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Isoflavones

Isoflavones are a class of naturally occurring plant compounds that have been the focus of extensive research due to their potential health benefits.
These polyphenolic compounds are found primarily in soy and other legumes, and have been studied for their antioxidant, anti-inflammatory, and potential cancer-preventive properties.
Isoflavones are structurally similar to the hormone estrogen and can interact with estrogen receptors, leading to their classification as phytoestrogens.
Researchers are actively investigating the optimal sources, dosages, and delivery methods for isoflavones to maximize their therapeutic potential and ensure reproducibility in clinical studies.
This MeSH term provides a concise overview of this important class of bioactive plant compounds.

Most cited protocols related to «Isoflavones»

1
Development and Validation of Short-Form FFQ
Cited 72 times
The long-FFQ consisted of 172 food and beverage items and nine frequency categories, ranging from almost never to seven or more times per day (or to 10 or more glasses per day, for beverages). It asked about the usual consumption of listed foods during the previous year. The food list was initially developed according to percentage contributions based on absolute values of energy and intake of 14 target nutrients from weighed food records in 1989–19918 (link) and used for the Japan Public Health Center-based prospective Study,8 (link)–12 (link) for which it was modified for middle-aged and elderly residents in a wide variety of areas of Japan. With regard to this modification, the following criteria were considered: calculation for an additional 17 nutrient items, such as fiber and folate, change of foods contributing to the absolute nutrient intake according to the updated Standard Tables of Food Composition in Japan,13 ,14 and dietary regionality and change in generation for the present cohort (data not shown). As a result, 33 foods were added, and 5 foods and beverages were excluded.15 (link) Moreover, six foods were also added to account for potential inter-individual variation in specific nutrients, such as isothiocyanate and isoflavone. With regard to alcoholic beverages, choices of intake amount were changed from the initial JPHC-FFQ.
To develop the food list for the short-FFQ, we selected and combined items and supporting questions from the original long-FFQ. We selected the three major foods and beverages that contributed to inter-individual variation for each of 40 nutrients according to a cumulative R2 for the 40 nutrients,16 based on the multiple regression coefficient with total intake of a specific nutrient as the dependent variable and its intake from each food as the explanatory variable. Inter-individual variation was calculated by gender among 45 869 men and 52 989 women who responded to the JPHC Study 10-year follow-up survey. Consequently, cumulative R2 for the nutrients ranged from 0.4 to 1.0. For potential inter-individual variation in intake of specific food groups, some foods, such as coffee, were added. Ultimately, 66 food and beverage items were selected for the short-FFQ. In this validation study, information on alcoholic beverages was substituted with those from the long-FFQ (united with overall information of lifestyle), because these questions were not included in the short-FFQ. This was because information on alcoholic beverage intake was structured in pages for lifestyle other than diet, such as smoking status and physical activity, and the reproducibility of alcoholic beverage intake was relatively high even if questionnaires were administered at a 1-year interval.17 (link),18 (link)Intakes of energy, 53 nutrients, and 29 food groups were calculated using the Standard Tables of Food Composition in Japan 2010,19 Standard Tables of Food Composition in Japan Fifth Revised and Enlarged Edition 2005 For Fatty Acids,20 and a specifically developed food composition table for isoflavones in Japanese foods.21 (link)
Validity of Short and Long Self-Administered Food Frequency Questionnaires in Ranking Dietary Intake in Middle-Aged and Elderly Japanese in the Japan Public Health Center-Based Prospective Study for the Next Generation (JPHC-NEXT) Protocol Area. (2016). Journal of Epidemiology, 26(8), 420-432.
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Publication 2016
Aged Alcoholic Beverages Beverages Coffee Diet Eating Eyeglasses Fatty Acids Fibrosis Folate Food Isoflavones isothiocyanate Japanese Nutrient Intake Nutrients Woman
2
HPLC Analysis of Medicinal Herb Extracts
Cited 14 times

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Publication 2004
Acetic Acid Anthocyanins Chalcones Coumaric Acids Coumarins Curcuminoid Ellagitannins Flavanones Flavones Flavonols formic acid Gallotannins High-Performance Liquid Chromatographies Hydroxybenzoic Acids Isoflavones Leucoanthocyanidins Lignans Medicinal Herbs Methanol Proanthocyanidins Quinones Retention (Psychology) sodium phosphate Stilbenes Tannins
3
Seasonal Dietary Intake Assessment Protocol
Cited 13 times
The subjects provided 7-day dietary records (DR) in 4 seasons (a total of 28 days): spring (May), summer (August), autumn (November) and winter (February). In Mito the PHC area, the study was launched in the spring of 1996, Half of the subjects from Chuo-higashi (n=32) joined the study in the summer of 1996, and the other half (n=44) in the winter of 1997. In other areas, the study began in winter of 1997.
Weighed DRs were collected over 7 consecutive days in each of the 4 seasons. Dietitians from the PHC, the cities or towns in each area instructed the subjects to weigh all foods and beverages using the measuring spoons, cups and an electronic scale provided, and to record them in a booklet especially designed for the purpose. The subjects gave detailed descriptions of each food, the method of preparation and names of the recipes. The dietitians checked the records at subjects' homes at least once during the survey.
At the end of each season, the dietitians from the PHC reviewed the records in a standardized way, and coded all the foods recorded according to the Standardized Tables of Food Composition, 4th edition,5 If codes were not available for certain local foods, the dietitians substituted the food considered to be most similar by asking subjects for details on the food. When ingredients were not obtained for any already prepared recipes, the standard recipes developed by the authors were used.
Nutrient and food calculation was done by the method used in the Cohort I validation study.6 (link) The mean daily intake of energy and 16 nutrients was calculated from the records using the Standardized Tables of Food Composition, 4th edition.5 For cholesterol, and additional nutrients and compounds such as fatty acids (saturated, monounsaturated, n-3 polyunsaturated, n-6 polyunsaturated)7 (link), dietary fiber (water-soluble, -insoluble),8 (link) selenium9 (link) and carotenoids (alpha-carotene, beta-carotene, lycopene),10 (link) the original food composition tables were developed by filling in the missing values for the Japanese composition tables. For isoflavones (daidzein and genistein), the values in the specially developed food composition table for isoflavones in Japanese foods were used.11 (link),12 (link)Additional information about the diet, the standard portions/units for rice and green tea, and brand names for usually used cooking oil, sugar, soy sauce and miso (fermented soybeans) were reported. The frequency of eating out and dietary supplement use for the week was also recorded. Name, age, sex and occupation of all members in the family, self-reported physical activity level, and the number of steps counted by pedometer for one arbitrary day in each season were reported for information on demographic status and physical activity.
Ishihara J., Sobue T., Yamamoto S., Yoshimi I., Sasaki S., Kobayashi M., Takahashi T., Iitoi Y., Akabane M, & Tsugane S. (2007). Validity and Reproducibility of a Self-administered Food Frequency Questionnaire in the JPHC Study Cohort II: Study Design, Participant Profile and Results in Comparison with Cohort I. Journal of Epidemiology, 13(1 Suppl), S134-S147.
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Publication 2003
alpha-carotene beta Carotene Beverages Carbohydrates Carotenoids Cholesterol daidzein Diet Dietary Fiber Dietary Supplements Dietitian Fatty Acids Food Genistein Green Tea Isoflavones Japanese Lycopene Miso Mitomycin Nutrients Oryza sativa Soybeans Soy Sauce
4
Dietary Inflammatory Index Protocol
Cited 11 times
Questionnaires at baseline obtained information on demographics, lifestyle factors, health history, diet, ethnic identity (Multigroup Ethnic Identity Measure [MEIM]), and several psychosocial measures including social approval and desirability, which have previously been shown to bias dietary and physical activity self-reporting (20 (link)–22 (link)). The 144-item food frequency questionnaire (FFQ) obtained information on frequency and serving size of commonly consumed foods and beverages which were used to estimate nutrient intake.
The DII is grounded in peer-reviewed research (i.e., 1,943 articles) examining the relationship between dietary components (termed food parameters) and inflammation to create inflammatory effect scores for each food parameter. At the same time, actual intake of each food parameter is standardized to a “world” database consisting of mean (and standard deviation) of the intake of that dietary component from 11 populations around the world (i.e., Australia, Bahrain, Denmark, India, Japan, Mexico, New Zealand, South Korea, Taiwan, the United Kingdom and the United States). A z-score was created by subtracting the “world” means from actual intake and dividing this by the standard deviation. In order to dampen the effect of [right] skewness, these z-scores were then converted to percentile values and centered on zero by doubling the percentile and subtracting 1. These values were multiplied by the literature derived inflammatory effect score and summed across food parameters. DII scores were calculated per 1,000 calories consumed to account for varying energy intake between people. DII information can be found elsewhere (3 (link)). These are the 31 DII food parameters available through HEALS: carbohydrates; protein; total, saturated, monounsaturated, polyunsaturated, and trans fat; alcohol; fiber; cholesterol; omega 3 and omega 6 fatty acids; niacin; thiamin; riboflavin; vitamins A, B6, B12, C, D, and E; iron; magnesium; zinc; selenium; folate; beta carotene; isoflavones; onion; garlic; and tea.
Wirth M.D., Shivappa N., Davis L., Hurley T.G., Ortaglia A., Drayton R., Blair S.N, & Hébert J.R. (2017). Construct Validation of the Dietary Inflammatory Index among African Americans. The journal of nutrition, health & aging, 21(5), 487-491.
Publication 2017
Acids, Omega-6 Fatty Allium cepa beta Carotene Beverages Carbohydrates Cholesterol Diet Eating Ethanol Fibrosis Folate Food Garlic Inflammation Iron Isoflavones Magnesium Niacin Nutrient Intake Omega-3 Fatty Acids PER1 protein, human Population Group Proteins Riboflavin Selenium Thiamine Vitamins Wound Healing Zinc
5
Soy Isoflavones Biomarker Validation Trial
Cited 7 times
This randomized, double-blind, placebo-controlled with two parallel arms was approved by the Institutional Review Board of the University of Texas Medical Branch (UTMB). Written informed consent was obtained from all subjects. The primary purpose was to study the biological effects of soy isoflavones in women, and those trial results will be reported separately. A secondary purpose was to validate riboflavin as a biomarker of adherence to daily ingestion of study pills in both placebo and active treatment arms of the study, as reported here. Trial registration: www.clinicaltrials.gov and the identifier is NCT00204490.
The study subjects were 197 premenopausal women between 30 and 42 years of age with regular monthly menstrual cycles. Four baseline visits consisted of two visits during each of two separate luteal phases not more than 6 months apart, after which 197 qualified subjects were randomized to treatment with isoflavone or placebo pills. Each placebo pill contained a 246 mg carbohydrate filler (90% maltodextrin and 10% Sethness caramel color). Each isoflavone pill contained 246 mg Nova Soy, which consisted of soy glycones (daidzin, genistin, and glycitin) and aglycones (daidzein, genistein, and glycitein) at a 9:1 molar ratio; the total aglycone equivalent amounts were 30 mg daidzein, 30 mg genistein, and 8.3 mg glycitein. Both the placebo pill and isoflavone pill also contained 15 mg riboflavin, 60 mg sorbitol, 3 mg magnesium stearate, and 676 mg dicalcium phosphate to give a final tablet weight of 1000 mg. Both pills were identical in appearance, designed by Dr. Brent Flickinger, and generously provided for this study at no cost by Archer Daniel Midland Co. (Decatur, IL).
Subjects were randomized in blocks of six using the PLAN procedure in SASã (SAS Version 9.3, SAS Institute, Inc. Cary, NC), which assured equal sizes of the study groups. All subjects, research staff, and investigators were blinded to the treatment assignments, which were known only to research pharmacists who dispensed supplies of the study pills but were not involved in other aspects of the trial. At each study visit subjects were given a three month supply of study pills in blister packs. Each blister for daily dosing contained two study pills and one prenatal vitamin pill (Rugby Prenavite Prenatal Formula, Swanson Health Products, Duluth, GA) that met the required daily intake of vitamins and minerals. Subjects were instructed to avoid vitamin supplements not provided by the study, and to take the pills contained in one blister pack daily for 5 days per week for up to 2 years.
Administration of study pills began on the second day of the menstrual bleeding following the fourth baseline visit. Study visits then occurred at 3-month intervals and between 20 to 24 days after onset of menstrual bleeding. Before each visit the subjects collected urine for 12 hours overnight in a 3 liter, light-protected container containing 1 gm sodium azide and 10 mL glycerol as preservatives. Aliquots of urine were stored at −20°C until analyzed for riboflavin by a high performance liquid chromatography (HPLC) with fluorescence detection (Chen et al., 2005 , Ramanujam et al., 2011 ), and for daidzein and genistein by a previously described gas chromatography-flame ionization detection (GC-FID) method (Lu et al., 1995 ).
All baseline and treatment phase urine samples were analyzed for riboflavin, daidzein, and genistein by one of the investigators who was blinded to treatment assignment. Riboflavin results were used in discussions with the study participants regarding their adherence to ingestion of study pills, whereas the isoflavone results remained blinded to the subjects and members of the study team until the trial ended and data were ready for analysis.
Ramanujam V.M., Nayeem F., Anderson K.E., Kuo Y.F., Chen N.W., Ju H, & Lu L.J. (2016). Riboflavin as an independent and accurate biomarker for adherence in a randomized double-blind and placebo-controlled clinical trial. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 22(6), 508-516.
Publication 2016
Arm, Upper Biological Markers Biopharmaceuticals caramel color Carbohydrates Contraceptives, Oral daidzein daidzin dicalcium phosphate Dietary Supplements Ethics Committees, Research Flame Ionization Fluorescence Gas Chromatography Genistein genistin Glycerin glycitein glycitin High-Performance Liquid Chromatographies Isoflavones Light Luteal Phase magnesium stearate maltodextrin Menstrual Cycle Menstruation Minerals Molar Pharmaceutical Preservatives Placebos Riboflavin Sodium Azide Sorbitol Tablet Urine Vitamins Woman

Most recents protocols related to «Isoflavones»

1
Genome-Wide Association Study of Soybean
A total number of 6,149,599 SNPs with MAF 0.01 from previously sequenced 2,241 soybean accessions were used for GWAS analysis (Li et al., 2022 (link)). GWAS was performed using the compressed mixed linear model (cMLM) in the GAPIT program (Lipka et al., 2012 (link)), where the first three principal component analysis (PCA) values were included as fixed effects in the mixed model to correct for stratification. The threshold for significance was estimated to be approximately P = 1 × 10-6 (that is, 1/6,149,599) by the Bonferroni correction method. These 6,149,599 SNPs were distributed equally across the 20 soybean chromosomes (one SNP per 154.3 bp). The extent of model fitting was confirmed using a quantile-quantile (Q-Q) plot for the expected and obtained p-values of each SNP to evaluate how much a significant result was produced by the analysis than expected by chance. The Manhattan plots for the isoflavone contents for each of the five environments were generated from GAPIT (Lipka et al., 2012 (link)). The Phytozome database (http://www.phytozome.org/) and the SoyBase database (http://www.soybase.org/) were used to predict and annotate the candidate genes.
Azam M., Zhang S., Li J., Ahsan M., Agyenim-Boateng K.G., Qi J., Feng Y., Liu Y., Li B., Qiu L, & Sun J. (2023). Identification of hub genes regulating isoflavone accumulation in soybean seeds via GWAS and WGCNA approaches. Frontiers in Plant Science, 14, 1120498.
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Publication 2023
Chromosomes, Human, Pair 20 Genes Genome-Wide Association Study Isoflavones Soybeans
2
Diverse Soybean Accessions Isoflavone Profiling
A total of 1551 natural population panel of diverse soybean accessions was used in this study. The accessions were selected from a mini core collection developed by Qiu et al. (2009) (link) based on their availability at the soybean genetic resource research group of the Institute of Crop Sciences, Chinese Academy of Agricultural Sciences (CAAS). The origin and number of soybean accessions from each country are Brazil (8), Canada (6), China (1283), Colombia (1), East Europe (3), Germany (4), Italy (2), Japan (21), Nigeria (1), North Korea (1), Russia (22), South Korea (4), Thailand (1), USA (194). Information on each accession is also presented in Supplementary Table 1. Field trials were conducted at three locations (Changping, Beijing (40° 13′ N and 116° 12′ E), Sanya, Hainan (18° 24′ N and 109° 5′ E) in 2017 and 2018, while, for only 2017, planted in Hefei, Anhui (33°61′ N and 117 °E). A randomized incomplete block design was employed to sow the cultivars, with the various planting sites serving as replications. The cultivars were replicated across different sites due to a large number of cultivars and the scarcity of available land resources. Each cultivar’s seeds were sown in 3 m long rows with 0.5 m inter-row and 0.1 m intra-row spacing. Fertilizer containing 30 kg/ha, 40 kg/ha, and 60 kg/ha of nitrogen, phosphorous, and potassium was applied to the field, respectively. From planting until harvest, the advised agronomic procedures were used. The seeds from each accession were pooled and used for soybean seed isoflavone determination (Azam et al., 2020 (link); Azam et al., 2021 (link)).
Azam M., Zhang S., Li J., Ahsan M., Agyenim-Boateng K.G., Qi J., Feng Y., Liu Y., Li B., Qiu L, & Sun J. (2023). Identification of hub genes regulating isoflavone accumulation in soybean seeds via GWAS and WGCNA approaches. Frontiers in Plant Science, 14, 1120498.
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Publication 2023
Chinese Crop, Avian DNA Replication Eastern European People Isoflavones Nitrogen Phosphorus Potassium Soybeans
3
Transcriptional analysis of soybean isoflavone biosynthesis
The four soybean varieties Luheidou (LHD), Zhonghuang 13 (ZH13), Zhonghuang 35 (ZH35), and Nanhuizao (NHZ), varying in their isoflavone contents, were used as materials for RNA seq-analysis. About 20 seeds were harvested at different developmental stages (R5 to R8) after 7 days intervals. Each sample was set with three replications for isoflavone contents, and RNA extraction. The total RNAs were extracted using the TRIzol method. The high-quality RNA samples were sent for RNA-seq analysis to BLgene co. LTD (Beijing, China). HISAT2 was used to map the clean RNA-seq data onto the reference genome (Kim et al., 2015 (link)). FeatureCounts calculated the transcriptional abundance and gene expression count matrix (Liao et al., 2014 (link)). TPM (transcripts per million) was used as the expression level, and log10 (TPM + 1) was used to standardize it (Feng et al., 2023 (link)).
Azam M., Zhang S., Li J., Ahsan M., Agyenim-Boateng K.G., Qi J., Feng Y., Liu Y., Li B., Qiu L, & Sun J. (2023). Identification of hub genes regulating isoflavone accumulation in soybean seeds via GWAS and WGCNA approaches. Frontiers in Plant Science, 14, 1120498.
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Publication 2023
DNA Replication Gene Expression Genome Isoflavones Plant Embryos RNA-Seq Soybeans Transcription, Genetic trizol
4
Quantification of Soybean Isoflavone Profiles
The isoflavone contents were determined using a previously reported method (Sun et al., 2011 (link)) and as follows. Around 20 g seeds of each accession were grounded by a cyclone mill (IKA, A10 basic, Rheinische, Germany). Approximately 0.1 g of the finely ground powder was placed in a 10 mL tube pre-filled with 5 mL of a solution containing 0.1% (v/v) acetic acid and 70% (v/v) ethanol and shaken for 12 hours on a twist mixer (TM – 300, AS ONE, Osaka, Japan). The mixture was centrifuged for 10 min at 6000 rpm, and the supernatant was filtered using a 0.2 μm YMC Duo filter (YMC Co., Kyoto, Japan). Samples were stored at 4°C prior to use and measured for isoflavones using an Agilent HPLC system (Agilent 1260, Santa Clara, CA, USA) having YMC ODS AM-303 column (250 mm × 4.6 mm I.D., S-5 μm, 120 Å, YMC Co., Kyoto, Japan). The identification and quantification of the isoflavone contents were carried out using the following isoflavone standards: daidzein (DE), glycitein (GLE), genistein (GE), daidzin (D), glycitin (GL), genistin (G), malonyldaidzin (MD), malonylglycitin (MGL), malonylgenistin (MG), acetyldaidzin (AD), acetylglycitin (AGL), and acetylgenistin (AG). The detected isoflavone component concentrations were determined using the formula provided by (Sun et al., 2011 (link)).
Azam M., Zhang S., Li J., Ahsan M., Agyenim-Boateng K.G., Qi J., Feng Y., Liu Y., Li B., Qiu L, & Sun J. (2023). Identification of hub genes regulating isoflavone accumulation in soybean seeds via GWAS and WGCNA approaches. Frontiers in Plant Science, 14, 1120498.
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Publication 2023
Acetic Acid Cyclonic Storms daidzein daidzin Ethanol Genistein genistin glycitein glycitin High-Performance Liquid Chromatographies Isoflavones malonyldaidzin malonylgenistin Plant Embryos Powder
5
Flavonoid and Isoflavone Intake Correlations
Continuous variables are presented as mean ± standard deviation, or mean (95% confidence intervals, 95% CIs) as indicated below each table, and categorical variables are presented as percentage (95% CIs). Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% CIs. The time in the Cox proportional model, as follow-up duration, was recorded from the household interview until death or lost to follow-up in months. The association among flavonoid intake and the association between isoflavone intake and urinary phytoestrogens were evaluated by the function “cor” and the R package “corrplot,” in which, p value <0.0001 was defined as significant and the absolute value of Pearson’s correlation coefficient r ≥ 0.8 was classified as strong correlation, 0.8 < r ≤ 0.5 as moderate correlation and 0.5 < r ≤ 0.2 as weak correlation; r < 0.2 as no correlation. In the remaining analysis, a p value < 0.05 was used as a cut-off for statistical significance. A feasible nomogram for weighted survey data was established and validated by calibration curve for predicting the 12.5-year survival probability in participants using the “rms” and “SvyNom” package in R (21 (link)). All analyses were conducted using the R software (version 4.1.3, the R Foundation for Statistical Computing, 181 Longwood Ave, Boston, MA 02115). The R package “nhanseR” and “survey” were employed for the data preparation and statistics analysis.
Zhou F., Gu K, & Zhou Y. (2023). Flavonoid intake is associated with lower all-cause and disease-specific mortality: The National Health and Nutrition Examination Survey 2007–2010 and 2017–2018. Frontiers in Nutrition, 10, 1046998.
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Publication 2023
Debility Flavonoids Households Isoflavones Phytoestrogens Urine

Top products related to «Isoflavones»

1
Genistein by Merck Group
Sourced in United States, Germany, China, France, United Kingdom, Sao Tome and Principe, Italy, Australia, Poland
Genistein is a lab equipment product from Merck Group. It is a naturally occurring isoflavone compound found in various plants. Genistein can be used as a research tool in various scientific applications.
2
Daidzein by Merck Group
Sourced in United States, Germany, Poland, Italy, United Kingdom
Daidzein is a naturally occurring isoflavone compound. It functions as an antioxidant and has been studied for its potential biological activities.
3
Genistin by Merck Group
Sourced in United States, Germany
Genistin is a laboratory equipment product manufactured by Merck Group. It is a chemical compound that serves as a key component in various analytical and experimental procedures within research and development settings. The core function of Genistin is to facilitate specific chemical reactions and analyses, but a detailed description of its intended use or applications would require further information that is not available in this context.
4
Daidzin by Merck Group
Sourced in United States, Germany
Daidzin is a laboratory equipment product manufactured by Merck Group. It is a chemical compound used in various research and analytical applications. Daidzin serves as a core function in specific laboratory procedures, but a detailed description cannot be provided while maintaining an unbiased and factual approach.
5
Dimethyl sulfoxide (dmso) by Merck Group
Sourced in United States, Germany, United Kingdom, China, Italy, Sao Tome and Principe, France, Macao, India, Canada, Switzerland, Japan, Australia, Spain, Poland, Belgium, Brazil, Czechia, Portugal, Austria, Denmark, Israel, Sweden, Ireland, Hungary, Mexico, Netherlands, Singapore, Indonesia, Slovakia, Cameroon, Norway, Thailand, Chile, Finland, Malaysia, Latvia, New Zealand, Hong Kong, Pakistan, Uruguay, Bangladesh
DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
6
Glycitein by Merck Group
Sourced in United States
Glycitein is a naturally occurring isoflavone compound found in soybeans and other legumes. It serves as a laboratory standard for the identification and quantification of this compound in various samples.
7
Acetonitrile by Merck Group
Sourced in Germany, United States, Italy, India, China, United Kingdom, France, Poland, Spain, Switzerland, Australia, Canada, Brazil, Sao Tome and Principe, Ireland, Belgium, Macao, Japan, Singapore, Mexico, Austria, Czechia, Bulgaria, Hungary, Egypt, Denmark, Chile, Malaysia, Israel, Croatia, Portugal, New Zealand, Romania, Norway, Sweden, Indonesia
Acetonitrile is a colorless, volatile, flammable liquid. It is a commonly used solvent in various analytical and chemical applications, including liquid chromatography, gas chromatography, and other laboratory procedures. Acetonitrile is known for its high polarity and ability to dissolve a wide range of organic compounds.
8
Gallic acid by Merck Group
Sourced in United States, Germany, Italy, Spain, France, India, China, Poland, Australia, United Kingdom, Sao Tome and Principe, Brazil, Chile, Ireland, Canada, Singapore, Switzerland, Malaysia, Portugal, Mexico, Hungary, New Zealand, Belgium, Czechia, Macao, Hong Kong, Sweden, Argentina, Cameroon, Japan, Slovakia, Serbia
Gallic acid is a naturally occurring organic compound that can be used as a laboratory reagent. It is a white to light tan crystalline solid with the chemical formula C6H2(OH)3COOH. Gallic acid is commonly used in various analytical and research applications.
9
Daidzein by LC Laboratories
Sourced in United States
Daidzein is a naturally occurring isoflavone compound found in various plants, including soybeans. It functions as a phytoestrogen, exhibiting structural and functional similarities to the human hormone estrogen. Daidzein is commonly used in scientific research and laboratory applications.
10
Formic acid by Merck Group
Sourced in Germany, United States, Italy, United Kingdom, France, Spain, China, Poland, India, Switzerland, Sao Tome and Principe, Belgium, Australia, Canada, Ireland, Macao, Hungary, Czechia, Netherlands, Portugal, Brazil, Singapore, Austria, Mexico, Chile, Sweden, Bulgaria, Denmark, Malaysia, Norway, New Zealand, Japan, Romania, Finland, Indonesia
Formic acid is a colorless, pungent-smelling liquid chemical compound. It is the simplest carboxylic acid, with the chemical formula HCOOH. Formic acid is widely used in various industrial and laboratory applications.

More about "Isoflavones"

Isoflavones are a class of polyphenolic phytoestrogens found primarily in soy and other legumes.
These bioactive plant compounds have been extensively researched for their potential health benefits, including antioxidant, anti-inflammatory, and cancer-preventive properties.
Structurally similar to the hormone estrogen, isoflavones can interact with estrogen receptors, leading to their classification as phytoestrogens.
Key isoflavone compounds include genistein, daidzein, genistin, and daidzin.
Researchers are actively investigating the optimal sources, dosages, and delivery methods for isoflavones, such as the use of solvents like DMSO and acetonitrile, as well as compounds like gallic acid and formic acid, to maximize their therapeutic potential and ensure reproducibility in clinical studies.
Understanding the nuances of isoflavone research is crucial for developing effective and reliable interventions.
By leveraging AI-driven platforms like PubCompare.ai, scientists can identify the most robust isoflavone protocols from the scientific literature, pre-prints, and patents, ensuring their research is efficient and yields reproducible results.
With this comprehensive understanding of isoflavones, researchers can unlock the full range of health benefits these plant-based compounds have to offer.