Children were randomly assigned to receive either lansoprazole (15 mg daily for children < 30 kg; 30 mg daily for children ≥ 30 kg) or a matching placebo. A permuted block treatment assignment schedule stratified by clinical center was used. Treatment assignments were masked throughout the study. After the screening and randomization visits, participants returned to the clinical centers for assessments every 4 weeks for 24 weeks. Throughout the study children kept daily diaries to record morning peak expiratory flow, asthma symptoms, nocturnal awakenings, use of short-acting β-agonists (excluding routine use before exercise), oral corticosteroid use, and unscheduled health care visits for asthma symptoms. Ambulatory esophageal pH monitoring prior to randomization was conducted in a subgroup of children who agreed to the procedure at 13 clinical centers with the capability of doing pH probe studies for the study. Participants were paid, on average, ($ ) for each study visit.
Lansoprazole
It works by reduceing the production of acid in the stomach.
Lansoprazole is available by prescript ion and over-the-counter, and is generallly considered safe and effective when used as directed.
Patients should consult their healthcare provider before starting or stopping Lansoprazole or any other medication.
Most cited protocols related to «Lansoprazole»
Exclusion criteria included: secondary hyperuricemia (for example, due to myeloproliferative disorder); xanthinuria; severe renal impairment (eCLcr <30 ml/minutes [37 (link),38 (link)]); alanine aminotransferase and aspartate aminotransferase values >1.5 times the upper limit of normal; consumption of more than 14 alcoholic drinks per week or a history of alcoholism or drug abuse within five years; or a medical condition that, in the investigator's opinion, would interfere with treatment, safety, or adherence to the protocol.
Subject screening evaluations included: physical examination and vital signs; medical history, a pre-specified CV history/risk form; laboratory tests (sUA, complete chemistry panel, hematology, urinalysis, and, for women, pregnancy test); echocardiogram; assessment for tophi and gout flare; and concomitant medication use. With the exception of tophus assessment, these elements, along with compliance, were repeated at bimonthly visits during the six-month treatment period. sUA was blinded after baseline determination at Day-4.
An Interactive Voice Response System was utilized by site personnel during screening visits to initiate double-blind randomization. Subjects were randomized 1:1:1 on Day 1 to receive daily febuxostat 40 mg, febuxostat 80 mg, or allopurinol (Apotex; Weston, FL, USA). Randomization was stratified by baseline renal function and prior completion of either of two open-label extension trials [13 (link),14 (link)]. Among subjects randomized to allopurinol, those with normal renal function or mild renal impairment received 300 mg daily, and those with moderate renal impairment received 200 mg.
During a 30-day washout period for subjects receiving prior ULT, and throughout the subsequent six-month treatment period for all subjects, prophylaxis for gout flares was given either as colchicine, 0.6 mg daily (West-Ward Pharmaceutical Corporation, Eatontown, NJ, USA) or naproxen, 250 mg twice daily (West-Ward Pharmaceutical Corporation). All subjects receiving naproxen prophylaxis also received lansoprazole 15 mg daily (Takeda Global Research & Development Center, Inc., Deerfield, IL, USA). Choice of prophylaxis regimen was made by the investigator and subject, taking into account prior drug tolerance and prophylaxis experience. In addition, subjects with eCLcr <50 ml/minute were not to receive naproxen. Gout flares were regarded as expected gout manifestations rather than as AEs.
The comparison study was conducted in 39 sites in Japan between October 2011 and August 2012, and the sequential long‐term maintenance study was conducted at the same sites between November 2011 and July 2013. The studies were approved by the Institutional Review Board at each study site. They were conducted in accordance with the Declaration of Helsinki and the ICH Harmonised Tripartite Guideline for Good Clinical Practice, and all patients provided written informed consent for the comparison study as well as the long‐term maintenance study. The studies were registered at ClinicalTrials.gov with the identifiers NCT01452698 and NCT01452776.
In the comparison study, following a 3–7 day screening period, patients were randomised to treatment with vonoprazan 20 mg or lansoprazole 30 mg, both administered orally once daily after breakfast, for 2, 4 or 8 weeks. Subjects completed double‐blind treatment after 2, 4 or 8 weeks when healing was endoscopically confirmed. If the EE was not healed after completing the 8‐week treatment period, the patient received vonoprazan 40 mg for 4 or 8 weeks in a non‐blinded manner.
Subjects with healed EE at week 2, 4 or 8 in the comparison study were randomised 1:1 to receive vonoprazan 10 or 20 mg orally once daily after breakfast for 52 weeks in the sequential long‐term maintenance study after providing additional informed consent.
Most recents protocols related to «Lansoprazole»
The remaining cohort (82.7% (568) individuals and 81.3% (2416) implants) served as control.
All the implants used were two-p, iece, internal hex, rough surface titanium (Tapered ® Screw-Vent Implant System, Zimmer Dental, (Warsaw, IN, USA); Lance®, MIS, (Bar Lev Industrial Park BAR-LEV, 2015600 Israel); MPI®, Ditron Dental, 2 Haofe St. South ind. Zone P.O.B 5010 Ashkelon 7815001 Israel). All treatments were performed by experienced oral and maxillofacial surgeons and prosthodontists. The study protocol was approved by the ethics committee of the Rabin Medical Center, Campus Beilinson, Israel (0674-19rmc). The present script complies with the STROBE guidelines [15 (link)]. Dental records of all individuals included were extracted and manually screened twice by 2 examiners (DM and LC).
The following information was collected: age, gender, physical status, systemic diseases, HbA1C values before and after implant-supported prosthesis delivery in cases of diabetes mellitus, smoking, implant location, number of implants per individual, bone augmentation, implant brand, length and width, and EIF.
EIF was defined as implant removal within a period of up to 12 months from loading.
Patients were divided into the following four groups: TC-/PPI-, TC + /PPI-, TC-/PPI + , and TC + /PPI + .
(1) The TC-/PPI- group consisted of patients who were neither on TC nor PPI therapy (control group).
(2) The TC + /PPI- group consisted of patients whose period of TC (doxycycline or minocycline) and EGFR-TKI therapy overlapped by at least 20% but were not on PPIs.
(3) The TC-/PPI + group consisted of patients whose period of PPI (esomeprazole, pantoprazole, rabeprazole, or lansoprazole) and EGFR-TKI therapy overlapped by at least 20% but were not on TCs.
(4) The TC + /PPI + group consisted of patients taking TCs and PPIs concomitantly with EGFR-TKI therapy, and both therapeutic regimens overlapped by at least 20%.
Age > 18 years.
Determination of gastric function using serological testing.
PPI use for at least 3 months prior to evaluation. Therapy with PPI included the following generic and brand drugs: Omeprazole (Antra®, Omeprazen®, Mepral®, and Losec®), Esomeprazole (Nexium®, Lucen®, Axagon®, and Esopral®, Pantoprazole (Pantorc®, Pantopan®, Pantecta®, Peptazol®), Rabeprazole (Pariet®), and Lansoprazole (Zoton®, Limpidex®, and Lansox®).
The presence of symptoms attributed to gastroesophageal acid-related disease, for which patients were on PPI therapy; symptoms were assigned to the following categories: pain symptoms (including epigastric and abdominal pain); reflux symptoms (including heartburn, acid regurgitation, persistent hiccup, belching, sialorrhea, and globus pharynges); maldigestion symptoms (including nausea, bloating, flatulence, rumbling abdomen, bitter taste in the mouth, and aerophagia); otorhinolaryngological symptoms (including hoarseness, chronic laryngitis, coughing, glossitis, and pharyngitis); and chest/cardiac symptoms (including thoracic pain, tachycardia, extrasystoles, and dyspnea).
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More about "Lansoprazole"
It works by reducing the amount of acid produced in the stomach, allowing the esophagus and stomach lining to heal.
Lansoprazole is available by prescription and over-the-counter, and is generally considered safe and effective when used as directed.
Patients should consult their healthcare provider before starting or stopping Lansoprazole or any other medication.
When researching Lansoprazole, it's important to consider related terms and substances.
DMSO (Dimethyl Sulfoxide) is a common solvent used in Lansoprazole research, while Omeprazole is another PPI medication similar to Lansoprazole.
Formic acid, Quercetin, Methanol, and Acetonitrile may also be encountered in studies involving Lansoprazole.
Additionally, FBS (Fetal Bovine Serum) and Dexamethasone are frequently used in cell culture and in vitro experiments.
Optimizing Lansoprazole research can be greatly assisted by tools like PubCompare.ai, which use AI-driven data analysis to help researchers locate the best protocols and improve the reproducibility and accuracy of their studies.
By incorporating insights from the literature, pre-prints, and patents, PubCompare.ai can empower researchers to experince the future of research optimization and make more informed decisions about their Lansoprazole research.