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Maltodextrin

Maltodextrin is a complex carbohydrate derived from the partial hydrolysis of starch.
It is commonly used as a food additive, binder, or filler due to its versatile properties.
Maltodextrin is easily digestible and provides a source of glucose, making it useful in various food and pharmaceutical applications.
It has a mild, slightly sweet flavor and can be used to modify the texture and mouthfeel of products.
Reserchers can optimize their maltodextrin studies using PubCompare.ai, an AI-driven protocol comparison tool that helps identify the best protocols from literature, preprints, and patents to ensure reliable, reproducable results.
Experieence the power of PubCompare.ai to streamline your maltodextrin research and make informed decisions.

Most cited protocols related to «Maltodextrin»

Figure 2 shows the study protocol. Participants were provided with verbal and written instructions to refrain from any exercise, alcohol, and caffeine in the 48 h before each of the three trial conditions. During this time, physical activity was objectively measured with an Actigraph GT1M accelerometer (Actigraph, Pensacola, FL) worn around the hip during waking hours. Data were recorded in 1-min epochs, with accelerometer counts ≥100/min classified as active time. This was further differentiated as moderate-to-vigorous intensity activity (≥1,952 counts/min) and light-intensity activity (100–1,951 counts/min) (29 (link)). Wear time and activity duration, type, and intensity undertaken during any nonwear periods were recorded in activity diaries. This information, in conjunction with an automated accelerometer wear-time estimation, was used to derive daily wear time.
Participants reported to the laboratory between 0700 and 0800 h, having fasted overnight. A catheter was inserted into an antecubital vein for hourly blood sampling. After the initial blood collection (time point: −2 h), participants remained seated for 2 h to achieve a steady state before the consumption of a standardized test drink (time point: 0 h). The 200-mL test drink consisted of 75 g carbohydrate (100% corn maltodextrin powder; Natural Health, Australia) and 50 g fat (Calogen; Nutricia, Australia). The specific nutritional components were energy, 3,195 kJ; fat, 50.0 g; saturated fat, 5 g; monounsaturated fat, 30.4 g; polyunsaturated fat, 14.3 g; carbohydrate, 75 g; total sugars, 12.8 g; protein, nil; fiber, <1 g; sodium, 46.9 mg; and water, 90 g. The grounds for inclusion of the fat content were based on 1) better simulation of a mixed meal and 2) its influence of slowing the ingested glucose production (gastrointestinal emptying) to spread the plasma glucose and insulin responses over more of the selected 5-h treatment period. Participants were then guided through the respective trial condition protocols for the remaining 5 h. The hourly blood collection was undertaken before activity bouts during the activity days (trial conditions 2 and 3 outlined below). The research staff directly supervised participants throughout each trial to ensure that full compliance with the trial protocols was achieved.
The trial conditions are listed as follows:
Participants watched television or DVDs; read books, magazines, or newspapers; performed light paperwork; or worked on a laptop computer throughout the three conditions. As expected, during the 5-h postprandial period in the moderate-intensity activity breaks condition, the mean ± SE accelerometer-measured time spent in moderate-intensity activity was 24.0 ± 1.8 min compared with 0.6 ± 0.4 min in the light-intensity condition. Activity levels were further monitored at the completion of each activity bout using the Borg RPE scale. The mean ± SE (range: min–max) RPEs during the light-intensity and moderate-intensity activity break conditions were 8 ± 0.4 (6–11) and 12 ± 0.4 (8–14), respectively.
Publication 2012
The experiments were conducted in compliance with the guidelines of animal experiments of Karolinska Institutet and the study protocol was approved by the regional ethical committee (Stockholm South ethical committee, approval number S184-10 and appendix S19-13). 8-week-old C57BL/6J mice were housed in standard cages with wood chip bedding and a paper roll for enrichment at constant ambient temperature (21–22°C) and humidity (40-50%) with a 12-hour light cycle. All animals had free access to tap water and the assigned diet. Before study start, all mice were allowed acclimatization to the animal facility conditions and the casein-based chow during a 7-day period.
To provide an adenine-containing chow consumed by the mice, adenine was mixed with a casein-based diet that blunted the smell and taste. Adenine was purchased from Sigma Aldrich (MO, USA) and the powdered casein-based diet from Special Diets Services (SDS, UK) (reference number 824522). Other ingredients of the diet are maize starch (39.3%), casein (20.0%), maltodextrin (14.0%), sucrose (9.2%), maize/corn oil (5%), cellulose (5%), vitamin mix (1.0%), DL-methionine (0.3%) and choline bitartrate (0.2%). Total phosphate content was 0.9% and total calcium content was 0.6%.
Data presented herein is derived from an 8-week experiment using 8-week-old C57BL/6J wild-type mice. To exclude the possibility of an impact of the casein diet per see on renal function, the control group (n = 5) was fed the same casein diet as the adenine group (n = 9) but without addition of adenine.
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Publication 2013
Acclimatization Adenine Animal Diseases Animals Calcium, Dietary Caseins Cellulose Choline Bitartrate Corn oil Corns Cornstarch Diet Dietary Services DNA Chips Humidity Kidney maltodextrin Mice, House Mice, Inbred C57BL Phosphates Racemethionine Sense of Smell Sucrose Taste Vitamins

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Publication 2013
Adult Animals Animals, Laboratory Carbohydrates Caseins Corns Diet Lactalbumin Macaca mulatta Macronutrient Males maltodextrin Milk, Cow's Monkeys Pigs Placebos Proteins Resveratrol Serum Soybean oil Soy Proteins Sucrose Therapy, Diet
This randomized, double-blind, placebo-controlled with two parallel arms was approved by the Institutional Review Board of the University of Texas Medical Branch (UTMB). Written informed consent was obtained from all subjects. The primary purpose was to study the biological effects of soy isoflavones in women, and those trial results will be reported separately. A secondary purpose was to validate riboflavin as a biomarker of adherence to daily ingestion of study pills in both placebo and active treatment arms of the study, as reported here. Trial registration: www.clinicaltrials.gov and the identifier is NCT00204490.
The study subjects were 197 premenopausal women between 30 and 42 years of age with regular monthly menstrual cycles. Four baseline visits consisted of two visits during each of two separate luteal phases not more than 6 months apart, after which 197 qualified subjects were randomized to treatment with isoflavone or placebo pills. Each placebo pill contained a 246 mg carbohydrate filler (90% maltodextrin and 10% Sethness caramel color). Each isoflavone pill contained 246 mg Nova Soy, which consisted of soy glycones (daidzin, genistin, and glycitin) and aglycones (daidzein, genistein, and glycitein) at a 9:1 molar ratio; the total aglycone equivalent amounts were 30 mg daidzein, 30 mg genistein, and 8.3 mg glycitein. Both the placebo pill and isoflavone pill also contained 15 mg riboflavin, 60 mg sorbitol, 3 mg magnesium stearate, and 676 mg dicalcium phosphate to give a final tablet weight of 1000 mg. Both pills were identical in appearance, designed by Dr. Brent Flickinger, and generously provided for this study at no cost by Archer Daniel Midland Co. (Decatur, IL).
Subjects were randomized in blocks of six using the PLAN procedure in SASã (SAS Version 9.3, SAS Institute, Inc. Cary, NC), which assured equal sizes of the study groups. All subjects, research staff, and investigators were blinded to the treatment assignments, which were known only to research pharmacists who dispensed supplies of the study pills but were not involved in other aspects of the trial. At each study visit subjects were given a three month supply of study pills in blister packs. Each blister for daily dosing contained two study pills and one prenatal vitamin pill (Rugby Prenavite Prenatal Formula, Swanson Health Products, Duluth, GA) that met the required daily intake of vitamins and minerals. Subjects were instructed to avoid vitamin supplements not provided by the study, and to take the pills contained in one blister pack daily for 5 days per week for up to 2 years.
Administration of study pills began on the second day of the menstrual bleeding following the fourth baseline visit. Study visits then occurred at 3-month intervals and between 20 to 24 days after onset of menstrual bleeding. Before each visit the subjects collected urine for 12 hours overnight in a 3 liter, light-protected container containing 1 gm sodium azide and 10 mL glycerol as preservatives. Aliquots of urine were stored at −20°C until analyzed for riboflavin by a high performance liquid chromatography (HPLC) with fluorescence detection (Chen et al., 2005 , Ramanujam et al., 2011 ), and for daidzein and genistein by a previously described gas chromatography-flame ionization detection (GC-FID) method (Lu et al., 1995 ).
All baseline and treatment phase urine samples were analyzed for riboflavin, daidzein, and genistein by one of the investigators who was blinded to treatment assignment. Riboflavin results were used in discussions with the study participants regarding their adherence to ingestion of study pills, whereas the isoflavone results remained blinded to the subjects and members of the study team until the trial ended and data were ready for analysis.
Publication 2016
Arm, Upper Biological Markers Biopharmaceuticals caramel color Carbohydrates Contraceptives, Oral daidzein daidzin dicalcium phosphate Dietary Supplements Ethics Committees, Research Flame Ionization Fluorescence Gas Chromatography Genistein genistin Glycerin glycitein glycitin High-Performance Liquid Chromatographies Isoflavones Light Luteal Phase magnesium stearate maltodextrin Menstrual Cycle Menstruation Minerals Molar Pharmaceutical Preservatives Placebos Riboflavin Sodium Azide Sorbitol Tablet Urine Vitamins Woman
The nutrition intervention will be a multi-micronutrient (MMN) fortified lipid-based supplement (Nutriset, Malauney, France). In addition to the MMN and polyunsaturated lipids (linoleic 4.9 g and α-linolenic 0.59 g), the composition includes dried skimmed milk, soybean and peanut extract, sugar, maltodextrin stabilizers, and emulsifiers. The specific preparation is a modification of Nutributter by iLiNS based at UC Davis for research use with pregnant and lactating women (LNS P&L). This preparation is currently in use in studies in Ghana and Malawi where it has had formal acceptability testing. The micronutrient content of the daily 20 g supplement to be administered in this trial (Table 1) is unchanged from the LNS P&L except for an increase in the Vitamin D to conform to a recent update in the recommendation by the Institute of Medicine [30 ], and to allow for potentially lower bioactivity of the ergo-calciferol form chosen for acceptability to vegetarian populations. The zinc content was reduced to a level close to the recommendation of the Institute of Medicine for pregnant women [31 ]. The LNS P&L is water-free and has a long shelf life of 18 mo at room temperature in hot, humid environments.
The intervention will be initiated in Arm 1 within 2 wk of enrollment to give time for baseline studies and in Arm 2 once participants in Stage 2 reach 12 wk gestation and have completed dietary assessments (if applicable), anthropometry measurements and biospecimen collection, and ultrasound exams. For each of these two arms, the intervention will be terminated at delivery.
Fourteen daily supplements will be provided biweekly in 20 g sachets with instructions to take one sachet per day. A rodent and water resistant plastic container will be provided to each participant for storage of the sachets. The supplement can be eaten as is or mixed in with other foods depending on the preference of the participant. A record will be maintained indicating if sachet is taken alone or with meals. Instructions will be given to the participant that although the supplement can be added to other foods before eating, it should not be added to foods while cooking.
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Publication 2014
Arachis hypogaea Arm, Upper Carbohydrates Diet Dietary Modification Dietary Supplements Ergocalciferol Food Hot Temperature Lipids maltodextrin Micronutrients Milk, Cow's Obstetric Delivery Population Group Pregnancy Pregnant Women Rodent Soybeans Ultrasonography Vegetarians Woman Zinc

Most recents protocols related to «Maltodextrin»

Maltodextrin debranched by isoamylase (IA) was used as the substrate for the production of PHB. Methods for IA treatment and quantification of maltodextrin were described previously32 (link). 1 mM maltodextrin refers to 1 mM glucose equivalent of maltodextrin. Proof-of-concept experiment was carried out at 37 °C in a 4-mL reaction mixture containing 200 mM Tris-HCl (pH 7.4), 10 mM MgCl2, 0.5 mM MnCl2, 10 μg/mL ampicillin, 5 μg/mL kanamycin, 10 mM sodium phosphate (pH 7.4), 0.5 mM TPP, 0.5 mM CoA, 2 mM NADP+, 10 g/L (around 55.6 mM glucose equivalent) IA-debranched maltodextrin, and enzymes. PhaA was loaded at a final concentration of 1 mg/mL (0.78 mU/mL), while each of the rest of the enzymes was loaded at a final concentration of 1 U/mL. The absorbance of the reaction mixture at 600 nm (OD600) was measured in real-time using a Cary 100 UV-Vis spectrophotometer (Agilent Technologies, USA). Unless specified, one-pot, one-step production of PHB from 100 mM maltodextrin was conducted at 37 °C in a 1-mL reaction mixture containing 200 mM Tris-HCl (pH 7.4), 10 mM MgCl2, 0.5 mM MnCl2, 10 μg/mL ampicillin, 5 μg/mL kanamycin, 10 mM sodium phosphate (pH 7.4), 0.5 mM TPP, 0.5 mM CoA, 2 mM NADP+, 100 mM IA-debranched maltodextrin, and enzymes. At different time points, a 0.1-mL aliquot was collected, and centrifuged at 8,000×g to harvest the pellet for PHB quantification.
For the complete utilization of maltodextrin, the reaction was performed in a one-pot, two-step mode. When 100 mM IA-debranched maltodextrin was used as the substrate, the first step was initiated under the abovementioned conditions at optimized enzyme concentrations predicted by Model 2 (displayed in Supplementary Table 6) and coenzyme concentrations (2 mM TPP, 0.5 mM CoA, 2 mM NADP+), except that the concentration of PhaC was raised to 20 U/mL. After 8 h, 4GT and PPGK were added to the reaction mixture at either 1-fold loading concentrations (0.1 U/mL 4GT, 1.0 U/mL PPGK) or 2-fold loading concentrations (0.2 U/mL 4GT, 2.0 U/mL PPGK) together with 20 mM sodium hexametaphosphate for further PHB production. For the complete utilization of 200 mM maltodextrin using a fed-batch substrate addition strategy, the initial reaction conditions were the same as those using 100 mM maltodextrin. At 4 h, another 100 mM maltodextrin and another 20 U/mL PhaC was added. At 12 h, 4GT, PPGK, and sodium hexametaphosphate were added to the system at 0.2 U/mL (approximately 0.67 mg/mL), 2 U/mL (approximately 0.02 mg/mL), and 20 mM, respectively. For the complete utilization of 200 mM maltodextrin upon a single addition of substrate at 0 h, the concentrations of substrate, MgCl2, MnCl2, sodium phosphate, TPP, CoA, NADP+, and enzymes were all two times those in the trial using 100 mM substrate. After 8 h, 40 mM sodium hexametaphosphate, 0.4 U/mL (approximately 1.33 mg/mL) 4GT, and 4.0 U/mL (approximately 0.04 mg/mL) PPGK were added to the reaction mixture for further PHB production. At different time points, samples were collected for quantification of maltodextrin and PHB. Residual maltodextrin in the sample supernatant was quantified by the total starch assay kit (Megazyme, Ireland) as instructed.
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Publication 2024

Example 22

Varenicline free base (7 g) was dissolved in methanol (140 ml) at 25-30° C. In a separate flask, tartaric acid (4.92 g) was dissolved in 70 ml water at 25-30° C. Varenicline solution was mixed with tartaric acid solution at 25-35° C. The resulting clear solution was stirred for 30 min at 25-35° C. to form the Varenicline tartrate salt solution. Maltodextrin (119.84 g) was dissolved in water (420.53 ml) at 25-35° C. separately and added this Maltodextrin solution into Varenicline tartrate solution prepared earlier. The resulting clear solution was stirred for 30 minutes, filtered through a micron filter and washed with water (2×70 ml). The clear filtrate was subjected to spray drying using a spray dryer to obtain the amorphous Varenicline Tartrate Maltodextrin Premix (1:10) API. Yield: 130.0 g. Purity by HPLC: 99.99%.

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Patent 2024
High-Performance Liquid Chromatographies maltodextrin Methanol Sodium Chloride tartaric acid Varenicline Varenicline Tartrate
Sweet cassava flour (250 g) was mixed with 500 mL of water and stirred overnight. The mixture was centrifuged at 14,300× g, at 4 °C for 20 min, and the supernatant was collected. The extraction was then repeated using the sediment and a second supernatant was obtained. The two supernatants were combined freeze-dried. The powder was kept in a vacuum container at −20 °C until used.
Maltodextrin was used as a reference for comparison and prepared in the same way. Maltodextrin and crude extract from sweet cassava were used throughout the experiments described in this study. Fresh solutions of these materials were prepared on the day of each experiment by dissolving them in DDD water at the required concentrations.
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Publication 2024

Example 5

The Scanning Electron Microscopy (SEM) was used for imaging of crystalline API-PAT (crystalline varenicline tartrate salt) (FIG. 2), maltodextrin (Glucidex 12D) (FIG. 3), API Premix (varenicline tartrate: Maltodextrin—1:10) PAT (FIG. 4) and API+Maltodextrin (Physical Mix) (1:10) (FIG. 5).

The spray drying process renders a near spherical morphology of the premix of the present disclosure, as observed from the SEM images. Such morphology is not observed in the physical mixture between varenicline tartrate and maltodextrin, in the same weight ratio as that used in the premix (i.e. 1:10). This result shows that the spray drying process of the present disclosure produces nearly spherical shaped particles, where varenicline tartrate is uniformly dispersed in maltodextrin matrix.

The near to spherical morphology of the spray dried premix, offers minimal surface area for the premix, as for a given volume, a spherical shape has the lowest surface area. This low surface area of the premix particles is likely to be a key factor, contributing to lower extent of interaction (contact) between the premix particles and the other excipients used in the formulation, thus reducing the chances of generation of any impurities that is likely to be formed because of such interaction (contact).

The reduction of the surface:volume ratio by creating spherical agglomerations of the varenicline/maltodextrin mixture reduces the amount of contact between the active and other excipients, thereby diminishing the likelihood of impurity generation.

Such morphology is not observed in the physical mixture between Varenicline Tartrate & Maltodextrin, in the same weight ratio as that used in the premix (i.e. 1:10). This shows that the spray drying process of the current disclosure produces nearly spherical shaped particles, where Varenicline tartrate is uniformly dispersed in maltodextrin matrix.

The near to spherical morphology of the spray dried premix, offers minimal surface area for the premix, as for a given volume, a spherical shape has the lowest surface area.

This low surface area of the premix particles is likely to be a key factor, contributing to lower extent of interaction (contact) between the premix particles and the other excipients used in the formulation, thus reducing the chances of generation of any impurities that is likely to be formed because of such interaction (contact).

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Patent 2024

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Publication 2024

Top products related to «Maltodextrin»

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Maltodextrin is a commonly used food ingredient and lab equipment product. It is a water-soluble polysaccharide produced from the partial hydrolysis of starch. Maltodextrin has a varying dextrose equivalent (DE) value, which reflects the degree of starch hydrolysis. It is used in a variety of applications, including as a thickening agent, filler, or bulking agent in food and pharmaceutical products.
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Gallic acid is a naturally occurring organic compound that can be used as a laboratory reagent. It is a white to light tan crystalline solid with the chemical formula C6H2(OH)3COOH. Gallic acid is commonly used in various analytical and research applications.
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DPPH is a chemical compound used as a free radical scavenger in various analytical techniques. It is commonly used to assess the antioxidant activity of substances. The core function of DPPH is to serve as a stable free radical that can be reduced, resulting in a color change that can be measured spectrophotometrically.
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The Folin-Ciocalteu reagent is a colorimetric reagent used for the quantitative determination of phenolic compounds. It is a mixture of phosphomolybdic and phosphotungstic acid complexes that undergo a color change when reduced by phenolic compounds.
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Methanol is a clear, colorless, and flammable liquid that is widely used in various industrial and laboratory applications. It serves as a solvent, fuel, and chemical intermediate. Methanol has a simple chemical formula of CH3OH and a boiling point of 64.7°C. It is a versatile compound that is widely used in the production of other chemicals, as well as in the fuel industry.
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Gum arabic is a natural, edible gum obtained from the hardened sap of certain Acacia tree species. It is commonly used as an emulsifier, stabilizer, and thickening agent in various food, pharmaceutical, and industrial applications.
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Ethanol is a clear, colorless liquid chemical compound commonly used in laboratory settings. It is a key component in various scientific applications, serving as a solvent, disinfectant, and fuel source. Ethanol has a molecular formula of C2H6O and a range of industrial and research uses.

More about "Maltodextrin"

Maltodextrin is a versatile and commonly used food additive, binder, and filler.
Derived from the partial hydrolysis of starch, this complex carbohydrate is easily digestible and provides a source of glucose, making it useful in various food and pharmaceutical applications.
Maltodextrin has a mild, slightly sweet flavor and can be used to modify the texture and mouthfeel of products.
Researchers can optimize their maltodextrin studies using PubCompare.ai, an AI-driven protocol comparison tool that helps identify the best protocols from literature, preprints, and patents to ensure reliable, reproducible results.
PubCompare.ai's intelligent analysis can streamline your maltodextrin research and help you make informed decisions.
Relared terms and concepts include: Gallic acid, a polyphenolic compound with antioxidant properties; Mini Spray Dryer B-290, a laboratory-scale spray drying system; DPPH, a free radical used to assess antioxidant activity; Folin-Ciocalteu reagent, a colorimetric assay for determining total phenolic content; Methanol, a common solvent used in extraction processes; B-290, the model number of the Mini Spray Dryer; Sucrose, a common sweetener; Gum arabic, a natural emulsifier and stabilizer; and Ethanol, another common solvent.
Experieence the power of PubCompare.ai to streamline your maltodextrin research and make informed decisions.