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Midazolam

Midazolam is a short-acting benzodiazepine medication used for sedation, anesthesia induction, and the treatment of certain types of seizures.
It has anxiolytic, amnestic, hypnotic, anticonvulsant, and muscle relaxant properties.
Midazolam is commonly administered intravenously, intramuscularly, or as a nasal spray.
It is important to carefully monitor patients receiving midazolam due to the risk of respiratory depression and other adverse effects.
Researchers can utilize PubCompare.ai's AI-driven tools to optimize midazolam research by locating and comparing protocols from published literature, preprints, and patents to identify the most effective and reproducible approaches.

Most cited protocols related to «Midazolam»

1
Esophageal Manometry and pH Monitoring

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Publication 2018
Antimony Atmospheric Pressure Catheters Conscious Sedation Endoscopes Endoscopy, Gastrointestinal Esophagus Fentanyl Manometry Midazolam Neoplasm Metastasis Pressure Swallows Upper Esophageal Sphincter
2
Evaluation of Dysphagia with HRM and FLIP
Patients presenting to the Esophageal Center of Northwestern for evaluation of dysphagia between November, 2012 and April, 2016 that completed HRM and FLIP during upper endoscopy were prospectively included. Upper endoscopy was completed using sedation with midazolam (2 - 15 mg) and fentanyl (0 - 300 mcg); propofol (in addition to midazolam and fentanyl) was used with anesthesiologist assistance at the discretion of the performing endoscopist in some cases. Patients with previous upper gastrointestinal surgery, significant medical co-morbidities, eosinophilic esophagitis, severe reflux esophagitis (LA-classification C or D), or large hiatal hernia were excluded. Patients were often identified by referral for manometry, thus FLIP was commonly included with the endoscopic evaluation if an esophageal motility disorder was suspected. Enrollment of achalasia patients was prioritized, but limited to 70 patients: 49 of the achalasia patients were previously described.(11 (link)) We intentionally included an excess of achalasia patients to evaluate the diagnostic effectiveness of FLIP topography for this important esophageal motility disorder. Additional clinical evaluation (e.g. barium esophagram) were obtained and management decisions made at the discretion of the primary treating gastroenterologist. The study protocol was approved by the Northwestern University Institutional Review Board.
Carlson D.A., Kahrilas P.J., Lin Z., Hirano I., Gonsalves N., Listernick Z., Ritter K., Tye M., Ponds F.A., Wong I, & Pandolfino J.E. (2016). Evaluation of esophageal motility utilizing the functional lumen imaging probe (FLIP). The American journal of gastroenterology, 111(12), 1726-1735.
Publication 2016
Anesthesiologist Barium Deglutition Disorders Diagnosis Endoscopy Endoscopy, Gastrointestinal Eosinophilic Esophagitis Esophageal Achalasia Ethics Committees, Research Fentanyl Gastroenterologist Hiatal Hernia Manometry Midazolam Motility Disorders, Esophageal Operative Surgical Procedures Patients Peptic Esophagitis Propofol Sedatives Upper Gastrointestinal Tract
3
Cerebral Oximetry Monitoring in Pediatric Cardiac Surgery
The Institutional Review Board at The Johns Hopkins Hospital approved this prospective, observational cohort study. Because NIRS is routine for pediatric cardiac surgery in our institution, the need for written informed consent was waived. All subjects received routine care, and caregivers were blinded to the COx. Pediatric patients undergoing CPB were eligible with the exception of patients with significant cyanosis (defined as oxygen saturation <95%) or coarctation of the aorta excluded. These latter subjects were excluded based on the theoretical concerns that: (1) patients with aortic coarctation are at risk for markedly abnormal pressure autoregulation associated with chronically high cerebral perfusion pressure; and (2) patients with cyanosis were excluded, because the COx has not been validated in this saturation range.8 (link),9 (link),12 (link) Therefore, of 91 patients identified for the study, 37 were excluded for cyanosis and/or coarctation, leaving 54 subjects enrolled.
All subjects received standard intraoperative monitoring, invasive ABP monitoring, and reflectance NIRS-based cerebral oximetry (INVOS; Somanetics, Troy, Mich). Nonprotocolized anesthetic management consisted of midazolam, fentanyl, isoflurane, and pancuronium. CPB was carried out with a nonocclusive roller pump, α-stat pH management, and priming with blood products for all patients who weighed <20 kg.
Brady K.M., Mytar J.O., Lee J.K., Cameron D.E., Vricella L.A., Thompson W.R., Hogue C.W, & Easley R.B. (2010). Monitoring Cerebral Blood Flow Pressure Autoregulation in Pediatric Patients During Cardiac Surgery. Stroke, 41(9), 1957-1962.
Publication 2010
Anesthetics BLOOD Coarctation, Aortic Cyanosis Ethics Committees, Research Fentanyl Homeostasis Isoflurane Midazolam Oximetry Oxygen Saturation Pancuronium Patients Pressure Spectroscopy, Near-Infrared Surgical Procedure, Cardiac
4
GI Cancer Surveillance in Eastern Golestan
The majority of cancer patients in eastern Golestan present first to the local general practitioners or to the medical and surgical specialists in the area, and only a small group of patients are first diagnosed in major cities outside the area. Before the study began, the investigators contacted all of the local medical practitioners and asked them to refer their patients with suspected GI tract cancers to the Atrak Clinic. From August 2001 to August 2003, 682 patients were referred to the Atrak Clinic. Based on the results of a recent cancer surveillance study and an ongoing cancer registration in Golestan Province, we have shown that approximately 70% of the incident cases of oesophageal cancer recorded in the eastern part of Golestan Province during the study period were referred to the Clinic (unpublished data), so the results of this report may be generalised to represent the experience of eastern Golestan Province.
All the 682 patients referred to the Atrak Clinic were suspected of having upper GI cancers. After signing an informed consent, the patients were interviewed by a physician using a structured questionnaire and underwent physical examination followed by oesophago-gastro-duodenal videoendoscopy. Intravenous Midazolam (5 mg) and 10% lidocaine spray to the pharynx were used as premedication. Local medical specialists, who had been given specific training, performed the endoscopies using Olympus GIF-XQ230 and Pentax EG-2900 video endoscopes. At least four biopsies were obtained from all of the tumours that were found during endoscopy and standard biopsies were taken from the antrum, the gastric body (lesser curvature), the cardia and the oesophagus in all patients. Two more biopsies were taken from columnar-lined distal oesophagus, if such tissue existed. The endoscopic data were entered on predesigned forms, and the location of the tumours was either captured and registered electronically (90% of the tumours), or precisely drawn on a specially designed form. An experienced endoscopist (R Malekzadeh) reviewed both the endoscopic reports and the captured images to confirm the exact site of the tumours. Biopsy specimens were oriented and spread on strips of filter paper and fixed immediately in 10% buffered formalin. The samples were sent to the DDRC, in Tehran, where they were embedded, sectioned and stained with haematoxylin and eosin and examined by experienced DDRC pathologists (M Sotoudeh and B Abedi).
The cancers were classified into four groups: oesophageal squamous cell carcinoma (ESCC), oesophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA) and gastric noncardia adenocarcinoma (GNCA). Adenocarcinomas of the stomach were classified as intestinal or diffuse type using Lauren's classification criteria (Lauren, 1965 ). Gastric cardia tumours were defined as adenocarcinoma with an estimated point of origin within 1 cm proximal or 3 cm distal of the oesophago-gastric junction.
The study was reviewed and approved by the Institutional Review Boards of the DDRC and the US National Cancer Institute.
Islami F., Kamangar F., Aghcheli K., Fahimi S., Semnani S., Taghavi N., Marjani H.A., Merat S., Nasseri-Moghaddam S., Pourshams A., Nouraie M., Khatibian M., Abedi B., Brazandeh M.H., Ghaziani R., Sotoudeh M., Dawsey S.M., Abnet C.C., Taylor P.R, & Malekzadeh R. (2004). Epidemiologic features of upper gastrointestinal tract cancers in Northeastern Iran. British Journal of Cancer, 90(7), 1402-1406.
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Publication 2004
Adenocarcinoma Adenocarcinoma Of Esophagus Antral Barrett Esophagus Biopsy Cardia Duodenum Endoscopes Endoscopy Endoscopy, Gastrointestinal Eosin Esophageal Cancer Esophageal Squamous Cell Carcinoma Esophagus Ethics Committees, Research Formalin Gastrointestinal Cancer General Practitioners Human Body Intestines Lidocaine Malignant Neoplasms Midazolam Neoplasms Neoplasms by Site Operative Surgical Procedures Pathologists Patients Pharynx Physical Examination Physicians Premedication Specialists Stomach Stomach Neoplasms Strains Tissues
5
SARS-CoV-2 Infection in Syrian Hamsters
Syrian hamsters (male, 4 weeks old) were purchased from Japan SLC and divided into groups by simple randomization. Baseline body weights were measured before infection. For the virus infection experiments, hamsters were anaesthetized by intramuscular injection of a mixture of 0.15 mg kg−1 medetomidine hydrochloride (Domitor, Nippon Zenyaku Kogyo), 2.0 mg kg−1 midazolam (Dormicum, FUJIFILM Wako Chemicals) and 2.5 mg kg−1 butorphanol (Vetorphale, Meiji Seika Pharma). The B.1.1 virus, Delta, Omicron (10,000 TCID50 in 100 µl) or saline (100 µl) were intranasally inoculated under anaesthesia. Oral swabs were daily collected under anaesthesia with isoflurane (Sumitomo Dainippon Pharma). Body weight, enhanced pause (Penh, see below), the ratio of time to peak expiratory follow relative to the total expiratory time (Rpef, see below) and subcutaneous oxygen saturation (SpO2, see below) were monitored at 1, 3, 5, 7, 10, and 15 d.p.i. Respiratory organs were anatomically collected at 1, 3, 5 and 7 d.p.i. (for lung) or 1, 3 and 7 d.p.i. (for trachea). Viral RNA load in the oral swabs and respiratory tissues was determined by RT–qPCR. Viral titres in the lung hilum were determined by TCID50. These tissues were also used for histopathological and IHC analyses (see below). No method of randomization was used to determine how the animals were allocated to the experimental groups and processed in this study because covariates (sex and age) were identical. The number of investigators was limited, as most of experiments were performed in high-containment laboratories. Therefore, blinding was not carried out.
Suzuki R., Yamasoba D., Kimura I., Wang L., Kishimoto M., Ito J., Morioka Y., Nao N., Nasser H., Uriu K., Kosugi Y., Tsuda M., Orba Y., Sasaki M., Shimizu R., Kawabata R., Yoshimatsu K., Asakura H., Nagashima M., Sadamasu K., Yoshimura K., Sawa H., Ikeda T., Irie T., Matsuno K., Tanaka S., Fukuhara T, & Sato K. (2022). Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant. Nature, 603(7902), 700-705.
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Publication 2022
Anesthesia Animals Body Weight Butorphanol Dormicum Exhaling Hamsters Herpesvirus 1, Cercopithecine Infection Intramuscular Injection Isoflurane Lung Males Medetomidine Hydrochloride Mesocricetus auratus Midazolam Oxygen Saturation Pneumonia, Viral Respiratory Rate Saline Solution Saturation of Peripheral Oxygen Tissues Trachea Virus Diseases

Most recents protocols related to «Midazolam»

1
Midazolam Powder Formulation Pharmacokinetics
Not available on PMC !

Example 7

Midazolam powder preparations were prepared by blending midazolam spray-dried with MCC and HPMC, and additional MCC. The midazolam powder formulation, midazolam liquid suspension and a midazolam powder formulation in a crystal form will be dosed to monkeys. Plasma midazolam concentrations and the corresponding pharmacokinetic parameters for each preparation will be determined.

US11872314B2. Pharmaceutical compositions (2024-01-16). Shin Nippon Biomedical Laboratories, Ltd. [JP]. Inventors: Shunji Haruta [JP].
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Patent 2024
Midazolam Monkeys Plasma Powder
2
Surgical Techniques for Eyelid Skin Cancer Removal
Anesthesiologists used neuroleptic sedation for each patient with a combination of ketamine, midazolam, fentanyl and propofol. The surgeon used loupes with a 3.3X magnification and a headlight. The tumour was assessed, measured (Figure 1A), and marked with standard four millimetre surgical margins for BCC and seven millimeter surgical margins for melanoma in situ (MIS). The width of the excised area was documented. The donor tissue width was estimated and marked (Figure 1B). The donor lid was then stretched horizontally, ensuring that the secondary defect could undergo direct closure. One drop of topical anesthesia was placed in each eye and the operative site was prepared with controlled use of chlorhexidine to limit the risk of corneal toxicity. The surgeon performed subcutaneous infiltration of the tumor and donor sites using lidocaine 2% with epinephrine 1:100,000; 2 ml or less per eyelid. All tissue was handled with 0.5 mm toothed forceps to preserve its architecture and integrity.
McDonald H.M., McDonald K.A, & McDonald H. (2023). The free bilamellar autograft (FBA) procedure: A comprehensive case series of an alternative surgical approach to reconstruction of large eyelid defects. Frontiers in Surgery, 10, 1038952.
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Publication 2023
Anesthesiologist Antipsychotic Agents Chlorhexidine Cornea Epinephrine Eyelids Fentanyl Forceps Ketamine Lidocaine Melanoma Midazolam Neoplasms Patients Propofol Sedatives Surgeons Surgical Margins Tissue Donors Tissues Topical Anesthetics
3
Animal Model for Behavioral Studies
Male C57Bl/6N mice purchased from SLC (Shizuoka, Japan) were maintained in a temperature- and humidity-controlled room with a 12-h light/dark cycle and free access to food and water. Animals associated with tissue or cell sampling were euthanized by cervical dislocation after intraperitoneal injection of an anesthetic mixture consisting of medetomidine (0.3 mg/kg, Meiji Seika Pharma, Tokyo, Japan), midazolam (4 mg/kg; Sandoz, Tokyo, Japan), and butorphanol (5 mg/kg, Meiji Seika Pharma); VPA was purchased from Sigma-Aldrich (St. Louis, MO, USA). All animal care and experimental procedures complied with the regulations for animal experiments and related activities of the Tohoku University. This study was approved by the Tohoku University Institutional Animal Care and Use Committee. This study was conducted in accordance with the ARRIVE guidelines.
Sakai K., Hara K, & Tanemura K. (2023). Testicular histone hyperacetylation in mice by valproic acid administration affects the next generation by changes in sperm DNA methylation. PLOS ONE, 18(3), e0282898.
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Publication 2023
Anesthetics Animals Butorphanol Cells Food Humidity Injections, Intraperitoneal Institutional Animal Care and Use Committees Joint Dislocations Males Medetomidine Mice, Inbred C57BL Midazolam Neck Tissues
4
Standardized Anesthesia and Multimodal Analgesia Protocols
In Yuan et al study,[29 (link)] patients received standardized general anesthesia and basic analgesic protocol. Intraoperatively, all patients received general anesthesia which was induced by sufentanil 0.5 μg/kg, midazolam 0.04 mg/kg, propofol 1 to 2 mg/kg, and Cisatracurium 2 μg/kg intravenously, followed by continuous intravenous infusion of remifentanil 0.1 to 0.3 μg/(kg·min), propofol 2 to 5 mg/(kg·hr) and inhalation of sevoflurane to maintain anesthesia. Since postoperative day 1, the protocol of oral celecoxib restarted till postoperative 3 weeks when the patients came back to the hospital for taking out the stitches. In Yadeau et al 2016 study,[6 (link)] patients received a standardized anesthetic and multimodal analgesic protocol. In Yadeau et al 2022 study,[28 (link)] patients received a standard intraoperative and postoperative multimodal anesthetic protocol: a spinal-epidural (subarachnoid mepivacaine, 45–60 mg); adductor canal block (ultrasound-guided; 15 cc bupivacaine, 0.25%, with 2 mg preservative-free dexamethasone). For postoperative pain management, patients were scheduled to receive the study medication once daily for 14 days; 4 doses of 1000 mg IV acetaminophen every 6 hours followed by 1000 mg oral acetaminophen every 8 hours; 4 doses of 15 mg IV ketorolac followed by 15 mg meloxicam every 24 hours; and 5 to 10 mg oral oxycodone was given as needed for pain. Patients could have pain medications adjusted as indicated. In Koh et al study,[12 (link)] all patients had a postoperative intravenous patient-controlled anesthesia (PCA) pump that administered 1 mL of a 100-mL mixture containing 2000 mg of fentanyl on demand. In Kim et al study,[27 ] all patients received intravenous PCA encompassing delivery of 1 mL of a 100 mL solution containing 2000 µg of fentanyl postoperatively. In Ho et al study,[26 (link)] patients were routinely offered a single shot spinal anesthesia consisting of an intrathecal dose of bupivacaine 10 to 12.5 mg with fentanyl 10 mg. After surgery, pain treatment consisted of PCA with intravenous injection of morphine. The settings were 1 mg bolus, 5 minutes lockout time, and a maximum hourly limit of 8 mg. All patients were also given acetaminophen 1 g 6 hourly.
Zhang L.K., Li Q., Fang Y.F, & Qi J.W. (2023). Effect of duloxetine on pain relief after total knee arthroplasty: A meta-analysis of randomized controlled trials. Medicine, 102(10), e33101.
Publication 2023
Acetaminophen Analgesics Anesthesia Anesthesia, Intravenous Anesthetics Bupivacaine Cardiac Arrest Celecoxib cisatracurium Dexamethasone Fentanyl General Anesthesia Inhalation Intravenous Infusion Ketorolac Management, Pain Meloxicam Mepivacaine Midazolam Morphine Multimodal Imaging Obstetric Delivery Operative Surgical Procedures Oxycodone Pain Pain, Postoperative Patients Pharmaceutical Preparations Pharmaceutical Preservatives Propofol Pulp Canals Remifentanil Sevoflurane Spinal Anesthesia Subarachnoid Space Sufentanil Ultrasonography
5
Cardiac Anesthesia Management Protocol
The patients received their usual cardiac medications in the early morning on the day of surgery. Upon arriving OR, the patients were premedicated with midazolam 0.02 mg/kg and fentanyl 1 mcg/kg. A five-lead EKG, pulse oximetry, and noninvasive blood pressure monitoring were initiated. Then, we inserted a catheter into the radial artery under local anesthesia for invasive blood pressure monitoring. General anesthesia induction consisted of fentanyl 5–10 mcg/kg, midazolam 0.2–0.4 mg/kg, and pancuronium 0.1–0.15 mg/kg. Additionally, propofol 0.5–1 mg/kg was administered as appropriate. After intubation, we inserted a right internal jugular multilumen central venous catheter. Maintenance of anesthesia was with sevoflurane 1%–2%, adjusted by clinical conditions and pancuronium as needed.
Sindhvananda W., Poopuangpairoj W., Jaiprasat T, & Ongcharit P. (2023). Comparison of Glucose Control by Added Liraglutide to Only Insulin Infusion in Diabetic Patient Undergoing Cardiac Surgery: A Preliminary Randomized-Controlled Trial. Annals of Cardiac Anaesthesia, 26(1), 63-71.
Publication 2023
Anesthesia Arteries, Radial Blood Pressure Catheters Fentanyl General Anesthesia Heart Intubation Local Anesthesia Midazolam Oximetry, Pulse Pancuronium Patients Pharmaceutical Preparations Propofol Sevoflurane Surgery, Day Training Programs Venous Catheter, Central

Top products related to «Midazolam»

1
Midazolam by Sandoz
Sourced in Japan, Finland, Canada
Midazolam is a laboratory equipment product manufactured by Sandoz. It is a short-acting benzodiazepine used for various medical purposes, including as a sedative, anxiolytic, and anticonvulsant agent. The core function of Midazolam is to provide a controlled and reliable source of this pharmaceutical compound for use in research, clinical trials, and other scientific applications.
2
Butorphanol by Meiji Seika Pharma
Sourced in Japan, Switzerland
Butorphanol is a synthetic opioid analgesic used as a laboratory reagent. It is a derivative of the naturally occurring alkaloid morphine and is classified as a mixed agonist-antagonist opioid. Butorphanol has analgesic and sedative properties, and is commonly used in research settings involving pain management and drug development studies.
3
Midazolam by Roche
Sourced in Switzerland, Germany, Denmark, United States, United Kingdom, Belgium, Finland
Midazolam is a benzodiazepine compound used as a sedative and hypnotic in medical and clinical settings. It is commonly used for the induction and maintenance of anesthesia, as well as for the management of certain types of seizures. Midazolam primarily functions as a short-acting central nervous system depressant, exhibiting anxiolytic, amnestic, hypnotic, anticonvulsant, and muscle relaxant properties.
4
Butorphanol tartrate by Meiji Seika Pharma
Sourced in Japan, Finland
Butorphanol tartrate is a synthetic opioid analgesic used as a pharmaceutical ingredient. It functions as a mu-opioid receptor agonist and kappa-opioid receptor agonist.
5
Midazolam by Merck Group
Sourced in United States, China, Germany, United Kingdom, Australia
Midazolam is a benzodiazepine drug used as a sedative and hypnotic. It has a short half-life and is primarily used for the induction of anesthesia, procedural sedation, and the treatment of seizures.
6
Vetorphale by Meiji Seika Pharma
Sourced in Japan
Vetorphale is a laboratory equipment designed for the separation and analysis of peptides and proteins. It utilizes a specialized chromatography technique to isolate and purify these biomolecules from complex samples. The core function of Vetorphale is to provide researchers and scientists with a reliable and efficient tool for the study of peptides and proteins, which are essential components in various biological and pharmaceutical applications.
7
Dormicum by Roche
Sourced in Switzerland, Belgium, United Kingdom, Germany, France, Japan, Sweden, United States, Turkiye
Dormicum is a drug used as a sedative and anesthetic in various medical procedures. It contains the active ingredient midazolam, which is a benzodiazepine medication. Dormicum is administered intravenously or intramuscularly by healthcare professionals to induce sedation or anesthesia.
8
Midazolam by Astellas Pharma
Sourced in Japan
Midazolam is a benzodiazepine medication that is used as a sedative and anesthetic. It has a rapid onset of action and a relatively short duration of effect. Midazolam is primarily used in medical settings, such as for procedural sedation, induction of anesthesia, and the treatment of certain types of seizures.
9
Phenacetin by Merck Group
Sourced in United States, China, Germany, United Kingdom, Poland
Phenacetin is a chemical compound used in the manufacturing of various pharmaceutical and laboratory products. It serves as a key ingredient in the production process. Phenacetin has specific functional properties that make it a valuable component in relevant applications, but a detailed description of its core function is beyond the scope of this response.
10
Medetomidine by Nippon Zenyaku Kogyo
Sourced in Japan
Medetomidine is a synthetic chemical compound used as a sedative and analgesic agent for laboratory animals. It acts as an alpha-2 adrenergic receptor agonist, providing a reversible state of unconsciousness and pain relief in research subjects.

More about "Midazolam"

Midazolam is a short-acting benzodiazepine medication with a wide range of clinical applications.
It is commonly used for sedation, anesthesia induction, and the treatment of certain types of seizures.
Midazolam possesses anxiolytic, amnestic, hypnotic, anticonvulsant, and muscle relaxant properties, making it a versatile pharmacological agent.
This benzodiazepine is typically administered through intravenous, intramuscular, or nasal spray routes, depending on the specific clinical needs.
It is important to closely monitor patients receiving midazolam due to the risk of respiratory depression and other potential adverse effects.
Researchers can optimize their midazolam studies by utilizing the advanced analytical tools provided by PubCompare.ai.
These AI-driven tools enable the identification and comparison of protocols from published literature, preprints, and patents, allowing researchers to identify the most effective and reproducible approaches for their midazolam-related investigations.
In addition to midazolam, related medications such as butorphanol, butorphanol tartrate, vetorphale, dormicum, phenacetin, and medetomidine may also be of interest to researchers exploring sedation, anesthesia, and pain management therapies.
By incorporating insights from these related pharmacological agents, researchers can gain a more comprehensive understanding of the field and develop more effective and safer treatment strategies.
It's important to note that while midazolam is a widely used medication, it should be administered with caution and under the close supervision of healthcare professionals to ensure patient safety and optimal therapeutic outcomes.
Researchers and clinicians should familiarize themselves with the latest guidelines and best practices for the use of midazolam and related pharmacotherapies.