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Omeprazole

Omeprazole is a proton pump inhibitor medication used to treat acid-related disorders of the gastrointestinal tract, such as gastroesophageal reflux disease (GERD) and peptic ulcers.
It works by reducing the production of stomach acid, allowing the damaged esophageal or stomach lining to heal.
Omeprazole is a widely studied and clinically important drug, with research focusing on its pharmacokinetics, efficacy, and safety.
PubCompare.ai, an AI-driven platform, can enhance the reproducibility and accuracy of Omeprazole research by helping researchers easily locate protocols from literature, preprints, and patents, and leverage AI-driven comparisons to identify the best protocols and products.
This powerful tool can take your Omeprazole research to the nex tlevel.

Most cited protocols related to «Omeprazole»

A second set of analyses was conducted using the best-minus-worst scores (Marley and Louviere, 2005 ; Flynn, 2010a (link)). Within the OMEP design, each attribute level appeared on four occasions within the 16 scenarios. It could therefore have been picked as best up to four times and as worst up to four times for each person. These best-minus-worst scores are calculated for each attribute by determining the number of times that a person picked an attribute level (for example, ‘I am able to be completely independent’) as best and subtracting from that the number of times that they picked it as worst. Scores can therefore range from −4 (never picked as best and always picked as worst) to +4 (never picked as worst and always as best). Scores for respondents provide an immediate indication of which attribute levels they value. Figure 1 gives an example of the scores for one individual.
It is important to adjust for heterogeneity in both preference and variance scale at the level of individual respondents (Louviere et al., 2000 ; Swait and Adamowicz, 2001 ; Louviere et al., 2002 ; Fiebig et al., 2010 ). Variance scale is concerned with how consistent individuals are in making their choices: some individuals are more consistent and others are less so. If this is not adjusted for, people may be thought to have different preferences where, in fact, their preferences are similar but they are just less consistent in making them. Although this makes the analysis considerably more complex, it is vital in estimating a set of population values (Flynn et al., 2010 (link)), because not accounting for this sort of heterogeneity leads to bias in the mean estimates obtained from limited dependent variable (such as probit and logit) models (Yatchew and Griliches, 1985 ). A series of cluster analyses based on functions of the best-minus-worst scores was conducted, with further details provided in Appendix 2 (Supporting Information). These did not provide the final capability scores but were essential in ensuring that the main scale-adjusted latent class analyses (SALCs) did not give spurious solutions, such as finishing at a local maximum of the likelihood function.
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Publication 2013
Genetic Heterogeneity Omeprazole

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Publication 2012
Animals, Laboratory Antibiotics Biological Assay Cre recombinase Deletion Mutation Enzyme-Linked Immunosorbent Assay Exons Gastrin Genes Helicobacter pylori hen egg lysozyme Histological Techniques Homozygote Institutional Animal Care and Use Committees Mice, Knockout Mice, Laboratory Mice, Transgenic Minor Lymphocyte Stimulatory Loci Myeloid Progenitor Cells Oligonucleotide Primers Omeprazole Parietal Cells, Gastric Polymerase Chain Reaction Radioimmunoassay Real-Time Polymerase Chain Reaction Transgenes Western Blot

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Publication 2011
Cells Cytochrome P-450 CYP1A1 DNA, Complementary Enzymes Genes Hyperoxia Oligonucleotide Primers Omeprazole Real-Time Polymerase Chain Reaction RNA, Messenger RNA-Directed DNA Polymerase Sulfoxide, Dimethyl SYBR Green I
Six individuals were included in this study: three control patients (A, B, and C), hereafter referred to as controls, with diagnosed dyspeptic disorders who did not receive any treatment and three patients (D, E, and F) that had either a gastric or duodenal ulcer and were treated twice a day for seven days with metronidazole 400 mg, clarithromycin 250 mg, and omeprazole 20 mg (Supplementary Table S6 for subject info). None of the patients had received any antibiotic treatment within four weeks prior to the start of the study and during the four-year course of the study no other antimicrobial treatment was allowed. The patients did not receive any diet restrictions or recommendations before inclusion into the study. A throat swab and a fecal sample were collected from each subject one day before treatment, immediately after (Control A: 13 days, control B: 12 days, control C: 13 days, patient D: 12 days, patient E: 8 days, patient F: day 10) and one and four years after treatment. All samples were stored at −70°C until analyzed. This material was part of a larger longitudinal cohort study where the aim was to study eradication of H. pylori using a common treatment regimen [11] (link).
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Publication 2010
Aftercare Antibiotics Clarithromycin Dietary Restriction Duodenal Ulcer Feces Helicobacter pylori Metronidazole Microbicides Omeprazole Patients Pharynx Stomach Treatment Protocols
The PPIs available in Taiwan between 2000 and 2013 and considered in this study included esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole. Patients' prescription histories of PPIs and H2RAs were included in this study. Use of medications was defined as prescription any of the medications studied in this work before the index date. No use of medication was defined as no history of prescription of any of the medications studied in this work before the index date.
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Publication 2017
Esomeprazole Lansoprazole Omeprazole Pantoprazole Patients Pharmaceutical Preparations Prepulse Inhibition Prescription Drugs Rabeprazole

Most recents protocols related to «Omeprazole»

Because both powders for injection were water-soluble, the sample solution was prepared with ultrapure water at the concentration of 200 mg mL−1 for penicillin sodium and 20 mg mL−1 for omeprazole sodium, respectively. Then the sample solution was extracted and eluted following the previously described procedure of the normal saline.
Publication 2023
Normal Saline Omeprazole Penicillins Powder Sodium Sodium-20

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Publication 2023
5-(6)-carboxyfluorescein diacetate succinimidyl ester Amiloride Biological Assay carboxyfluorescein Cells Cell Survival Chlorpromazine Cytotoxin Esters Filipin Flow Cytometry Fluorescent Dyes Homo sapiens inhibitors Mammals Obesity Omeprazole Psychological Inhibition
The PK endpoints included the PK characteristics of each of the probe drugs administered, either as a component of the probe-drug cocktail (midazolam, S-warfarin, R-warfarin, omeprazole) or alone (digoxin), in the absence of BI 425809 in period 1 and on a background of steady-state BI 425809 in period 2. The PK characteristics of interest were area under the concentration-time curve (AUC) of the probe drug in plasma from administration (time t = 0) to the last quantifiable data point (AUC0–tz), the maximum measured concentration of the probe drug in plasma (Cmax), time from dosing to maximum measured concentration of the probe drug in plasma (tmax), and terminal half-life of the probe drug in plasma (t1/2). The attainment of BI 425809 steady state was explored by assessing trough plasma concentration immediately before the next dose (Cpre) on days 8, 9, and 10 in period 2. For BI 425809 at steady state, AUC over a uniform dosing interval (AUCτ,ss), Cmax over a uniform dosing interval (Cmax,ss), and tmax (tmax,ss) were also described. Plasma samples for probe drugs were collected on days 1 to 6 of period 1 and on days 10 to 15 of period 2. Plasma samples for BI 425809 were collected on days 1 to 4, 6, and 8 to 15 of period 2 and at the end-of-trial visit.
Plasma concentrations of BI 425809 and probe drugs were assessed using validated liquid chromatography–tandem mass spectrometry methods (details are shown in Supplementary Table S2, http://links.lww.com/JCP/A836).
Publication 2023
BI 425809 Digoxin Liquid Chromatography Midazolam Omeprazole Pharmaceutical Preparations Plasma Tandem Mass Spectrometry Warfarin
This was a Phase I, open-label, single-sequence crossover study conducted in healthy male participants at the Boehringer Ingelheim Human Pharmacology Center, Biberach, Germany (Clinicaltrials.gov identifier, NCT02783040). The study consisted of 2 treatment periods in a fixed sequence. In period 1, participants received a single dose of a probe-drug cocktail containing midazolam (2 mg), warfarin (10 mg), and omeprazole (20 mg) on day 1 and a single dose of digoxin (0.25 mg) on day 2. Period 1 was followed by a wash-out period of ≥5 days. In period 2, participants received BI 425809 25 mg once daily on days 1 to 14, a single dose of the probe-drug cocktail on day 10, and a single dose of digoxin on day 11. On days 1 and 2 of period 1 and days 10 and 11 of period 2, participants fasted overnight for at least 10 hours before dosing and for 4 hours afterward. All participants attended an end-of-trial visit 11 to 16 days after the last administration of BI 425809.
Publication 2023
Aftercare BI 425809 Digoxin Healthy Volunteers Homo sapiens Males Midazolam Omeprazole Pharmaceutical Preparations Warfarin
The same mice as above were used and subjected to the same acclimatization procedures. Mice were randomly selected from cages for all experiments. Mice were randomly divided into two groups (n = 3), both orally administered with 100 µL Fe‐CDs (2 mg mL−1), and fed after 10 min. Then, one group was orally administered 50 µL Omeprazole (OMG) water solution (20 mg mL−1), and the other group was orally administered 50 µL water. NIR imaging of mice was conducted at different times following feeding. For non‐invasive imaging, all mice were anesthetized using a rodent ventilator with 2 L min−1 air mixed with 4% isoflurane, and imaging was performed at the left lateral aspect of the mouse abdomen. For invasive imaging, mice were sacrificed and dissected along the upper part of the abdomen. The stomach was exposed outside of the abdomen for imaging. For gastric fluid imaging, the excised stomachs were cut open along the greater curvature, excess gastric content was removed, and imaging was performed on the inner wall of the stomach. The excitation source was provided by an 808 nm diode laser with a fluence rate of ≈200 mW cm−2, and the emission signals were collected at 1000 nm with an exposure time of 50 ms. Ratio images were processed using Matlab software, and average ratios were taken from the same region of interest in various images.
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Publication 2023
Abdominal Cavity Acclimatization Isoflurane Lasers, Semiconductor Mice, House Omeprazole Rodent Stomach Stomach Contents

Top products related to «Omeprazole»

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Omeprazole is a proton pump inhibitor (PPI) medication used to reduce gastric acid production. It is a colorless or slightly yellow crystalline powder. Omeprazole functions by inhibiting the H+/K+ ATPase enzyme system in the parietal cells of the stomach, thereby reducing the secretion of gastric acid.
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Phenacetin is a chemical compound used in the manufacturing of various pharmaceutical and laboratory products. It serves as a key ingredient in the production process. Phenacetin has specific functional properties that make it a valuable component in relevant applications, but a detailed description of its core function is beyond the scope of this response.
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DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
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Methanol is a clear, colorless, and flammable liquid that is widely used in various industrial and laboratory applications. It serves as a solvent, fuel, and chemical intermediate. Methanol has a simple chemical formula of CH3OH and a boiling point of 64.7°C. It is a versatile compound that is widely used in the production of other chemicals, as well as in the fuel industry.
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Dextromethorphan is a laboratory chemical compound used as a research tool. It is a dissociative anesthetic and cough suppressant. Dextromethorphan is commonly used in scientific research, but its specific applications and intended uses should not be extrapolated or interpreted beyond its core function as a laboratory product.
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Ketoconazole is a laboratory product manufactured by Merck Group. It is an antifungal agent used for research and development purposes. The core function of Ketoconazole is to inhibit the synthesis of ergosterol, a key component of fungal cell membranes.
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Bupropion is a laboratory equipment product manufactured by Merck Group. It is a chemical compound used in various scientific and research applications. Bupropion is utilized for its specific chemical properties and functions, but a detailed description cannot be provided while maintaining an unbiased and factual approach.
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Midazolam is a benzodiazepine drug used as a sedative and hypnotic. It has a short half-life and is primarily used for the induction of anesthesia, procedural sedation, and the treatment of seizures.
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Rifampicin is a lab equipment product manufactured by Merck Group. It is a chemical compound used in various laboratory applications and research purposes.
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Indomethacin is a laboratory reagent used in various research applications. It is a non-steroidal anti-inflammatory drug (NSAID) that inhibits the production of prostaglandins, which are involved in inflammation and pain. Indomethacin can be used to study the role of prostaglandins in biological processes.

More about "Omeprazole"

Omeprazole, a proton pump inhibitor (PPI), is a widely used medication for the treatment of various acid-related disorders of the gastrointestinal tract, such as gastroesophageal reflux disease (GERD) and peptic ulcers.
This drug works by reducing the production of stomach acid, allowing the damaged esophageal or stomach lining to heal.
Omeprazole has been extensively studied, with research focusing on its pharmacokinetics, efficacy, and safety.
It is a clinically important drug, and its use is often compared to other medications like Phenacetin, DMSO, Methanol, Dextromethorphan, Ketoconazole, Bupropion, Midazolam, Rifampicin, and Indomethacin.
The AI-driven platform PubCompare.ai can enhance the reproducibility and accuracy of Omeprazole research by helping researchers easily locate protocols from the literature, preprints, and patents.
This powerful tool also allows for AI-driven comparisons, enabling researchers to identify the best protocols and products for their Omeprazole studies.
By utilizing PubCompare.ai, researchers can take their Omeprazole research to the next level, benefiting from improved reproducibility, accuracy, and access to a wealth of relevant information.
The platform's features and capabilities can streamline the research process and lead to more robust and reliable findings.