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Intralipid

Intralipid is a lipid emulsion commonly used for parenteral nutrition.
It is composed of soybean oil, egg phospholipids, and glycerin, providing a source of essential fatty acids and calories.
Intralipid is administered intravenously to patients unable to maintain adequate nutrition through oral or enteral routes.
Researching the optimal use of Intralipid, including dosage, administration protocols, and potential side effects, is important for improving patient outcomes.
PubCompare.ai's AI-driven tool can help researchers easily identify and compare the best Intralipid procedures from published literature, preprints, and patents, enhancing the reproducibility and accurracy of Intralipid research.

Most cited protocols related to «Intralipid»

1
Ethanol Exposure Model in Neonatal Mice
Cited 11 times
Mice (C57BL/6) were purchased from Jackson Laboratories. A breeding colony was established in the institution’s Division of Laboratory Animal Medicine facility to produce neonatal mice from multiparous dams. All animal protocols were approved by the University of Arkansas for Medical Sciences Institutional Animal Care and Use Committee. Ethanol in Intralipid 20% (Fresnius Kabi, Uppsala, Sweden) nutritional vehicle or Intralipid 20% alone was administered daily by intra-esophageal gavage at 4 g/kg/day on P4–9. Mice were also administered either pioglitazone (12.5 mg/kg/day as used in our previous studies (Diab et al., 2004 (link)); Cayman, Ann Arbor, MI) or water vehicle by gavage on P4–9. On P4, drug or water vehicle was given two hr before ethanol treatment and on P5–9 it was given one hr before ethanol treatment. Animals in the ethanol, pioglitazone plus ethanol, and vehicle treatment groups were distributed in multiple litters across a total of 11 litters for histology and 10 litters for RNA analysis. Additional litters of handled-only control animals were not gavaged but were handled only for marking and weighing. A group of pioglitazone plus vehicle animals was not included in this study as we have previously published the lack of an effect of pioglitazone alone in a related FASD model (Kane et al., 2011 (link)). Both sexes of animals were analyzed and no significant difference in the treatment response was identified between the sexes. Tissue was harvested one day after the final ethanol treatment. In separate animals, blood ethanol concentrations were evaluated on P9 at several intervals between 30–360 minutes following ethanol treatment using an Analox AM1 Alcohol Analyzer (Analox Instruments, Lunenburg, MA).
Drew P.D., Johnson J.W., Douglas J.C., Phelan K.D, & Kane C.J. (2015). Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders. Alcoholism, clinical and experimental research, 39(3), 445-454.
Publication 2014
Animals Animals, Laboratory Caimans Ethanol Fetal Alcohol Syndrome Infant, Newborn Institutional Animal Care and Use Committees Intralipid Mice, House Patient Holding Stretchers Pharmaceutical Preparations Pioglitazone Tissues
2
Fabrication of Multimodal Tissue Phantoms
Cited 10 times
Phantoms were prepared by combining type-A, 300-Bloom gelatin derived from acid-cured porcine skin (G2500, Sigma-Aldrich Corp., St. Louis, MO) with ultrapure deionized water. The water was heated to 30°C and combined with formaldehyde (37% by weight, Thermo-Fisher Scientific Inc., Waltham, MA) to enhance cross-linking of the phantom and improve its long-term stability [18 (link)]. The mixture was vigorously stirred, and gelatin powder was slowly added to mitigate aggregation of the powder in the water. The solution was continuously stirred, covered to minimize vapor loss, and slowly heated to 45°C over the course of 10 minutes. To remove the entrapped air that resulted from the stirring process, the samples were placed into a vacuum chamber at 21 kPAabsolute for approximately 10 minutes. The solution was then transferred into a mold with a syringe to further minimize the reintroduction of air. Finally, the mold was placed into a 4°C refrigerator for one day to allow the solution to fully cross-link.
To enhance ultrasonic backscatter, 40-µm diameter silica particles (MIN-U-SIL-40, U.S. Silica Co., Mill Creek, OK) were added to the gelatin solution before the addition of the formaldehyde. India Ink (Dr. Ph. Martin’s Bombay Black, Salis International Inc., Golden, CO), Direct Red 81 (Sigma-Aldrich Corp., St. Louis, MO), and Evans Blue (Sigma-Aldrich Corp., St. Louis, MO) were added to the water solution to increase the optical absorption properties of the phantom. The optical scattering of the phantom was increased by adding Intralipid® 20% IV fat emulsion (2B6022, Baxter International Inc., Deerfield, IL).
Cook J.R., Bouchard R.R, & Emelianov S.Y. (2011). Tissue-mimicking phantoms for photoacoustic and ultrasonic imaging. Biomedical Optics Express, 2(11), 3193-3206.
Publication 2011
Acids Direct Red 81 Emulsions Evans Blue Formaldehyde Fungus, Filamentous Gelatins India ink Intralipid Pigs Powder Retreatments Silicon Dioxide Skin Syringes Ultrasonics Vacuum Vision
3
Honokiol Inhibits Breast Tumor Growth
Cited 9 times
MDA-MB-231 (5 × 106) cells in 0.1 ml of HBSS were injected subcutaneously into the right gluteal region of 4- to 6-week-old female athymic nude mice. Two weeks after initial implantation, the animals were placed into two experimental groups. Mice were treated with intraperitoneal injections of (a) control (saline and Intralipidor (b) honokiol, at 3 mg/mouse/day in 20% Intralipid (Baxter Healthcare, Deerfield, IL, USA), 3 times per week for the duration of the experiment. Tumors were measured by using vernier calipers, with tumor volume calculated by using the formula (V = a/2 × b2), where V is the tumor volume in cubic millimeters, and a and b are the largest and smallest diameters in millimeters, respectively. All animals were killed after 4 weeks of treatment. Tumors were collected; weighed, fixed in 10% neutral-buffered formalin; and subjected to further analysis with immunohistochemistry.
Nagalingam A., Arbiser J.L., Bonner M.Y., Saxena N.K, & Sharma D. (2012). Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis. Breast Cancer Research : BCR, 14(1), R35.
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Publication 2012
Animals Cells Cuboid Bone Formalin Gluteal Region Hemoglobin, Sickle honokiol Immunohistochemistry Injections, Intraperitoneal Intralipid Mice, Nude Mus Neoplasms Ovum Implantation Saline Solution Woman
4
Measuring Tissue Lipid Metabolism In Vivo
Cited 8 times
For measurements of endogenous triolein clearance rates, tissue-specific lipid-uptake and β-oxidation rates in transgenic tissues, methodologies were adapted from previously detailed studies56 (link),57 (link). Briefly, 3H-triolein was tail-vein injected (2 µCi/mouse in 100 ul of 5% intralipid) into mice following a 16 h fast. Briefly, blood samples (0.15 ml) were then collected at 1, 2, 5, 10 and 15 min post injection. After 20 min following injection, mice were sacrificed, blood samples were taken and tissues were quickly excised, weighed and frozen at –80 °C until processing. Lipids were then extracted using a chloroform-to-methanol based extraction method58 (link). The radioactivity content of tissues, including blood samples, was quantified as described previously57 (link).
Kusminski C.M., Holland W.L., Sun K., Park J., Spurgin S.B., Lin Y., Askew G.R., Simcox J.A., McClain D.A., Li C, & Scherer P.E. (2012). MitoNEET, a key regulator of mitochondrial function and lipid homeostasis. Nature medicine, 18(10), 1539-1549.
Publication 2012
Animals, Transgenic BLOOD Chloroform Freezing Intralipid Lipids Metabolic Clearance Rate Methanol Mice, Laboratory Radioactivity Tail Tissues Tissue Specificity Triolein Veins
5
Intralipid Infusion and Hyperinsulinemic-Euglycemic Clamp
Cited 7 times
Wild-type and knockout mice were randomly assigned to either saline or 20% intralipid (20% soybean oil, 1.2% egg phospholipids, and 2.2% glycerin) infusion groups. Five days prior to the experiment, mice were anesthetized and catheters inserted into the left common carotid artery and the right jugular vein for blood sampling and infusions, respectively. The free catheter ends were tunneled under the skin, externalized at the neck, and sealed. Mice were fasted for 5 h before the clamp procedure. The intravenous infusion catheters were connected to a swivel 1 h prior to the infusion, and the mice were unrestrained and not handled thereafter to minimize stress. Before the onset of the infusion protocol (t = −10 min), blood samples were obtained to determine preinfusion FFA levels. At t = 0 min, the 6-h saline (5 ml · kg−1· h−1) or intralipid (5 ml · kg−1· h−1) (Baxter, Ontario, Canada) infusion protocol with 20 IU/ml heparin (LEO Pharma, Ontario, Canada) was initiated (t = 0–360 min). Two and a half hours into the infusion (t = 150 min), the hyperinsulinemic-euglycemic clamp (HIEC) was initiated according to previously described methodology (13 (link)). At the end of the clamp, mice were anesthetized, cardiac punctures were performed, and liver and hindlimb muscles were excised, freeze-clamped, and stored at −80°C until further analyses.
Charbonneau A, & Marette A. (2010). Inducible Nitric Oxide Synthase Induction Underlies Lipid-Induced Hepatic Insulin Resistance in Mice: Potential Role of Tyrosine Nitration of Insulin Signaling Proteins. Diabetes, 59(4), 861-871.
Publication 2010
BLOOD Catheters Common Carotid Artery Euglycemic Clamp Freezing Glycerin Heart Heparin Hindlimb Intralipid Intravenous Infusion Jugular Vein Liver Mice, House Mice, Knockout Muscle Tissue Neck Phospholipids Punctures Saline Solution Skin Soybean oil

Most recents protocols related to «Intralipid»

1
Nanoparticle-based Intralipid Formulation
We used 10% Intralipid (Fresenius Kabi, Bad Homberg, Germany) as the blank IL. Avastin® was from Roche-Genentech (South San Francisco, CA, USA). Avn was synthesized in-house [32 (link)]. Rapa, isopropanol, and trifluoroacetic acid (TFA) were from Alfa-Aesar (Haverhill, MA, USA). Sodium docusate (AOT) was from Merck (Darmstadt, Germany). Polystyrene sulfonate (PS), 60.000–90.000 dextran, and acetonitrile were from Sigma-Aldrich (St. Louis, MO, USA).
Perrelli A., Bozza A., Ferraris C., Osella S., Moglia A., Mioletti S., Battaglia L, & Retta S.F. (2023). Multidrug-Loaded Lipid Nanoemulsions for the Combinatorial Treatment of Cerebral Cavernous Malformation Disease. Biomedicines, 11(2), 480.
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Publication 2023
acetonitrile Avastin Dextran Docusate Sodium Intralipid Isopropyl Alcohol polystyrene sulfonate Trifluoroacetic Acid
2
Phantom-Based Evaluation of Photoacoustic Imaging
For in vitro studies using SG-OR-PAM and CFT-UT-PAM, ReST were dispersed in DI water, and a “D” shape pattern was deposited using the red ReST suspension on a glass slide. After the water evaporated, a thin layer of ReST remained on the slide for imaging. For in vitro studies using PACT, the red or black ReST were mixed with Matrigel and implanted in an agar phantom. One agar phantom with the red ReST contained 7 wt. % agar and 5 vol. % intralipid. Two additional agar phantoms with black and red ReST contained 7 wt. % agar, 5 vol. % intralipid, and 10 vol. % bovine blood to provide the background signals.
Ma C., Kuang X., Chen M., Menozzi L., Jiang L., Zhou Q., Zhang Y.S, & Yao J. (2023). Multiscale photoacoustic tomography using reversibly switchable thermochromics. Journal of Biomedical Optics, 28(8), 082804.
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Publication 2023
Agar BLOOD Bos taurus Intralipid matrigel
3
Neuroprotective Effects of Propofol and Hypoxic Preconditioning
In the first phase of the study, primary hippocampal neurons (8 DIV) were randomly divided into the following five groups using a randomization table: Group C (control group), Group I (intralipid vehicle group), Group P (propofol group), Group H (hypoxic preconditioning group) and Group HP (hypoxic preconditioning + propofol group). The cells in Group C and Group I were incubated with fresh maintenance medium and intralipid vehicle, respectively. The cells in Group P were treated with 100 μM propofol for 3 h. Cells in Group H were treated with hypoxic preconditioning, and cells in Group HP were given hypoxic preconditioning before incubation with propofol (Figure 1).
In the second phase of the study, primary hippocampal neurons (8 DIV) were randomly divided into the following seven groups: Group C (control group), Group I (intralipid vehicle group), Group P (propofol group), Group H (hypoxic preconditioning group), Group HP (hypoxic preconditioning + propofol group), Group FP (ferrostatin-1 + propofol group) and Group HRP (hypoxic preconditioning + propofol + RSL3 group). The cells in Group C, Group I, Group P, Group H and Group HP were processed the same as the first phase of the study. The cells in Group FP were given 2 μM ferrostatin-1 for 30 min (Huang et al., 2022 (link)) before incubation with propofol. The cells in Group HRP were given 10 μM RSL3 for 6 h (Zhang Y et al., 2019 (link)) after hypoxic preconditioning followed by incubation with 100 μM propofol for 3 h (Figure 1).
Chen J., Xiao F., Chen L., Zhou Z., Wei Y., Zhong Y., Li L, & Xie Y. (2023). Role of ferroptosis in hypoxic preconditioning to reduce propofol neurotoxicity. Frontiers in Pharmacology, 14, 1121280.
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Publication 2023
ferrostatin-1 Hypoxia Intralipid Neurons Propofol
4
Intralipid Infusion Protocol for VLDL1 Accumulation

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Publication 2023
BLOOD Body Weight Cardiac Arrest Catheters Forearm Infusion Pump Intralipid LPL protein, human Plasma Syringes Veins
5
Intralipid Removal from Plasma Samples

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Publication 2023
BLOOD Centrifugation Centrifugation, Density Gradient Intralipid isolation Lipoproteins Micelles Movement Needles Plasma Sodium Chloride Suby's G solution Syringes Ultracentrifugation

Top products related to «Intralipid»

1
Intralipid by Merck Group
Sourced in United States
Intralipid is a parenteral nutrition solution that provides essential fatty acids and energy. It is a sterile, non-pyrogenic, lipid emulsion for intravenous administration. Intralipid is composed of soybean oil, egg yolk phospholipids, glycerin, and water for injection.
2
Intralipid by Fresenius
Sourced in Sweden, Germany, United States, United Kingdom
Intralipid is a parenteral nutrition product manufactured by Fresenius. It is a fat emulsion that provides calories and essential fatty acids for patients who require intravenous nutritional support.
3
Intralipid by Baxter
Sourced in United States
Intralipid is a sterile, non-pyrogenic, lipid emulsion for intravenous administration. It is composed of a 10% or 20% soybean oil, 1.2% egg yolk phospholipids, and 2.25% glycerin in water. Intralipid provides a source of calories and essential fatty acids for patients who cannot maintain adequate nutrition through oral or enteral intake.
4
Intralipid 20 by Fresenius
Sourced in Sweden, Germany, Canada, France
Intralipid 20% is a parenteral nutrition product used as a source of calories and essential fatty acids. It is an emulsion of refined soybean oil, egg phospholipids, and glycerin in water. Intralipid 20% is intended for intravenous administration as part of a balanced parenteral nutrition regimen.
5
Intralipid 20 emulsion by Merck Group
Sourced in United States
Intralipid 20% emulsion is a sterile, non-pyrogenic, lipid emulsion for intravenous administration. It is composed of soybean oil, egg yolk phospholipids, glycerin, and water for injection. Intralipid 20% emulsion provides a source of calories and essential fatty acids for patients requiring parenteral nutrition.
6
Propofol by Merck Group
Sourced in United States, Germany, United Kingdom, China, Sao Tome and Principe
Propofol is a sterile, injectable emulsion used as a general anesthetic and sedative agent. It is a colorless to slightly yellow oil-in-water emulsion. Propofol is intended for intravenous administration.
7
Intralipid 20 by Merck Group
Sourced in United Kingdom, Switzerland
Intralipid 20% is a parenteral nutrition product manufactured by Merck Group. It is a sterile, nonpyrogenic, lipid emulsion for intravenous administration. Intralipid 20% provides a source of calories and essential fatty acids for patients who cannot maintain adequate oral nutrition.
8
L name by Merck Group
Sourced in United States, Germany, United Kingdom, Sao Tome and Principe, France, Brazil, Italy, Belgium, China, Canada, Spain
L-NAME is a synthetic compound that functions as a nitric oxide synthase inhibitor. It is commonly used in research applications to study the role of nitric oxide in biological processes.
9
Intralipid emulsion by Merck Group
Sourced in United States
Intralipid emulsion is a sterile, non-pyrogenic, lipid emulsion for intravenous administration. It is composed of soybean oil, egg yolk phospholipids, glycerin, and water for injection.
10
Diprivan by AstraZeneca
Sourced in United Kingdom, Italy, Japan, China, Turkiye
Diprivan is a laboratory equipment product manufactured by AstraZeneca. It is an intravenous anesthetic agent primarily used for the induction and maintenance of general anesthesia. The core function of Diprivan is to provide a controlled and safe administration of anesthesia in clinical settings.

More about "Intralipid"

Intralipid, a lipid emulsion, is a widely used parenteral nutrition solution composed of soybean oil, egg phospholipids, and glycerin.
It provides a source of essential fatty acids and calories for patients unable to maintain adequate nutrition through oral or enteral routes.
Researchers are constantly exploring the optimal use of Intralipid, including dosage, administration protocols, and potential side effects, to improve patient outcomes.
PubCompare.ai's AI-driven tool can help researchers easily identify and compare the best Intralipid procedures from published literature, preprints, and patents, enhancing the reproducibility and accuracy of Intralipid research.
Intralipid 20% and Intralipid 20% emulsion are specific formulations of Intralipid, while Propofol and L-NAME are related compounds that may be used in conjunction with Intralipid.
Understanding the nuances of Intralipid emulsion and its interactions with other substances is crucial for optimizing its clinical application and ensuring the safety and efficacy of parenteral nutrition therapy.