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Nifedipine

Nifedipine is a calcium channel blocker used to treat high blood pressure and angina.
It works by relaxing blood vessels and reducing the workload on the heart.
Nifedipine is commonly prescribed to manage cardiovacular conditions, and researchers are exploring its potential applications in other areas.
PubCompare.ai can help optimize Nifedipine research by identifying the most reproducilbe and effective protocols from scientific literature, preprints, and patents.
Leverage AI-powered protocol comparison to streamline your Nifedipine studies and achieve more reliable results.

Most cited protocols related to «Nifedipine»

1
In Vivo Whole-Cell Recordings and Pharmacological Manipulations
Cited 12 times
During an initial surgical step, a stainless steel headplate was affixed to the skull. A small (~ 200 μm) craniotomy was made over HVC. Whole-cell recordings were made with glass electrodes (5–8 MΩ) using techniques described elsewhere 46 (link). Signals were measured using an Axoclamp 2B (Molecular Devices). In some experiments, an injection pipette (20–30 μm opening) was positioned less than 100 μm from the recording site for the injection (Nanoject II, Drummond Scientific) of a small volume (5–20 nL) of 100μM (+/−)BAY K 8644 (A.G. Scientific) or 100μM Nifedipine (Sigma).
Long M.A., Jin D.Z, & Fee M.S. (2010). Support for a synaptic chain model of neuronal sequence generation. Nature, 468(7322), 394-399.
Publication 2010
Bay-K-8644 Craniotomy Cranium Medical Devices Nifedipine Operative Surgical Procedures Stainless Steel
2
In Vivo Whole-Cell Recordings and Pharmacological Manipulations
Cited 12 times
During an initial surgical step, a stainless steel headplate was affixed to the skull. A small (~ 200 μm) craniotomy was made over HVC. Whole-cell recordings were made with glass electrodes (5–8 MΩ) using techniques described elsewhere 46 (link). Signals were measured using an Axoclamp 2B (Molecular Devices). In some experiments, an injection pipette (20–30 μm opening) was positioned less than 100 μm from the recording site for the injection (Nanoject II, Drummond Scientific) of a small volume (5–20 nL) of 100μM (+/−)BAY K 8644 (A.G. Scientific) or 100μM Nifedipine (Sigma).
Long M.A., Jin D.Z, & Fee M.S. (2010). Support for a synaptic chain model of neuronal sequence generation. Nature, 468(7322), 394-399.
Publication 2010
Bay-K-8644 Craniotomy Cranium Medical Devices Nifedipine Operative Surgical Procedures Stainless Steel
3
Evaluating Osteoarthritis Functional Outcomes
Cited 9 times
The Lequesne questionnaire [11 (link)] was modified to incorporate the patient’s weight and height. The Lequesne score is a standardized questionnaire focused on osteoarthritis. It is a 24-scale questionary in which low scores indicate low functional activity (Table 1).

Lequesne score

DrugsTreated patients (mean score)Number of patientsSDpvalue
Adalat® (Nifedipine)4.0530
Amlodipine® (Amlodipine)3.5222.970
Azupamil® (Verapamil)683.590
Carmen® (Lercanidipine)3212.910
Escor® (Nilvadipine)654.720
Felodipine® (Felodipine)574.10
Nifedipine® (Nifedipine)6.2155.210
Nitrendipine® (Nitrendipin)2.182.80
Norvasc® (Amlodipine)4.84850
Verapamil® (Verapamil)6.94950
Control group6.22124.850

SD standard deviation.

It was answered by 400 patients with osteoarthritis (207 women and 193 men). More than 99% of the patients were older than 50 years. Both the control and the active treatment groups have been diagnosed for osteoarthritis for more than 1 year before and the active treatment group has received calcium antagonists for more than 1 year.
Pre-study calculations revealed that 198 patients for each group were required to arrive at a statistical significance of p < 0.05 and a power of 80% for a difference in one unit in the Lequesne score. Matched pairs were established for potential interference variables such as gender, age, and body mass index. The first evaluations of equivalences were performed stepwise with 100, 200, 300, and 400 patients. Finally, a complete equivalence could not be achieved for gender (55% women in the active treatment group and 45% women in the control group) and body mass index (76.27 ± 9.1 kg in the control group).
The Lequesne score correlates significantly with pain and consists of three subscores which were calculated individually and together: pain and discomfort, maximum distance walked, and activities of daily living with a maximum score of 8 for each subscore and a total score of 24 (see Additional file 1). A difference in one score unit is regarded as clinically relevant. The groups were evaluated by the Levene test for equality of variance and by the T-test for equality of the mean.
Daniilidis K., Georges P., Tibesku C.O, & Prehm P. (2015). Positive side effects of Ca antagonists for osteoarthritic joints—results of an in vivo pilot study. Journal of Orthopaedic Surgery and Research, 10, 1.
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Publication 2015
Amlodipine Calcium Channel Blockers Degenerative Arthritides Felodipine Gender Index, Body Mass lercanidipine Nifedipine nilvadipine Pain Patients Verapamil Woman
4
Electrophysiological Characterization of Dissociated DRG Neurons
Cited 8 times
Recordings were obtained from acutely dissociated DRG neurons as described previously.12 (link) To isolate calcium currents, Na+ and K+ currents were blocked with 1 μM tetrodotoxin (TTX; Alomone Laboratories, Jerusalem, Israel) and 30 mM tetraethylammonium chloride (TEA-Cl; Sigma). Extracellular recording solution (at ~315 mOsm) consisted of the following (in mM): 110 N-methyl-d-glucamine (NMDG), 10 BaCl2, 30 TEA-Cl, 10 HEPES, 10 glucose, 0.001 TTX, 0.005 nifedipine, 0.0005 ω-conotoxin GVIA, and 0.0002 ω-agatoxin IVA. The intracellular recording solution (at ~305 mOsm) consisted of the following (in mM): contained 150 CsCl2, 10 HEPES, 5 Mg-ATP, 5 BAPTA, pH at 7.2 with KOH. The internal solution for recording Na+ currents contained the following (in mM): 110 CsCl, 5 MgSO4, 10 EGTA, 4 ATPNa2, and 25 HEPES (pH 7.2, 290–310 mOsm/L). For recording Na+ currents, the external solution contained the following (in mM): 100 NaCl, 10 tetraethylammonium chloride (TEA-Cl), 1 CaCl2, 1 CdCl2, 1 MgCl2, 10 d-glucose, 44-AP, 0.1 NiCl2, 10 HEPES (pH 7.3, 310–315 mOsm/L).
For current clamp recordings, the extracellular recording solution (at ~305 mOsm; pH 7.2) consisted of the following (in mM): 154 NaCl, 5.6 KCl, 2 CaCl2, 2.0 MgCl2, 1.0 Glucose, and 10 HEPES pH 8.0. The intracellular recording solution (at ~295 mOsm) consisted of the following (in mM): 140 KCl, 10 NaCl, 1 MgCl2, 1 EGTA, 10 HEPES (pH 7.2), and 1 ATP-Mg. To assess excitability, DRG neurons were held at their resting potentials (range, −40 to −62 mV), and a step of depolarizing current (1 second in duration) was applied to the neuron wherein the amplitude of the step was adjusted to produce 5 or more action potentials (APs) under control conditions. The stimulation amplitude (2 to 4 times the rheobase) then remained constant throughout the recording period for each individual neuron.25 (link)Fire-polished recording pipettes, 2 to 5 MΩ resistances were used for all recordings. Whole-cell recordings were obtained with a HEKA EPC-10 USB (HEKA Instruments Inc., Lambrecht/Pfalz, Germany); data were acquired with a Patchmaster (HEKA) and analyzed with a Fitmaster (HEKA). Capacitive artifacts were fully compensated, and series resistance was compensated by ~70%. Recordings made from cells with greater than a 5 mV shift in series resistance compensation error were excluded from analysis. All experiments were performed at room temperature (~23°C). The currents were filtered at 5 kHz and sampled at 2 kHz using a Patchmaster (HEKA).
François-Moutal L., Wang Y., Moutal A., Cottier K.E., Melemedjian O.K., Yang X., Wang Y., Ju W., Largent-Milnes T.M., Khanna M., Vanderah T.W, & Khanna R. (2015). A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Pain, 156(7), 1247-1264.
Publication 2015
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid Action Potentials ARID1A protein, human barium chloride Calcium Cells cesium chloride Chloride, Cadmium Egtazic Acid Glucose HEPES Magnesium Chloride Neurons Nifedipine omega-Conotoxin GVIA Protoplasm Resting Potentials Sodium Chloride Sulfate, Magnesium Tetraethylammonium Chloride Training Programs
5
Sodium Current Measurement in Myocytes
Cited 8 times
Ruptured-patch whole-cell voltage-clamp was used to measure INa as described previously [24 (link), 26 (link)]. Microelectrodes (2–3 MΩ) were filled with (mmol/L) 40 CsCl, 80 Cs-glutamate, 10 NaCl, 0.92 MgCl2, 5 Mg-ATP, 0.3 Li-GTP, 10 HEPES, 0.03 niflumic acid, 0.02 nifedipine, 0.004 strophanthidin, 5 BAPTA (tetracesium salt), 1 5,5′-dibromo BAPTA (tetrapotassium salt), 1.49 CaCl2 (free [Ca2+]i = 100 nmol/L; pH 7.2, CsOH). The bath solution contained (mmol/L) 130 NaCl, 10 tetraethylammonium chloride, 4 CsCl, 1 MgCl2, 10 glucose, 10 HEPES, (pH 7.4, NaOH). Myocytes were mounted on the stage of a microscope (Nikon Eclipse TE2000-U, Düsseldorf, Germany). Fast capacitance which is generated largely by the pipette itself was compensated in cell-attached configuration. Liquid junction potentials (3–6 mV) were corrected. Membrane capacitance was compensated after patch rupture, access resistance was typically <7 MΩ. All recordings were started 5 min after rupture. Signals were filtered with 2.9 and 10 kHz Bessel filters and recorded with an EPC10 amplifier (HEKA Elektronik Dr. Schulze GmbH, Lambrecht/Pfalz, Germany). Myocytes were held at −120 mV and late INa was elicited using 250 ms depolarizing pulses to −30 mV. Each pulse was preceded by a 5 ms pre-pulse to +50 mV in order to optimize voltage control. The measured currents were normalized to the membrane capacitance. INa decay (first 200 ms) was fitted using a double exponential function y(t) = A1 exp (–t/τ1) + A2 exp (–t/τ2) + y0. All patch-clamp experiments were conducted at room temperature.
Sossalla S., Maurer U., Schotola H., Hartmann N., Didié M., Zimmermann W.H., Jacobshagen C., Wagner S, & Maier L.S. (2010). Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIδC can be reversed by inhibition of late Na+ current. Basic Research in Cardiology, 106(2), 263-272.
Publication 2010
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 5,5'-dibromo-1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid ARID1A protein, human Bath Cells cesium chloride Glucose Glutamate HEPES Magnesium Chloride Microelectrodes Microscopy Muscle Cells Nifedipine Niflumic Acid Pulse Rate Pulses Sodium Chloride Strophanthidin Tetraethylammonium Chloride Tissue, Membrane

Most recents protocols related to «Nifedipine»

1
ATP Regulation of FGF21 in Muscle
To determine the effect of ATP (Adenosine 5′-triphosphate, Sigma-Aldrich Corp, St. Louis, MO, USA) on either FGF21 protein or mRNA levels, isolated fiber cultures or FDB muscles were previously serum-starved for 2 h (DMEM culture medium without horse serum). Subsequently, muscles were stimulated with exogenous ATP at selected concentrations (0.1-100 µM), for different times (30-360 min). When blockers or inhibitors were used, they were incubated 30 min before and during the stimulation with ATP. Evaluation of changes in mRNA and protein levels in response to ATP was performed in the presence of 100 μM Suramin (Sigma-Aldrich Corp, St. Louis, MO, USA), 25 μM Nifedipine (Sigma-Aldrich Corp, St. Louis, MO, USA), 100 nM Rapamycin (Sigma-Aldrich Corp, St. Louis, MO, USA), 50 μM LY294002 (Cell Signaling Technology, Danvers, MA, EEUU), 10 μM Akt VIII (Sigma-Aldrich Corp, St. Louis, MO, USA) 30 μM Cycloheximide (Sigma-Aldrich Corp, St. Louis, MO, USA) or 0.5 μM actinomycin-D (Sigma-Aldrich Corp, St. Louis, MO, USA).
Arias-Calderón M., Casas M., Balanta-Melo J., Morales-Jiménez C., Hernández N., Llanos P., Jaimovich E, & Buvinic S. (2023). Fibroblast growth factor 21 is expressed and secreted from skeletal muscle following electrical stimulation via extracellular ATP activation of the PI3K/Akt/mTOR signaling pathway. Frontiers in Endocrinology, 14, 1059020.
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Publication 2023
Adenosine Triphosphate Culture Media Cycloheximide Dactinomycin Equus caballus fibroblast growth factor 21 Fibrosis inhibitors LY 294002 Muscle Tissue Nifedipine Proteins RNA, Messenger Serum Sirolimus Suramin
2
Factors Influencing Bepridil Plasma Concentrations
The collection time of the plasma sample included data from before administration of bepridil to up to 6 h after administration. To assess risk factors for achieving plasma bepridil concentrations ≥800 ng/mL at steady state, the eligible patients were divided into two groups based on their bepridil concentrations: ≥800 ng/mL and < 800 ng/mL.
The C/D ratio was calculated using the following equation:
C/D ratio of bepridil = plasma concentration of bepridil (ng/mL) / dose of bepridil (mg/day/kg body weight).
In this study, we defined the polypharmacy group as those who use six or more drugs, whereas the non-polypharmacy group was those who took fewer than six drugs. The relationship between plasma bepridil concentrations ≥800 ng/mL and baseline characteristics, including sex, age, height, body weight, body mass index, serum creatinine, creatinine clearance (Ccr), number of concomitant drugs used, typical inducers of CYPs (phenytoin, carbamazepine, phenobarbital, and rifampicin) [15 (link)], typical inhibitors of CYPs (erythromycin, clarithromycin, protease inhibitors, and azole antifungals) [15 (link)], aprindine, a competitive inhibitor of CYP2D6 [12 (link)], typical inhibitor of P-gp (amiodarone, diltiazem, nicardipine, nifedipine, propranolol, quinidine, cyclosporin, and tacrolimus) [16 (link)–18 (link)], and left ventricular ejection fraction (LVEF), were examined. LVEF was measured using echocardiographic equipment provided at each hospital. Ccr was estimated using the Cockcroft–Gault formula [19 (link)].
The patient’s medical history and duration of bepridil treatment were collected from medical records.
Asai Y., Arihara H., Omote S., Tanio E., Yamashita S., Higuchi T., Hashimoto E., Yamada M., Tsuji H., Kondo Y., Hayashi M, & Yamamoto Y. (2023). Effect of polypharmacy on plasma bepridil concentration in patients with heart failure: a multicenter retrospective study. Journal of Pharmaceutical Health Care and Sciences, 9, 10.
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Publication 2023
Amiodarone Antifungal Agents Aprindine Azoles Bepridil Body Weight Carbamazepine Clarithromycin Creatinine Cyclosporine Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P450 Diltiazem Echocardiography Erythromycin Index, Body Mass inhibitors Nicardipine Nifedipine Patients Pharmaceutical Preparations Phenobarbital Phenytoin Plasma Polypharmacy Propranolol Protease Inhibitors Quinidine Rifampin Serum Specimen Collection Tacrolimus Ventricular Ejection Fraction
3
Calcium Imaging in Chromaffin Cells

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Publication 2023
Calcium Calcium Channel Blockers Cells Chromaffin Cells Fluo 4 Fluorescence Glucose HEPES Light Magnesium Chloride Microscopy Nifedipine Orcinus orca Proteins Protoplasm scorpion toxin I'' Sodium Chloride Synapsin I Toxins, Biological
4
Venom Screening for Ion Channel Activity
Venom fractions were screened for neuroactivity at human (h) NaV, CaV1, CaV2 and the α7 subtype of the human nicotinic acetylcholine receptor (nAChR-α7) as previously described (Cardoso et al., 2015 (link)). Briefly, SH-SY5Y cells were plated at 40,000 cells per well in 384-well flat clear-bottom black plates (Corning, NY, United States) and cultured at 37°C in a humidified 5% CO2 incubator for 48 h. Cells were loaded with 20 μL per well Calcium 4 dye (Molecular Devices) reconstituted in assay buffer containing (in mM) 140 NaCl, 11.5 glucose, 5.9 KCl, 1.4 MgCl2, 1.2 NaH2PO4, 5 NaHCO3, 1.8 CaCl2 and 10 HEPES pH 7.4 and incubated for 30 min at 37°C in a humidified 5% CO2 incubator. For the hCaV1 assay, the dye was supplemented with 1 μM ω-conotoxin-CVIF (CVIF) to inhibit CaV2, and in the hCav2 assay the dye was supplemented with 10 μM nifedipine to inhibit CaV1. For the nAChR-α7 assay, the dye was supplemented with PNU-120596 (Sigma-Aldrich), a positive allosteric modulator of nAChR-α7. Venom fractions were assayed in singleton for each ion channel tested. Fluorescence responses were recorded using excitation at 470–495 nm and emission at 515–575 nm for 10 s to set the baseline, then 300 s after addition of 10% venom fraction serial diluted at 1, 1:10, and 1:100, and for a further 300 s after addition of 50 μM veratridine for hNaV, 90 mM KCl and 5 mM CaCl2 for hCaV, and 30 μM choline for nAChR-α7.
Cardoso F.C., Walker A.A., King G.F, & Gomez M.V. (2023). Holistic profiling of the venom from the Brazilian wandering spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomics. Frontiers in Molecular Biosciences, 10, 1069764.
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Publication 2023
Bicarbonate, Sodium Buffers Calcium Cardiac Arrest CAV1 protein, human CAV2 protein, human Cells Choline Fluorescence Glucose HEPES Homo sapiens Ion Channel Magnesium Chloride Medical Devices Nicotinic Receptors Nifedipine omega-Conotoxins PNU 120596 Sodium Chloride Venoms Veratridine
5
Vasodilator Pharmacology Protocols
(R)-(-)-Phenylephrine hydrochloride, prazosin hydrochloride, nifedipine, chelerythrine, and cromakalim were purchased from Sigma-Aldrich (St. Louis, MO, USA), propranolol hydrochloride, and amphotericin B were purchased from FUJIFILM Wako Pure Chemical Corporation (Osaka, Japan). nifedipine, prazosin, chelerythrine, and cromakalim were dissolved in dimethyl sulfoxide. Small aliquots were added to the extracellular solution to obtain the desired final concentration. The other chemicals were dissolved in distilled water. All other chemicals were commercial products of the highest available quality.
Hamaguchi S., Morinou I., Shiseki Y., Mikami A., Seki M., Namekata I, & Tanaka H. (2023). Mechanisms for the α-Adrenoceptor-Mediated Positive Inotropy in Mouse Ventricular Myocardium: Enhancing Effect of Action Potential Prolongation. International Journal of Molecular Sciences, 24(4), 3926.
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Publication 2023
Amphotericin B chelerythrine Cromakalim Nifedipine Phenylephrine Phenylephrine Hydrochloride Prazosin Prazosin Hydrochloride Propranolol Hydrochloride Sulfoxide, Dimethyl

Top products related to «Nifedipine»

1
Nifedipine by Merck Group
Sourced in United States, Germany, United Kingdom, China, Sao Tome and Principe, France, Italy, Australia, Canada, Israel, Belgium, Sweden, Brazil, Spain, India
Nifedipine is a pharmaceutical compound used in the production of lab equipment. It is a calcium channel blocker that can be used to regulate the flow of calcium into cells. The core function of Nifedipine is to control and maintain the balance of calcium levels within a controlled environment.
2
Nifedipine by Bio-Techne
Sourced in United Kingdom, United States
Nifedipine is a calcium channel blocker laboratory product manufactured by Bio-Techne. It is used to inhibit the movement of calcium ions across cell membranes, a key process in various biological functions.
3
Dimethyl sulfoxide (dmso) by Merck Group
Sourced in United States, Germany, United Kingdom, China, Italy, Sao Tome and Principe, France, Macao, India, Canada, Switzerland, Japan, Australia, Spain, Poland, Belgium, Brazil, Czechia, Portugal, Austria, Denmark, Israel, Sweden, Ireland, Hungary, Mexico, Netherlands, Singapore, Indonesia, Slovakia, Cameroon, Norway, Thailand, Chile, Finland, Malaysia, Latvia, New Zealand, Hong Kong, Pakistan, Uruguay, Bangladesh
DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
4
Verapamil by Merck Group
Sourced in United States, Germany, France, United Kingdom, China, Japan, Spain, Italy, Sao Tome and Principe, Switzerland, Australia, Ireland, Belgium
Verapamil is a laboratory product manufactured by Merck Group. It is a calcium channel blocker that inhibits the movement of calcium ions through cell membranes, which can affect various physiological processes. The core function of Verapamil is to serve as a research tool for the study of calcium-dependent mechanisms in biological systems.
5
Fura 2 am by Thermo Fisher Scientific
Sourced in United States, United Kingdom, Germany, Italy, France, Spain, Australia, Japan, China, Canada, Belgium, Austria, Hungary, Macao
Fura-2 AM is a fluorescent calcium indicator used for measuring intracellular calcium levels. It is a cell-permeable derivative of the parent compound Fura-2. Fura-2 AM can be loaded into cells, where intracellular esterases cleave off the acetoxymethyl (AM) ester group, trapping the Fura-2 indicator inside the cell.
6
Fetal bovine serum (fbs) by Thermo Fisher Scientific
Sourced in United States, China, United Kingdom, Germany, Australia, Japan, Canada, Italy, France, Switzerland, New Zealand, Brazil, Belgium, India, Spain, Israel, Austria, Poland, Ireland, Sweden, Macao, Netherlands, Denmark, Cameroon, Singapore, Portugal, Argentina, Holy See (Vatican City State), Morocco, Uruguay, Mexico, Thailand, Sao Tome and Principe, Hungary, Panama, Hong Kong, Norway, United Arab Emirates, Czechia, Russian Federation, Chile, Moldova, Republic of, Gabon, Palestine, State of, Saudi Arabia, Senegal
Fetal Bovine Serum (FBS) is a cell culture supplement derived from the blood of bovine fetuses. FBS provides a source of proteins, growth factors, and other components that support the growth and maintenance of various cell types in in vitro cell culture applications.
7
Bovine serum albumin (bsa) by Merck Group
Sourced in United States, Germany, United Kingdom, China, Italy, Japan, France, Sao Tome and Principe, Canada, Macao, Spain, Switzerland, Australia, India, Israel, Belgium, Poland, Sweden, Denmark, Ireland, Hungary, Netherlands, Czechia, Brazil, Austria, Singapore, Portugal, Panama, Chile, Senegal, Morocco, Slovenia, New Zealand, Finland, Thailand, Uruguay, Argentina, Saudi Arabia, Romania, Greece, Mexico
Bovine serum albumin (BSA) is a common laboratory reagent derived from bovine blood plasma. It is a protein that serves as a stabilizer and blocking agent in various biochemical and immunological applications. BSA is widely used to maintain the activity and solubility of enzymes, proteins, and other biomolecules in experimental settings.
8
Ethylene glycol tetraacetic acid (egta) by Merck Group
Sourced in United States, Germany, United Kingdom, Italy, Macao, Sao Tome and Principe, France, China, Japan, Poland, Hungary, Canada, Ireland, Spain
EGTA is a chemical compound commonly used as a chelating agent in laboratory settings. It is capable of binding to metal ions, such as calcium, and is often utilized in experimental procedures to control the concentration of specific ions within a sample.
9
Fluo 4 am by Thermo Fisher Scientific
Sourced in United States, United Kingdom, Germany, Canada, China, France, Spain, Italy, Sweden, Japan, Switzerland, Belgium, Australia, Austria, Finland, New Zealand
Fluo-4 AM is a fluorescent calcium indicator used for the detection and measurement of intracellular calcium levels. It functions by binding to calcium ions, which results in an increase in fluorescence intensity. This product is commonly used in various cell-based assays and research applications involving calcium signaling.
10
Bay k8644 by Merck Group
Sourced in United States, Germany
Bay K8644 is a calcium channel activator. It functions by enhancing the activation of L-type calcium channels.

More about "Nifedipine"

Nifedipine is a calcium channel blocker, a class of drugs used to manage cardiovascular conditions like high blood pressure (hypertension) and angina.
It works by relaxing blood vessels, reducing the workload on the heart.
Nifedipine is commonly prescribed to treat these cardiovascular issues, but researchers are also exploring its potential applications in other areas.
DMSO (Dimethyl sulfoxide) and Verapamil are other calcium channel blockers that may be used in conjunction with or as alternatives to Nifedipine.
Fura-2 AM and Fluo-4 AM are fluorescent calcium indicators that can be used to study the effects of these calcium channel blockers on intracellular calcium levels.
FBS (Fetal Bovine Serum) and Bovine Serum Albumin are commonly used in cell culture media to provide nutrients and support cell growth.
EGTA is a chelating agent that can be used to control calcium levels in experimental settings.
Bay K8644 is a calcium channel agonist that can be used to study the effects of calcium channel modulation, providing a counterpoint to the actions of Nifedipine and other calcium channel blockers.
PubCompare.ai can help optimize Nifedipine research by identifying the most reproducible and effective protocols from scientific literature, preprints, and patents.
Leverage AI-powered protocol comparison to streamline your Nifedipine studies and achive more reliable results.