2
Hydroxypropyl Cellulose Hydrogel Synthesis
Hydroxypropyl
cellulose (HPC)
was supplied by NIPPON SIDA CO., LTD, with a relative molecular weight
(Mw) of 40000. Tetraethylene glycol dimethyl
ether (TEG-DE, Mw = 222), diethylene glycol
ethyl ether acrylate (DEG-EEA, Mw = 188),
and diethylene glycol diacrylate (DEG-DA, Mw = 214) were purchased from Sigma-Aldrich Co. Ltd. Hydrochloric acid
(HCl, 37%) and glutaraldehyde were purchased from Fisher Scientific.
All remaining chemicals were of analytical grade and were employed
without any additional purification steps.
Huang L., Zhang X., Deng L., Wang Y., Liu Y, & Zhu H. (2024). Sustainable Cellulose-Derived Organic Photonic Gels with Tunable and Dynamic Structural Color. ACS Nano, 18(4), 3627-3635.
Full text: Click here
Publication 2024
3
Transdermal delivery of NAR
NAR ((2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one, purity ≥ 98%, lot MKCD1056) was obtained from Sigma-Aldrich (St. Louis, MO, USA). The polymer Parteck® MXP (PVA, polyvinyl alcohol, lot F1952064) was donated by Merck (Darmstadt, Germany). KlucelTM EF (HPC, hydroxypropylcellulose, lot 40915) and Soluplus® (SOL, polyvinyl-caprolactam-polyvinyl-acetate-polyethyleneglycol, lot 844143368EO) were donated by Ashland Specialty Ingredients (Covington, LA, USA) and BASF (Ludwigshafen, Germany), respectively. Glycerin (GLY, lot 58591) and Tween 80 (polysorbate, lot 105896) were obtained from Dinâmica® (Sao Paulo, Brazil). Skin from porcine ears was obtained from a local slaughterhouse (Via Carnes Indústria e Comércio, Brasilia, Brazil). The whole skin was removed from the outer region of the ear, separated from its underlying layer, and used full thickness.
Pinho L.A., Lima A.L., Chen Y., Sa-Barreto L.L., Marreto R.N., Gelfuso G.M., Gratieri T, & Cunha-Filho M. (2024). Customizable Three-Dimensional Printed Earring Tap for Treating Affections Caused by Aesthetic Perforations. Pharmaceutics, 16(1), 77.
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Publication 2024
4
Formulation and Characterization of ENZ Tablets
ENZ was purchased from MSN Laboratories Private Ltd. (Telangana, India). Copovidone (Abbreviated as Kollidon VA64) and colloidal silica were supplied by Boryung Pharmaceutical. Co., Ltd. (Seoul, Republic of Korea). Hydroxypropylcellulose (Abbreviated as HPC-L) was supplied by Cosmax Pharmaceutical. Co., Ltd. (Cheongju, Republic of Korea). Hydroxypropylmethylcellulose phthalate (HPMCP HP55) was provided by Hanmi Pharmaceutical. Co., Ltd. (Seoul, Republic of Korea). N,N-dimethylaminoethyl methacrylate (abbreviated as Eudragit E PO) was obtained from Evonik (Essen, Germany). Propylene glycol dicaprylocaprate (abbreviated as Labrafa PG) and Diethylene glycol monoethyl ether (abbreviated as Transcutol P) were acquired from Gattefosse (St. Priest, France). Macrogoli 15 hydroxystearas (abbreviated as Solutol HS15) was sourced from BASF (Ludwigshafen, Germany). Sodium carboxymethyl cellulose was purchased from Duksan Chemicals (Ansan, Republic of Korea). Acetonitrile, ammonium acetate, and acetone were purchased from Daejung Chemicals (Siheung, Republic of Korea). Other chemicals used were of the appropriate class for analysis.
Lee S.M., Lee J.G., Yun T.H., Kim C.H., Cho J.H, & Kim K.S. (2024). The Impact of Polymers on Enzalutamide Solid Self-Nanoemulsifying Drug Delivery System and Improved Bioavailability. Pharmaceutics, 16(4), 457.
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Publication 2024
5
Lignosulfonate-Polyamine Composite Synthesis
Not available on PMC !

Example 1

Calcium lignosulfonate (Borrement CA 2120) was provided by Borregaard LignoTech. Sodium lignosulfonate was purchased from Aldrich, and ammonium lignosulfonate was obtained from TemBac.

Sodium carboxymethylcellulose (NaCMC), hydroxypropylcellulose (HPC) and hydroxyethylcellulose (HEC) were obtained from Aldrich and showed a Mw of approx. 250 kDa, 100 kDa and 100 kDa, respectively.

The amine functional material such as hexamethylene diamine (HMDA) and diethylenetriamine (DETA) were obtained from Aldrich. Different types of polyethylenimines (Lupasol® EO, Lupasol® PS, Lupasol® P and Lupasol® G100), polyvinyl amines (Luredur® VM, Luredur® VH and Luredur® VI), were obtained from BASF Chemical Company, and polyetheramines (JeffamineED600, JeffamineEDR148, JeffamineT403) from Huntsman Holland BV.

The required amounts of polymer and lignosulfonate (LS) were dissolved in water individually. The required amount of polyamine functional compound was added to the LS solution followed by homogenization. The polymer solution and LS-amine solution were then combined at ambient temperature and stirred at 500 rpm for 30 minutes.

US11879063B2. Binder compositions and uses thereof (2024-01-23). KNAUF INSULATION SPRL [BE], KNAUF INSULATION, INC. [US]. Inventors: Carl Hampson [GB], Ferdous Khan [GB].
Full text: Click here
Patent 2024
Amines Ammonium calcium lignosulfonate Cyclohexane Diamines diethylenetriamine hydroxyethylcellulose hydroxypropylcellulose lignosulfonates Polyamines Polyethyleneimine Polymers Polyvinyls Sodium Sodium Carboxymethylcellulose TLR4 agonist G100

Top products related to «Hydroxypropylcellulose»

1
Hydroxypropyl cellulose by Merck Group
Sourced in United States, Germany, Poland, United Kingdom
Hydroxypropyl cellulose is a water-soluble, thermoplastic cellulose ether used as a binder, emulsifier, and thickener in various laboratory applications. It is a versatile material that can be used to modify the physical and chemical properties of formulations.
2
Bovine serum albumin (bsa) by Merck Group
Sourced in United States, Germany, United Kingdom, China, Italy, Japan, France, Sao Tome and Principe, Canada, Macao, Spain, Switzerland, Australia, India, Israel, Belgium, Poland, Sweden, Denmark, Ireland, Hungary, Netherlands, Czechia, Brazil, Austria, Singapore, Portugal, Panama, Chile, Senegal, Morocco, Slovenia, New Zealand, Finland, Thailand, Uruguay, Argentina, Saudi Arabia, Romania, Greece, Mexico
Bovine serum albumin (BSA) is a common laboratory reagent derived from bovine blood plasma. It is a protein that serves as a stabilizer and blocking agent in various biochemical and immunological applications. BSA is widely used to maintain the activity and solubility of enzymes, proteins, and other biomolecules in experimental settings.
3
γ globulin by Merck Group
Sourced in United States, Germany
γ-globulin is a type of laboratory equipment used for the separation and detection of immunoglobulins, a class of proteins found in the blood and other bodily fluids. It functions as a tool for the analysis and characterization of the immune system.
4
Sodium hydroxide (naoh) by Merck Group
Sourced in Germany, United States, India, United Kingdom, Italy, China, Spain, France, Australia, Canada, Poland, Switzerland, Singapore, Belgium, Sao Tome and Principe, Ireland, Sweden, Brazil, Israel, Mexico, Macao, Chile, Japan, Hungary, Malaysia, Denmark, Portugal, Indonesia, Netherlands, Czechia, Finland, Austria, Romania, Pakistan, Cameroon, Egypt, Greece, Bulgaria, Norway, Colombia, New Zealand, Lithuania
Sodium hydroxide is a chemical compound with the formula NaOH. It is a white, odorless, crystalline solid that is highly soluble in water and is a strong base. It is commonly used in various laboratory applications as a reagent.
5
D mannitol by Merck Group
Sourced in United States, United Kingdom, Germany, Canada, Spain, Italy, Japan, France
D-mannitol is a type of sugar alcohol commonly used in the production of pharmaceutical and laboratory equipment. It serves as a bulking agent, sweetener, and excipient in various formulations. D-mannitol is a white, crystalline powder with a sweet taste and is soluble in water. It is widely utilized in the pharmaceutical and biotechnology industries as a component in drug tablets, capsules, and other medicinal products.
6
Magnesium stearate by Merck Group
Sourced in Germany, United Kingdom, United States, Spain, Italy, Poland
Magnesium stearate is a fine, white powder that is commonly used as a lubricant in the manufacture of pharmaceutical tablets and capsules. It is an inert substance that helps improve the flow and release properties of the final product.
7
Hydrochloric acid (hcl) by Merck Group
Sourced in Germany, United States, United Kingdom, India, Italy, France, Spain, Australia, China, Poland, Switzerland, Canada, Ireland, Japan, Singapore, Sao Tome and Principe, Malaysia, Brazil, Hungary, Chile, Belgium, Denmark, Macao, Mexico, Sweden, Indonesia, Romania, Czechia, Egypt, Austria, Portugal, Netherlands, Greece, Panama, Kenya, Finland, Israel, Hong Kong, New Zealand, Norway
Hydrochloric acid is a commonly used laboratory reagent. It is a clear, colorless, and highly corrosive liquid with a pungent odor. Hydrochloric acid is an aqueous solution of hydrogen chloride gas.
8
Cas 518 47 8 by Merck Group
Sourced in United States
CAS 518-47-8 is a chemical compound with the molecular formula C6H6O2. It is a white crystalline solid at room temperature. This compound is commonly used as a laboratory reagent and intermediate in organic synthesis.
9
Ethanol by Merck Group
Sourced in Germany, United States, United Kingdom, Italy, India, France, China, Australia, Spain, Canada, Switzerland, Japan, Brazil, Poland, Sao Tome and Principe, Singapore, Chile, Malaysia, Belgium, Macao, Mexico, Ireland, Sweden, Indonesia, Pakistan, Romania, Czechia, Denmark, Hungary, Egypt, Israel, Portugal, Taiwan, Province of China, Austria, Thailand
Ethanol is a clear, colorless liquid chemical compound commonly used in laboratory settings. It is a key component in various scientific applications, serving as a solvent, disinfectant, and fuel source. Ethanol has a molecular formula of C2H6O and a range of industrial and research uses.
10
Dp manager by Olympus
Sourced in Japan, United States
The DP Manager is a software application designed to manage and control digital microscope cameras from Olympus. It allows users to capture, save, and share high-quality images and videos from Olympus microscopes.

More about "Hydroxypropylcellulose"

Hydroxypropylcellulose (HPC) is a versatile, water-soluble cellulose derivative with a wide range of applications in the pharmaceutical, cosmetic, and food industries.
It's commonly used as a thickening agent, emulsifier, and stabilizer, thanks to its ability to increase viscosity and improve texture in various formulations.
HPC is also known for its bioadhesive properties, making it useful in drug delivery systems.
Researchers can optimize their HPC studies by utilizing PubCompare.ai, an AI-driven platform that helps locate reliable protocols from literature, pre-prints, and patents, while providing advanced comparisons to identify the most effective methods.
This tool can enhance reproducibility and accuracy, ensuring the best possible outcomes for HPC research.
Related terms and compounds like Hydroxypropyl cellulose, Bovine serum albumin, γ-globulin, Sodium hydroxide, D-mannitol, Magnesium stearate, and Hydrochloric acid (CAS 518-47-8) can also be incorporated into HPC research.
Ethanol and DP Manager are additional tools that can aid in the optimization of HPC studies.
By leveraging these insights and resources, researchers can unlock the full potential of Hydroxypropylcellulose and drive innovative advancements in their respective fields.